Mechano-transduction in osteoblastic cells involves strain-regulated estrogen receptor alpha-mediated control of insulin-like growth factor (IGF) I receptor sensitivity to Ambient IGF, leading to phosphatidylinositol 3-kinase/AKT-dependent Wnt/LRP5 receptor-independent activation of beta-catenin signaling.

PubWeight™: 1.22‹?› | Rank: Top 10%

🔗 View Article (PMC 2838297)

Published in J Biol Chem on December 30, 2009

Authors

Andrew Sunters1, Victoria J Armstrong, Gul Zaman, Robert M Kypta, Yoshiaki Kawano, Lance E Lanyon, Joanna S Price

Author Affiliations

1: Department of Veterinary Basic Sciences, Royal Veterinary College, Royal College Street, London NW1 0TU, United Kingdom. asunters@rvc.ac.uk

Articles citing this

Mechanical regulation of signaling pathways in bone. Gene (2012) 1.65

Estrogen receptor-α signaling in osteoblast progenitors stimulates cortical bone accrual. J Clin Invest (2012) 1.36

Sex steroid actions in male bone. Endocr Rev (2014) 1.26

Estrogen receptor-α is required for the osteogenic response to mechanical loading in a ligand-independent manner involving its activation function 1 but not 2. J Bone Miner Res (2013) 1.22

Analysis of multiple bone responses to graded strains above functional levels, and to disuse, in mice in vivo show that the human Lrp5 G171V High Bone Mass mutation increases the osteogenic response to loading but that lack of Lrp5 activity reduces it. Bone (2011) 1.21

Estrogen receptor α mediates proliferation of osteoblastic cells stimulated by estrogen and mechanical strain, but their acute down-regulation of the Wnt antagonist Sost is mediated by estrogen receptor β. J Biol Chem (2013) 1.11

Osteocyte-driven bone remodeling. Calcif Tissue Int (2013) 1.08

Sost down-regulation by mechanical strain in human osteoblastic cells involves PGE2 signaling via EP4. FEBS Lett (2011) 1.04

Deletion of a single β-catenin allele in osteocytes abolishes the bone anabolic response to loading. J Bone Miner Res (2014) 1.02

Mechanical loading-related bone gain is enhanced by tamoxifen but unaffected by fulvestrant in female mice. Endocrinology (2010) 0.99

Beta-catenin--a supporting role in the skeleton. J Cell Biochem (2010) 0.99

In vivo mechanical loading rapidly activates β-catenin signaling in osteocytes through a prostaglandin mediated mechanism. Bone (2015) 0.98

Age-related impairment of bones' adaptive response to loading in mice is associated with sex-related deficiencies in osteoblasts but no change in osteocytes. J Bone Miner Res (2014) 0.97

Mechanical regulation of glycogen synthase kinase 3β (GSK3β) in mesenchymal stem cells is dependent on Akt protein serine 473 phosphorylation via mTORC2 protein. J Biol Chem (2011) 0.97

The Contribution of Experimental in vivo Models to Understanding the Mechanisms of Adaptation to Mechanical Loading in Bone. Front Endocrinol (Lausanne) (2014) 0.97

Mechanical load increases in bone formation via a sclerostin-independent pathway. J Bone Miner Res (2014) 0.95

Crosstalk between caveolin-1/extracellular signal-regulated kinase (ERK) and β-catenin survival pathways in osteocyte mechanotransduction. J Biol Chem (2013) 0.89

Loading-related regulation of transcription factor EGR2/Krox-20 in bone cells is ERK1/2 protein-mediated and prostaglandin, Wnt signaling pathway-, and insulin-like growth factor-I axis-dependent. J Biol Chem (2011) 0.89

The fragile elderly hip: mechanisms associated with age-related loss of strength and toughness. Bone (2014) 0.86

Lrp5 is not required for the proliferative response of osteoblasts to strain but regulates proliferation and apoptosis in a cell autonomous manner. PLoS One (2012) 0.86

