Published in Cancer Res on January 01, 1985
NAD(P)H:quinone oxidoreductase 1 (NQO1) in the sensitivity and resistance to antitumor quinones. Biochem Pharmacol (2011) 1.41
Deficient activation by a human cell strain leads to mitomycin resistance under aerobic but not hypoxic conditions. Br J Cancer (1989) 1.03
DT-diaphorase protects cells from the hypoxic cytotoxicity of indoloquinone EO9. Br J Cancer (1994) 1.00
Enzymology of bioreductive drug activation. Br J Cancer Suppl (1996) 0.94
DT-diaphorase: questionable role in mitomycin C resistance, but a target for novel bioreductive drugs? Br J Cancer (1989) 0.89
Nitroimidazole adducts as markers for tissue hypoxia: mechanistic studies in aerobic normal tissues and tumour cells. Br J Cancer (1992) 0.88
Expression of human NAD(P)H: quinone oxidoreductase (DT-diaphorase) in Chinese hamster ovary cells: effect on the toxicity of antitumor quinones. Mol Pharmacol (1996) 0.80
The leukotriene C(4) transporter MRP1 regulates CCL19 (MIP-3beta, ELC)-dependent mobilization of dendritic cells to lymph nodes. Cell (2000) 2.76
Use of sarcoma 180/TG to prepare hyperimmune ascitic fluid in the mouse. J Immunol (1966) 2.68
Hypoxic fractions of solid tumors: experimental techniques, methods of analysis, and a survey of existing data. Int J Radiat Oncol Biol Phys (1984) 2.47
The sexual history in general medicine practice. Arch Intern Med (1984) 2.42
Genetic instability induced by the tumor microenvironment. Cancer Res (1996) 2.33
Choroid plexus epithelial expression of MDR1 P glycoprotein and multidrug resistance-associated protein contribute to the blood-cerebrospinal-fluid drug-permeability barrier. Proc Natl Acad Sci U S A (1999) 2.02
The immunophilin FKBP12 functions as a common inhibitor of the TGF beta family type I receptors. Cell (1996) 1.99
Classification of antineoplastic agents by their selective toxicities toward oxygenated and hypoxic tumor cells. Cancer Res (1981) 1.91
Triapine (3-aminopyridine-2-carboxaldehyde- thiosemicarbazone): A potent inhibitor of ribonucleotide reductase activity with broad spectrum antitumor activity. Biochem Pharmacol (2000) 1.87
WAG-F8(m1Ycb) rats harboring a factor VIII gene mutation provide a new animal model for hemophilia A. J Thromb Haemost (2010) 1.69
Mitomycin C as an adjunct to postoperative radiation therapy in squamous cell carcinoma of the head and neck: results from two randomized clinical trials. Int J Radiat Oncol Biol Phys (1993) 1.52
Disruption of the murine MRP (multidrug resistance protein) gene leads to increased sensitivity to etoposide (VP-16) and increased levels of glutathione. Cancer Res (1997) 1.50
In vivo-in vitro tumor systems: new models for studing the response of tumours to therapy. Lab Anim Sci (1977) 1.49
Tumor hypoxia: its impact on cancer therapy. Cancer Metastasis Rev (1987) 1.48
Induction of the differentiation of HL-60 and WEHI-3B D+ leukemia cells by lithium chloride. Leuk Res (1993) 1.46
Diminished DNA repair and elevated mutagenesis in mammalian cells exposed to hypoxia and low pH. Cancer Res (2000) 1.37
Comparison of DNA lesions produced by tumor-inhibitory 1,2-bis(sulfonyl)hydrazines and chloroethylnitrosoureas. Biochem Pharmacol (2000) 1.37
Differentiation of immortal cells inhibits telomerase activity. Proc Natl Acad Sci U S A (1995) 1.36
Triapine (3-aminopyridine-2-carboxaldehyde thiosemicarbazone; 3-AP): an inhibitor of ribonucleotide reductase with antineoplastic activity. Adv Enzyme Regul (1999) 1.34
1,2-Bis(methylsulfonyl)-1-(2-chloroethyl)-2-(methylamino)carbonylhydrazine (101M): a novel sulfonylhydrazine prodrug with broad-spectrum antineoplastic activity. Cancer Res (2001) 1.30
Inosinic acid dehydrogenase of sarcoma 180 cells. J Biol Chem (1968) 1.29
Coupling of transmembrane proton gradients to platelet serotonin transport. J Biol Chem (1982) 1.28
Evidence that the multidrug resistance protein (MRP) functions as a co-transporter of glutathione and natural product toxins. Cancer Res (1997) 1.27
Repair of potentially lethal damage in vivo in solid tumor cells after x-irradiation. Cancer Res (1974) 1.27
Cellular radiosensitivity and tumor radiation response in the EMT6 tumor cell system. Radiat Res (1973) 1.25
The hypoxic tumor cell: a target for selective cancer chemotherapy. Biochem Pharmacol (1980) 1.24
Polarographic measurements of oxygen tension in human glioma and surrounding peritumoural brain tissue. Radiother Oncol (1999) 1.22
