Lipid droplets hypertrophy: a crucial determining factor in insulin regulation by adipocytes.

PubWeight™: 0.88‹?›

🔗 View Article (PMC 4649717)

Published in Sci Rep on March 06, 2015

Authors

Bahram Sanjabi1, Monireh Dashty2, Behiye Özcan3, Vishtaseb Akbarkhanzadeh4, Mehran Rahimi5, Manlio Vinciguerra6, Felix van Rooij7, Saad Al-Lahham8, Fareeba Sheedfar9, Theo G van Kooten10, C Arnold Spek11, Ajda T Rowshani12, Johannes van der Want13, Rene Klaassen14, Eric Sijbrands7, Maikel P Peppelenbosch15, Farhad Rezaee2

Author Affiliations

1: Department of Genetics, University Medical Center Groningen, Groningen. The Netherlands.
2: 1] Department of Gastroenterology and Hepatology, Erasmus Medical Center, University of Rotterdam, Rotterdam, The Netherlands [2] Department of Cell Biology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands.
3: Department of endocrinology, Erasmus Medical Center, Rotterdam, The Netherlands.
4: Institute Center-45, Medical University of Amsterdam, University of Amsterdam, The Netherlands.
5: Faculty of Medical Science, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands.
6: 1] Institute for Liver and Digestive Health, Division of Medicine, University College London (UCL), London, UK [2] Gastroenterology Unit, IRCCS Casa Sollievo della Sofferenza, San Giovanni Rotondo, Italy.
7: Department of cardiovascular genetics, Metabolism, Erasmus Medical Center, Rotterdam, The Netherlands.
8: Department of Medical Biology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands.
9: 1] Department of Medical Biology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands [2] Department of Physiology, Radboud University Medical Center, Nijmegen, The Netherlands.
10: Department of Biomedical Engineering, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands.
11: Department for Experimental and Molecular Medicine, Academic Medical Center, University of Amsterdam, The Netherlands.
12: Department of Internal Medicine, section Nephrology and Transplantation, Erasmus Medical Center, Rotterdam, the Netherlands.
13: Department of Laboratory Medicine, Children's and Women's Health, Norwegian University of Science and Technology, Trondheim, Norway.
14: Department of Surgery, Bariatric Surgery, Maas City Hospital, Rotterdam, The Netherlands.
15: Department of Gastroenterology and Hepatology, Erasmus Medical Center, University of Rotterdam, Rotterdam, The Netherlands.

Articles cited by this

Chronic inflammation in fat plays a crucial role in the development of obesity-related insulin resistance. J Clin Invest (2003) 32.01

Inflammation and insulin resistance. J Clin Invest (2006) 18.76

Microarray data normalization and transformation. Nat Genet (2002) 15.04

Macrophages, inflammation, and insulin resistance. Annu Rev Physiol (2010) 11.77

Adipocyte dysfunctions linking obesity to insulin resistance and type 2 diabetes. Nat Rev Mol Cell Biol (2008) 8.43

Pancreatic Extracts in the Treatment of Diabetes Mellitus. Can Med Assoc J (1922) 7.97

Thematic review series: adipocyte biology. The perilipin family of structural lipid droplet proteins: stabilization of lipid droplets and control of lipolysis. J Lipid Res (2007) 6.03

Banting lecture 2001: dysregulation of fatty acid metabolism in the etiology of type 2 diabetes. Diabetes (2002) 5.21

Obesity and impaired prohormone processing associated with mutations in the human prohormone convertase 1 gene. Nat Genet (1997) 4.77

A paracrine loop between adipocytes and macrophages aggravates inflammatory changes: role of free fatty acids and tumor necrosis factor alpha. Arterioscler Thromb Vasc Biol (2005) 3.98

Lipid droplets in lipogenesis and lipolysis. Endocrinology (2008) 3.02

Fat-specific protein 27, a novel lipid droplet protein that enhances triglyceride storage. J Biol Chem (2007) 2.90

The perfect storm: obesity, adipocyte dysfunction, and metabolic consequences. Clin Chem (2008) 2.72

Cidea is associated with lipid droplets and insulin sensitivity in humans. Proc Natl Acad Sci U S A (2008) 2.71

Separation of human adipocytes by size: hypertrophic fat cells display distinct gene expression. FASEB J (2006) 2.41

Prevention of glucose toxicity in HIT-T15 cells and Zucker diabetic fatty rats by antioxidants. Proc Natl Acad Sci U S A (1999) 1.94

