Published in J Bacteriol on October 01, 2005
Clinically relevant chromosomally encoded multidrug resistance efflux pumps in bacteria. Clin Microbiol Rev (2006) 4.77
Efflux-mediated drug resistance in bacteria: an update. Drugs (2009) 3.18
Drug export pathway of multidrug exporter AcrB revealed by DARPin inhibitors. PLoS Biol (2007) 2.89
Mechanisms of RND multidrug efflux pumps. Biochim Biophys Acta (2008) 2.60
Broad-specificity efflux pumps and their role in multidrug resistance of Gram-negative bacteria. FEMS Microbiol Rev (2011) 2.46
Structures of the multidrug exporter AcrB reveal a proximal multisite drug-binding pocket. Nature (2011) 1.89
The challenge of efflux-mediated antibiotic resistance in Gram-negative bacteria. Clin Microbiol Rev (2015) 1.81
Crystal structures of the CusA efflux pump suggest methionine-mediated metal transport. Nature (2010) 1.76
Transport of drugs by the multidrug transporter AcrB involves an access and a deep binding pocket that are separated by a switch-loop. Proc Natl Acad Sci U S A (2012) 1.66
Conformation of the AcrB multidrug efflux pump in mutants of the putative proton relay pathway. J Bacteriol (2006) 1.66
Crystal structure of the CusBA heavy-metal efflux complex of Escherichia coli. Nature (2011) 1.56
Mechanism of recognition of compounds of diverse structures by the multidrug efflux pump AcrB of Escherichia coli. Proc Natl Acad Sci U S A (2010) 1.54
Bypass of genetic constraints during mutator evolution to antibiotic resistance. Proc Biol Sci (2015) 1.44
Direct metal transfer between periplasmic proteins identifies a bacterial copper chaperone. Biochemistry (2008) 1.44
Site-directed disulfide cross-linking shows that cleft flexibility in the periplasmic domain is needed for the multidrug efflux pump AcrB of Escherichia coli. J Bacteriol (2007) 1.39
Threonine-978 in the transmembrane segment of the multidrug efflux pump AcrB of Escherichia coli is crucial for drug transport as a probable component of the proton relay network. J Bacteriol (2006) 1.31
Assembly and transport mechanism of tripartite drug efflux systems. Biochim Biophys Acta (2009) 1.31
Structural basis for the inhibition of bacterial multidrug exporters. Nature (2013) 1.31
Structure and mechanism of RND-type multidrug efflux pumps. Adv Enzymol Relat Areas Mol Biol (2011) 1.30
Efflux pump, the masked side of beta-lactam resistance in Klebsiella pneumoniae clinical isolates. PLoS One (2009) 1.27
Multidrug binding properties of the AcrB efflux pump characterized by molecular dynamics simulations. Proc Natl Acad Sci U S A (2012) 1.25
Substrate path in the AcrB multidrug efflux pump of Escherichia coli. Mol Microbiol (2010) 1.24
Fitting periplasmic membrane fusion proteins to inner membrane transporters: mutations that enable Escherichia coli AcrA to function with Pseudomonas aeruginosa MexB. J Bacteriol (2007) 1.19
The efflux inhibitor phenylalanine-arginine beta-naphthylamide (PAβN) permeabilizes the outer membrane of gram-negative bacteria. PLoS One (2013) 1.18
Substrate competition studies using whole-cell accumulation assays with the major tripartite multidrug efflux pumps of Escherichia coli. Antimicrob Agents Chemother (2007) 1.14
Switch or funnel: how RND-type transport systems control periplasmic metal homeostasis. J Bacteriol (2011) 1.13
Crystal structure of the Campylobacter jejuni CmeC outer membrane channel. Protein Sci (2014) 1.13
Mutations in the central cavity and periplasmic domain affect efflux activity of the resistance-nodulation-division pump EmhB from Pseudomonas fluorescens cLP6a. J Bacteriol (2006) 1.10
Recent advances toward a molecular mechanism of efflux pump inhibition. Front Microbiol (2015) 1.08
Bacterial multidrug efflux transporters. Annu Rev Biophys (2014) 1.08
Ligand-transporter interaction in the AcrB multidrug efflux pump determined by fluorescence polarization assay. FEBS Lett (2007) 1.05
