Published in Nature on March 16, 2008
Association analyses of 249,796 individuals reveal 18 new loci associated with body mass index. Nat Genet (2010) 23.08
Mapping the genetic architecture of gene expression in human liver. PLoS Biol (2008) 19.44
WGCNA: an R package for weighted correlation network analysis. BMC Bioinformatics (2008) 18.58
Twelve type 2 diabetes susceptibility loci identified through large-scale association analysis. Nat Genet (2010) 16.96
Host-microbe interactions have shaped the genetic architecture of inflammatory bowel disease. Nature (2012) 16.13
Genetic mapping in human disease. Science (2008) 15.12
Transcriptome genetics using second generation sequencing in a Caucasian population. Nature (2010) 14.85
Large-scale association analysis identifies 13 new susceptibility loci for coronary artery disease. Nat Genet (2011) 13.25
Genome-wide association yields new sequence variants at seven loci that associate with measures of obesity. Nat Genet (2008) 12.43
Genome-wide association study of blood pressure and hypertension. Nat Genet (2009) 11.54
Common regulatory variation impacts gene expression in a cell type-dependent manner. Science (2009) 11.28
Large-scale association analysis provides insights into the genetic architecture and pathophysiology of type 2 diabetes. Nat Genet (2012) 11.09
The Genotype-Tissue Expression (GTEx) project. Nat Genet (2013) 10.77
Trait-associated SNPs are more likely to be eQTLs: annotation to enhance discovery from GWAS. PLoS Genet (2010) 10.75
High-resolution mapping of expression-QTLs yields insight into human gene regulation. PLoS Genet (2008) 9.68
Genomewide association studies and human disease. N Engl J Med (2009) 9.05
Transcriptome and genome sequencing uncovers functional variation in humans. Nature (2013) 8.89
Genetic studies of body mass index yield new insights for obesity biology. Nature (2015) 8.27
Meta-analysis identifies 13 new loci associated with waist-hip ratio and reveals sexual dimorphism in the genetic basis of fat distribution. Nat Genet (2010) 7.94
Genome-wide association studies: potential next steps on a genetic journey. Hum Mol Genet (2008) 7.54
Genetics and beyond--the transcriptome of human monocytes and disease susceptibility. PLoS One (2010) 7.48
Mapping complex disease traits with global gene expression. Nat Rev Genet (2009) 7.44
Genome-wide association analysis identifies 13 new risk loci for schizophrenia. Nat Genet (2013) 7.44
Parental origin of sequence variants associated with complex diseases. Nature (2009) 7.21
Mapping cis- and trans-regulatory effects across multiple tissues in twins. Nat Genet (2012) 6.97
Eosinophils sustain adipose alternatively activated macrophages associated with glucose homeostasis. Science (2011) 6.83
Inflammatory links between obesity and metabolic disease. J Clin Invest (2011) 6.73
Sequence variant on 8q24 confers susceptibility to urinary bladder cancer. Nat Genet (2008) 6.69
Computational solutions to large-scale data management and analysis. Nat Rev Genet (2010) 6.58
Needles in stacks of needles: finding disease-causal variants in a wealth of genomic data. Nat Rev Genet (2011) 6.52
Genome-wide methylation profiles reveal quantitative views of human aging rates. Mol Cell (2012) 6.50
The architecture of gene regulatory variation across multiple human tissues: the MuTHER study. PLoS Genet (2011) 5.95
Revealing the architecture of gene regulation: the promise of eQTL studies. Trends Genet (2008) 5.78
The cellular and signaling networks linking the immune system and metabolism in disease. Nat Med (2012) 5.63
Genome-wide meta-analysis identifies 56 bone mineral density loci and reveals 14 loci associated with risk of fracture. Nat Genet (2012) 5.48
Systems genetics of complex traits in Drosophila melanogaster. Nat Genet (2009) 5.41
Patterns of cis regulatory variation in diverse human populations. PLoS Genet (2012) 5.28
Candidate causal regulatory effects by integration of expression QTLs with complex trait genetic associations. PLoS Genet (2010) 4.95
Global patterns of cis variation in human cells revealed by high-density allelic expression analysis. Nat Genet (2009) 4.72
Genetic architecture of quantitative traits in mice, flies, and humans. Genome Res (2009) 4.62
Integrated systems approach identifies genetic nodes and networks in late-onset Alzheimer's disease. Cell (2013) 4.45
Digital RNA allelotyping reveals tissue-specific and allele-specific gene expression in human. Nat Methods (2009) 4.38
The PhenX Toolkit: get the most from your measures. Am J Epidemiol (2011) 4.19
