Published in Curr Opin Microbiol on January 28, 2015
The Borrelia burgdorferi RelA/SpoT Homolog and Stringent Response Regulate Survival in the Tick Vector and Global Gene Expression during Starvation. PLoS Pathog (2015) 1.54
Bacterial Signal Transduction by Cyclic Di-GMP and Other Nucleotide Second Messengers. J Bacteriol (2016) 0.93
Growth rate and cell size: a re-examination of the growth law. Curr Opin Microbiol (2015) 0.87
Catalytic mechanism and allosteric regulation of an oligomeric (p)ppGpp synthetase by an alarmone. Proc Natl Acad Sci U S A (2015) 0.87
ComGA-RelA interaction and persistence in the Bacillus subtilis K-state. Mol Microbiol (2015) 0.80
The Complex Relationship between Virulence and Antibiotic Resistance. Genes (Basel) (2017) 0.79
Composition of the outgrowth medium modulates wake-up kinetics and ampicillin sensitivity of stringent and relaxed Escherichia coli. Sci Rep (2016) 0.78
CodY Regulates SigD Levels and Activity by Binding to Three Sites in the fla/che Operon. J Bacteriol (2015) 0.77
Cyclic diguanylate signaling in Gram-positive bacteria. FEMS Microbiol Rev (2016) 0.77
Non-canonical roles of tRNAs and tRNA mimics in bacterial cell biology. Mol Microbiol (2016) 0.77
Dynamical Allocation of Cellular Resources as an Optimal Control Problem: Novel Insights into Microbial Growth Strategies. PLoS Comput Biol (2016) 0.76
Fatty Acid Availability Sets Cell Envelope Capacity and Dictates Microbial Cell Size. Curr Biol (2017) 0.76
Molecular mutagenesis of ppGpp: turning a RelA activator into an inhibitor. Sci Rep (2017) 0.75
Contributions of Sinorhizobium meliloti Transcriptional Regulator DksA to Bacterial Growth and Efficient Symbiosis with Medicago sativa. J Bacteriol (2016) 0.75
Insights on Osmotic Tolerance Mechanisms in Escherichia coli Gained from an rpoC Mutation. Bioengineering (Basel) (2017) 0.75
Sizing up the bacterial cell cycle. Nat Rev Microbiol (2017) 0.75
Toxin ζ Triggers a Survival Response to Cope with Stress and Persistence. Front Microbiol (2017) 0.75
Residual guanosine 3',5'-bispyrophosphate synthetic activity of relA null mutants can be eliminated by spoT null mutations. J Biol Chem (1991) 6.66
(p)ppGpp: still magical? Annu Rev Microbiol (2008) 5.88
DksA: a critical component of the transcription initiation machinery that potentiates the regulation of rRNA promoters by ppGpp and the initiating NTP. Cell (2004) 3.89
Active starvation responses mediate antibiotic tolerance in biofilms and nutrient-limited bacteria. Science (2011) 3.66
Regulation through the secondary channel--structural framework for ppGpp-DksA synergism during transcription. Cell (2004) 3.39
(p)ppGpp controls bacterial persistence by stochastic induction of toxin-antitoxin activity. Cell (2013) 3.28
Advances in bacterial promoter recognition and its control by factors that do not bind DNA. Nat Rev Microbiol (2008) 3.05
Control of bacterial transcription, translation and replication by (p)ppGpp. Curr Opin Microbiol (2008) 2.91
Response of guanosine 5'-triphosphate concentration to nutritional changes and its significance for Bacillus subtilis sporulation. J Bacteriol (1981) 2.86
Internalization of Salmonella by macrophages induces formation of nonreplicating persisters. Science (2014) 2.84
The global, ppGpp-mediated stringent response to amino acid starvation in Escherichia coli. Mol Microbiol (2008) 2.57
CodY, a global regulator of stationary phase and virulence in Gram-positive bacteria. Curr Opin Microbiol (2005) 2.56
Transcription profiling of the stringent response in Escherichia coli. J Bacteriol (2007) 2.54
RNA polymerase modulators and DNA repair activities resolve conflicts between DNA replication and transcription. Mol Cell (2005) 2.32