Molecular mechanism of MBX2319 inhibition of Escherichia coli AcrB multidrug efflux pump and comparison with other inhibitors. Antimicrob Agents Chemother (2014) 1.05
Vestibules are part of the substrate path in the multidrug efflux transporter AcrB of Escherichia coli. J Bacteriol (2011) 1.04
The Cus efflux system removes toxic ions via a methionine shuttle. Protein Sci (2011) 1.04
Site-directed mutagenesis reveals amino acid residues in the Escherichia coli RND efflux pump AcrB that confer macrolide resistance. Antimicrob Agents Chemother (2008) 1.03
Crystal structure of the multidrug efflux transporter AcrB at 3.1A resolution reveals the N-terminal region with conserved amino acids. J Struct Biol (2006) 1.03
Multicomponent drug efflux complexes: architecture and mechanism of assembly. Future Microbiol (2009) 1.02
Identification of MrtAB, an ABC transporter specifically required for Yersinia pseudotuberculosis to colonize the mesenteric lymph nodes. PLoS Pathog (2012) 1.02
Mechanisms of drug resistance: quinolone resistance. Ann N Y Acad Sci (2015) 1.00
Structure and mechanism of the tripartite CusCBA heavy-metal efflux complex. Philos Trans R Soc Lond B Biol Sci (2012) 0.97
Dynamics of the trimeric AcrB transporter protein inferred from a B-factor analysis of the crystal structure. Proteins (2006) 0.95
Drug-induced conformational changes in multidrug efflux transporter AcrB from Haemophilus influenzae. J Bacteriol (2007) 0.93
Characterization of the RND family of multidrug efflux pumps: in silico to in vivo confirmation of four functionally distinct subgroups. Microb Biotechnol (2010) 0.91
Physiological responses of Pseudomonas putida to formaldehyde during detoxification. Microb Biotechnol (2008) 0.90
Efflux in Acinetobacter baumannii can be determined by measuring accumulation of H33342 (bis-benzamide). J Antimicrob Chemother (2013) 0.89
Structural basis of RND-type multidrug exporters. Front Microbiol (2015) 0.88
Crystal structures of CusC review conformational changes accompanying folding and transmembrane channel formation. J Mol Biol (2013) 0.88
Some ligands enhance the efflux of other ligands by the Escherichia coli multidrug pump AcrB. Biochemistry (2013) 0.88
Molecular Dynamics Computer Simulations of Multidrug RND Efflux Pumps. Comput Struct Biotechnol J (2013) 0.87
Crystal structure of AcrB complexed with linezolid at 3.5 Å resolution. J Struct Funct Genomics (2013) 0.87
Crystal structure of the open state of the Neisseria gonorrhoeae MtrE outer membrane channel. PLoS One (2014) 0.86
Yersinia pestis AcrAB-TolC in antibiotic resistance and virulence. Antimicrob Agents Chemother (2011) 0.86
New antibiotic molecules: bypassing the membrane barrier of gram negative bacteria increases the activity of peptide deformylase inhibitors. PLoS One (2009) 0.86
Exploring the HME and HAE1 efflux systems in the genus Burkholderia. BMC Evol Biol (2010) 0.85
Crystal structure of the Neisseria gonorrhoeae MtrD inner membrane multidrug efflux pump. PLoS One (2014) 0.84
Structural mechanisms of heavy-metal extrusion by the Cus efflux system. Biometals (2013) 0.82
Single nucleotide polymorphism analysis of the major tripartite multidrug efflux pump of Escherichia coli: functional conservation in disparate animal reservoirs despite exposure to antimicrobial chemotherapy. Antimicrob Agents Chemother (2009) 0.82
Different functions of MdtB and MdtC subunits in the heterotrimeric efflux transporter MdtB(2)C complex of Escherichia coli. Biochemistry (2012) 0.82
MexY-promoted aminoglycoside resistance in Pseudomonas aeruginosa: involvement of a putative proximal binding pocket in aminoglycoside recognition. MBio (2014) 0.81
Functional relevance of AcrB Trimerization in pump assembly and substrate binding. PLoS One (2014) 0.79
Interplay between two RND systems mediating antimicrobial resistance in Brucella suis. J Bacteriol (2009) 0.79