Genetics of human gene expression: mapping DNA variants that influence gene expression. Nat Rev Genet (2009) 4.05
NF-κB, inflammation, and metabolic disease. Cell Metab (2011) 4.00
Systems medicine: the future of medical genomics and healthcare. Genome Med (2009) 3.85
Progress and promise of genome-wide association studies for human complex trait genetics. Genetics (2010) 3.81
A high-resolution association mapping panel for the dissection of complex traits in mice. Genome Res (2010) 3.81
Genetics of gene expression in primary immune cells identifies cell type-specific master regulators and roles of HLA alleles. Nat Genet (2012) 3.77
Human genome sequencing in health and disease. Annu Rev Med (2012) 3.76
Liver and adipose expression associated SNPs are enriched for association to type 2 diabetes. PLoS Genet (2010) 3.75
Trans-eQTLs reveal that independent genetic variants associated with a complex phenotype converge on intermediate genes, with a major role for the HLA. PLoS Genet (2011) 3.65
Integrating pathway analysis and genetics of gene expression for genome-wide association studies. Am J Hum Genet (2010) 3.63
Thirty new loci for age at menarche identified by a meta-analysis of genome-wide association studies. Nat Genet (2010) 3.37
Molecular pathology of age-related macular degeneration. Prog Retin Eye Res (2008) 3.35
Genetic control of human brain transcript expression in Alzheimer disease. Am J Hum Genet (2009) 3.35
Several common variants modulate heart rate, PR interval and QRS duration. Nat Genet (2010) 3.34
Genome-wide meta-analysis identifies 11 new loci for anthropometric traits and provides insights into genetic architecture. Nat Genet (2013) 3.25
A Bayesian framework to account for complex non-genetic factors in gene expression levels greatly increases power in eQTL studies. PLoS Comput Biol (2010) 3.23
Identification of an imprinted master trans regulator at the KLF14 locus related to multiple metabolic phenotypes. Nat Genet (2011) 3.20
Genome-wide association study identifies loci influencing concentrations of liver enzymes in plasma. Nat Genet (2011) 3.18
Innate immune activity conditions the effect of regulatory variants upon monocyte gene expression. Science (2014) 3.16
Targeted screening of cis-regulatory variation in human haplotypes. Genome Res (2008) 3.10
Interpreting noncoding genetic variation in complex traits and human disease. Nat Biotechnol (2012) 3.01
A survey of the genetics of stomach, liver, and adipose gene expression from a morbidly obese cohort. Genome Res (2011) 3.00
Validation of candidate causal genes for obesity that affect shared metabolic pathways and networks. Nat Genet (2009) 2.97
A network view of disease and compound screening. Nat Rev Drug Discov (2009) 2.90
Genetic correction of PSA values using sequence variants associated with PSA levels. Sci Transl Med (2010) 2.83
A robust approach to identifying tissue-specific gene expression regulatory variants using personalized human induced pluripotent stem cells. PLoS Genet (2009) 2.78
Characterizing the genetic basis of transcriptome diversity through RNA-sequencing of 922 individuals. Genome Res (2013) 2.77
Common variants near CAV1 and CAV2 are associated with primary open-angle glaucoma. Nat Genet (2010) 2.75
Genetic variation near IRS1 associates with reduced adiposity and an impaired metabolic profile. Nat Genet (2011) 2.73
Genome-wide allele-specific analysis: insights into regulatory variation. Nat Rev Genet (2010) 2.68
Genetical genomics: spotlight on QTL hotspots. PLoS Genet (2008) 2.63
Transcriptional regulatory circuits: predicting numbers from alphabets. Science (2009) 2.61
Genome-wide association study identifies sequence variants on 6q21 associated with age at menarche. Nat Genet (2009) 2.58
A sequence variant at 4p16.3 confers susceptibility to urinary bladder cancer. Nat Genet (2010) 2.56
Allele-specific chromatin remodeling in the ZPBP2/GSDMB/ORMDL3 locus associated with the risk of asthma and autoimmune disease. Am J Hum Genet (2009) 2.56
Integrative eQTL-based analyses reveal the biology of breast cancer risk loci. Cell (2013) 2.56
Evaluation of the 8q24 prostate cancer risk locus and MYC expression. Cancer Res (2009) 2.54
Single-tissue and cross-tissue heritability of gene expression via identity-by-descent in related or unrelated individuals. PLoS Genet (2011) 2.53
Dissecting the regulatory architecture of gene expression QTLs. Genome Biol (2012) 2.51
Bayesian method to predict individual SNP genotypes from gene expression data. Nat Genet (2012) 2.50
