AAV-expressed eCD4-Ig provides durable protection from multiple SHIV challenges.

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Published in Nature on February 18, 2015

Authors

Matthew R Gardner1, Lisa M Kattenhorn2, Hema R Kondur1, Markus von Schaewen3, Tatyana Dorfman1, Jessica J Chiang2, Kevin G Haworth4, Julie M Decker5, Michael D Alpert6, Charles C Bailey1, Ernest S Neale2, Christoph H Fellinger1, Vinita R Joshi1, Sebastian P Fuchs7, Jose M Martinez-Navio7, Brian D Quinlan1, Annie Y Yao2, Hugo Mouquet8, Jason Gorman9, Baoshan Zhang9, Pascal Poignard10, Michel C Nussenzweig11, Dennis R Burton12, Peter D Kwong9, Michael Piatak13, Jeffrey D Lifson13, Guangping Gao14, Ronald C Desrosiers15, David T Evans16, Beatrice H Hahn5, Alexander Ploss3, Paula M Cannon4, Michael S Seaman17, Michael Farzan1

Author Affiliations

1: Department of Infectious Diseases, The Scripps Research Institute, Jupiter, Florida 33458, USA.
2: Department of Comparative Pathology, Harvard Medical School, New England Primate Research Center, Southborough, Massachusetts 01772, USA.
3: Department of Molecular Biology, Princeton University, Princeton, New Jersey 08544, USA.
4: Department of Molecular Microbiology and Immunology, Keck School of Medicine of the University of Southern California, Los Angeles, California 90033, USA.
5: Departments of Medicine and Microbiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA.
6: 1] Department of Comparative Pathology, Harvard Medical School, New England Primate Research Center, Southborough, Massachusetts 01772, USA [2] Immunathon Inc., Cambridge, Massachusetts 02141, USA.
7: Department of Pathology, University of Miami Miller School of Medicine, Miami, Florida 33136, USA.
8: 1] Laboratory of Molecular Immunology, The Rockefeller University, New York, New York 10065, USA [2] Department of Immunology, Institut Pasteur, Paris, 75015, France.
9: Vaccine Research Center, National Institutes of Health, Bethesda, Maryland 20892, USA.
10: Department of Immunology and Microbial Science, IAVI Neutralizing Antibody Center, and Center for HIV/AIDS Vaccine Immunology and Immunogen Discovery, The Scripps Research Institute, La Jolla, California 92037, USA.
11: 1] Laboratory of Molecular Immunology, The Rockefeller University, New York, New York 10065, USA [2] Howard Hughes Medical Institute, New York, New York 10065, USA.
12: 1] Department of Immunology and Microbial Science, IAVI Neutralizing Antibody Center, and Center for HIV/AIDS Vaccine Immunology and Immunogen Discovery, The Scripps Research Institute, La Jolla, California 92037, USA [2] Ragon Institute of MGH, MIT and Harvard, Cambridge, Massachusetts 02139, USA.
13: AIDS and Cancer Virus Program, Leidos Biomedical Research, Incorporated, Frederick National Laboratory for Cancer Research, Frederick, Maryland 21702, USA.
14: Gene Therapy Center, University of Massachusetts Medical School, Worcester, Massachusetts 01655, USA.
15: 1] Department of Comparative Pathology, Harvard Medical School, New England Primate Research Center, Southborough, Massachusetts 01772, USA [2] Department of Pathology, University of Miami Miller School of Medicine, Miami, Florida 33136, USA.
16: Department of Pathology and Laboratory Medicine, University of Wisconsin, Madison, Wisconsin 53711, USA.
17: Beth Israel Deaconess Medical Center, Boston, Massachusetts 02215, USA.

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