Stepwise substrate translocation mechanism revealed by free energy calculations of doxorubicin in the multidrug transporter AcrB. Sci Rep (2015) 0.77
Occurrence of efflux mechanism and cephalosporinase variant in a population of Enterobacter aerogenes and Klebsiella pneumoniae isolates producing extended-spectrum beta-lactamases. Antimicrob Agents Chemother (2009) 0.77
Mutagenesis and modeling to predict structural and functional characteristics of the Staphylococcus aureus MepA multidrug efflux pump. J Bacteriol (2012) 0.77
Computational analysis of structure-based interactions and ligand properties can predict efflux effects on antibiotics. Eur J Med Chem (2012) 0.76
Heavy metal transport by the CusCFBA efflux system. Protein Sci (2015) 0.76
Repressive mutations restore function-loss caused by the disruption of trimerization in Escherichia coli multidrug transporter AcrB. Front Microbiol (2015) 0.75
Basic local alignment search tool. J Mol Biol (1990) 659.07
Refinement of macromolecular structures by the maximum-likelihood method. Acta Crystallogr D Biol Crystallogr (1997) 137.43
Improved methods for building protein models in electron density maps and the location of errors in these models. Acta Crystallogr A (1991) 119.63
Free R value: a novel statistical quantity for assessing the accuracy of crystal structures. Nature (1992) 36.50
Over-production of proteins in Escherichia coli: mutant hosts that allow synthesis of some membrane proteins and globular proteins at high levels. J Mol Biol (1996) 13.17
Genes acrA and acrB encode a stress-induced efflux system of Escherichia coli. Mol Microbiol (1995) 8.41
An approach to multi-copy search in molecular replacement. Acta Crystallogr D Biol Crystallogr (2000) 7.78
Crystal structure of the bacterial membrane protein TolC central to multidrug efflux and protein export. Nature (2000) 7.30
Crystal structure of bacterial multidrug efflux transporter AcrB. Nature (2002) 6.47
Molecular cloning and characterization of acrA and acrE genes of Escherichia coli. J Bacteriol (1993) 6.24
Evidence that TolC is required for functioning of the Mar/AcrAB efflux pump of Escherichia coli. J Bacteriol (1996) 5.58
Analysis of a complete library of putative drug transporter genes in Escherichia coli. J Bacteriol (2001) 4.69
The RND permease superfamily: an ancient, ubiquitous and diverse family that includes human disease and development proteins. J Mol Microbiol Biotechnol (1999) 4.64
Antibiotic susceptibility profiles of Escherichia coli strains lacking multidrug efflux pump genes. Antimicrob Agents Chemother (2001) 3.87
Antibiotic resistance caused by gram-negative multidrug efflux pumps. Clin Infect Dis (1998) 3.85
Structural basis of multiple drug-binding capacity of the AcrB multidrug efflux pump. Science (2003) 3.64
Bypassing the periplasm: reconstitution of the AcrAB multidrug efflux pump of Escherichia coli. Proc Natl Acad Sci U S A (1999) 3.53
The human nuclear xenobiotic receptor PXR: structural determinants of directed promiscuity. Science (2001) 3.27
Structural mechanisms of QacR induction and multidrug recognition. Science (2001) 3.10
The kamikaze approach to membrane transport. Nat Rev Mol Cell Biol (2001) 3.09
Substrate specificity of the RND-type multidrug efflux pumps AcrB and AcrD of Escherichia coli is determined predominantly by two large periplasmic loops. J Bacteriol (2002) 2.98
Crystal structure of the membrane fusion protein, MexA, of the multidrug transporter in Pseudomonas aeruginosa. J Biol Chem (2004) 2.74
Structure of the periplasmic component of a bacterial drug efflux pump. Proc Natl Acad Sci U S A (2004) 2.66
Role of outer membrane barrier in efflux-mediated tetracycline resistance of Escherichia coli. J Bacteriol (1995) 2.52
AcrA, AcrB, and TolC of Escherichia coli Form a Stable Intermembrane Multidrug Efflux Complex. J Biol Chem (2004) 2.48