A specific role for phosphoinositide 3-kinase and AKT in osteoblasts? Front Endocrinol (Lausanne) (2012) 0.86

Bacterial siderophores that evade or overwhelm lipocalin 2 induce hypoxia inducible factor 1α and proinflammatory cytokine secretion in cultured respiratory epithelial cells. Infect Immun (2014) 0.85

The lncRNA MALAT1 is a novel biomarker for gastric cancer metastasis. Oncotarget (2016) 0.85

Is interaction between age-dependent decline in mechanical stimulation and osteocyte-estrogen receptor levels the culprit for postmenopausal-impaired bone formation? Osteoporos Int (2012) 0.84

LRP5 and bone mass regulation: Where are we now? Bonekey Rep (2012) 0.83

Regulation of skeletal growth and mineral acquisition by the GH/IGF-1 axis: Lessons from mouse models. Growth Horm IGF Res (2015) 0.82

Estrogen receptors' roles in the control of mechanically adaptive bone (re)modeling. Bonekey Rep (2013) 0.82

Protein kinase Cα (PKCα) regulates bone architecture and osteoblast activity. J Biol Chem (2014) 0.82

β-Catenin independent cross-control between the estradiol and Wnt pathways in osteoblasts. Gene (2011) 0.81

Planar cell polarity aligns osteoblast division in response to substrate strain. J Bone Miner Res (2015) 0.81

Estrogens and Androgens in Skeletal Physiology and Pathophysiology. Physiol Rev (2017) 0.81

Exercise does not enhance aged bone's impaired response to artificial loading in C57Bl/6 mice. Bone (2015) 0.79

Extracellular Signal-regulated Kinase (ERK)-dependent Phosphorylation of Y-Box-binding Protein 1 (YB-1) Enhances Gene Expression in Granulosa Cells in Response to Follicle-stimulating Hormone (FSH). J Biol Chem (2016) 0.78

Intense Walking Exercise Affects Serum IGF-1 and IGFBP3. J Lifestyle Med (2015) 0.78

Mechanical stimulation enhanced estrogen receptor expression and callus formation in diaphyseal long bone fracture healing in ovariectomy-induced osteoporotic rats. Osteoporos Int (2016) 0.76

Role of cortical bone in hip fracture. Bonekey Rep (2017) 0.75

Sclerostin's role in bone's adaptive response to mechanical loading. Bone (2016) 0.75

Serum sclerostin decreases following 12months of resistance- or jump-training in men with low bone mass. Bone (2016) 0.75

A novel isoform of IL-33 revealed by screening for transposable element promoted genes in human colorectal cancer. PLoS One (2017) 0.75

Articles cited by this

(truncated to the top 100)

AKT/PKB signaling: navigating downstream. Cell (2007) 31.26

LDL receptor-related protein 5 (LRP5) affects bone accrual and eye development. Cell (2001) 11.99

New insights into tumor suppression: PTEN suppresses tumor formation by restraining the phosphoinositide 3-kinase/AKT pathway. Proc Natl Acad Sci U S A (1999) 11.38

A mutation in the LDL receptor-related protein 5 gene results in the autosomal dominant high-bone-mass trait. Am J Hum Genet (2001) 6.56

Prostaglandin E2 promotes colon cancer cell growth through a Gs-axin-beta-catenin signaling axis. Science (2005) 5.68

Direct derivation of conditionally immortal cell lines from an H-2Kb-tsA58 transgenic mouse. Proc Natl Acad Sci U S A (1991) 5.52

Mechanical stimulation of bone in vivo reduces osteocyte expression of Sost/sclerostin. J Biol Chem (2007) 4.74

Phosphorylation of beta-catenin by AKT promotes beta-catenin transcriptional activity. J Biol Chem (2007) 4.60

Regulation of G1 progression by the PTEN tumor suppressor protein is linked to inhibition of the phosphatidylinositol 3-kinase/Akt pathway. Proc Natl Acad Sci U S A (1999) 4.19

