In vivo mechanical loading rapidly activates β-catenin signaling in osteocytes through a prostaglandin mediated mechanism.

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Knee loading inhibits osteoclast lineage in a mouse model of osteoarthritis. Sci Rep (2016) 0.77

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Morc3 mutant mice exhibit reduced cortical area and thickness, accompanied by altered haematopoietic stem cells niche and bone cell differentiation. Sci Rep (2016) 0.75

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Postnatal β-catenin deletion from Dmp1-expressing osteocytes/osteoblasts reduces structural adaptation to loading, but not periosteal load-induced bone formation. Bone (2016) 0.75

Serum sclerostin decreases following 12months of resistance- or jump-training in men with low bone mass. Bone (2016) 0.75

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T-Type voltage-sensitive calcium channels mediate mechanically-induced intracellular calcium oscillations in osteocytes by regulating endoplasmic reticulum calcium dynamics. Bone (2016) 0.75

Evidence of the Role of R-Spondin 1 and Its Receptor Lgr4 in the Transmission of Mechanical Stimuli to Biological Signals for Bone Formation. Int J Mol Sci (2017) 0.75

Sclerostin's role in bone's adaptive response to mechanical loading. Bone (2016) 0.75

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Wnt proteins prevent apoptosis of both uncommitted osteoblast progenitors and differentiated osteoblasts by beta-catenin-dependent and -independent signaling cascades involving Src/ERK and phosphatidylinositol 3-kinase/AKT. J Biol Chem (2005) 2.69

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Wnt/beta-catenin signaling is a component of osteoblastic bone cell early responses to load-bearing and requires estrogen receptor alpha. J Biol Chem (2007) 2.24

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Mechanical loading-related changes in osteocyte sclerostin expression in mice are more closely associated with the subsequent osteogenic response than the peak strains engendered. Osteoporos Int (2011) 1.61

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Mechanical induction of PGE2 in osteocytes blocks glucocorticoid-induced apoptosis through both the β-catenin and PKA pathways. J Bone Miner Res (2010) 1.47

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Effects of mechanical strain on the function of Gap junctions in osteocytes are mediated through the prostaglandin EP2 receptor. J Biol Chem (2003) 1.39

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Activation of β-catenin signaling in MLO-Y4 osteocytic cells versus 2T3 osteoblastic cells by fluid flow shear stress and PGE2: Implications for the study of mechanosensation in bone. Bone (2010) 1.33

Gene expression patterns in bone following mechanical loading. J Bone Miner Res (2011) 1.32

Tissue strain amplification at the osteocyte lacuna: a microstructural finite element analysis. J Biomech (2007) 1.24

Mechano-transduction in osteoblastic cells involves strain-regulated estrogen receptor alpha-mediated control of insulin-like growth factor (IGF) I receptor sensitivity to Ambient IGF, leading to phosphatidylinositol 3-kinase/AKT-dependent Wnt/LRP5 receptor-independent activation of beta-catenin signaling. J Biol Chem (2009) 1.22

Analysis of multiple bone responses to graded strains above functional levels, and to disuse, in mice in vivo show that the human Lrp5 G171V High Bone Mass mutation increases the osteogenic response to loading but that lack of Lrp5 activity reduces it. Bone (2011) 1.21

Suppression of prostaglandin synthesis with NS-398 has different effects on endocortical and periosteal bone formation induced by mechanical loading. Calcif Tissue Int (2002) 1.12

In vitro and in vivo approaches to study osteocyte biology. Bone (2012) 1.09

Diminished response to in vivo mechanical loading in trabecular and not cortical bone in adulthood of female C57Bl/6 mice coincides with a reduction in deformation to load. Bone (2013) 1.06

Gap junction and hemichannel functions in osteocytes. Bone (2012) 1.04

Sost down-regulation by mechanical strain in human osteoblastic cells involves PGE2 signaling via EP4. FEBS Lett (2011) 1.04

Deletion of a single β-catenin allele in osteocytes abolishes the bone anabolic response to loading. J Bone Miner Res (2014) 1.02

Early activation of the beta-catenin pathway in osteocytes is mediated by nitric oxide, phosphatidyl inositol-3 kinase/Akt, and focal adhesion kinase. Biochem Biophys Res Commun (2009) 1.01

In situ intracellular calcium oscillations in osteocytes in intact mouse long bones under dynamic mechanical loading. FASEB J (2013) 1.00

DMP1 and MEPE expression are elevated in osteocytes after mechanical loading in vivo: theoretical role in controlling mineral quality in the perilacunar matrix. J Musculoskelet Neuronal Interact (2007) 0.99

Mechanical regulation of glycogen synthase kinase 3β (GSK3β) in mesenchymal stem cells is dependent on Akt protein serine 473 phosphorylation via mTORC2 protein. J Biol Chem (2011) 0.97

High-frequency, low-intensity vibrations increase bone mass and muscle strength in upper limbs, improving autonomy in disabled children. J Bone Miner Res (2011) 0.96

Prostaglandin E2 signals through PTGER2 to regulate sclerostin expression. PLoS One (2011) 0.92

Experimental and finite element analysis of strains induced by axial tibial compression in young-adult and old female C57Bl/6 mice. J Biomech (2013) 0.89

Studying osteocytes within their environment. Bone (2013) 0.86

Load/strain distribution between ulna and radius in the mouse forearm compression loading model. Med Eng Phys (2011) 0.86

Bone anabolic responses to mechanical load in vitro involve COX-2 and constitutive NOS. Connect Tissue Res (2004) 0.84

Functions of the osteocyte network in the regulation of bone mass. Cell Tissue Res (2013) 0.82

Numerical modeling of long bone adaptation due to mechanical loading: correlation with experiments. Ann Biomed Eng (2009) 0.82

Characterization of cancellous and cortical bone strain in the in vivo mouse tibial loading model using microCT-based finite element analysis. Bone (2014) 0.79

Experimental and finite element analysis of dynamic loading of the mouse forearm. J Orthop Res (2014) 0.79