Cytoplasmic PELP1 and ERRgamma protect human mammary epithelial cells from Tam-induced cell death.

PubWeight™: 0.79‹?›

🔗 View Article (PMC 4366195)

Published in PLoS One on March 19, 2015

Authors

Brian J Girard1, Tarah M Regan Anderson1, Siya Lem Welch2, Julie Nicely2, Victoria L Seewaldt2, Julie H Ostrander1

Author Affiliations

1: Department of Medicine, Masonic Cancer Center, University of Minnesota, Minneapolis, Minnesota, 55455, United States of America.
2: Department of Medicine, Duke University Medical Center, Durham, North Carolina, 27710, United States of America.

Articles cited by this

Tamoxifen for prevention of breast cancer: report of the National Surgical Adjuvant Breast and Bowel Project P-1 Study. J Natl Cancer Inst (1998) 22.10

Morphogenesis and oncogenesis of MCF-10A mammary epithelial acini grown in three-dimensional basement membrane cultures. Methods (2003) 18.51

Rapid flow cytofluorometric analysis of mammalian cell cycle by propidium iodide staining. J Cell Biol (1975) 8.68

Identity of an estrogen membrane receptor coupled to a G protein in human breast cancer cells. Endocrinology (2004) 5.20

A study of some variables in a tetrazolium dye (MTT) based assay for cell growth and chemosensitivity. Br J Cancer (1987) 3.62

Basic guide to the mechanisms of antiestrogen action. Pharmacol Rev (1998) 2.50

Molecular distinctions between stasis and telomere attrition senescence barriers shown by long-term culture of normal human mammary epithelial cells. Cancer Res (2009) 2.28

Mechanisms of tamoxifen-induced apoptosis. Apoptosis (2001) 2.26

Gene expression preferentially regulated by tamoxifen in breast cancer cells and correlations with clinical outcome. Cancer Res (2006) 2.02

Estrogen-related receptor alpha and estrogen-related receptor gamma associate with unfavorable and favorable biomarkers, respectively, in human breast cancer. Cancer Res (2002) 1.91

Molecular cloning and characterization of PELP1, a novel human coregulator of estrogen receptor alpha. J Biol Chem (2001) 1.86

Structural and functional evidence for ligand-independent transcriptional activation by the estrogen-related receptor 3. Mol Cell (2002) 1.58

Inhibition of protein kinase C by tamoxifen. Cancer Res (1985) 1.56

Estrogen responsiveness and control of normal human breast proliferation. J Mammary Gland Biol Neoplasia (1998) 1.52

Tamoxifen antiestrogens. A comparison of the activity, pharmacokinetics, and metabolic activation of the cis and trans isomers of tamoxifen. J Steroid Biochem (1982) 1.41

Functional implications of altered subcellular localization of PELP1 in breast cancer cells. Cancer Res (2005) 1.39

Cell death and autophagy: cytokines, drugs, and nutritional factors. Toxicology (2008) 1.31

Optical redox ratio differentiates breast cancer cell lines based on estrogen receptor status. Cancer Res (2010) 1.28

The prognostic significance of PELP1 expression in invasive breast cancer with emphasis on the ER-positive luminal-like subtype. Breast Cancer Res Treat (2009) 1.27

ERRgamma mediates tamoxifen resistance in novel models of invasive lobular breast cancer. Cancer Res (2008) 1.24

Autophagy: a critical regulator of cellular metabolism and homeostasis. Mol Cells (2013) 1.24

Ca2(+)-dependent binding of tamoxifen to calmodulin isolated from bovine brain. Cancer Res (1990) 1.16

Significance of ER-Src axis in hormonal therapy resistance. Breast Cancer Res Treat (2010) 1.10

4-Hydroxytamoxifen is an isoform-specific inhibitor of orphan estrogen-receptor-related (ERR) nuclear receptors beta and gamma. Endocrinology (2001) 1.07

Immortalization of normal human mammary epithelial cells in two steps by direct targeting of senescence barriers does not require gross genomic alterations. Cell Cycle (2014) 1.05