Phosphatidylinositol 3-kinase/AKT-mediated activation of estrogen receptor alpha: a new model for anti-estrogen resistance. J Biol Chem (2001) 3.86

Wnt signaling in osteoblasts and bone diseases. Gene (2004) 3.72

High bone mass in mice expressing a mutant LRP5 gene. J Bone Miner Res (2003) 3.48

The Wnt co-receptor LRP5 is essential for skeletal mechanotransduction but not for the anabolic bone response to parathyroid hormone treatment. J Biol Chem (2006) 3.04

Rac1 activation controls nuclear localization of beta-catenin during canonical Wnt signaling. Cell (2008) 3.02

Wnt-4 is a mesenchymal signal for epithelial transformation of metanephric mesenchyme in the developing kidney. Development (1998) 2.90

Six novel missense mutations in the LDL receptor-related protein 5 (LRP5) gene in different conditions with an increased bone density. Am J Hum Genet (2003) 2.86

Functional and structural diversity of the human Dickkopf gene family. Gene (1999) 2.82

Sensitivity of osteocytes to biomechanical stress in vitro. FASEB J (1995) 2.53

Insulin and IGF-1 stimulate the beta-catenin pathway through two signalling cascades involving GSK-3beta inhibition and Ras activation. Oncogene (2001) 2.25

Oscillating fluid flow activation of gap junction hemichannels induces ATP release from MLO-Y4 osteocytes. J Cell Physiol (2007) 2.24

Wnt/beta-catenin signaling is a component of osteoblastic bone cell early responses to load-bearing and requires estrogen receptor alpha. J Biol Chem (2007) 2.24

Linkage of rapid estrogen action to MAPK activation by ERalpha-Shc association and Shc pathway activation. Mol Endocrinol (2002) 2.18

Phosphatidylinositol-3-OH Kinase (PI3K)/AKT2, activated in breast cancer, regulates and is induced by estrogen receptor alpha (ERalpha) via interaction between ERalpha and PI3K. Cancer Res (2001) 2.10

Estrogen receptor alpha rapidly activates the IGF-1 receptor pathway. J Biol Chem (2000) 2.07

The skeletal structure of insulin-like growth factor I-deficient mice. J Bone Miner Res (2001) 2.03

The role of Shc and insulin-like growth factor 1 receptor in mediating the translocation of estrogen receptor alpha to the plasma membrane. Proc Natl Acad Sci U S A (2004) 1.89

Generation of osteoclast-inductive and osteoclastogenic cell lines from the H-2KbtsA58 transgenic mouse. Proc Natl Acad Sci U S A (1993) 1.80

Endocrinology: bone adaptation requires oestrogen receptor-alpha. Nature (2003) 1.76

Mechanical stimulation prevents osteocyte apoptosis: requirement of integrins, Src kinases, and ERKs. Am J Physiol Cell Physiol (2005) 1.70

Up-regulation of the Wnt, estrogen receptor, insulin-like growth factor-I, and bone morphogenetic protein pathways in C57BL/6J osteoblasts as opposed to C3H/HeJ osteoblasts in part contributes to the differential anabolic response to fluid shear. J Biol Chem (2006) 1.63

Requirement of estrogen receptor-alpha in insulin-like growth factor-1 (IGF-1)-induced uterine responses and in vivo evidence for IGF-1/estrogen receptor cross-talk. J Biol Chem (2001) 1.60

Beta-catenin levels influence rapid mechanical responses in osteoblasts. J Biol Chem (2008) 1.60

Nitric oxide and bone. Immunology (2001) 1.60

Prostaglandin E2 reduces radiation-induced epithelial apoptosis through a mechanism involving AKT activation and bax translocation. J Clin Invest (2004) 1.59

Akt1 in osteoblasts and osteoclasts controls bone remodeling. PLoS One (2007) 1.56

Clinical and molecular findings in osteoporosis-pseudoglioma syndrome. Am J Hum Genet (2005) 1.52