Antisense oligonucleotides to the p65 subunit of NF-kappa B block CD11b expression and alter adhesion properties of differentiated HL-60 granulocytes. Blood (1993) 1.21
Independent regulation of invasion and anchorage-independent growth by different autophosphorylation sites of the macrophage colony-stimulating factor 1 receptor. Cancer Res (1996) 1.21
Antitumor 2-(aminocarbonyl)-1,2-bis(methylsulfonyl)-1-(2-chloroethyl)- hydrazines. J Med Chem (1996) 1.18
The molecular and cellular basis of radiosensitivity: implications for understanding how normal tissues and tumors respond to therapeutic radiation. Cancer Invest (1999) 1.16
Generation of reactive oxygen radicals through bioactivation of mitomycin antibiotics. Cancer Res (1986) 1.16
Synthesis and antitumor activity of amino derivatives of pyridine-2-carboxaldehyde thiosemicarbazone. J Med Chem (1992) 1.16
Cancer chemotherapy. Annu Rev Pharmacol (1969) 1.16
Regulation of growth and differentiation of human keratinocytes by type beta transforming growth factor and epidermal growth factor. Cancer Res (1987) 1.15
Activity of fluoroquinolone antibiotics against Plasmodium falciparum in vitro. Antimicrob Agents Chemother (1988) 1.15
Comparison of anthracycline concentrations in S180 cell lines of varying sensitivity. Eur J Cancer Clin Oncol (1983) 1.14
Biochemical properties of cytochrome b5-dependent microsomal fatty acid elongation and identification of products. J Biol Chem (1980) 1.13
Scatter factor modulates the metastatic phenotype of the EMT6 mouse mammary tumor. Int J Cancer (1994) 1.13
Role of lipocortin I in the glucocorticoid induction of the terminal differentiation of a human squamous carcinoma. J Cell Physiol (1990) 1.13
1,2-Bis(methylsulfonyl)-1-(2-chloroethyl)-2-[(methylamino)carbonyl]hydrazine (VNP40101M): I. Direct inhibition of O6-alkylguanine-DNA alkyltransferase (AGT) by electrophilic species generated by decomposition. Cancer Chemother Pharmacol (2003) 1.12
Induction of tumor cell differentiation as a therapeutic approach: preclinical models for hematopoietic and solid neoplasms. Cancer Treat Rep (1986) 1.12
Enhancement by hyperthermia of the in vitro cytotoxicity of mitomycin C toward hypoxic tumor cells. Cancer Res (1981) 1.12
Reductive activation of mitomycin C by NADH:cytochrome b5 reductase. Cancer Res (1993) 1.11
Scatter factor protects epithelial and carcinoma cells against apoptosis induced by DNA-damaging agents. Oncogene (1998) 1.10
The 1985 Walter Hubert lecture. Malignant cell differentiation as a potential therapeutic approach. Br J Cancer (1985) 1.10
Transcriptional regulation of the vitamin D(3) receptor gene by ZEB. Cell Growth Differ (2001) 1.09
Inhibitors of ribonucleotide reductase. Comparative effects of amino- and hydroxy-substituted pyridine-2-carboxaldehyde thiosemicarbazones. Biochem Pharmacol (1994) 1.09
8-Substituted guanosine and 2'-deoxyguanosine derivatives as potential inducers of the differentiation of Friend erythroleukemia cells. J Med Chem (1985) 1.08
1,2-Bis(methylsulfonyl)-1-(2-chloroethyl)-2-[(methylamino)carbonyl]hydrazine (VNP40101M): II. Role of O6-alkylguanine-DNA alkyltransferase in cytotoxicity. Cancer Chemother Pharmacol (2003) 1.08
Role of NADPH:cytochrome c reductase and DT-diaphorase in the biotransformation of mitomycin C1. Cancer Res (1984) 1.07
Mitomycin C: a prototype bioreductive agent. Oncol Res (1994) 1.06
Effects of adriamycin on surface properties of sarcoma 180 ascites cells. Biochem Pharmacol (1976) 1.06
Hypoxia-selective nitrobenzyloxycarbonyl derivatives of 1,2-bis(methylsulfonyl)-1-(2-chloroethyl)hydrazines. J Med Chem (1999) 1.04
Synthesis and evaluation of 1,2,2-tris(sulfonyl)hydrazines as antineoplastic and trypanocidal agents. J Med Chem (1990) 1.04
Production of membrane whorls in rat liver by some inhibitors of protein synthesis. J Cell Biol (1974) 1.04
Preferential activation of mitomycin C to cytotoxic metabolites by hypoxic tumor cells. Cancer Res (1980) 1.03
Modification of the metabolism and cytotoxicity of bioreductive alkylating agents by dicoumarol in aerobic and hypoxic murine tumor cells. Cancer Res (1989) 1.01
Reengineering granulocyte colony-stimulating factor for enhanced stability. J Biol Chem (2001) 1.01
In vivo-in vitro tumour cell lines: characteristics and limitations as models for human cancer. Br J Cancer Suppl (1980) 1.01