Metabolic syndrome: from epidemiology to systems biology. Nat Rev Genet (2008) 2.49
An integration of genome-wide association study and gene expression profiling to prioritize the discovery of novel susceptibility Loci for osteoporosis-related traits. PLoS Genet (2010) 2.43
New insights into the genetic control of gene expression using a Bayesian multi-tissue approach. PLoS Comput Biol (2010) 2.43
Polymorphic cis- and trans-regulation of human gene expression. PLoS Biol (2010) 2.42
Geographical genomics of human leukocyte gene expression variation in southern Morocco. Nat Genet (2009) 2.38
Iron behaving badly: inappropriate iron chelation as a major contributor to the aetiology of vascular and other progressive inflammatory and degenerative diseases. BMC Med Genomics (2009) 2.36
Statistical estimation of correlated genome associations to a quantitative trait network. PLoS Genet (2009) 2.34
Stratifying type 2 diabetes cases by BMI identifies genetic risk variants in LAMA1 and enrichment for risk variants in lean compared to obese cases. PLoS Genet (2012) 2.34
Unraveling the regulatory mechanisms underlying tissue-dependent genetic variation of gene expression. PLoS Genet (2012) 2.29
Genetic variability in the regulation of gene expression in ten regions of the human brain. Nat Neurosci (2014) 2.23
Brain expression genome-wide association study (eGWAS) identifies human disease-associated variants. PLoS Genet (2012) 2.23
Mass-spectrometry-based metabolomics: limitations and recommendations for future progress with particular focus on nutrition research. Metabolomics (2009) 2.21
Epigenetic epidemiology of common complex disease: prospects for prediction, prevention, and treatment. PLoS Med (2010) 2.20
Population genomics in a disease targeted primary cell model. Genome Res (2009) 2.20
System-wide molecular evidence for phenotypic buffering in Arabidopsis. Nat Genet (2009) 2.20
Metabonomic, transcriptomic, and genomic variation of a population cohort. Mol Syst Biol (2010) 2.17
Temperature stress mediates decanalization and dominance of gene expression in Drosophila melanogaster. PLoS Genet (2015) 2.14
Finding the missing heritability of complex diseases. Nature (2009) 67.95
Dabigatran versus warfarin in patients with atrial fibrillation. N Engl J Med (2009) 39.97
Meta-analysis of genome-wide association data and large-scale replication identifies additional susceptibility loci for type 2 diabetes. Nat Genet (2008) 35.06
A high-resolution recombination map of the human genome. Nat Genet (2002) 28.66
Biological, clinical and population relevance of 95 loci for blood lipids. Nature (2010) 28.21
Genome-wide atlas of gene expression in the adult mouse brain. Nature (2006) 28.02
Apixaban versus warfarin in patients with atrial fibrillation. N Engl J Med (2011) 23.50
Association analyses of 249,796 individuals reveal 18 new loci associated with body mass index. Nat Genet (2010) 23.08
Genetics of gene expression surveyed in maize, mouse and man. Nature (2003) 22.17
Common variants at 30 loci contribute to polygenic dyslipidemia. Nat Genet (2008) 20.66
Large recurrent microdeletions associated with schizophrenia. Nature (2008) 20.25
Hundreds of variants clustered in genomic loci and biological pathways affect human height. Nature (2010) 20.01
Association between microdeletion and microduplication at 16p11.2 and autism. N Engl J Med (2008) 19.71
Mapping the genetic architecture of gene expression in human liver. PLoS Biol (2008) 19.44
Genome-wide association study identifies a second prostate cancer susceptibility variant at 8q24. Nat Genet (2007) 19.18
Variant of transcription factor 7-like 2 (TCF7L2) gene confers risk of type 2 diabetes. Nat Genet (2006) 19.03
A common variant on chromosome 9p21 affects the risk of myocardial infarction. Science (2007) 18.96
New genetic loci implicated in fasting glucose homeostasis and their impact on type 2 diabetes risk. Nat Genet (2010) 17.89
Twelve type 2 diabetes susceptibility loci identified through large-scale association analysis. Nat Genet (2010) 16.96
Genome-wide survey of human alternative pre-mRNA splicing with exon junction microarrays. Science (2003) 16.80
Host-microbe interactions have shaped the genetic architecture of inflammatory bowel disease. Nature (2012) 16.13
Missing heritability and strategies for finding the underlying causes of complex disease. Nat Rev Genet (2010) 14.81
A common inversion under selection in Europeans. Nat Genet (2005) 13.66
A common variant associated with prostate cancer in European and African populations. Nat Genet (2006) 13.47