Published in Science on February 27, 2015
CRISPR Inversion of CTCF Sites Alters Genome Topology and Enhancer/Promoter Function. Cell (2015) 2.59
3D Chromosome Regulatory Landscape of Human Pluripotent Cells. Cell Stem Cell (2015) 1.81
Formation of Chromosomal Domains by Loop Extrusion. Cell Rep (2016) 1.60
The Shh Topological Domain Facilitates the Action of Remote Enhancers by Reducing the Effects of Genomic Distances. Dev Cell (2016) 1.45
CTCF/cohesin-binding sites are frequently mutated in cancer. Nat Genet (2015) 1.36
The interplay of histone modifications - writers that read. EMBO Rep (2015) 1.15
An Overview of Genome Organization and How We Got There: from FISH to Hi-C. Microbiol Mol Biol Rev (2015) 1.10
Bipartite structure of the inactive mouse X chromosome. Genome Biol (2015) 1.10
Analysis methods for studying the 3D architecture of the genome. Genome Biol (2015) 1.09
Editing DNA Methylation in the Mammalian Genome. Cell (2016) 1.04
Organization and function of the 3D genome. Nat Rev Genet (2016) 1.03
Chromatin Domains: The Unit of Chromosome Organization. Mol Cell (2016) 1.02
A collagen VI-dependent pathogenic mechanism for Hirschsprung's disease. J Clin Invest (2015) 1.00
Regulation of gene transcription by Polycomb proteins. Sci Adv (2015) 0.99
CTCF: making the right connections. Genes Dev (2016) 0.97
Getting the genome in shape: the formation of loops, domains and compartments. Genome Biol (2015) 0.96
Insulated Neighborhoods: Structural and Functional Units of Mammalian Gene Control. Cell (2016) 0.91
The second decade of 3C technologies: detailed insights into nuclear organization. Genes Dev (2016) 0.91
Targeted Degradation of CTCF Decouples Local Insulation of Chromosome Domains from Genomic Compartmentalization. Cell (2017) 0.90
Pan-cancer analysis of somatic copy-number alterations implicates IRS4 and IGF2 in enhancer hijacking. Nat Genet (2016) 0.89
Quantification of Retinogenesis in 3D Cultures Reveals Epigenetic Memory and Higher Efficiency in iPSCs Derived from Rod Photoreceptors. Cell Stem Cell (2015) 0.89
Differential contribution of cis-regulatory elements to higher order chromatin structure and expression of the CFTR locus. Nucleic Acids Res (2015) 0.88
Breaking TADs: insights into hierarchical genome organization. Epigenomics (2015) 0.88
Architectural proteins, transcription, and the three-dimensional organization of the genome. FEBS Lett (2015) 0.87
A new class of temporarily phenotypic enhancers identified by CRISPR/Cas9-mediated genetic screening. Genome Res (2016) 0.85
CTCF-mediated topological boundaries during development foster appropriate gene regulation. Genes Dev (2016) 0.85
Identification of multi-loci hubs from 4C-seq demonstrates the functional importance of simultaneous interactions. Nucleic Acids Res (2016) 0.84
TAD disruption as oncogenic driver. Curr Opin Genet Dev (2016) 0.84
Long-Range Regulation of V(D)J Recombination. Adv Immunol (2015) 0.84
DNA replication origins-where do we begin? Genes Dev (2016) 0.83
The TDH-GCN5L1-Fbxo15-KBP axis limits mitochondrial biogenesis in mouse embryonic stem cells. Nat Cell Biol (2017) 0.83
Regulatory networks of non-coding RNAs in brown/beige adipogenesis. Biosci Rep (2015) 0.82
Polycomb Repressive Complex 1 Generates Discrete Compacted Domains that Change during Differentiation. Mol Cell (2017) 0.82
Ever-Changing Landscapes: Transcriptional Enhancers in Development and Evolution. Cell (2016) 0.82
Effects on the transcriptome upon deletion of a distal element cannot be predicted by the size of the H3K27Ac peak in human cells. Nucleic Acids Res (2016) 0.80
Topoisomerase II beta interacts with cohesin and CTCF at topological domain borders. Genome Biol (2016) 0.80
Regulation of disease-associated gene expression in the 3D genome. Nat Rev Mol Cell Biol (2016) 0.80
Co-repressor CBFA2T2 regulates pluripotency and germline development. Nature (2016) 0.79
Tissue-specific CTCF-cohesin-mediated chromatin architecture delimits enhancer interactions and function in vivo. Nat Cell Biol (2017) 0.79
The retrovirus HTLV-1 inserts an ectopic CTCF-binding site into the human genome. Proc Natl Acad Sci U S A (2016) 0.79
Strategies for precision modulation of gene expression by epigenome editing: an overview. Epigenetics Chromatin (2015) 0.79
Integration of Signaling Pathways with the Epigenetic Machinery in the Maintenance of Stem Cells. Stem Cells Int (2015) 0.78
Towards a predictive model of chromatin 3D organization. Semin Cell Dev Biol (2015) 0.78
Different enhancer classes in Drosophila bind distinct architectural proteins and mediate unique chromatin interactions and 3D architecture. Nucleic Acids Res (2016) 0.78
Form and function of topologically associating genomic domains in budding yeast. Proc Natl Acad Sci U S A (2017) 0.78