Human primary adipocytes exhibit immune cell function: adipocytes prime inflammation independent of macrophages. PLoS One (2011) 1.77

Preadipocytes mediate lipopolysaccharide-induced inflammation and insulin resistance in primary cultures of newly differentiated human adipocytes. Endocrinology (2006) 1.77

The diabetic syndrome of the 'BB' Wistar rat: possible relevance to type 1 (insulin-dependent) diabetes in man. Diabetologia (1982) 1.76

Macrophage-secreted factors impair human adipogenesis: involvement of proinflammatory state in preadipocytes. Endocrinology (2006) 1.73

Extrapancreatic insulin-producing cells in multiple organs in diabetes. Proc Natl Acad Sci U S A (2004) 1.67

Endotoxin rapidly induces changes in lipid metabolism that produce hypertriglyceridemia: low doses stimulate hepatic triglyceride production while high doses inhibit clearance. J Lipid Res (1992) 1.64

Inflammation and impaired adipogenesis in hypertrophic obesity in man. Am J Physiol Endocrinol Metab (2009) 1.63

In-depth analysis of the adipocyte proteome by mass spectrometry and bioinformatics. Mol Cell Proteomics (2007) 1.45

Brain insulin: regulation, mechanisms of action and functions. Cell Mol Neurobiol (2003) 1.42

Co-localization of nephrin, podocin, and the actin cytoskeleton: evidence for a role in podocyte foot process formation. Am J Pathol (2002) 1.34

Biological effects and metabolic rates of glucagonlike peptide-1 7-36 amide and glucagonlike peptide-1 7-37 in healthy subjects are indistinguishable. Diabetes (1993) 1.30

Crucial roles of neuronatin in insulin secretion and high glucose-induced apoptosis in pancreatic beta-cells. Cell Signal (2008) 1.26

Type 1 diabetes in the BB rat: a polygenic disease. Diabetes (2009) 1.21

Spontaneous autoimmune diabetes mellitus in the BB rat. Diabetes (1982) 1.15

Adipocyte biology. Obes Rev (2007) 1.13

Evidence that an isoform of calpain-10 is a regulator of exocytosis in pancreatic beta-cells. Mol Endocrinol (2004) 1.10

Lipid droplets: FSP27 knockout enhances their sizzle. J Clin Invest (2008) 1.09

Restoration of impaired intestinal barrier function by the hydrolysed casein diet contributes to the prevention of type 1 diabetes in the diabetes-prone BioBreeding rat. Diabetologia (2010) 1.06

Characterization of coagulation factor synthesis in nine human primary cell types. Sci Rep (2012) 1.06

Homogeneous insulin and C-Peptide sensors for rapid assessment of insulin and C-peptide secretion by the islets. Diabetes (2010) 1.03

LPS induces interleukin-6 and interleukin-8 but not tumor necrosis factor-alpha in human adipocytes. Cytokine (2007) 1.03

Suppressive actions of eicosapentaenoic acid on lipid droplet formation in 3T3-L1 adipocytes. Lipids Health Dis (2010) 0.96

Proteome of human plasma very low-density lipoprotein and low-density lipoprotein exhibits a link with coagulation and lipid metabolism. Thromb Haemost (2014) 0.93

Human anti-CD38 autoantibodies raise intracellular calcium and stimulate insulin release in human pancreatic islets. Diabetes (2001) 0.91

Potential mechanisms explaining why hydrolyzed casein-based diets outclass single amino acid-based diets in the prevention of autoimmune diabetes in diabetes-prone BB rats. Diabetes Metab Res Rev (2012) 0.88

Lycopus lucidus inhibits high glucose-induced vascular inflammation in human umbilical vein endothelial cells. Vascul Pharmacol (2007) 0.86

Differential roles of CIDEA and CIDEC in insulin-induced anti-apoptosis and lipid droplet formation in human adipocytes. J Lipid Res (2010) 0.83

Plasma glycosylphosphatidylinositol-specific phospholipase D predicts the change in insulin sensitivity in response to a low-fat but not a low-carbohydrate diet in obese women. Metabolism (2008) 0.82

Effect of glucose on lipolysis and on release of lipolytic products in isolated adipocytes. Am J Physiol (1975) 0.80

Endotoxin influence on lipolysis in isolated human and primate adipocytes. J Surg Res (1977) 0.79