Chimeric analysis of the multicomponent multidrug efflux transporters from gram-negative bacteria. J Bacteriol (2002) 2.38
Cross-linked complex between oligomeric periplasmic lipoprotein AcrA and the inner-membrane-associated multidrug efflux pump AcrB from Escherichia coli. J Bacteriol (2000) 2.17
Purification and characterization of the membrane-associated components of the maltose transport system from Escherichia coli. J Biol Chem (1991) 2.16
Inhibitors of efflux pumps in Pseudomonas aeruginosa potentiate the activity of the fluoroquinolone antibacterial levofloxacin. J Med Chem (1999) 2.10
Evidence for two nonidentical drug-interaction sites in the human P-glycoprotein. Proc Natl Acad Sci U S A (1997) 2.10
Interactions underlying assembly of the Escherichia coli AcrAB-TolC multidrug efflux system. Mol Microbiol (2004) 2.07
A bacterial antibiotic-resistance gene that complements the human multidrug-resistance P-glycoprotein gene. Nature (1998) 2.05
Structural basis of multidrug recognition by BmrR, a transcription activator of a multidrug transporter. Cell (1999) 1.95
Anticancer drugs, ionophoric peptides, and steroids as substrates of the yeast multidrug transporter Pdr5p. J Biol Chem (1996) 1.79
On the mechanism of substrate specificity by resistance nodulation division (RND)-type multidrug resistance pumps: the large periplasmic loops of MexD from Pseudomonas aeruginosa are involved in substrate recognition. Mol Microbiol (2002) 1.77
AcrB multidrug efflux pump of Escherichia coli: composite substrate-binding cavity of exceptional flexibility generates its extremely wide substrate specificity. J Bacteriol (2003) 1.62
Structural mechanisms of multidrug recognition and regulation by bacterial multidrug transcription factors. Mol Microbiol (2002) 1.59
Bioenergetics of the staphylococcal multidrug export protein QacA. Identification of distinct binding sites for monovalent and divalent cations. J Biol Chem (1999) 1.57
Identification of essential charged residues in transmembrane segments of the multidrug transporter MexB of Pseudomonas aeruginosa. J Bacteriol (2001) 1.55
Differential impact of MexB mutations on substrate selectivity of the MexAB-OprM multidrug efflux pump of Pseudomonas aeruginosa. J Bacteriol (2004) 1.54
Structural mechanism of the simultaneous binding of two drugs to a multidrug-binding protein. EMBO J (2004) 1.47
An elegant means of self-protection in gram-negative bacteria by recognizing and extruding xenobiotics from the periplasmic space. J Biol Chem (2002) 1.30
The secondary multidrug transporter LmrP contains multiple drug interaction sites. Biochemistry (1999) 1.28
Contributions of MexAB-OprM and an EmrE homolog to intrinsic resistance of Pseudomonas aeruginosa to aminoglycosides and dyes. Antimicrob Agents Chemother (2003) 1.25
Extramembrane central pore of multidrug exporter AcrB in Escherichia coli plays an important role in drug transport. J Biol Chem (2003) 1.23
Crystal structures of QacR-diamidine complexes reveal additional multidrug-binding modes and a novel mechanism of drug charge neutralization. J Biol Chem (2004) 1.22
Mystery of multidrug transporters: the answer can be simple. Mol Microbiol (2002) 1.18
Complexes of porcine odorant binding protein with odorant molecules belonging to different chemical classes. J Mol Biol (2000) 1.09
Amino acid residues essential for function of the MexF efflux pump protein of Pseudomonas aeruginosa. Antimicrob Agents Chemother (2002) 0.84
Efflux-mediated drug resistance in bacteria. Drugs (2004) 3.90
Structural basis of multiple drug-binding capacity of the AcrB multidrug efflux pump. Science (2003) 3.64
Efflux-mediated drug resistance in bacteria: an update. Drugs (2009) 3.18
Substrate specificity of the RND-type multidrug efflux pumps AcrB and AcrD of Escherichia coli is determined predominantly by two large periplasmic loops. J Bacteriol (2002) 2.98
