Published in Neurobiol Dis on March 14, 2015
Collapsin Response Mediator Protein-2 (CRMP2) is a Plausible Etiological Factor and Potential Therapeutic Target in Alzheimer's Disease: Comparison and Contrast with Microtubule-Associated Protein Tau. J Alzheimers Dis (2016) 0.77
Mild mitochondrial metabolic deficits by α-ketoglutarate dehydrogenase inhibition cause prominent changes in intracellular autophagic signaling: Potential role in the pathobiology of Alzheimer's disease. Neurochem Int (2016) 0.76
H2S- and NO-Signaling Pathways in Alzheimer's Amyloid Vasculopathy: Synergism or Antagonism? Front Physiol (2015) 0.75
The Sulfur Metabolite Lanthionine: Evidence for a Role as a Novel Uremic Toxin. Toxins (Basel) (2017) 0.75
The DPYSL2 gene connects mTOR and schizophrenia. Transl Psychiatry (2016) 0.75
Guidelines for the use and interpretation of assays for monitoring autophagy. Autophagy (2012) 20.08
Ragulator-Rag complex targets mTORC1 to the lysosomal surface and is necessary for its activation by amino acids. Cell (2010) 12.24
Ablation in mice of the mTORC components raptor, rictor, or mLST8 reveals that mTORC2 is required for signaling to Akt-FOXO and PKCalpha, but not S6K1. Dev Cell (2006) 11.48
TSC2 integrates Wnt and energy signals via a coordinated phosphorylation by AMPK and GSK3 to regulate cell growth. Cell (2006) 7.49
Dysregulation of the TSC-mTOR pathway in human disease. Nat Genet (2005) 7.15
Regulation of mammalian autophagy in physiology and pathophysiology. Physiol Rev (2010) 6.35
The autophagy-related protein beclin 1 shows reduced expression in early Alzheimer disease and regulates amyloid beta accumulation in mice. J Clin Invest (2008) 4.09
Ragulator is a GEF for the rag GTPases that signal amino acid levels to mTORC1. Cell (2012) 3.77
Inhibition of mTOR by rapamycin abolishes cognitive deficits and reduces amyloid-beta levels in a mouse model of Alzheimer's disease. PLoS One (2010) 3.62
Phosphorylation of mammalian target of rapamycin (mTOR) at Ser-2448 is mediated by p70S6 kinase. J Biol Chem (2005) 3.56
Amino acid signalling upstream of mTOR. Nat Rev Mol Cell Biol (2013) 3.36
Collapsin-induced growth cone collapse mediated by an intracellular protein related to UNC-33. Nature (1995) 2.78
mTOR inhibits autophagy by controlling ULK1 ubiquitylation, self-association and function through AMBRA1 and TRAF6. Nat Cell Biol (2013) 2.73
Spatial control of the TSC complex integrates insulin and nutrient regulation of mTORC1 at the lysosome. Cell (2014) 2.68
Rapalogs and mTOR inhibitors as anti-aging therapeutics. J Clin Invest (2013) 2.14
Autophagy failure in Alzheimer's disease--locating the primary defect. Neurobiol Dis (2011) 2.14
mTOR Ser-2481 autophosphorylation monitors mTORC-specific catalytic activity and clarifies rapamycin mechanism of action. J Biol Chem (2009) 1.93
Autophagy as a new therapeutic target in Duchenne muscular dystrophy. Cell Death Dis (2012) 1.89
Semaphorin3A signalling is mediated via sequential Cdk5 and GSK3beta phosphorylation of CRMP2: implication of common phosphorylating mechanism underlying axon guidance and Alzheimer's disease. Genes Cells (2005) 1.86
CRMP-2 is involved in kinesin-1-dependent transport of the Sra-1/WAVE1 complex and axon formation. Mol Cell Biol (2005) 1.64
The role of lipids in the control of autophagy. Curr Biol (2013) 1.59
Autophagosome formation--the role of ULK1 and Beclin1-PI3KC3 complexes in setting the stage. Semin Cancer Biol (2013) 1.48
Collapsin response mediator protein-2: an emerging pathologic feature and therapeutic target for neurodisease indications. Mol Neurobiol (2011) 1.33
The serine/threonine kinase ULK1 is a target of multiple phosphorylation events. Biochem J (2011) 1.30
Collapsin response mediator protein-2 is associated with neurofibrillary tangles in Alzheimer's disease. J Biol Chem (1998) 1.23