Functional and physiological genomics of estrogen-related receptors (ERRs) in health and disease. Biochim Biophys Acta (2010) 1.04

Significance of PELP1 in ER-negative breast cancer metastasis. Mol Cancer Res (2011) 1.02

Hypoxia induces PDK4 gene expression through induction of the orphan nuclear receptor ERRγ. PLoS One (2012) 1.02

Tamoxifen but not 4-hydroxytamoxifen initiates apoptosis in p53(-) normal human mammary epithelial cells by inducing mitochondrial depolarization. J Biol Chem (2000) 1.01

Induction of autophagy and cell death by tamoxifen in cultured retinal pigment epithelial and photoreceptor cells. Invest Ophthalmol Vis Sci (2012) 1.01

Parkin degrades estrogen-related receptors to limit the expression of monoamine oxidases. Hum Mol Genet (2010) 1.00

Extranuclear coactivator signaling confers insensitivity to tamoxifen. Clin Cancer Res (2009) 0.97

Identifying the estrogen receptor coactivator PELP1 in autophagosomes. Cancer Res (2007) 0.95

Orphan nuclear receptors in breast cancer pathogenesis and therapeutic response. Endocr Relat Cancer (2010) 0.93

PELP1: a review of PELP1 interactions, signaling, and biology. Mol Cell Endocrinol (2013) 0.92

Tamoxifen and its active metabolite inhibit growth of estrogen receptor-negative MDA-MB-435 cells. Biochem Pharmacol (1995) 0.89

4-Hydroxytamoxifen induces autophagic death through K-Ras degradation. Cancer Res (2013) 0.89

Estrogen-related receptor γ modulates cell proliferation and estrogen signaling in breast cancer. J Steroid Biochem Mol Biol (2010) 0.88

Synthesis and secretion of transforming growth factor beta isoforms by primary cultures of human breast tumour fibroblasts in vitro and their modulation by tamoxifen. Br J Cancer (1996) 0.88

ESR1 promoter hypermethylation does not predict atypia in RPFNA nor persistent atypia after 12 months tamoxifen chemoprevention. Cancer Epidemiol Biomarkers Prev (2008) 0.85

ERK/MAPK regulates ERRγ expression, transcriptional activity and receptor-mediated tamoxifen resistance in ER+ breast cancer. FEBS J (2014) 0.84

Distinction of the binding modes for human nuclear receptor ERRgamma between bisphenol A and 4-hydroxytamoxifen. J Biochem (2010) 0.84

Recent advances in understanding the molecular mechanisms of tamoxifen action. Cancer Invest (1998) 0.83

Delivery of cytoplasmic proteins to autophagosomes. Autophagy (2007) 0.83

Phenotypic characterization, karyotype analysis and in vitro tamoxifen sensitivity of new ER-negative vulvar carcinoma cell lines, UM-SCV-1A and UM-SCV-1B. Int J Cancer (1990) 0.83

Use of tamoxifen in hepatocellular carcinoma: a review and paradigm shift. J Gastroenterol Hepatol (2000) 0.82

Regulation of aromatase induction by nuclear receptor coregulator PELP1. J Steroid Biochem Mol Biol (2009) 0.82

The roles of reactive oxygen species and autophagy in mediating the tolerance of tumor cells to cycling hypoxia. Semin Radiat Oncol (2013) 0.80

Tamoxifen and tamoxifen ethyl bromide induce apoptosis in acutely damaged mammary epithelial cells through modulation of AKT activity. Oncogene (2004) 0.80

Establishment and characterization of UM-EC-2, a tamoxifen-sensitive, estrogen receptor-negative human endometrial carcinoma cell line. Gynecol Oncol (1990) 0.78

Recent advance in the design of small molecular modulators of estrogen-related receptors. Curr Pharm Des (2012) 0.78

Human papillomavirus type 16 E6 inactivation of p53 in normal human mammary epithelial cells promotes tamoxifen-mediated apoptosis. Cancer Res (2001) 0.77