Published in Curr Protoc Cell Biol on March 02, 2015
Definition of a consensus integrin adhesome and its dynamics during adhesion complex assembly and disassembly. Nat Cell Biol (2015) 1.02
Modulation of FAK and Src adhesion signaling occurs independently of adhesion complex composition. J Cell Biol (2016) 0.81
The integrin adhesome network at a glance. J Cell Sci (2016) 0.80
Proteomic analysis of integrin-associated complexes from mesenchymal stem cells. Proteomics Clin Appl (2015) 0.79
Laminin-binding integrin gene copy number alterations in distinct epithelial-type cancers. Am J Transl Res (2016) 0.75
Functional atlas of the integrin adhesome. Nat Cell Biol (2007) 6.89
Analysis of the myosin-II-responsive focal adhesion proteome reveals a role for β-Pix in negative regulation of focal adhesion maturation. Nat Cell Biol (2011) 4.59
β1- and αv-class integrins cooperate to regulate myosin II during rigidity sensing of fibronectin-based microenvironments. Nat Cell Biol (2013) 2.52
Proteomic analysis of integrin-associated complexes identifies RCC2 as a dual regulator of Rac1 and Arf6. Sci Signal (2009) 2.26
Quantitative proteomics of the integrin adhesome show a myosin II-dependent recruitment of LIM domain proteins. EMBO Rep (2011) 1.96
The integrin adhesome: from genes and proteins to human disease. Nat Rev Mol Cell Biol (2014) 1.57
Dynamic regulation of the structure and functions of integrin adhesions. Dev Cell (2013) 1.57
Structure and function of focal adhesions. Curr Opin Cell Biol (2011) 1.38
Preparation of extracellular matrices produced by cultured and primary fibroblasts. Curr Protoc Cell Biol (2007) 1.27
Proteomic analysis of integrin adhesion complexes. Sci Signal (2011) 1.06
Proteomic analysis of α4β1 integrin adhesion complexes reveals α-subunit-dependent protein recruitment. Proteomics (2012) 0.98
Integrin ligands at a glance. J Cell Sci (2006) 4.76
Vinculin controls focal adhesion formation by direct interactions with talin and actin. J Cell Biol (2007) 4.28
Rab25 associates with alpha5beta1 integrin to promote invasive migration in 3D microenvironments. Dev Cell (2007) 3.84
Demonstration of catch bonds between an integrin and its ligand. J Cell Biol (2009) 3.26
Synergistic control of cell adhesion by integrins and syndecans. Nat Rev Mol Cell Biol (2007) 3.21
Integrin structure, activation, and interactions. Cold Spring Harb Perspect Biol (2011) 2.58
Syndecan-4-dependent Rac1 regulation determines directional migration in response to the extracellular matrix. J Cell Biol (2007) 2.33
Proteomic analysis of integrin-associated complexes identifies RCC2 as a dual regulator of Rac1 and Arf6. Sci Signal (2009) 2.26
Neuropilin-1/GIPC1 signaling regulates alpha5beta1 integrin traffic and function in endothelial cells. PLoS Biol (2009) 2.16
Linking integrin conformation to function. J Cell Sci (2009) 2.15
Heparin-II domain of fibronectin is a vascular endothelial growth factor-binding domain: enhancement of VEGF biological activity by a singular growth factor/matrix protein synergism. Circ Res (2006) 2.08
SHARPIN is an endogenous inhibitor of β1-integrin activation. Nat Cell Biol (2011) 2.01
Integrin-specific signaling pathways controlling focal adhesion formation and cell migration. J Cell Biol (2003) 1.90
Fibronectin regulates latent transforming growth factor-beta (TGF beta) by controlling matrix assembly of latent TGF beta-binding protein-1. J Biol Chem (2005) 1.82
Structure of an integrin-ligand complex deduced from solution x-ray scattering and site-directed mutagenesis. J Biol Chem (2003) 1.81
Conformational changes in the integrin beta A domain provide a mechanism for signal transduction via hybrid domain movement. J Biol Chem (2003) 1.80
Anti-integrin monoclonal antibodies. J Cell Sci (2009) 1.72
Fast and accurate search for non-coding RNA pseudoknot structures in genomes. Bioinformatics (2008) 1.69
Integrin activation involves a conformational change in the alpha 1 helix of the beta subunit A-domain. J Biol Chem (2002) 1.65
Quantification of integrin receptor agonism by fluorescence lifetime imaging. J Cell Sci (2008) 1.64
Regulation of alpha5beta1 integrin conformation and function by urokinase receptor binding. J Cell Biol (2005) 1.44
A specific alpha5beta1-integrin conformation promotes directional integrin translocation and fibronectin matrix formation. J Cell Sci (2004) 1.42
p190RhoGAP is the convergence point of adhesion signals from alpha 5 beta 1 integrin and syndecan-4. J Cell Biol (2008) 1.41
Cytoplasmic interactions of syndecan-4 orchestrate adhesion receptor and growth factor receptor signalling. Biochem J (2002) 1.39
Regulation of integrin function through conformational complexity: not simply a knee-jerk reaction? Curr Opin Cell Biol (2004) 1.38
Role of ADMIDAS cation-binding site in ligand recognition by integrin alpha 5 beta 1. J Biol Chem (2003) 1.36
Site-directed perturbation of protein kinase C- integrin interaction blocks carcinoma cell chemotaxis. Mol Cell Biol (2002) 1.35
Cell adhesion to fibrillin-1 molecules and microfibrils is mediated by alpha 5 beta 1 and alpha v beta 3 integrins. J Biol Chem (2003) 1.32
A syndecan-4 hair trigger initiates wound healing through caveolin- and RhoG-regulated integrin endocytosis. Dev Cell (2011) 1.31
