Haematological malignancies: at the forefront of immunotherapeutic innovation.

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Published in Nat Rev Cancer on March 19, 2015

Authors

Pavan Bachireddy1, Ute E Burkhardt2, Mohini Rajasagi3, Catherine J Wu1

Author Affiliations

1: 1] Department of Medical Oncology and the Cancer Vaccine Center, Dana-Farber Cancer Institute, Boston, Massachusetts 02215, USA. [2] Broad Institute, Cambridge, Massachusetts 02142, USA. [3] Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA.
2: Department of Medical Oncology and the Cancer Vaccine Center, Dana-Farber Cancer Institute, Boston, Massachusetts 02215, USA.
3: 1] Department of Medical Oncology and the Cancer Vaccine Center, Dana-Farber Cancer Institute, Boston, Massachusetts 02215, USA. [2] Broad Institute, Cambridge, Massachusetts 02142, USA. [3] Bristol-Meyers Squibb, Princeton, New Jersey 08540, USA.

Associated clinical trials:

A Study Of PF-05082566 As A Single Agent And In Combination With Rituximab | NCT01307267

Combination Study of Urelumab and Rituximab in Patients With B-cell Non-Hodgkins Lymphoma | NCT01775631

A Phase I Study With a Personalized NeoAntigen Cancer Vaccine in Melanoma | NCT01970358

IVAC MUTANOME Phase I Clinical Trial | NCT02035956

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Bone marrow as a priming site for T-cell responses to blood-borne antigen. Nat Med (2003) 2.01

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Selective elimination of leukemic CD34(+) progenitor cells by cytotoxic T lymphocytes specific for WT1. Blood (2000) 1.94

Clinical regressions and broad immune activation following combination therapy targeting human NKT cells in myeloma. Blood (2012) 1.94

A unique cell surface antigen identifying lymphoid malignancies of B cell origin. J Clin Invest (1981) 1.93

Systematic identification of personal tumor-specific neoantigens in chronic lymphocytic leukemia. Blood (2014) 1.92

A clinical and immunologic phase 2 trial of Wilms tumor gene product 1 (WT1) peptide vaccination in patients with AML and MDS. Blood (2009) 1.90