The role of membranes in the mechanism of action of the antineoplastic agent adriamycin. Spin-labeling studies with chronically hypoxic and drug-resistant tumor cells. J Biol Chem (1983) 1.01
Induction of the differentiation of HL-60 cells by phorbol 12-myristate 13-acetate activates a Na(+)-dependent uridine-transport system. Involvement of protein kinase C. Biochem J (1991) 1.01
The intracellular location of NADH:cytochrome b5 reductase modulates the cytotoxicity of the mitomycins to Chinese hamster ovary cells. J Biol Chem (1998) 1.00
The pharmacological phenotype of combined multidrug-resistance mdr1a/1b- and mrp1-deficient mice. Cancer Res (2001) 0.99
A technique for determining the proportion of the clonogenic cells in S phase in ENT6 cell cultures and tumors. Cell Tissue Kinet (1976) 0.99
Cellular pharmacology of quinone bioreductive alkylating agents. Cancer Metastasis Rev (1993) 0.99
Adriamycin: a proposal on the specificity of drug action. Biochem Biophys Res Commun (1978) 0.98
Overexpression of the multidrug resistance genes mdr1, mdr3, and mrp in L1210 leukemia cells resistant to inhibitors of ribonucleotide reductase. Biochem Pharmacol (1997) 0.98
Fluorometric assay for the determination of DNA-DNA cross-links utilizing Hoechst 33258 at neutral pH values. Anal Biochem (1997) 0.98
Induction of phenobarbital of microsomal mixed oxidase enzymes in regenerating rat liver. J Biol Chem (1970) 0.98
Studies on the mechanism of decomposition and structural factors affecting the aqueous stability of 1,2-bis(sulfonyl)-1-alkylhydrazines. J Med Chem (1994) 0.97
IL-11 enhances survival and decreases TNF production after radiation-induced thoracic injury. J Immunol (1996) 0.97
Differential toxicity of mitomycin C and porfiromycin to aerobic and hypoxic Chinese hamster ovary cells overexpressing human NADPH:cytochrome c (P-450) reductase. Proc Natl Acad Sci U S A (1996) 0.96
Changes in microtubules, microtubule-associated proteins, and intermediate filaments during the differentiation of HL-60 leukemia cells. Cancer Res (1992) 0.96
Rat liver microsomal elongation of fatty acids. Possible involvement of cytochrome b5. J Biol Chem (1979) 0.96
The role of phosphohydrolases in the mechanism of resistance of neoplastic cells to 6-thiopurines. Cancer Res (1971) 0.95
Chemotherapy as an adjunct to radiation in the treatment of squamous cell carcinoma of the head and neck: results of the Yale Mitomycin Randomized Trials. J Clin Oncol (1997) 0.94
Physical examination as a screening test for pelvic fractures in blunt trauma patients. W V Med J (1997) 0.93
Regulation of protein phosphotyrosine content by changes in tyrosine kinase and protein phosphotyrosine phosphatase activities during induced granulocytic and monocytic differentiation of HL-60 leukemia cells. Biochem Biophys Res Commun (1986) 0.93
Transforming growth factor-beta 1 overexpression produces drug resistance in vivo: reversal by decorin. In Vivo (1998) 0.93
Effect of some proliferative and environmental factors on the toxicity of mitomycin C to tumor cells in vitro. Int J Cancer (1986) 0.93
Potential bioreductive alkylating agents. 1. Benzoquinone derivatives. J Med Chem (1972) 0.92
Alterations in glycoprotein synthesis and guanosine triphosphate levels associated with the differentiation of HL-60 leukemia cells produced by inhibitors of inosine 5'-phosphate dehydrogenase. Cancer Res (1986) 0.92
Transport of fluorescein in MDCKII-MRP1 transfected cells and mrp1-knockout mice. Biochem Biophys Res Commun (2001) 0.92
Erythrocyte membrane ATP binding cassette (ABC) proteins: MRP1 and CFTR as well as CD39 (ecto-apyrase) involved in RBC ATP transport and elevated blood plasma ATP of cystic fibrosis. Blood Cells Mol Dis (2001) 0.92
Adducts of mitomycin C and DNA in EMT6 mouse mammary tumor cells: effects of hypoxia and dicumarol on adduct patterns. Cancer Res (1993) 0.91
Genetic analysis of 2',3'-dideoxycytidine incorporation into cultured human T lymphoblasts. J Biol Chem (1988) 0.91
1,2-Bis(sulfonyl)hydrazines. 3. Effects of structural modification on antineoplastic activity. J Med Chem (1987) 0.91
One-electron reduction of 2- and 6-methyl-1,4-naphthoquinone bioreductive alkylating agents. J Med Chem (1986) 0.91
Attenuation of the induced differentiation of HL-60 leukemia cells by mitochondrial chaperone HSP70. Oncol Res (1999) 0.91