Phosphatidylinositol 3-kinase-Akt pathway plays a critical role in early cardiomyogenesis by regulating canonical Wnt signaling. Circ Res (2005) 1.46

Estrogen receptor protein interaction with phosphatidylinositol 3-kinase leads to activation of phosphorylated Akt and extracellular signal-regulated kinase 1/2 in the same population of cortical neurons: a unified mechanism of estrogen action. J Neurosci (2006) 1.43

Fluid shear stress induces beta-catenin signaling in osteoblasts. Calcif Tissue Int (2004) 1.42

Inflammation and IGF-I activate the Akt pathway in breast cancer. Int J Cancer (2007) 1.38

Indomethacin modulation of load-related stimulation of new bone formation in vivo. Calcif Tissue Int (1989) 1.37

Exercise and mechanical loading increase periosteal bone formation and whole bone strength in C57BL/6J mice but not in C3H/Hej mice. Calcif Tissue Int (2000) 1.36

Lifelong accumulation of bone in mice lacking Pten in osteoblasts. Proc Natl Acad Sci U S A (2007) 1.36

Fluid flow stimulates rapid and continuous release of nitric oxide in osteoblasts. Am J Physiol (1996) 1.34

Defective bone formation and anabolic response to exogenous estrogen in mice with targeted disruption of endothelial nitric oxide synthase. Endocrinology (2001) 1.32

Insulin-like growth factor-I is essential for embryonic bone development. Endocrinology (2006) 1.32

Mechanical strain stimulates nitric oxide production by rapid activation of endothelial nitric oxide synthase in osteocytes. J Bone Miner Res (1999) 1.31

Characterization of fetal and postnatal enteric neuronal cell lines with improvement in intestinal neural function. Gastroenterology (2008) 1.27

Osteocytes use estrogen receptor alpha to respond to strain but their ERalpha content is regulated by estrogen. J Bone Miner Res (2006) 1.25

Prostaglandin E2 induces vascular endothelial growth factor secretion in prostate cancer cells through EP2 receptor-mediated cAMP pathway. Mol Carcinog (2007) 1.25

The adaptive response of bone to mechanical loading in female transgenic mice is deficient in the absence of oestrogen receptor-alpha and -beta. J Endocrinol (2004) 1.23

Calcium regulates the PI3K-Akt pathway in stretched osteoblasts. FEBS Lett (2003) 1.19

A novel ligand-independent function of the estrogen receptor is essential for osteocyte and osteoblast mechanotransduction. J Biol Chem (2007) 1.19

Phosphatidylinositol 3-kinase mediates neuroprotection by estrogen in cultured cortical neurons. J Neurosci Res (2000) 1.18

Mechanical loading stimulates rapid changes in periosteal gene expression. Calcif Tissue Int (1994) 1.17

Glucocorticoids inhibit the transcriptional activity of LEF/TCF in differentiating osteoblasts in a glycogen synthase kinase-3beta-dependent and -independent manner. J Biol Chem (2004) 1.16

Increased insulin-like growth factor I mRNA expression in rat osteocytes in response to mechanical stimulation. Am J Physiol (1995) 1.15

Mechanical strain-induced NO production by bone cells: a possible role in adaptive bone (re)modeling? FASEB J (1995) 1.14

Accelerated cell cycle progression in osteoblasts overexpressing the c-fos proto-oncogene: induction of cyclin A and enhanced CDK2 activity. J Biol Chem (2003) 1.13

Suppression of prostaglandin synthesis with NS-398 has different effects on endocortical and periosteal bone formation induced by mechanical loading. Calcif Tissue Int (2002) 1.12

SV40-dependent AKT activity drives mesothelial cell transformation after asbestos exposure. Cancer Res (2005) 1.11

Prostaglandin E2 stimulates angiogenesis by activating the nitric oxide/cGMP pathway in human umbilical vein endothelial cells. Exp Mol Med (2005) 1.09

Mechanical strain stimulates osteoblast proliferation through the estrogen receptor in males as well as females. J Bone Miner Res (2000) 1.08