Functional Dissection of the Blocking and Bypass Activities of the Fab-8 Boundary in the Drosophila Bithorax Complex. PLoS Genet (2016) 0.77
The boundary paradox in the Bithorax complex. Mech Dev (2015) 0.77
The cohesin-associated protein Wapal is required for proper Polycomb-mediated gene silencing. Epigenetics Chromatin (2016) 0.76
Barcelona conference on epigenetics and cancer 2015: Coding and non-coding functions of the genome. Epigenetics (2016) 0.76
Applying CRISPR-Cas9 tools to identify and characterize transcriptional enhancers. Nat Rev Mol Cell Biol (2016) 0.76
ISL1 and JMJD3 synergistically control cardiac differentiation of embryonic stem cells. Nucleic Acids Res (2016) 0.76
YY1 and CTCF orchestrate a 3D chromatin looping switch during early neural lineage commitment. Genome Res (2017) 0.76
SET1A/COMPASS and shadow enhancers in the regulation of homeotic gene expression. Genes Dev (2017) 0.76
A CRISPR Connection between Chromatin Topology and Genetic Disorders. Cell (2015) 0.75
Effects of Gene Dose, Chromatin, and Network Topology on Expression in Drosophila melanogaster. PLoS Genet (2016) 0.75
Chromatin Domain Organization of the TCRb Locus and Its Perturbation by Ectopic CTCF Binding. Mol Cell Biol (2017) 0.75
Negative Regulators of an RNAi-Heterochromatin Positive Feedback Loop Safeguard Somatic Genome Integrity in Tetrahymena. Cell Rep (2017) 0.75
Models of global gene expression define major domains of cell type and tissue identity. Nucleic Acids Res (2017) 0.75
The Chromatin Signature of Pluripotency: Establishment and Maintenance. Curr Stem Cell Rep (2016) 0.75
HOXA repression is mediated by nucleoporin Nup93 assisted by its interactors Nup188 and Nup205. Epigenetics Chromatin (2016) 0.75
Chromatin boundary elements organize genomic architecture and developmental gene regulation in Drosophila Hox clusters. World J Biol Chem (2016) 0.75
The BET Protein BRD2 Cooperates with CTCF to Enforce Transcriptional and Architectural Boundaries. Mol Cell (2017) 0.75
The Glucocorticoid Receptor Regulates the ANGPTL4 Gene in a CTCF-Mediated Chromatin Context in Human Hepatic Cells. PLoS One (2017) 0.75
Deciphering the DNA code for the function of the Drosophila polydactyl zinc finger protein Suppressor of Hairy-wing. Nucleic Acids Res (2017) 0.75
Spatial Organization of Epigenomes. Curr Mol Biol Rep (2016) 0.75
Establishment of expression-state boundaries by Rif1 and Taz1 in fission yeast. Proc Natl Acad Sci U S A (2017) 0.75
Functional assessment of CTCF sites at cytokine-sensing mammary enhancers using CRISPR/Cas9 gene editing in mice. Nucleic Acids Res (2017) 0.75
Chromatin organization in pluripotent cells: emerging approaches to study and disrupt function. Brief Funct Genomics (2015) 0.75
Making Sense of the Tangle: Insights into Chromatin Folding and Gene Regulation. Genes (Basel) (2016) 0.75
Regions of very low H3K27me3 partition the Drosophila genome into topological domains. PLoS One (2017) 0.75
Spatial Genome Organization and Its Emerging Role as a Potential Diagnosis Tool. Front Genet (2016) 0.75
Embryonic timing, axial stem cells, chromatin dynamics, and the Hox clock. Genes Dev (2017) 0.75
Intranuclear and higher-order chromatin organization of the major histone gene cluster in breast cancer. J Cell Physiol (2017) 0.75
Computational Prediction of Position Effects of Apparently Balanced Human Chromosomal Rearrangements. Am J Hum Genet (2017) 0.75
The interplay of epigenetic marks during stem cell differentiation and development. Nat Rev Genet (2017) 0.75
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A gene complex controlling segmentation in Drosophila. Nature (1978) 23.75
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Robust 4C-seq data analysis to screen for regulatory DNA interactions. Nat Methods (2012) 2.42
Mutation of a single CTCF target site within the H19 imprinting control region leads to loss of Igf2 imprinting and complex patterns of de novo methylation upon maternal inheritance. Mol Cell Biol (2004) 2.24
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H3K27 modifications define segmental regulatory domains in the Drosophila bithorax complex. Elife (2014) 1.03
Close proximity to Igh is a contributing factor to AID-mediated translocations. Mol Cell (2012) 1.23
Breaking TADs: insights into hierarchical genome organization. Epigenomics (2015) 0.88
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miRNAs Are Essential for the Regulation of the PI3K/AKT/FOXO Pathway and Receptor Editing during B Cell Maturation. Cell Rep (2016) 0.75
Wolf-Hirschhorn Syndrome Candidate 1 Is Necessary for Correct Hematopoietic and B Cell Development. Cell Rep (2017) 0.75