Published in Circulation on September 04, 2007
Effects of disturbed flow on vascular endothelium: pathophysiological basis and clinical perspectives. Physiol Rev (2011) 5.51
Partial carotid ligation is a model of acutely induced disturbed flow, leading to rapid endothelial dysfunction and atherosclerosis. Am J Physiol Heart Circ Physiol (2009) 3.11
Discovery of novel mechanosensitive genes in vivo using mouse carotid artery endothelium exposed to disturbed flow. Blood (2010) 2.23
Anti-inflammatory and antiatherogenic role of BMP receptor II in endothelial cells. Arterioscler Thromb Vasc Biol (2013) 1.78
Activation of vascular bone morphogenetic protein signaling in diabetes mellitus. Circ Res (2010) 1.58
A role for the endothelium in vascular calcification. Circ Res (2013) 1.47
Mechanosensitive PPAP2B Regulates Endothelial Responses to Atherorelevant Hemodynamic Forces. Circ Res (2015) 1.45
Target accessibility and signal specificity in live-cell detection of BMP-4 mRNA using molecular beacons. Nucleic Acids Res (2008) 1.44
The regulation of valvular and vascular sclerosis by osteogenic morphogens. Circ Res (2011) 1.29
Elevated cyclic stretch induces aortic valve calcification in a bone morphogenic protein-dependent manner. Am J Pathol (2010) 1.29
BMP signaling in vascular development and disease. Cytokine Growth Factor Rev (2010) 1.26
High-density lipoproteins affect endothelial BMP-signaling by modulating expression of the activin-like kinase receptor 1 and 2. Arterioscler Thromb Vasc Biol (2008) 1.20
HuR regulates the expression of stress-sensitive genes and mediates inflammatory response in human umbilical vein endothelial cells. Proc Natl Acad Sci U S A (2010) 1.11
Heat shock protein 70 enhances vascular bone morphogenetic protein-4 signaling by binding matrix Gla protein. Circ Res (2009) 1.09
Differential proinflammatory and prooxidant effects of bone morphogenetic protein-4 in coronary and pulmonary arterial endothelial cells. Am J Physiol Heart Circ Physiol (2008) 1.08
Cellular mechanisms of aortic valve calcification. Circ Cardiovasc Interv (2012) 1.03
Biomechanical factors in atherosclerosis: mechanisms and clinical implications. Eur Heart J (2014) 1.03
Force-specific activation of Smad1/5 regulates vascular endothelial cell cycle progression in response to disturbed flow. Proc Natl Acad Sci U S A (2012) 1.03
Hemodynamic forces, vascular oxidative stress, and regulation of BMP-2/4 expression. Antioxid Redox Signal (2009) 1.02
Animal, in vitro, and ex vivo models of flow-dependent atherosclerosis: role of oxidative stress. Antioxid Redox Signal (2010) 0.97
Bioinformatic identification and characterization of human endothelial cell-restricted genes. BMC Genomics (2010) 0.95
Circulating Bmp10 acts through endothelial Alk1 to mediate flow-dependent arterial quiescence. Development (2013) 0.94
Preferential activation of SMAD1/5/8 on the fibrosa endothelium in calcified human aortic valves--association with low BMP antagonists and SMAD6. PLoS One (2011) 0.93
Bmper inhibits endothelial expression of inflammatory adhesion molecules and protects against atherosclerosis. Arterioscler Thromb Vasc Biol (2012) 0.88
Distinct functionalities of bone morphogenetic protein antagonists during fracture healing in mice. J Anat (2010) 0.87
Regional and cellular localisation of BMPs and their inhibitors' expression in human fractures. Int Orthop (2008) 0.87
In vitro and In vivo imaging of antivasculogenesis induced by Noggin protein expression in human venous endothelial cells. FASEB J (2009) 0.85
The Interaction between Fluid Wall Shear Stress and Solid Circumferential Strain Affects Endothelial Gene Expression. PLoS One (2015) 0.84
Gremlin-1 is an inhibitor of macrophage migration inhibitory factor and attenuates atherosclerotic plaque growth in ApoE-/- Mice. J Biol Chem (2013) 0.84
Noggin inhibits hypoxia-induced proliferation by targeting store-operated calcium entry and transient receptor potential cation channels. Am J Physiol Cell Physiol (2015) 0.83
Concise review: applying stem cell biology to vascular structures. Stem Cells (2012) 0.82
BMP4 is increased in the aortas of diabetic ApoE knockout mice and enhances uptake of oxidized low density lipoprotein into peritoneal macrophages. J Inflamm (Lond) (2013) 0.80
