Quinoline compound KM11073 enhances BMP-2-dependent osteogenic differentiation of C2C12 cells via activation of p38 signaling and exhibits in vivo bone forming activity.

PubWeight™: 0.76‹?›

🔗 View Article (PMC 4366212)

Published in PLoS One on March 19, 2015

Authors

Seung-hwa Baek1, Sik-Won Choi2, Sang-Joon Park3, Sang-Han Lee4, Hang-Suk Chun5, Seong Hwan Kim2

Author Affiliations

1: Laboratory of Translational Therapeutics, Pharmacology Research Center, Korea Research Institute of Chemical Technology, Daejeon, 305-600, Republic of Korea; Department of Food Science & Biotechnology, Kyungpook National University, Daegu, 702-701, Republic of Korea.
2: Laboratory of Translational Therapeutics, Pharmacology Research Center, Korea Research Institute of Chemical Technology, Daejeon, 305-600, Republic of Korea.
3: Department of Histology, College of Veterinary Medicine, Kyungpook National University, Daegu, 702-701, Republic of Korea.
4: Department of Food Science & Biotechnology, Kyungpook National University, Daegu, 702-701, Republic of Korea.
5: Alternative Toxicological Methods Research Center, Department of Predictive Toxicology, Korea Institute of Toxicology, Daejeon, 305-600, Republic of Korea.

Articles cited by this

Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) Method. Methods (2001) 414.27

Primer3 on the WWW for general users and for biologist programmers. Methods Mol Biol (2000) 128.08

A critical review of recombinant human bone morphogenetic protein-2 trials in spinal surgery: emerging safety concerns and lessons learned. Spine J (2011) 10.70

Genetic regulation of osteoclast development and function. Nat Rev Genet (2003) 7.94

Bone morphogenetic protein-2 converts the differentiation pathway of C2C12 myoblasts into the osteoblast lineage. J Cell Biol (1994) 5.93

Therapeutic approaches to bone diseases. Science (2000) 5.60

Osteogenic activity of the fourteen types of human bone morphogenetic proteins (BMPs). J Bone Joint Surg Am (2003) 3.36

A comprehensive clinical review of recombinant human bone morphogenetic protein-2 (INFUSE Bone Graft). Int Orthop (2007) 2.17

Clinical applications of BMP-7/OP-1 in fractures, nonunions and spinal fusion. Int Orthop (2007) 2.02

Both the Smad and p38 MAPK pathways play a crucial role in Runx2 expression following induction by transforming growth factor-beta and bone morphogenetic protein. Oncogene (2002) 1.89

The application of bone morphogenetic proteins to dental tissue engineering. Nat Biotechnol (2003) 1.61

Smad5 and DPC4 are key molecules in mediating BMP-2-induced osteoblastic differentiation of the pluripotent mesenchymal precursor cell line C2C12. J Biol Chem (1998) 1.54

Bone morphogenetic protein 2 (BMP-2) enhances BMP-3, BMP-4, and bone cell differentiation marker gene expression during the induction of mineralized bone matrix formation in cultures of fetal rat calvarial osteoblasts. Calcif Tissue Int (1997) 1.51

Tracking gene expression during zebrafish osteoblast differentiation. Dev Dyn (2009) 1.50

Activation of mitogen-activated protein kinase cascades is involved in regulation of bone morphogenetic protein-2-induced osteoblast differentiation in pluripotent C2C12 cells. Bone (2001) 1.48

Conservation of BMP signaling in zebrafish mesoderm patterning. Mech Dev (1997) 1.46

Clinical evaluation of recombinant human bone morphogenetic protein-2. Clin Orthop Relat Res (2002) 1.46

Effects of BMP-2, BMP-4, and BMP-6 on osteoblastic differentiation of bone marrow-derived stromal cell lines, ST2 and MC3T3-G2/PA6. Biochem Biophys Res Commun (1996) 1.42

Delivery of bone morphogenetic proteins for orthopedic tissue regeneration. Cytokine Growth Factor Rev (2005) 1.42

Duplicate zebrafish runx2 orthologues are expressed in developing skeletal elements. Gene Expr Patterns (2004) 1.28

Extracellular matrix-mediated signaling by dentin phosphophoryn involves activation of the Smad pathway independent of bone morphogenetic protein. J Biol Chem (2005) 1.26

Statin-induced Ras activation integrates the phosphatidylinositol 3-kinase signal to Akt and MAPK for bone morphogenetic protein-2 expression in osteoblast differentiation. J Biol Chem (2006) 1.20

Initiation of Smad-dependent and Smad-independent signaling via distinct BMP-receptor complexes. J Bone Joint Surg Am (2003) 1.18

Activation of p38 and Smads mediates BMP-2 effects on human trabecular bone-derived osteoblasts. Exp Cell Res (2003) 1.10

Cloning and expression of three members of the zebrafish Bmp family: Bmp2a, Bmp2b and Bmp4. Gene (1997) 1.10

Endoglin is involved in BMP-2-induced osteogenic differentiation of periodontal ligament cells through a pathway independent of Smad-1/5/8 phosphorylation. J Cell Physiol (2010) 1.08

Recombinant human bone morphogenetic protein-2 and collagen for bone regeneration. J Biomed Mater Res (1998) 1.08

Healing of a critical-sized defect in the rat femur with use of a vascularized periosteal flap, a biodegradable matrix, and bone morphogenetic protein. J Bone Joint Surg Am (2005) 1.06

Osteogenic protein-1 (OP-1, BMP-7) induces osteoblastic cell differentiation of the pluripotent mesenchymal cell line C2C12. J Cell Biochem (2002) 1.04

RNA interference for noggin enhances the biological activity of bone morphogenetic proteins in vivo and in vitro. J Bone Miner Metab (2009) 1.02

Repair of a proximal femoral bone defect in dogs using a porous surfaced prosthesis in combination with recombinant BMP-2 and a synthetic polymer carrier. Biomaterials (2003) 0.94

Anabolic agents and the bone morphogenetic protein pathway. Curr Top Dev Biol (2007) 0.93

Identification of small molecule activators of BMP signaling. PLoS One (2013) 0.90

The role of small molecules in musculoskeletal regeneration. Regen Med (2012) 0.90

Immobilized recombinant human bone morphogenetic protein-2 enhances the phosphorylation of receptor-activated Smads. J Biomed Mater Res A (2009) 0.88

A synthetic compound that potentiates bone morphogenetic protein-2-induced transdifferentiation of myoblasts into the osteoblastic phenotype. Mol Cell Biochem (2010) 0.86

Tanshinone IIA enhances BMP-2-stimulated commitment of C2C12 cells into osteoblasts via p38 activation. Amino Acids (2010) 0.86

Vgr-1/BMP-6 induces osteoblastic differentiation of pluripotential mesenchymal cells. Cell Growth Differ (1995) 0.84

In vitro and in vivo osteogenic activity of licochalcone A. Amino Acids (2011) 0.83

Simultaneous gene transfer of bone morphogenetic protein (BMP) -2 and BMP-7 by in vivo electroporation induces rapid bone formation and BMP-4 expression. BMC Musculoskelet Disord (2006) 0.81

Expression profiles of BMP-related molecules induced by BMP-2 or -4 in muscle-derived primary culture cells. J Bone Miner Metab (2005) 0.80