The Novel Metabotropic Glutamate Receptor 2 Positive Allosteric Modulator, AZD8529, Decreases Nicotine Self-Administration and Relapse in Squirrel Monkeys.

PubWeight™: 0.89‹?›

🔗 View Article (PMID 25802079)

Published in Biol Psychiatry on February 07, 2015

Authors

Zuzana Justinova1, Leigh V Panlilio2, Maria E Secci2, Godfrey H Redhi2, Charles W Schindler2, Alan J Cross3, Ladislav Mrzljak4, Amy Medd4, Yavin Shaham2, Steven R Goldberg2

Author Affiliations

1: Behavioral Neuroscience Research Branch, National Institute on Drug Abuse Intramural Research Program, National Institutes of Health, Department of Health and Human Services, Baltimore, Maryland. Electronic address: zjustino@intra.nida.nih.gov.
2: Behavioral Neuroscience Research Branch, National Institute on Drug Abuse Intramural Research Program, National Institutes of Health, Department of Health and Human Services, Baltimore, Maryland.
3: AstraZeneca Neuroscience Innovative Medicines, Cambridge, Massachusetts.
4: AstraZeneca Pharmaceuticals, Wilmington, Delaware.

Articles citing this

Effect of the Novel Positive Allosteric Modulator of Metabotropic Glutamate Receptor 2 AZD8529 on Incubation of Methamphetamine Craving After Prolonged Voluntary Abstinence in a Rat Model. Biol Psychiatry (2015) 0.99

Practical Strategies and Concepts in GPCR Allosteric Modulator Discovery: Recent Advances with Metabotropic Glutamate Receptors. Chem Rev (2016) 0.97

The Nucleus Accumbens: Mechanisms of Addiction across Drug Classes Reflect the Importance of Glutamate Homeostasis. Pharmacol Rev (2016) 0.86

Signals from the Fourth Dimension Regulate Drug Relapse. Trends Neurosci (2016) 0.84

Attenuation of nicotine-taking and nicotine-seeking behavior by the mGlu2 receptor positive allosteric modulators AZD8418 and AZD8529 in rats. Psychopharmacology (Berl) (2016) 0.81

Blockade of Nicotine and Cannabinoid Reinforcement and Relapse by a Cannabinoid CB1-Receptor Neutral Antagonist AM4113 and Inverse Agonist Rimonabant in Squirrel Monkeys. Neuropsychopharmacology (2016) 0.78

The mGluR2 Positive Allosteric Modulator, AZD8529, and Cue-Induced Relapse to Alcohol Seeking in Rats. Neuropsychopharmacology (2016) 0.76

The CHRNA5-A3-B4 Gene Cluster and Smoking: From Discovery to Therapeutics. Trends Neurosci (2016) 0.75

Presynaptic G Protein-Coupled Receptors: Gatekeepers of Addiction? Front Cell Neurosci (2016) 0.75

Dopamine in the Brain: Hypothesizing Surfeit or Deficit Links to Reward and Addiction. J Reward Defic Syndr (2015) 0.75

Metabotropic Glutamate Receptor 2 Positive Allosteric Modulators: Closing the Gate on Drug Abuse? Biol Psychiatry (2015) 0.75

From bench to bedside: mGluR2 positive allosteric modulators as medications to treat substance use disorders. Psychopharmacology (Berl) (2016) 0.75

Articles cited by this

The reinstatement model of drug relapse: history, methodology and major findings. Psychopharmacology (Berl) (2002) 9.90

First lapses to smoking: within-subjects analysis of real-time reports. J Consult Clin Psychol (1996) 5.42

Reinstatement of cocaine-reinforced responding in the rat. Psychopharmacology (Berl) (1981) 3.90

The scientific case that nicotine is addictive. Psychopharmacology (Berl) (1995) 3.78

Prevalence and demographic correlates of symptoms of last year dependence on alcohol, nicotine, marijuana and cocaine in the U.S. population. Drug Alcohol Depend (1997) 3.61

Activation of metabotropic glutamate receptors as a novel approach for the treatment of schizophrenia. Trends Pharmacol Sci (2008) 3.22

Neurobiology of addiction. Curr Opin Neurobiol (1996) 2.93

Cue dependency of nicotine self-administration and smoking. Pharmacol Biochem Behav (2001) 2.93

Unveiling the functions of presynaptic metabotropic glutamate receptors in the central nervous system. J Pharmacol Exp Ther (2001) 2.55

Tobacco, alcohol, and caffeine use: a review of their interrelationships. Psychol Bull (1984) 2.51

Complex interactions between nicotine and nonpharmacological stimuli reveal multiple roles for nicotine in reinforcement. Psychopharmacology (Berl) (2005) 2.49

Predictors of smoking relapse by duration of abstinence: findings from the International Tobacco Control (ITC) Four Country Survey. Addiction (2009) 2.36

A role of ventral tegmental area glutamate in contextual cue-induced relapse to heroin seeking. J Neurosci (2004) 2.23

Preferential effects of the metabotropic glutamate 2/3 receptor agonist LY379268 on conditioned reinstatement versus primary reinforcement: comparison between cocaine and a potent conventional reinforcer. J Neurosci (2004) 1.99

The ups and downs of addiction: role of metabotropic glutamate receptors. Trends Pharmacol Sci (2004) 1.90