Cyclooxygenase-2 inhibits UVB-induced apoptosis in mouse skin by activating the prostaglandin E2 receptors, EP2 and EP4. Cancer Res (2007) 1.08

Mechanical strain and fluid movement both activate extracellular regulated kinase (ERK) in osteoblast-like cells but via different signaling pathways. Bone (2002) 1.07

Interaction between simian virus 40 large T antigen and insulin receptor substrate 1 is disrupted by the K1 mutation, resulting in the loss of large T antigen-mediated phosphorylation of Akt. J Virol (2008) 1.07

Akt-mediated phosphorylation and activation of estrogen receptor alpha is required for endometrial neoplastic transformation in Pten+/- mice. Cancer Res (2006) 1.07

Estrogen receptor alpha forms estrogen-dependent multimolecular complexes with insulin-like growth factor receptor and phosphatidylinositol 3-kinase in the adult rat brain. Brain Res Mol Brain Res (2003) 1.04

Response to mechanical strain in an immortalized pre-osteoblast cell is dependent on ERK1/2. J Cell Physiol (2006) 1.03

Fluid shear stress inhibits TNF-alpha-induced apoptosis in osteoblasts: a role for fluid shear stress-induced activation of PI3-kinase and inhibition of caspase-3. J Cell Physiol (2003) 1.03

ATP activates DNA synthesis by acting on P2X receptors in human osteoblast-like MG-63 cells. Am J Physiol Cell Physiol (2000) 1.03

Osteoblast-like cells from estrogen receptor alpha knockout mice have deficient responses to mechanical strain. J Bone Miner Res (2004) 1.03

IGF-1 as an early marker for low bone mass or osteoporosis in premenopausal and postmenopausal women. J Bone Miner Metab (2008) 1.01

Transformation by the simian virus 40 T antigen is regulated by IGF-I receptor and IRS-1 signaling. Oncogene (2006) 1.01

Primary human osteoblast proliferation and prostaglandin E2 release in response to mechanical strain in vitro. Bone (1998) 1.01

Role of receptor complexes in the extranuclear actions of estrogen receptor alpha in breast cancer. Endocr Relat Cancer (2006) 1.00

Phosphatidylinositol 3-kinase and Akt protein kinase mediate IGF-I- and prosaptide-induced survival in Schwann cells. J Neurosci Res (1999) 0.99

Estrogen suppresses activation but enhances formation phase of osteogenic response to mechanical stimulation in rat bone. J Clin Invest (1996) 0.98

Cross-talk between estrogen receptors and insulin-like growth factor-I receptor in the brain: cellular and molecular mechanisms. Front Neuroendocrinol (2006) 0.98

Effect of mechanical loading on insulin-like growth factor-I gene expression in rat tibia. J Endocrinol (2007) 0.98

Pathogenic mutations and polymorphisms in the lipoprotein receptor-related protein 5 reveal a new biological pathway for the control of bone mass. Curr Opin Lipidol (2005) 0.97

Early responses to dynamic strain change and prostaglandins in bone-derived cells in culture. J Bone Miner Res (1997) 0.97

Mechanical strain and estrogen activate estrogen receptor alpha in bone cells. J Bone Miner Res (2001) 0.96

Loading-related increases in prostaglandin production in cores of adult canine cancellous bone in vitro: a role for prostacyclin in adaptive bone remodeling? J Bone Miner Res (1991) 0.95

Is estrogen receptor alpha key to controlling bones' resistance to fracture? J Endocrinol (2004) 0.95

The estrogen receptor's involvement in osteoblasts' adaptive response to mechanical strain. J Bone Miner Res (1998) 0.93

Human osteoblasts' proliferative responses to strain and 17beta-estradiol are mediated by the estrogen receptor and the receptor for insulin-like growth factor I. J Bone Miner Res (2002) 0.92

The H-2KbtsA58 transgenic mouse: a new tool for the rapid generation of novel cell lines. Transgenic Res (1995) 0.91

