Published in Front Microbiol on January 22, 2015
NIH Image to ImageJ: 25 years of image analysis. Nat Methods (2012) 84.41
Jalview Version 2--a multiple sequence alignment editor and analysis workbench. Bioinformatics (2009) 31.84
Membrane protein folding and stability: physical principles. Annu Rev Biophys Biomol Struct (1999) 10.13
Blue native PAGE. Nat Protoc (2006) 8.04
Hydrophobicity of amino acid residues in globular proteins. Science (1985) 5.64
Crystal structures of a multidrug transporter reveal a functionally rotating mechanism. Nature (2006) 5.35
Structural asymmetry of AcrB trimer suggests a peristaltic pump mechanism. Science (2006) 4.21
Multidrug resistance mechanisms: drug efflux across two membranes. Mol Microbiol (2000) 3.71
Substrate specificity of the RND-type multidrug efflux pumps AcrB and AcrD of Escherichia coli is determined predominantly by two large periplasmic loops. J Bacteriol (2002) 2.98
Microscale fluorescent thermal stability assay for membrane proteins. Structure (2008) 2.95
Drug export pathway of multidrug exporter AcrB revealed by DARPin inhibitors. PLoS Biol (2007) 2.89
Mechanisms of RND multidrug efflux pumps. Biochim Biophys Acta (2008) 2.60
AcrA, AcrB, and TolC of Escherichia coli Form a Stable Intermembrane Multidrug Efflux Complex. J Biol Chem (2004) 2.48
Broad-specificity efflux pumps and their role in multidrug resistance of Gram-negative bacteria. FEMS Microbiol Rev (2011) 2.46
A periplasmic drug-binding site of the AcrB multidrug efflux pump: a crystallographic and site-directed mutagenesis study. J Bacteriol (2005) 2.35
Cross-linked complex between oligomeric periplasmic lipoprotein AcrA and the inner-membrane-associated multidrug efflux pump AcrB from Escherichia coli. J Bacteriol (2000) 2.17
Structures of the multidrug exporter AcrB reveal a proximal multisite drug-binding pocket. Nature (2011) 1.89
Three's company: component structures bring a closer view of tripartite drug efflux pumps. Curr Opin Struct Biol (2004) 1.84
Engineered disulfide bonds support the functional rotation mechanism of multidrug efflux pump AcrB. Nat Struct Mol Biol (2008) 1.81
Structure, function and inhibition of RND efflux pumps in Gram-negative bacteria: an update. Curr Opin Microbiol (2009) 1.79
Drug transport mechanism of the AcrB efflux pump. Biochim Biophys Acta (2009) 1.76
Transport of drugs by the multidrug transporter AcrB involves an access and a deep binding pocket that are separated by a switch-loop. Proc Natl Acad Sci U S A (2012) 1.66
Conformation of the AcrB multidrug efflux pump in mutants of the putative proton relay pathway. J Bacteriol (2006) 1.66
Structure of the AcrAB-TolC multidrug efflux pump. Nature (2014) 1.66
Differential impact of MexB mutations on substrate selectivity of the MexAB-OprM multidrug efflux pump of Pseudomonas aeruginosa. J Bacteriol (2004) 1.54
Mechanism of recognition of compounds of diverse structures by the multidrug efflux pump AcrB of Escherichia coli. Proc Natl Acad Sci U S A (2010) 1.54
Covalently linked trimer of the AcrB multidrug efflux pump provides support for the functional rotating mechanism. J Bacteriol (2008) 1.45
Optimized Nile Red efflux assay of AcrAB-TolC multidrug efflux system shows competition between substrates. Antimicrob Agents Chemother (2010) 1.30
Multidrug binding properties of the AcrB efflux pump characterized by molecular dynamics simulations. Proc Natl Acad Sci U S A (2012) 1.25
Substrate path in the AcrB multidrug efflux pump of Escherichia coli. Mol Microbiol (2010) 1.24
Vestibules are part of the substrate path in the multidrug efflux transporter AcrB of Escherichia coli. J Bacteriol (2011) 1.04
Coupling of remote alternating-access transport mechanisms for protons and substrates in the multidrug efflux pump AcrB. Elife (2014) 1.04
Protein intrinsic disorder and oligomericity in cell signaling. Mol Biosyst (2009) 0.99
Structural and functional aspects of the multidrug efflux pump AcrB. Biol Chem (2009) 0.92
Assembly and channel opening of outer membrane protein in tripartite drug efflux pumps of Gram-negative bacteria. J Biol Chem (2012) 0.90
Some ligands enhance the efflux of other ligands by the Escherichia coli multidrug pump AcrB. Biochemistry (2013) 0.88
Folding of AcrB Subunit Precedes Trimerization. J Mol Biol (2011) 0.88
Understanding cytokine and growth factor receptor activation mechanisms. Crit Rev Biochem Mol Biol (2012) 0.88
β-Lactam selectivity of multidrug transporters AcrB and AcrD resides in the proximal binding pocket. J Biol Chem (2014) 0.85
AcrB trimer stability and efflux activity, insight from mutagenesis studies. PLoS One (2011) 0.83
Functional relevance of AcrB Trimerization in pump assembly and substrate binding. PLoS One (2014) 0.79