Published in Am J Physiol Cell Physiol on March 04, 2015
"TRP inflammation" relationship in cardiovascular system. Semin Immunopathol (2015) 0.78
NOGGIN: a new therapeutic target for PH? Focus on "Noggin inhibits hypoxia-induced proliferation by targeting store-operated calcium entry and transient receptor potential cation channels". Am J Physiol Cell Physiol (2015) 0.76
Altered vasoreactivity in neonatal rats with pulmonary hypertension associated with bronchopulmonary dysplasia: Implication of both eNOS phosphorylation and calcium signaling. PLoS One (2017) 0.75
BMP4 inhibits PDGF-induced proliferation and collagen synthesis via PKA-mediated inhibition of calpain-2 in pulmonary artery smooth muscle cells. Am J Physiol Lung Cell Mol Physiol (2017) 0.75
The Role of Transient Receptor Potential Channel 6 Channels in the Pulmonary Vasculature. Front Immunol (2017) 0.75
A new mathematical model for relative quantification in real-time RT-PCR. Nucleic Acids Res (2001) 124.61
Novel regulators of bone formation: molecular clones and activities. Science (1988) 10.74
Heterozygous germline mutations in BMPR2, encoding a TGF-beta receptor, cause familial primary pulmonary hypertension. Nat Genet (2000) 7.20
Pulmonary arterial hypertension. N Engl J Med (2004) 6.69
The Spemann organizer signal noggin binds and inactivates bone morphogenetic protein 4. Cell (1996) 5.66
The regulation of TGFbeta signal transduction. Development (2009) 4.59
Bone morphogenetic protein receptors and signal transduction. J Biochem (2009) 4.51
Familial primary pulmonary hypertension (gene PPH1) is caused by mutations in the bone morphogenetic protein receptor-II gene. Am J Hum Genet (2000) 4.42
Bone morphogenetic proteins, their antagonists, and the skeleton. Endocr Rev (2003) 3.85
Noggin-mediated antagonism of BMP signaling is required for growth and patterning of the neural tube and somite. Genes Dev (1998) 3.46
Dysfunctional Smad signaling contributes to abnormal smooth muscle cell proliferation in familial pulmonary arterial hypertension. Circ Res (2005) 3.16
The Xenopus dorsalizing factor Gremlin identifies a novel family of secreted proteins that antagonize BMP activities. Mol Cell (1998) 2.89
Hypoxia inducible factor 1 mediates hypoxia-induced TRPC expression and elevated intracellular Ca2+ in pulmonary arterial smooth muscle cells. Circ Res (2006) 2.82
An antiproliferative BMP-2/PPARgamma/apoE axis in human and murine SMCs and its role in pulmonary hypertension. J Clin Invest (2008) 2.71
Direct binding of follistatin to a complex of bone-morphogenetic protein and its receptor inhibits ventral and epidermal cell fates in early Xenopus embryo. Proc Natl Acad Sci U S A (1998) 1.86
Matrix GLA protein, a regulatory protein for bone morphogenetic protein-2. J Biol Chem (2001) 1.72
Biological activity of follistatin isoforms and follistatin-like-3 is dependent on differential cell surface binding and specificity for activin, myostatin, and bone morphogenetic proteins. Endocrinology (2006) 1.71
Capacitative calcium entry and TRPC channel proteins are expressed in rat distal pulmonary arterial smooth muscle. Am J Physiol Lung Cell Mol Physiol (2003) 1.67
Bone morphogenetic proteins in the nervous system. Trends Neurosci (1997) 1.62
Rho/Rho kinase signaling mediates increased basal pulmonary vascular tone in chronically hypoxic rats. Am J Physiol Lung Cell Mol Physiol (2003) 1.61
Bone morphogenetic protein 4 promotes pulmonary vascular remodeling in hypoxic pulmonary hypertension. Circ Res (2005) 1.61
Angiotensin-converting enzyme 2 attenuates oxidative stress and VSMC proliferation via the JAK2/STAT3/SOCS3 and profilin-1/MAPK signaling pathways. Regul Pept (2013) 1.54
Regulation of bone morphogenetic protein-4 by matrix GLA protein in vascular endothelial cells involves activin-like kinase receptor 1. J Biol Chem (2006) 1.43