Extracellular nucleotides activate Runx2 in the osteoblast-like HOBIT cell line: a possible molecular link between mechanical stress and osteoblasts' response. Bone (2005) 0.90

Estrogen exerts neuroprotective effects via membrane estrogen receptors and rapid Akt/NOS activation. FASEB J (2004) 0.90

Low-dose estrogen treatment suppresses periosteal bone formation in response to mechanical loading. Bone (2006) 0.89

Insulin-like growth factor-I receptor and estrogen receptor crosstalk mediates hormone-induced neurite outgrowth in PC12 cells. Brain Res (2004) 0.89

The transduction of mechanical force into biochemical events in bone cells may involve activation of phospholipase A2. Calcif Tissue Int (1988) 0.89

Transforming growth factor-beta prevents osteoblast apoptosis induced by skeletal unloading via PI3K/Akt, Bcl-2, and phospho-Bad signaling. Am J Physiol Endocrinol Metab (2008) 0.88

Role of estrogen receptor (ER) alpha in insulin-like growth factor (IGF)-I-induced responses in MCF-7 breast cancer cells. J Mol Endocrinol (2005) 0.87

Mechanotransduction in stretched osteocytes--temporal expression of immediate early and other genes. Biochem Biophys Res Commun (1998) 0.87

Mechanical strain stimulates ROS cell proliferation through IGF-II and estrogen through IGF-I. J Bone Miner Res (1999) 0.84

The role of prostaglandins and nitric oxide in the response of bone to mechanical forces. Osteoarthritis Cartilage (1999) 0.84

Early strain-related changes in cultured embryonic chick tibiotarsi parallel those associated with adaptive modeling in vivo. J Bone Miner Res (1993) 0.83

Prostaglandin E2 increases the skeletal response to mechanical loading. J Bone Miner Res (1997) 0.82

Articles by these authors

Non-invasive axial loading of mouse tibiae increases cortical bone formation and modifies trabecular organization: a new model to study cortical and cancellous compartments in a single loaded element. Bone (2005) 2.36

Wnt/beta-catenin signaling is a component of osteoblastic bone cell early responses to load-bearing and requires estrogen receptor alpha. J Biol Chem (2007) 2.24

Mechanical strain and bone cell function: a review. Osteoporos Int (2002) 2.10

Endocrinology: bone adaptation requires oestrogen receptor-alpha. Nature (2003) 1.76

Mechanical loading enhances the anabolic effects of intermittent parathyroid hormone (1-34) on trabecular and cortical bone in mice. Bone (2008) 1.76

Functional adaptation to mechanical loading in both cortical and cancellous bone is controlled locally and is confined to the loaded bones. Bone (2009) 1.70

Inhibition of glycogen synthase kinase-3 represses androgen receptor activity and prostate cancer cell growth. Oncogene (2004) 1.54

Multiple roles of vertebrate REV genes in DNA repair and recombination. Mol Cell Biol (2005) 1.52

Mechanical loading: biphasic osteocyte survival and targeting of osteoclasts for bone destruction in rat cortical bone. Am J Physiol Cell Physiol (2002) 1.51

Bones' adaptive response to mechanical loading is essentially linear between the low strains associated with disuse and the high strains associated with the lamellar/woven bone transition. J Bone Miner Res (2012) 1.33

Histological classification of ovarian cancer. Med Electron Microsc (2003) 1.30

Osteocytes use estrogen receptor alpha to respond to strain but their ERalpha content is regulated by estrogen. J Bone Miner Res (2006) 1.25

Presenilin-dependent gamma-secretase activity mediates the intramembranous cleavage of CD44. Oncogene (2003) 1.24

Estrogen receptor-α is required for the osteogenic response to mechanical loading in a ligand-independent manner involving its activation function 1 but not 2. J Bone Miner Res (2013) 1.22

Analysis of multiple bone responses to graded strains above functional levels, and to disuse, in mice in vivo show that the human Lrp5 G171V High Bone Mass mutation increases the osteogenic response to loading but that lack of Lrp5 activity reduces it. Bone (2011) 1.21