The bone morphogenic protein inhibitor, noggin, reduces glycemia and vascular inflammation in db/db mice. Am J Physiol Heart Circ Physiol (2013) 0.79
The association of matrix Gla protein isomers with calcification in capsules surrounding silicone breast implants. Biomaterials (2011) 0.79
The role of endothelial mechanosensitive genes in atherosclerosis and omics approaches. Arch Biochem Biophys (2015) 0.78
Endothelium-derived bone morphogenic protein antagonists may counteract the proatherogenic vascular effects of bone morphogenic protein 4. Circulation (2007) 0.78
Disturbed flow enhances inflammatory signaling and atherogenesis by increasing thioredoxin-1 level in endothelial cell nuclei. PLoS One (2014) 0.78
Shear-Sensitive Genes in Aortic Valve Endothelium. Antioxid Redox Signal (2016) 0.77
Circulating follistatin in patients with chronic kidney disease: implications for muscle strength, bone mineral density, inflammation, and survival. Clin J Am Soc Nephrol (2011) 0.76
Bone Morphogenetic Protein-Modulator BMPER Regulates Endothelial Barrier Function. Inflammation (2017) 0.76
Serum Bone Morphogenic Protein-4 Contributes to Discriminating Coronary Artery Disease Severity. Medicine (Baltimore) (2015) 0.75
Whole-Exome Sequencing to Identify Novel Biological Pathways Associated With Infertility After Pelvic Inflammatory Disease. Sex Transm Dis (2017) 0.75
Overexpression of follistatin in the mouse epididymis disrupts fluid resorption and sperm transit in testicular excurrent ducts. Biol Reprod (2012) 0.75
Venous Endothelial Marker COUP-TFII Regulates the Distinct Pathologic Potentials of Adult Arteries and Veins. Sci Rep (2015) 0.75
Blood Brothers: Hemodynamics and Cell-Matrix Interactions in Endothelial Function. Antioxid Redox Signal (2016) 0.75
Regulators and effectors of bone morphogenetic protein signalling in the cardiovascular system. J Physiol (2015) 0.75
Not at random location of atherosclerotic lesions in thoracic aorta and their prognostic significance in relation to the risk of cardiovascular events. Pol J Radiol (2013) 0.75
Orthotopic expression of noggin protein in cancer cells inhibits human lung carcinoma growth in vivo. Mol Imaging Biol (2012) 0.75
Remodeling of rat pulmonary artery induced by chronic smoking exposure. J Thorac Dis (2014) 0.75
Endothelial BMP4 Regulates Leukocyte Diapedesis and Promotes Inflammation. Inflammation (2017) 0.75
Mechanical Activation of Hypoxia-Inducible Factor 1α Drives Endothelial Dysfunction at Atheroprone Sites. Arterioscler Thromb Vasc Biol (2017) 0.75
Superoxide production and expression of nox family proteins in human atherosclerosis. Circulation (2002) 3.95
Role of p47(phox) in vascular oxidative stress and hypertension caused by angiotensin II. Hypertension (2002) 3.23
Nox1 overexpression potentiates angiotensin II-induced hypertension and vascular smooth muscle hypertrophy in transgenic mice. Circulation (2005) 3.12
Partial carotid ligation is a model of acutely induced disturbed flow, leading to rapid endothelial dysfunction and atherosclerosis. Am J Physiol Heart Circ Physiol (2009) 3.11
Shear stress stimulates phosphorylation of endothelial nitric-oxide synthase at Ser1179 by Akt-independent mechanisms: role of protein kinase A. J Biol Chem (2001) 2.52
Quantitative microcomputed tomography analysis of collateral vessel development after ischemic injury. Am J Physiol Heart Circ Physiol (2004) 2.38
Hemodynamic shear stresses in mouse aortas: implications for atherogenesis. Arterioscler Thromb Vasc Biol (2006) 2.34
Increased circulating endothelial progenitor cells are associated with survival in acute lung injury. Am J Respir Crit Care Med (2005) 2.33
Coronary artery wall shear stress is associated with progression and transformation of atherosclerotic plaque and arterial remodeling in patients with coronary artery disease. Circulation (2011) 2.27
Discovery of novel mechanosensitive genes in vivo using mouse carotid artery endothelium exposed to disturbed flow. Blood (2010) 2.23
The role of the adventitia in vascular inflammation. Cardiovasc Res (2007) 2.21
Role of xanthine oxidoreductase and NAD(P)H oxidase in endothelial superoxide production in response to oscillatory shear stress. Am J Physiol Heart Circ Physiol (2003) 2.09