Metabotropic glutamate 2/3 receptors in the ventral tegmental area and the nucleus accumbens shell are involved in behaviors relating to nicotine dependence. J Neurosci (2007) 1.85

Glutamate-based therapeutic approaches: allosteric modulators of metabotropic glutamate receptors. Curr Opin Pharmacol (2005) 1.80

Distribution of metabotropic glutamate receptor mGluR3 in the mouse CNS: differential location relative to pre- and postsynaptic sites. Neuroscience (2001) 1.80

The group II metabotropic glutamate receptor agonist, LY379268, inhibits both cocaine- and food-seeking behavior in rats. Psychopharmacology (Berl) (2006) 1.74

Group II metabotropic glutamate receptors modulate extracellular glutamate in the nucleus accumbens. J Pharmacol Exp Ther (2002) 1.70

Comparable behavior maintained under fixed-ratio and second-order schedules of food presentation, cocaine injection or d-amphetamine injection in the squirrel monkey. J Pharmacol Exp Ther (1973) 1.68

Biphenyl-indanone A, a positive allosteric modulator of the metabotropic glutamate receptor subtype 2, has antipsychotic- and anxiolytic-like effects in mice. J Pharmacol Exp Ther (2006) 1.60

Relapse to smoking after 1 year of abstinence: a meta-analysis. Addict Behav (2008) 1.52

Systemic and central amygdala injections of the mGluR(2/3) agonist LY379268 attenuate the expression of incubation of cocaine craving. Biol Psychiatry (2006) 1.49

Synthesis, pharmacological characterization, and molecular modeling of heterobicyclic amino acids related to (+)-2-aminobicyclo[3.1.0] hexane-2,6-dicarboxylic acid (LY354740): identification of two new potent, selective, and systemically active agonists for group II metabotropic glutamate receptors. J Med Chem (1999) 1.46

Incubation of cue-induced cigarette craving during abstinence in human smokers. Biol Psychiatry (2011) 1.44

The genetics of addiction-a translational perspective. Transl Psychiatry (2012) 1.30

Role of the glutamatergic system in nicotine dependence : implications for the discovery and development of new pharmacological smoking cessation therapies. CNS Drugs (2008) 1.24

The mGluR2 positive allosteric modulator BINA decreases cocaine self-administration and cue-induced cocaine-seeking and counteracts cocaine-induced enhancement of brain reward function in rats. Neuropsychopharmacology (2010) 1.23

The metabotropic glutamate 2/3 receptor agonist LY404039 reduces alcohol-seeking but not alcohol self-administration in alcohol-preferring (P) rats. Behav Brain Res (2006) 1.23

Pharmacological characterization and identification of amino acids involved in the positive modulation of metabotropic glutamate receptor subtype 2. Mol Pharmacol (2003) 1.23

The mGluR2/3 agonist LY379268 attenuates context- and discrete cue-induced reinstatement of sucrose seeking but not sucrose self-administration in rats. Behav Brain Res (2006) 1.19

Blockade of nicotine reward and reinstatement by activation of alpha-type peroxisome proliferator-activated receptors. Biol Psychiatry (2011) 1.18

The novel mGluR2/3 agonist LY379268 attenuates cue-induced reinstatement of heroin seeking. Neuroreport (2005) 1.15

Pharmacological stimulation of group ii metabotropic glutamate receptors reduces cocaine self-administration and cocaine-induced reinstatement of drug seeking in squirrel monkeys. J Pharmacol Exp Ther (2006) 1.15

Stimuli associated with drug injections as events that control behavior. Pharmacol Rev (1975) 1.08

The reinforcement-enhancing effects of nicotine: implications for the relationship between smoking, eating and weight. Physiol Behav (2011) 1.07

Nicotinic alpha 7 receptors as a new target for treatment of cannabis abuse. J Neurosci (2007) 1.04

Novel use of a lipid-lowering fibrate medication to prevent nicotine reward and relapse: preclinical findings. Neuropsychopharmacology (2012) 1.01

Effect of the Novel Positive Allosteric Modulator of Metabotropic Glutamate Receptor 2 AZD8529 on Incubation of Methamphetamine Craving After Prolonged Voluntary Abstinence in a Rat Model. Biol Psychiatry (2015) 0.99

Attenuation of methamphetamine seeking by the mGluR2/3 agonist LY379268 in rats with histories of restricted and escalated self-administration. Neuropharmacology (2012) 0.97

Recent progress in the synthesis and characterization of group II metabotropic glutamate receptor allosteric modulators. ACS Chem Neurosci (2011) 0.97

Molecular basis for the differential agonist affinities of group III metabotropic glutamate receptors. Mol Pharmacol (2004) 0.96

Design and synthesis of an orally active metabotropic glutamate receptor subtype-2 (mGluR2) positive allosteric modulator (PAM) that decreases cocaine self-administration in rats. J Med Chem (2010) 0.90

Development of novel pharmacotherapeutics for tobacco dependence: progress and future directions. Nicotine Tob Res (2012) 0.88

New findings on nicotine addiction and treatment. Nebr Symp Motiv (2009) 0.86

Modulation of group III metabotropic glutamate receptors by hydrogen ions. Pharmacology (2008) 0.82

Discovery and characterization of AZD9272 and AZD6538-Two novel mGluR5 negative allosteric modulators selected for clinical development. Bioorg Med Chem Lett (2012) 0.78