The mouse fibula as a suitable bone for the study of functional adaptation to mechanical loading. Bone (2009) 1.20

Loading-related regulation of gene expression in bone in the contexts of estrogen deficiency, lack of estrogen receptor alpha and disuse. Bone (2009) 1.19

Sympathetic nervous system does not mediate the load-induced cortical new bone formation. J Bone Miner Res (2005) 1.19

Wnt-11 promotes neuroendocrine-like differentiation, survival and migration of prostate cancer cells. Mol Cancer (2010) 1.18

Analysis of Wnt gene expression in prostate cancer: mutual inhibition by WNT11 and the androgen receptor. Cancer Res (2004) 1.15

Role of endocrine and paracrine factors in the adaptation of bone to mechanical loading. Curr Osteoporos Rep (2011) 1.13

Estrogen receptor α mediates proliferation of osteoblastic cells stimulated by estrogen and mechanical strain, but their acute down-regulation of the Wnt antagonist Sost is mediated by estrogen receptor β. J Biol Chem (2013) 1.11

Mechanical loading influences bone mass through estrogen receptor alpha. Exerc Sport Sci Rev (2004) 1.07

Risedronate does not reduce mechanical loading-related increases in cortical and trabecular bone mass in mice. Bone (2011) 1.06

Sost down-regulation by mechanical strain in human osteoblastic cells involves PGE2 signaling via EP4. FEBS Lett (2011) 1.04

Osteoblast-like cells from estrogen receptor alpha knockout mice have deficient responses to mechanical strain. J Bone Miner Res (2004) 1.03

The neuron-specific isoform of glycogen synthase kinase-3beta is required for axon growth. J Neurochem (2010) 1.03

Crystal structures of an archaeal oligosaccharyltransferase provide insights into the catalytic cycle of N-linked protein glycosylation. Proc Natl Acad Sci U S A (2013) 1.02

Kinetic and structural studies on the catalytic role of the aspartic acid residue conserved in copper amine oxidase. Biochemistry (2006) 1.01

Improbable appendages: Deer antler renewal as a unique case of mammalian regeneration. Semin Cell Dev Biol (2008) 1.01

Male mice housed in groups engage in frequent fighting and show a lower response to additional bone loading than females or individually housed males that do not fight. Bone (2013) 1.00

Structure of thiocyanate hydrolase: a new nitrile hydratase family protein with a novel five-coordinate cobalt(III) center. J Mol Biol (2006) 0.99

Glucocorticoids inhibit apoptosis during fibrosarcoma development by transcriptionally activating Bcl-xL. J Biol Chem (2003) 0.99

Mechanical loading-related bone gain is enhanced by tamoxifen but unaffected by fulvestrant in female mice. Endocrinology (2010) 0.99

Current status of pharmacotherapy against metastatic renal cell carcinoma in Japan. Int J Urol (2012) 0.98

Age-related impairment of bones' adaptive response to loading in mice is associated with sex-related deficiencies in osteoblasts but no change in osteocytes. J Bone Miner Res (2014) 0.97

Distinct expression and activity of GSK-3α and GSK-3β in prostate cancer. Int J Cancer (2012) 0.96

Is estrogen receptor alpha key to controlling bones' resistance to fracture? J Endocrinol (2004) 0.95

[Protein micro-crystallography with a new micro-beam beamline]. Yakugaku Zasshi (2010) 0.95

Structural basis for catalytic activation of thiocyanate hydrolase involving metal-ligated cysteine modification. J Am Chem Soc (2009) 0.95

Distinct roles for Wnt-4 and Wnt-11 during retinoic acid-induced neuronal differentiation. Stem Cells (2011) 0.93

Adult rat bones maintain distinct regionalized expression of markers associated with their development. PLoS One (2009) 0.93

Human osteoblasts' proliferative responses to strain and 17beta-estradiol are mediated by the estrogen receptor and the receptor for insulin-like growth factor I. J Bone Miner Res (2002) 0.92

