Activation of the PD-1 pathway contributes to immune escape in EGFR-driven lung tumors.

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Published in Cancer Discov on September 27, 2013

Authors

Esra A Akbay1, Shohei Koyama, Julian Carretero, Abigail Altabef, Jeremy H Tchaicha, Camilla L Christensen, Oliver R Mikse, Andrew D Cherniack, Ellen M Beauchamp, Trevor J Pugh, Matthew D Wilkerson, Peter E Fecci, Mohit Butaney, Jacob B Reibel, Margaret Soucheray, Travis J Cohoon, Pasi A Janne, Matthew Meyerson, D Neil Hayes, Geoffrey I Shapiro, Takeshi Shimamura, Lynette M Sholl, Scott J Rodig, Gordon J Freeman, Peter S Hammerman, Glenn Dranoff, Kwok-Kin Wong

Author Affiliations

1: Departments of 1Medicine and 2Medical Oncology and Cancer Vaccine Center, Dana-Farber Cancer Institute; 3Harvard Medical School; 4Ludwig Institute for Cancer Research; 5Department of Neurosurgery, Massachusetts General Hospital; 6Belfer Institute for Applied Cancer Science; 7Department of Pathology, Brigham and Women's Hospital, Boston; 8Broad Institute, Cambridge, Massachusetts; 9UNC Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina; and 10Department of Molecular Pharmacology and Therapeutics, Oncology Institute, Loyola University, Chicago, Illinois; 11Department of Physiology, University of Valencia, Valencia, Spain.

Associated clinical trials:

Atezolizumab in Combination With Bevacizumab, Carboplatin and Pemetrexed for EGFR-mutant Metastatic NSCLC Patients After Failure of EGFR Tyrosine Kinase Inhibitors | NCT03647956

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