The role of glutamine transaminase K (GTK) in sulfur and alpha-keto acid metabolism in the brain, and in the possible bioactivation of neurotoxicants. Neurochem Int (2004) 1.21
Collapsin response mediator protein-2 hyperphosphorylation is an early event in Alzheimer's disease progression. J Neurochem (2007) 1.20
Oxidative stress, inflammation, and autophagic stress as the key mechanisms of premature age-related hearing loss in SAMP8 mouse Cochlea. Antioxid Redox Signal (2011) 1.05
Identification of lanthionine synthase C-like protein-1 as a prominent glutathione binding protein expressed in the mammalian central nervous system. Biochemistry (2007) 1.03
Sulfur-containing cyclic ketimines and imino acids. A novel family of endogenous products in the search for a role. Eur J Biochem (1991) 1.01
Collapsin response mediator protein-2 (Crmp2) regulates trafficking by linking endocytic regulatory proteins to dynein motors. J Biol Chem (2010) 0.99
Oxidative stress and autophagy in the regulation of lysosome-dependent neuron death. Antioxid Redox Signal (2009) 0.99
Proteomic identification of binding partners for the brain metabolite lanthionine ketimine (LK) and documentation of LK effects on microglia and motoneuron cell cultures. J Neurosci (2010) 0.98
Emerging biological importance of central nervous system lanthionines. Molecules (2010) 0.98
Impaired autophagy flux is associated with neuronal cell death after traumatic brain injury. Autophagy (2014) 0.96
Opening Pandora's jar: a primer on the putative roles of CRMP2 in a panoply of neurodegenerative, sensory and motor neuron, and central disorders. Future Neurol (2012) 0.95
Structure of human lanthionine synthetase C-like protein 1 and its interaction with Eps8 and glutathione. Genes Dev (2009) 0.94
Systems analysis of genetic variation in MPTP neurotoxicity in mice. Neurotoxicology (2013) 0.92
Disruption of the autophagy-lysosome pathway is involved in neuropathology of the nclf mouse model of neuronal ceroid lipofuscinosis. PLoS One (2012) 0.91
Temsirolimus promotes autophagic clearance of amyloid-β and provides protective effects in cellular and animal models of Alzheimer's disease. Pharmacol Res (2014) 0.91
Everolimus. Recent Results Cancer Res (2014) 0.91
A derivative of the CRMP2 binding compound lanthionine ketimine provides neuroprotection in a mouse model of cerebral ischemia. Neurochem Int (2012) 0.89
Neuroprotective effects of autophagy induced by rapamycin in rat acute spinal cord injury model. Neuroimmunomodulation (2014) 0.86
Lanthionine synthetase C-like protein 2 (LanCL2) is a novel regulator of Akt. Mol Biol Cell (2014) 0.86
Detection of cystathionine ketimine and lanthionine ketimine in human brain. Neurochem Res (1997) 0.85
Rapamycin nanoparticles target defective autophagy in muscular dystrophy to enhance both strength and cardiac function. FASEB J (2014) 0.84
Quercetin alleviates high glucose-induced Schwann cell damage by autophagy. Neural Regen Res (2014) 0.83
Developmental and activity-dependent expression of LanCL1 confers antioxidant activity required for neuronal survival. Dev Cell (2014) 0.83
Nitrone-based therapeutics for neurodegenerative diseases: their use alone or in combination with lanthionines. Free Radic Biol Med (2013) 0.81
Alternative functions of the brain transsulfuration pathway represent an underappreciated aspect of brain redox biochemistry with significant potential for therapeutic engagement. Free Radic Biol Med (2014) 0.81
A derivative of the brain metabolite lanthionine ketimine improves cognition and diminishes pathology in the 3 × Tg-AD mouse model of Alzheimer disease. J Neuropathol Exp Neurol (2013) 0.80
Early signalling events of autophagy. Essays Biochem (2013) 0.80
Lanthionine ketimine ethyl ester partially rescues neurodevelopmental defects in unc-33 (DPYSL2/CRMP2) mutants. J Neurosci Res (2013) 0.79