Gene expression in transformed lymphocytes reveals variation in endomembrane and HLA pathways modifying cystic fibrosis pulmonary phenotypes.

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Published in Am J Hum Genet on January 29, 2015

Authors

Wanda K O'Neal1, Paul Gallins2, Rhonda G Pace3, Hong Dang3, Whitney E Wolf3, Lisa C Jones3, XueLiang Guo3, Yi-Hui Zhou4, Vered Madar5, Jinyan Huang6, Liming Liang7, Miriam F Moffatt8, Garry R Cutting9, Mitchell L Drumm10, Johanna M Rommens11, Lisa J Strug12, Wei Sun13, Jaclyn R Stonebraker3, Fred A Wright14, Michael R Knowles3

Author Affiliations

1: Marsico Lung Institute/UNC CF Research Center, School of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA. Electronic address: wanda_o'neal@med.unc.edu.
2: Department of Genetics, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA.
3: Marsico Lung Institute/UNC CF Research Center, School of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA.
4: Bioinformatics Research Center and Department of Statistics, North Carolina State University, Raleigh, NC 27695, USA.
5: Department of Biostatistics, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA.
6: State Key Laboratory of Medical Genomics, Shanghai Institute of Hematology, Rui Jin Hospital affiliated with Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China.
7: Department of Biostatistics, Harvard University, Boston, MA 02115, USA.
8: National Heart and Lung Institute, Imperial College London, London SW7 2AZ, UK.
9: McKusick-Nathans Institute of Genetic Medicine and Department of Pediatrics, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA.
10: Department of Pediatrics, School of Medicine, Case Western Reserve University, Cleveland, OH 44106, USA.
11: Program in Genetics and Genome Biology, The Hospital for Sick Children and Department of Molecular Genetics, University of Toronto, Toronto, ON M5G 1X8, Canada.
12: Program in Child Health Evaluative Sciences, The Hospital for Sick Children, and Division of Biostatistics, Dalla Lana School of Public Health, University of Toronto, ON M5G 1X8, Canada.
13: Department of Genetics, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA; Department of Biostatistics, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA.
14: Bioinformatics Research Center and Department of Statistics, North Carolina State University, Raleigh, NC 27695, USA; Department of Biological Sciences, North Carolina State University, Raleigh, NC 27695, USA.

Associated clinical trials:

Gene Modifiers of Cystic Fibrosis Lung Disease | NCT00037765

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