The baeSR two-component regulatory system activates transcription of the yegMNOB (mdtABCD) transporter gene cluster in Escherichia coli and increases its resistance to novobiocin and deoxycholate. J Bacteriol (2002) 2.46
Bile salts and fatty acids induce the expression of Escherichia coli AcrAB multidrug efflux pump through their interaction with Rob regulatory protein. Mol Microbiol (2003) 2.18
Structure of the Nogo receptor ectodomain: a recognition module implicated in myelin inhibition. Neuron (2003) 2.06
Regulation of Salmonella typhimurium virulence gene expression by cationic antimicrobial peptides. Mol Microbiol (2003) 2.01
X-ray tomography of whole cells. Curr Opin Struct Biol (2005) 1.87
The structure of Escherichia coli cytosine deaminase. J Mol Biol (2002) 1.81
Quantitative 3-D imaging of eukaryotic cells using soft X-ray tomography. J Struct Biol (2008) 1.79
Aminoglycosides are captured from both periplasm and cytoplasm by the AcrD multidrug efflux transporter of Escherichia coli. J Bacteriol (2005) 1.78
PhoPQ-mediated regulation produces a more robust permeability barrier in the outer membrane of Salmonella enterica serovar typhimurium. J Bacteriol (2007) 1.70
Conformation of the AcrB multidrug efflux pump in mutants of the putative proton relay pathway. J Bacteriol (2006) 1.66
Efflux pump-mediated intrinsic drug resistance in Mycobacterium smegmatis. Antimicrob Agents Chemother (2004) 1.63
AcrB multidrug efflux pump of Escherichia coli: composite substrate-binding cavity of exceptional flexibility generates its extremely wide substrate specificity. J Bacteriol (2003) 1.62
Kinetic behavior of the major multidrug efflux pump AcrB of Escherichia coli. Proc Natl Acad Sci U S A (2009) 1.55
Mechanism of recognition of compounds of diverse structures by the multidrug efflux pump AcrB of Escherichia coli. Proc Natl Acad Sci U S A (2010) 1.54
Chimeric analysis of AcrA function reveals the importance of its C-terminal domain in its interaction with the AcrB multidrug efflux pump. J Bacteriol (2003) 1.53
Export of autotransported proteins proceeds through an oligomeric ring shaped by C-terminal domains. EMBO J (2002) 1.50
Covalently linked trimer of the AcrB multidrug efflux pump provides support for the functional rotating mechanism. J Bacteriol (2008) 1.45
Soft X-ray tomography of phenotypic switching and the cellular response to antifungal peptoids in Candida albicans. Proc Natl Acad Sci U S A (2009) 1.41
Site-directed disulfide cross-linking shows that cleft flexibility in the periplasmic domain is needed for the multidrug efflux pump AcrB of Escherichia coli. J Bacteriol (2007) 1.39
Threonine-978 in the transmembrane segment of the multidrug efflux pump AcrB of Escherichia coli is crucial for drug transport as a probable component of the proton relay network. J Bacteriol (2006) 1.31
Optimized Nile Red efflux assay of AcrAB-TolC multidrug efflux system shows competition between substrates. Antimicrob Agents Chemother (2010) 1.30
Quantitative analysis of yeast internal architecture using soft X-ray tomography. Yeast (2010) 1.30
Kinetic parameters of efflux of penicillins by the multidrug efflux transporter AcrAB-TolC of Escherichia coli. Antimicrob Agents Chemother (2010) 1.30
Crystal structure of the transcriptional regulator CmeR from Campylobacter jejuni. J Mol Biol (2007) 1.28
Multidrug binding properties of the AcrB efflux pump characterized by molecular dynamics simulations. Proc Natl Acad Sci U S A (2012) 1.25
Contributions of MexAB-OprM and an EmrE homolog to intrinsic resistance of Pseudomonas aeruginosa to aminoglycosides and dyes. Antimicrob Agents Chemother (2003) 1.25
Substrate path in the AcrB multidrug efflux pump of Escherichia coli. Mol Microbiol (2010) 1.24
Pseudomonas aeruginosa porin OprF exists in two different conformations. J Biol Chem (2006) 1.22
Structural and functional analyses of the major outer membrane protein of Chlamydia trachomatis. J Bacteriol (2007) 1.21