Oscillatory shear stress stimulates endothelial production of O2- from p47phox-dependent NAD(P)H oxidases, leading to monocyte adhesion. J Biol Chem (2003) 2.09
Bone morphogenic protein 4 produced in endothelial cells by oscillatory shear stress stimulates an inflammatory response. J Biol Chem (2003) 2.03
Flow-dependent regulation of endothelial nitric oxide synthase: role of protein kinases. Am J Physiol Cell Physiol (2003) 2.00
In vivo imaging of hydrogen peroxide with chemiluminescent nanoparticles. Nat Mater (2007) 1.99
Bioartificial matrices for therapeutic vascularization. Proc Natl Acad Sci U S A (2009) 1.99
Compensatory phosphorylation and protein-protein interactions revealed by loss of function and gain of function mutants of multiple serine phosphorylation sites in endothelial nitric-oxide synthase. J Biol Chem (2003) 1.98
Expression of CYP1A1 and CYP1B1 in human endothelial cells: regulation by fluid shear stress. Cardiovasc Res (2009) 1.93
Human heart failure is associated with abnormal C-terminal splicing variants in the cardiac sodium channel. Circ Res (2007) 1.93
Deoxycorticosterone acetate salt hypertension in apolipoprotein E-/- mice results in accelerated atherosclerosis: the role of angiotensin II. Hypertension (2007) 1.87
Anti-inflammatory and antiatherogenic role of BMP receptor II in endothelial cells. Arterioscler Thromb Vasc Biol (2013) 1.78
Impaired angiogenesis, early callus formation, and late stage remodeling in fracture healing of osteopontin-deficient mice. J Bone Miner Res (2007) 1.73
Hydrocyanines: a class of fluorescent sensors that can image reactive oxygen species in cell culture, tissue, and in vivo. Angew Chem Int Ed Engl (2009) 1.69
Inhibition and genetic ablation of the B7/CD28 T-cell costimulation axis prevents experimental hypertension. Circulation (2010) 1.68
Altered shear stress stimulates upregulation of endothelial VCAM-1 and ICAM-1 in a BMP-4- and TGF-beta1-dependent pathway. Arterioscler Thromb Vasc Biol (2008) 1.60
MicroRNA-663 upregulated by oscillatory shear stress plays a role in inflammatory response of endothelial cells. Am J Physiol Heart Circ Physiol (2011) 1.59
Reactive oxygen species-selective regulation of aortic inflammatory gene expression in Type 2 diabetes. Am J Physiol Heart Circ Physiol (2007) 1.57
Shear stress stimulates phosphorylation of eNOS at Ser(635) by a protein kinase A-dependent mechanism. Am J Physiol Heart Circ Physiol (2002) 1.56
Knowledge-based 3D segmentation and reconstruction of coronary arteries using CT images. Conf Proc IEEE Eng Med Biol Soc (2004) 1.53
NAD(P)H oxidase-derived hydrogen peroxide mediates endothelial nitric oxide production in response to angiotensin II. J Biol Chem (2002) 1.53
Bone morphogenic protein-4 induces hypertension in mice: role of noggin, vascular NADPH oxidases, and impaired vasorelaxation. Circulation (2006) 1.50
Vascular hypertrophy in angiotensin II-induced hypertension is mediated by vascular smooth muscle cell-derived H2O2. Hypertension (2005) 1.49
Target accessibility and signal specificity in live-cell detection of BMP-4 mRNA using molecular beacons. Nucleic Acids Res (2008) 1.44
Chronic shear induces caveolae formation and alters ERK and Akt responses in endothelial cells. Am J Physiol Heart Circ Physiol (2003) 1.43
Elevated cyclic stretch alters matrix remodeling in aortic valve cusps: implications for degenerative aortic valve disease. Am J Physiol Heart Circ Physiol (2009) 1.42
Evaluation of a novel kallikrein inhibitor on hemostatic activation in vitro. Thromb Res (2004) 1.42
Transcriptional profiles of valvular and vascular endothelial cells reveal phenotypic differences: influence of shear stress. Arterioscler Thromb Vasc Biol (2005) 1.41
Folate receptor-targeted antioxidant therapy ameliorates renal ischemia-reperfusion injury. J Am Soc Nephrol (2012) 1.41
NOX and inflammation in the vascular adventitia. Free Radic Biol Med (2009) 1.37
An ex vivo study of the biological properties of porcine aortic valves in response to circumferential cyclic stretch. Ann Biomed Eng (2006) 1.34
Mice with enhanced macrophage angiotensin-converting enzyme are resistant to melanoma. Am J Pathol (2007) 1.30