Guanosine tetra- and pentaphosphate promote accumulation of inorganic polyphosphate in Escherichia coli. J Biol Chem (1997) 2.27
Molecular mechanisms underlying bacterial persisters. Cell (2014) 2.16
The identity of the transcription +1 position is crucial for changes in gene expression in response to amino acid starvation in Bacillus subtilis. Mol Microbiol (2008) 2.10
YybT is a signaling protein that contains a cyclic dinucleotide phosphodiesterase domain and a GGDEF domain with ATPase activity. J Biol Chem (2009) 2.04
An alternative strategy for bacterial ribosome synthesis: Bacillus subtilis rRNA transcription regulation. EMBO J (2004) 1.96
The magic spot: a ppGpp binding site on E. coli RNA polymerase responsible for regulation of transcription initiation. Mol Cell (2013) 1.80
The Bacillus subtilis sigma(M) regulon and its contribution to cell envelope stress responses. Mol Microbiol (2008) 1.78
The mechanism of E. coli RNA polymerase regulation by ppGpp is suggested by the structure of their complex. Mol Cell (2013) 1.73
The RelA/SpoT homolog (RSH) superfamily: distribution and functional evolution of ppGpp synthetases and hydrolases across the tree of life. PLoS One (2011) 1.70
The mechanism of amino acid control of guanylate and adenylate biosynthesis. J Biol Chem (1971) 1.64
Binding mechanism of metal⋅NTP substrates and stringent-response alarmones to bacterial DnaG-type primases. Structure (2012) 1.64
Structural and functional insights into the mode of action of a universally conserved Obg GTPase. PLoS Biol (2014) 1.60
The transcription factor DksA prevents conflicts between DNA replication and transcription machinery. Cell (2010) 1.60
Broad-spectrum anti-biofilm peptide that targets a cellular stress response. PLoS Pathog (2014) 1.58
Direct regulation of Escherichia coli ribosomal protein promoters by the transcription factors ppGpp and DksA. Proc Natl Acad Sci U S A (2011) 1.56
The structure of CodY, a GTP- and isoleucine-responsive regulator of stationary phase and virulence in gram-positive bacteria. J Biol Chem (2006) 1.54
Molecular mechanism of bacterial persistence by HipA. Mol Cell (2013) 1.48
Interaction of Bacillus subtilis CodY with GTP. J Bacteriol (2007) 1.45
Still looking for the magic spot: the crystallographically defined binding site for ppGpp on RNA polymerase is unlikely to be responsible for rRNA transcription regulation. J Mol Biol (2008) 1.44
Differential regulation by ppGpp versus pppGpp in Escherichia coli. Nucleic Acids Res (2013) 1.43
Direct regulation of GTP homeostasis by (p)ppGpp: a critical component of viability and stress resistance. Mol Cell (2012) 1.37
ppGpp is the major source of growth rate control in E. coli. Environ Microbiol (2010) 1.36
The molecular alarmone (p)ppGpp mediates stress responses, vancomycin tolerance, and virulence in Enterococcus faecalis. J Bacteriol (2009) 1.35
The stringent response and cell cycle arrest in Escherichia coli. PLoS Genet (2008) 1.33
DksA and ppGpp directly regulate transcription of the Escherichia coli flagellar cascade. Mol Microbiol (2009) 1.29
Role of the (p)ppGpp synthase RSH, a RelA/SpoT homolog, in stringent response and virulence of Staphylococcus aureus. Infect Immun (2010) 1.29
Role of RelA of Streptococcus mutans in global control of gene expression. J Bacteriol (2007) 1.25
Direct interactions between the coiled-coil tip of DksA and the trigger loop of RNA polymerase mediate transcriptional regulation. Genes Dev (2012) 1.25
Linkage between the bacterial acid stress and stringent responses: the structure of the inducible lysine decarboxylase. EMBO J (2011) 1.16
Relacin, a novel antibacterial agent targeting the Stringent Response. PLoS Pathog (2012) 1.14
Whole-genome sequencing reveals a link between β-lactam resistance and synthetases of the alarmone (p)ppGpp in Staphylococcus aureus. Microb Drug Resist (2013) 1.14