Evidence that monoclonal antibodies directed against the integrin beta subunit plexin/semaphorin/integrin domain stimulate function by inducing receptor extension. J Biol Chem (2004) 1.29
Focal adhesions are sites of integrin extension. J Cell Biol (2010) 1.26
Molecular interplay between endostatin, integrins, and heparan sulfate. J Biol Chem (2009) 1.25
Alpha v beta3 integrin spatially regulates VASP and RIAM to control adhesion dynamics and migration. J Cell Biol (2010) 1.24
The integrins of the urochordate Ciona intestinalis provide novel insights into the molecular evolution of the vertebrate integrin family. BMC Evol Biol (2005) 1.23
Fibronectin-tissue transglutaminase matrix rescues RGD-impaired cell adhesion through syndecan-4 and beta1 integrin co-signaling. J Biol Chem (2008) 1.21
Giving off mixed signals--distinct functions of alpha5beta1 and alphavbeta3 integrins in regulating cell behaviour. IUBMB Life (2009) 1.14
Molecular basis for the dynamic strength of the integrin alpha4beta1/VCAM-1 interaction. Biophys J (2004) 1.14
RCP-driven α5β1 recycling suppresses Rac and promotes RhoA activity via the RacGAP1-IQGAP1 complex. J Cell Biol (2013) 1.13
Syndecan-4 phosphorylation is a control point for integrin recycling. Dev Cell (2013) 1.12
Osteoblast mineralization requires beta1 integrin/ICAP-1-dependent fibronectin deposition. J Cell Biol (2011) 1.09
Cell adhesion to fibrillin-1: identification of an Arg-Gly-Asp-dependent synergy region and a heparin-binding site that regulates focal adhesion formation. J Cell Sci (2007) 1.08
Proteomic analysis of integrin adhesion complexes. Sci Signal (2011) 1.06
Interaction of filamin A with the integrin beta 7 cytoplasmic domain: role of alternative splicing and phosphorylation. FEBS Lett (2004) 1.05
Cyclic mechanical reinforcement of integrin-ligand interactions. Mol Cell (2013) 1.05
An integrin-alpha4-14-3-3zeta-paxillin ternary complex mediates localised Cdc42 activity and accelerates cell migration. J Cell Sci (2009) 1.04
Integrin alpha5beta1 and ADAM-17 interact in vitro and co-localize in migrating HeLa cells. J Biol Chem (2004) 1.03
Defining the extracellular matrix using proteomics. Int J Exp Pathol (2013) 1.03
Syndecans shed their reputation as inert molecules. Sci Signal (2009) 1.02
Proteomic analysis of extracellular matrix from the hepatic stellate cell line LX-2 identifies CYR61 and Wnt-5a as novel constituents of fibrotic liver. J Proteome Res (2012) 1.00
Preconditioning injury-induced neurite outgrowth of adult rat sensory neurons on fibronectin is mediated by mobilisation of axonal alpha5 integrin. Mol Cell Neurosci (2007) 1.00
Distinct roles of beta1 metal ion-dependent adhesion site (MIDAS), adjacent to MIDAS (ADMIDAS), and ligand-associated metal-binding site (LIMBS) cation-binding sites in ligand recognition by integrin alpha2beta1. J Biol Chem (2008) 1.00
Novel activating and inactivating mutations in the integrin beta1 subunit A domain. Biochem J (2004) 0.99
Proteomic analysis of α4β1 integrin adhesion complexes reveals α-subunit-dependent protein recruitment. Proteomics (2012) 0.98
Integrin-binding RGD peptides induce rapid intracellular calcium increases and MAPK signaling in cortical neurons. Mol Cell Neurosci (2006) 0.98
Rac1 is deactivated at integrin activation sites through an IQGAP1-filamin-A-RacGAP1 pathway. J Cell Sci (2013) 0.97
Role of adhesion receptor trafficking in 3D cell migration. Curr Opin Cell Biol (2013) 0.97
Divalent cations regulate the folding and activation status of integrins during their intracellular trafficking. J Cell Sci (2011) 0.96
E-cadherin is a ligand for integrin alpha2beta1. Matrix Biol (2002) 0.96
Dual functionality of the anti-beta1 integrin antibody, 12G10, exemplifies agonistic signalling from the ligand binding pocket of integrin adhesion receptors. J Biol Chem (2005) 0.96
Identification of multiple integrin beta1 homologs in zebrafish (Danio rerio). BMC Cell Biol (2006) 0.95
An unraveling tale of how integrins are activated from within. Trends Pharmacol Sci (2003) 0.95
Integrins and syndecan-4 make distinct, but critical, contributions to adhesion contact formation. Soft Matter (2007) 0.95
Alternative splicing of the IIICS domain in fibronectin governs the role of the heparin II domain in fibrillogenesis and cell spreading. J Biol Chem (2002) 0.95
Comparative proteomic analysis of supportive and unsupportive extracellular matrix substrates for human embryonic stem cell maintenance. J Biol Chem (2013) 0.95
Distinct biophysical mechanisms of focal adhesion kinase mechanoactivation by different extracellular matrix proteins. Proc Natl Acad Sci U S A (2013) 0.94
Therapeutic ultrasound bypasses canonical syndecan-4 signaling to activate rac1. J Biol Chem (2009) 0.92
A novel gain-of-function mutation of the integrin alpha2 VWFA domain. Eur J Biochem (2002) 0.92
Activation of beta 1 but not beta 3 integrin increases cell traction forces. FEBS Lett (2013) 0.92
Mapping the ligand-binding pocket of integrin alpha5beta1 using a gain-of-function approach. Biochem J (2009) 0.91
Activation of integrin alpha5beta1 delays apoptosis of Ntera2 neuronal cells. Mol Cell Neurosci (2005) 0.85