Randomized, open-label trial of primaquine against vivax malaria relapse in Indonesia. Antimicrob Agents Chemother (2012) 1.30
Elevated cyclic stretch induces aortic valve calcification in a bone morphogenic protein-dependent manner. Am J Pathol (2010) 1.29
Off-pump coronary artery bypass disproportionately benefits high-risk patients. Ann Thorac Surg (2009) 1.26
Off-pump coronary bypass provides reduced mortality and morbidity and equivalent 10-year survival. Ann Thorac Surg (2008) 1.25
Moderate hypothermia and unilateral selective antegrade cerebral perfusion: a contemporary cerebral protection strategy for aortic arch surgery. Ann Thorac Surg (2010) 1.24
Pharmacological suppression of hepcidin increases macrophage cholesterol efflux and reduces foam cell formation and atherosclerosis. Arterioscler Thromb Vasc Biol (2011) 1.23
Early determinants of H2O2-induced endothelial dysfunction. Free Radic Biol Med (2006) 1.22
Expression of cathepsin K is regulated by shear stress in cultured endothelial cells and is increased in endothelium in human atherosclerosis. Am J Physiol Heart Circ Physiol (2006) 1.22
The role of osteopontin in recovery from hind limb ischemia. Arterioscler Thromb Vasc Biol (2007) 1.21
Simulated microgravity using the Random Positioning Machine inhibits differentiation and alters gene expression profiles of 2T3 preosteoblasts. Am J Physiol Cell Physiol (2005) 1.20
Coordinated regulation of endothelial nitric oxide synthase activity by phosphorylation and subcellular localization. Free Radic Biol Med (2006) 1.19
Angiopoietin-2 stimulates blood flow recovery after femoral artery occlusion by inducing inflammation and arteriogenesis. Arterioscler Thromb Vasc Biol (2008) 1.19
Laminar shear inhibits tubule formation and migration of endothelial cells by an angiopoietin-2 dependent mechanism. Arterioscler Thromb Vasc Biol (2007) 1.18
Flow-dependent epigenetic DNA methylation regulates endothelial gene expression and atherosclerosis. J Clin Invest (2014) 1.18
Granulocyte colony-stimulating factor and granulocyte macrophage colony-stimulating factor exacerbate atherosclerosis in apolipoprotein E-deficient mice. Circulation (2007) 1.18
Endothelial NO synthase phosphorylated at SER635 produces NO without requiring intracellular calcium increase. Free Radic Biol Med (2003) 1.16
Laminar shear stress inhibits cathepsin L activity in endothelial cells. Arterioscler Thromb Vasc Biol (2006) 1.16
Polyketal microparticles: a new delivery vehicle for superoxide dismutase. Bioconjug Chem (2007) 1.12
Activation of extracellular signal-regulated kinase is involved in mechanical strain inhibition of RANKL expression in bone stromal cells. J Bone Miner Res (2002) 1.11
HuR regulates the expression of stress-sensitive genes and mediates inflammatory response in human umbilical vein endothelial cells. Proc Natl Acad Sci U S A (2010) 1.11
Laminar shear stress up-regulates peroxiredoxins (PRX) in endothelial cells: PRX 1 as a mechanosensitive antioxidant. J Biol Chem (2007) 1.08
Differential proinflammatory and prooxidant effects of bone morphogenetic protein-4 in coronary and pulmonary arterial endothelial cells. Am J Physiol Heart Circ Physiol (2008) 1.08
Peroxiredoxin 2 deficiency exacerbates atherosclerosis in apolipoprotein E-deficient mice. Circ Res (2011) 1.08
Vasculogenic bio-synthetic hydrogel for enhancement of pancreatic islet engraftment and function in type 1 diabetes. Biomaterials (2013) 1.07
A model of disturbed flow-induced atherosclerosis in mouse carotid artery by partial ligation and a simple method of RNA isolation from carotid endothelium. J Vis Exp (2010) 1.07
Long-term outcomes after isolated aortic valve replacement in octogenarians: a modern perspective. Ann Thorac Surg (2008) 1.05
Design of an ex vivo culture system to investigate the effects of shear stress on cardiovascular tissue. J Biomech Eng (2008) 1.04
Identification of mechanosensitive genes in osteoblasts by comparative microarray studies using the rotating wall vessel and the random positioning machine. J Cell Biochem (2007) 1.03
Nucleoside reverse transcriptase inhibitors impair endothelium-dependent relaxation by increasing superoxide. Am J Physiol Heart Circ Physiol (2002) 1.03