Physiological analysis of the stringent response elicited in an extreme thermophilic bacterium, Thermus thermophilus. J Bacteriol (2006) 1.07
A metazoan ortholog of SpoT hydrolyzes ppGpp and functions in starvation responses. Nat Struct Mol Biol (2010) 1.06
Molecular mechanisms underlying the positive stringent response of the Bacillus subtilis ilv-leu operon, involved in the biosynthesis of branched-chain amino acids. J Bacteriol (2008) 1.05
Probing teichoic acid genetics with bioactive molecules reveals new interactions among diverse processes in bacterial cell wall biogenesis. Chem Biol (2009) 1.04
Two small (p)ppGpp synthases in Staphylococcus aureus mediate tolerance against cell envelope stress conditions. J Bacteriol (2013) 1.04
Role of a Zn-independent DksA in Zn homeostasis and stringent response. Mol Microbiol (2010) 1.02
Effects of guanosine 3',5'-bisdiphosphate (ppGpp) on rate of transcription elongation in isoleucine-starved Escherichia coli. J Biol Chem (1994) 1.01
Dissecting complex metabolic integration provides direct genetic evidence for CodY activation by guanine nucleotides. J Bacteriol (2011) 1.00
Positive allosteric feedback regulation of the stringent response enzyme RelA by its product. EMBO Rep (2012) 0.99
The stringent response controls catalases in Pseudomonas aeruginosa and is required for hydrogen peroxide and antibiotic tolerance. J Bacteriol (2013) 0.99
Thermodynamic characterization of ppGpp binding to EF-G or IF2 and of initiator tRNA binding to free IF2 in the presence of GDP, GTP, or ppGpp. J Mol Biol (2010) 0.98
DksA guards elongating RNA polymerase against ribosome-stalling-induced arrest. Mol Cell (2014) 0.97
The mechanism of heterogeneous beta-lactam resistance in MRSA: key role of the stringent stress response. PLoS One (2013) 0.97
GTP dysregulation in Bacillus subtilis cells lacking (p)ppGpp results in phenotypic amino acid auxotrophy and failure to adapt to nutrient downshift and regulate biosynthesis genes. J Bacteriol (2013) 0.95
Dose-dependent reduction of replication elongation rate by (p)ppGpp in Escherichia coli and Bacillus subtilis. Mol Microbiol (2013) 0.95
The ribosome triggers the stringent response by RelA via a highly distorted tRNA. EMBO Rep (2013) 0.95
Basal levels of (p)ppGpp in Enterococcus faecalis: the magic beyond the stringent response. MBio (2013) 0.92
MS_RHII-RSD, a dual-function RNase HII-(p)ppGpp synthetase from Mycobacterium smegmatis. J Bacteriol (2012) 0.91
Global transcriptional analysis of the stringent response in Enterococcus faecalis. Microbiology (2012) 0.91
Molecular mechanism and evolution of guanylate kinase regulation by (p)ppGpp. Mol Cell (2015) 0.89
Transcription of the Escherichia coli fatty acid synthesis operon fabHDG is directly activated by FadR and inhibited by ppGpp. J Bacteriol (2013) 0.88
Different effects of ppGpp on Escherichia coli DNA replication in vivo and in vitro. FEBS Open Bio (2013) 0.85
Lowering GTP level increases survival of amino acid starvation but slows growth rate for Bacillus subtilis cells lacking (p)ppGpp. J Bacteriol (2014) 0.84
Dependence of RelA-mediated (p)ppGpp formation on tRNA identity. Biochemistry (2011) 0.84
Role of toxin ζ and starvation responses in the sensitivity to antimicrobials. PLoS One (2014) 0.80
A Rhodobacter sphaeroides protein mechanistically similar to Escherichia coli DksA regulates photosynthetic growth. MBio (2014) 0.80
Stringent response processes suppress DNA damage sensitivity caused by deficiency in full-length translation initiation factor 2 or PriA helicase. Mol Microbiol (2014) 0.79
Molecular mechanism and evolution of guanylate kinase regulation by (p)ppGpp. Mol Cell (2015) 0.89