Enhancement of human cancer cell motility and invasiveness by anaphylatoxin C5a via aberrantly expressed C5a receptor (CD88). Clin Cancer Res (2013) 0.91

Crystal structure of the histidine-containing phosphotransfer protein ZmHP2 from maize. Protein Sci (2004) 0.90

Loading-related regulation of transcription factor EGR2/Krox-20 in bone cells is ERK1/2 protein-mediated and prostaglandin, Wnt signaling pathway-, and insulin-like growth factor-I axis-dependent. J Biol Chem (2011) 0.89

A switch from canonical to noncanonical Wnt signaling mediates early differentiation of human neural stem cells. Stem Cells (2014) 0.89

A case of pregnancy complicated by the development of a tubo-ovarian abscess following in vitro fertilization and embryo transfer. Am J Perinatol (2003) 0.88

Downregulation of Dickkopf-3 disrupts prostate acinar morphogenesis through TGF-β/Smad signalling. J Cell Sci (2013) 0.87

Severe bleeding tendency caused by a rare complication of excessive fibrinolysis with disseminated intravascular coagulation in a 51-year-old Japanese man with prostate cancer: a case report. J Med Case Rep (2012) 0.86

Lrp5 is not required for the proliferative response of osteoblasts to strain but regulates proliferation and apoptosis in a cell autonomous manner. PLoS One (2012) 0.86

A specific role for phosphoinositide 3-kinase and AKT in osteoblasts? Front Endocrinol (Lausanne) (2012) 0.86

Mammalian Sulf1 RNA alternative splicing and its significance to tumour growth regulation. Tumour Biol (2012) 0.85

Mutational study on alphaGln90 of Fe-type nitrile hydratase from Rhodococcus sp. N771. Biosci Biotechnol Biochem (2006) 0.85

Global stability of vector-host disease with variable population size. Biomed Res Int (2013) 0.84

Biochemical markers of bone turnover in the domestic cat: relationships with age and feline osteoclastic resorptive lesions. J Nutr (2002) 0.83

Sulf2 gene is alternatively spliced in mammalian developing and tumour tissues with functional implications. Biochem Biophys Res Commun (2011) 0.82

Issues associated with the use of phosphospecific antibodies to localise active and inactive pools of GSK-3 in cells. Biol Direct (2011) 0.82

Evaluation of serum concentrations of biochemical markers of bone metabolism and insulin-like growth factor I associated with treadmill exercise in young horses. Am J Vet Res (2003) 0.82

Planar cell polarity aligns osteoblast division in response to substrate strain. J Bone Miner Res (2015) 0.81

Systemic and contralateral responses to loading of bones. J Bone Miner Res (2009) 0.81

Expression, purification, crystallization, and preliminary X-ray crystallographic studies of the human adiponectin receptors, AdipoR1 and AdipoR2. J Struct Funct Genomics (2015) 0.80

Exercise affects joint injury risk in young Thoroughbreds in training. Vet J (2012) 0.79

The in vitro effect of pH on osteoclasts and bone resorption in the cat: implications for the pathogenesis of FORL. J Cell Physiol (2007) 0.79

Structural insights into the substrate specificity of bacterial copper amine oxidase obtained by using irreversible inhibitors. J Biochem (2011) 0.78

Relationship between serum biomarkers of cartilage and bone metabolism and joint injury in young Thoroughbred racehorses in training. Am J Vet Res (2015) 0.77

A scanning electron microscopy study of idiopathic external tooth resorption in the cat. J Periodontol (2005) 0.77

Retracted Electroporation-mediated muscarinic M3 receptor gene transfer into rat urinary bladder. Int J Urol (2004) 0.76

Fracture rate in Thoroughbred racehorses is affected by dam age and parity. Vet J (2006) 0.76

Correction: Approximating a Giving Up Smoking Dynamic on Adolescent Nicotine Dependence in Fractional Order. PLoS One (2016) 0.75