Crystal structure of the transcriptional regulator AcrR from Escherichia coli. J Mol Biol (2007) 1.21
OmpA is the principal nonspecific slow porin of Acinetobacter baumannii. J Bacteriol (2012) 1.09
The C-terminal domain of Salmonella enterica serovar typhimurium OmpA is an immunodominant antigen in mice but appears to be only partially exposed on the bacterial cell surface. Infect Immun (2003) 1.09
Pseudomonas aeruginosa porin OprF: properties of the channel. J Biol Chem (2006) 1.06
Crystal structures of RAE-1beta and its complex with the activating immunoreceptor NKG2D. Immunity (2002) 1.06
Ligand-transporter interaction in the AcrB multidrug efflux pump determined by fluorescence polarization assay. FEBS Lett (2007) 1.05
Vestibules are part of the substrate path in the multidrug efflux transporter AcrB of Escherichia coli. J Bacteriol (2011) 1.04
3D structure of AcrB: the archetypal multidrug efflux transporter of Escherichia coli likely captures substrates from periplasm. Drug Resist Updat (2003) 1.02
Permeation rates of penicillins indicate that Escherichia coli porins function principally as nonspecific channels. Proc Natl Acad Sci U S A (2013) 1.02
It takes three to tango. Nat Biotechnol (2002) 0.96
Multidrug efflux pump MdtBC of Escherichia coli is active only as a B2C heterotrimer. J Bacteriol (2009) 0.96
Nanoimaging cells using soft X-ray tomography. Methods Mol Biol (2013) 0.96
The structure of Escherichia coli ATP-phosphoribosyltransferase: identification of substrate binding sites and mode of AMP inhibition. J Mol Biol (2004) 0.96
Characterization of a novel pyranopyridine inhibitor of the AcrAB efflux pump of Escherichia coli. Antimicrob Agents Chemother (2013) 0.95
Mycobacterial outer membrane is a lipid bilayer and the inner membrane is unusually rich in diacyl phosphatidylinositol dimannosides. Proc Natl Acad Sci U S A (2014) 0.93
Factors affecting the folding of Pseudomonas aeruginosa OprF porin into the one-domain open conformer. MBio (2010) 0.90
Some ligands enhance the efflux of other ligands by the Escherichia coli multidrug pump AcrB. Biochemistry (2013) 0.88
Quantitative lipid composition of cell envelopes of Corynebacterium glutamicum elucidated through reverse micelle extraction. Proc Natl Acad Sci U S A (2011) 0.88
Putting molecules in their place. J Cell Biochem (2014) 0.88
Alternative folding pathways of the major porin OprF of Pseudomonas aeruginosa. FEBS J (2012) 0.85
Correlative microscopy methods that maximize specimen fidelity and data completeness, and improve molecular localization capabilities. J Struct Biol (2013) 0.85
Cloning, expression, purification, crystallization and preliminary X-ray diffraction analysis of the regulator AcrR from Escherichia coli. Acta Crystallogr Sect F Struct Biol Cryst Commun (2006) 0.85
Site-directed disulfide cross-linking to probe conformational changes of a transporter during its functional cycle: Escherichia coli AcrB multidrug exporter as an example. Methods Mol Biol (2010) 0.84
Different functions of MdtB and MdtC subunits in the heterotrimeric efflux transporter MdtB(2)C complex of Escherichia coli. Biochemistry (2012) 0.82
Preliminary structural studies of the transcriptional regulator CmeR from Campylobacter jejuni. Acta Crystallogr Sect F Struct Biol Cryst Commun (2006) 0.81
Conformational change of the AcrR regulator reveals a possible mechanism of induction. Acta Crystallogr Sect F Struct Biol Cryst Commun (2008) 0.81
Crystallization and preliminary X-ray diffraction analysis of the multidrug efflux transporter NorM from Neisseria gonorrhoeae. Acta Crystallogr Sect F Struct Biol Cryst Commun (2008) 0.78
In Pseudomonas aeruginosa ethidium bromide does not induce its own degradation or the assembly of pumps involved in its efflux. Biochem Biophys Res Commun (2004) 0.76
Christian Raetz: scientist and friend extraordinaire. Annu Rev Biochem (2013) 0.75