The mGluR2 positive allosteric modulator BINA decreases cocaine self-administration and cue-induced cocaine-seeking and counteracts cocaine-induced enhancement of brain reward function in rats.

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Published in Neuropsychopharmacology on June 16, 2010

Authors

Xinchun Jin1, Svetlana Semenova, Li Yang, Robert Ardecky, Douglas J Sheffler, Russell Dahl, P Jeffrey Conn, Nicholas D P Cosford, Athina Markou

Author Affiliations

1: Department of Psychiatry, University of California San Diego, La Jolla, 92093-0603, USA.

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N-{4-Chloro-2-[(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)methyl]phenyl}-2-hydroxybenzamide (CPPHA) acts through a novel site as a positive allosteric modulator of group 1 metabotropic glutamate receptors. Mol Pharmacol (2007) 1.56

Efficacy of contrast-enhanced US and magnetic microbubbles targeted to vascular cell adhesion molecule-1 for molecular imaging of atherosclerosis. Radiology (2011) 1.55

Group III metabotropic glutamate receptor-mediated modulation of the striatopallidal synapse. J Neurosci (2003) 1.55