Differences in STIM1 and TRPC expression in proximal and distal pulmonary arterial smooth muscle are associated with differences in Ca2+ responses to hypoxia. Am J Physiol Lung Cell Mol Physiol (2008) 1.42
Bone morphogenetic protein (BMP) ligands and receptors in bovine ovarian follicle cells: actions of BMP-4, -6 and -7 on granulosa cells and differential modulation of Smad-1 phosphorylation by follistatin. Reproduction (2004) 1.30
Regulation of cell proliferation, apoptosis, and carcinogenesis by activin. Exp Biol Med (Maywood) (2002) 1.26
Matrix Gla protein deficiency causes arteriovenous malformations in mice. J Clin Invest (2011) 1.23
The bone morphogenic protein antagonist gremlin regulates proximal-distal patterning of the lung. Dev Dyn (2001) 1.19
Thrombin regulates vascular smooth muscle cell growth and heat shock proteins via the JAK-STAT pathway. J Biol Chem (2001) 1.18
Lung-selective gene responses to alveolar hypoxia: potential role for the bone morphogenetic antagonist gremlin in pulmonary hypertension. Am J Physiol Lung Cell Mol Physiol (2008) 1.15
Sildenafil inhibits chronically hypoxic upregulation of canonical transient receptor potential expression in rat pulmonary arterial smooth muscle. Am J Physiol Cell Physiol (2009) 1.12
Gremlin plays a key role in the pathogenesis of pulmonary hypertension. Circulation (2012) 1.11
Role of the JAK-STAT pathway in PDGF-stimulated proliferation of human airway smooth muscle cells. Am J Physiol Lung Cell Mol Physiol (2002) 1.09
PDGF-induced human airway smooth muscle cell proliferation requires STAT3 and the small GTPase Rac1. Am J Physiol Lung Cell Mol Physiol (2008) 1.08
Activation of the JAK/STAT pathway in vascular smooth muscle by serotonin. Am J Physiol Cell Physiol (2004) 1.05
Transforming growth factor beta/bone morphogenic protein signaling in pulmonary arterial hypertension: remodeling revisited. Trends Cardiovasc Med (2007) 1.04
Follistatin inhibits the function of the oocyte-derived factor BMP-15. Biochem Biophys Res Commun (2001) 1.02
Gremlin localization and expression levels partially differentiate idiopathic interstitial pneumonia severity and subtype. J Pathol (2008) 1.02
NIP-121 is more effective than nifedipine in acutely reversing chronic pulmonary hypertension. J Appl Physiol (1985) (1993) 0.99
Gremlin promotes vascular smooth muscle cell proliferation and migration. J Mol Cell Cardiol (2007) 0.99
Smad-dependent and smad-independent induction of id1 by prostacyclin analogues inhibits proliferation of pulmonary artery smooth muscle cells in vitro and in vivo. Circ Res (2010) 0.97
Bone morphogenetic protein 4 enhances canonical transient receptor potential expression, store-operated Ca2+ entry, and basal [Ca2+]i in rat distal pulmonary arterial smooth muscle cells. Am J Physiol Cell Physiol (2010) 0.96
Sildenafil inhibits hypoxia-induced transient receptor potential canonical protein expression in pulmonary arterial smooth muscle via cGMP-PKG-PPARγ axis. Am J Respir Cell Mol Biol (2013) 0.92
BMP4 increases canonical transient receptor potential protein expression by activating p38 MAPK and ERK1/2 signaling pathways in pulmonary arterial smooth muscle cells. Am J Respir Cell Mol Biol (2013) 0.87
Mobilization of intracellular Ca(2+) by endothelin-1 in rat intrapulmonary arterial smooth muscle cells. Am J Physiol Lung Cell Mol Physiol (2000) 0.87
Elevated levels of activin A in clinical and experimental pulmonary hypertension. J Appl Physiol (1985) (2009) 0.83
Calcium homeostasis and sensitization in pulmonary arterial smooth muscle. Microcirculation (2014) 0.82
NOGGIN: a new therapeutic target for PH? Focus on "Noggin inhibits hypoxia-induced proliferation by targeting store-operated calcium entry and transient receptor potential cation channels". Am J Physiol Cell Physiol (2015) 0.76
Deletion of Gremlin1 increases cell proliferation and migration responses in mouse embryonic fibroblasts. Cell Signal (2011) 0.76