Published in Front Cell Neurosci on March 17, 2015
Precision Medicine in Multiple Sclerosis: Future of PET Imaging of Inflammation and Reactive Astrocytes. Front Mol Neurosci (2016) 0.80
Homer1a attenuates glutamate-induced oxidative injury in HT-22 cells through regulation of store-operated calcium entry. Sci Rep (2016) 0.79
Induction of Neuronal Morphology in the 661W Cone Photoreceptor Cell Line with Staurosporine. PLoS One (2015) 0.77
Targeted Gene Expression in Zebrafish Exposed to Chlorpyrifos-Oxon Confirms Phenotype-Specific Mechanisms Leading to Adverse Outcomes. Bull Environ Contam Toxicol (2016) 0.76
Effects of phenolic constituents of daylily flowers on corticosterone- and glutamate-treated PC12 cells. BMC Complement Altern Med (2017) 0.75
Glypican 6 Enhances N-Methyl-D-Aspartate Receptor Function in Human-Induced Pluripotent Stem Cell-Derived Neurons. Front Cell Neurosci (2016) 0.75
Aquaporin 4-Mediated Glutamate-Induced Astrocyte Swelling Is Partially Mediated through Metabotropic Glutamate Receptor 5 Activation. Front Cell Neurosci (2017) 0.75
Concentration-Dependent Dual Role of Thrombin in Protection of Cultured Rat Cortical Neurons. Neurochem Res (2015) 0.75
The Role of Ca(2+) Imbalance in the Induction of Acute Oxidative Stress and Cytotoxicity in Cultured Rat Cerebellar Granule Cells Challenged with Tetrabromobisphenol A. Neurochem Res (2016) 0.75
Dynamic NHERF interaction with TRPC4/5 proteins is required for channel gating by diacylglycerol. Proc Natl Acad Sci U S A (2016) 0.75
Inhibition of TLR4 alleviates the inflammation and apoptosis of retinal ganglion cells in high glucose. Graefes Arch Clin Exp Ophthalmol (2017) 0.75
O-GlcNAc Glycosylation of nNOS Promotes Neuronal Apoptosis Following Glutamate Excitotoxicity. Cell Mol Neurobiol (2017) 0.75
Berberine protects against glutamate-induced oxidative stress and apoptosis in PC12 and N2a cells. Iran J Basic Med Sci (2017) 0.75
Upstream and downstream of mTOR. Genes Dev (2004) 21.61
Establishment of a noradrenergic clonal line of rat adrenal pheochromocytoma cells which respond to nerve growth factor. Proc Natl Acad Sci U S A (1976) 21.06
Molecular characterization of mitochondrial apoptosis-inducing factor. Nature (1999) 14.41
Glutamate uptake. Prog Neurobiol (2001) 13.59
Pharmacology and functions of metabotropic glutamate receptors. Annu Rev Pharmacol Toxicol (1997) 10.26
S-nitrosylated GAPDH initiates apoptotic cell death by nuclear translocation following Siah1 binding. Nat Cell Biol (2005) 7.25
Heteromeric NMDA receptors: molecular and functional distinction of subtypes. Science (1992) 6.49
MAPK cascade signalling and synaptic plasticity. Nat Rev Neurosci (2004) 5.95
Peroxynitrite oxidation of sulfhydryls. The cytotoxic potential of superoxide and nitric oxide. J Biol Chem (1991) 5.84
Apoptosis and necrosis: two distinct events induced, respectively, by mild and intense insults with N-methyl-D-aspartate or nitric oxide/superoxide in cortical cell cultures. Proc Natl Acad Sci U S A (1995) 4.84
Peroxynitrite-induced membrane lipid peroxidation: the cytotoxic potential of superoxide and nitric oxide. Arch Biochem Biophys (1991) 4.71
A role for Pyk2 and Src in linking G-protein-coupled receptors with MAP kinase activation. Nature (1996) 4.23
Immortalization of hypothalamic GnRH neurons by genetically targeted tumorigenesis. Neuron (1990) 4.15
Glutamate-induced neuronal death: a succession of necrosis or apoptosis depending on mitochondrial function. Neuron (1995) 4.07
A family of AMPA-selective glutamate receptors. Science (1990) 3.85
Cellular response to endoplasmic reticulum stress: a matter of life or death. Cell Death Differ (2006) 3.50
A forensic path to RGC-5 cell line identification: lessons learned. Invest Ophthalmol Vis Sci (2013) 3.31
Astrocyte glutamate transport: review of properties, regulation, and physiological functions. Glia (2000) 3.26
Glutamate toxicity in a neuronal cell line involves inhibition of cystine transport leading to oxidative stress. Neuron (1989) 3.06
Guanylate cyclase and the .NO/cGMP signaling pathway. Biochim Biophys Acta (1999) 3.01
Energy metabolism in astrocytes: high rate of oxidative metabolism and spatiotemporal dependence on glycolysis/glycogenolysis. J Cereb Blood Flow Metab (2006) 2.86
Physiology and pathophysiology of the calcium store in the endoplasmic reticulum of neurons. Physiol Rev (2005) 2.77
Crosstalk between apoptosis, necrosis and autophagy. Biochim Biophys Acta (2013) 2.61
Nitric oxide-induced nuclear GAPDH activates p300/CBP and mediates apoptosis. Nat Cell Biol (2008) 2.56
Persistent activation of ERK contributes to glutamate-induced oxidative toxicity in a neuronal cell line and primary cortical neuron cultures. J Biol Chem (2000) 2.43
Astrocyte metabolism and signaling during brain ischemia. Nat Neurosci (2007) 2.39
Apoptosis-inducing factor triggered by poly(ADP-ribose) polymerase and Bid mediates neuronal cell death after oxygen-glucose deprivation and focal cerebral ischemia. J Neurosci (2005) 2.32
Glutamate induces the production of reactive oxygen species in cultured forebrain neurons following NMDA receptor activation. J Neurosci (1995) 2.31
The molecular basis of retinal ganglion cell death in glaucoma. Prog Retin Eye Res (2011) 2.26
Neuroprotection by brain-derived neurotrophic factor is mediated by extracellular signal-regulated kinase and phosphatidylinositol 3-kinase. J Biol Chem (1999) 2.25
BDNF protects the neonatal brain from hypoxic-ischemic injury in vivo via the ERK pathway. J Neurosci (2000) 2.22
Nitric oxide-induced S-nitrosylation of glyceraldehyde-3-phosphate dehydrogenase inhibits enzymatic activity and increases endogenous ADP-ribosylation. J Biol Chem (1992) 2.03
NF-kappaB regulates phagocytic NADPH oxidase by inducing the expression of gp91phox. J Biol Chem (2006) 2.00
The endoplasmic reticulum stress-responsive protein GRP78 protects neurons against excitotoxicity and apoptosis: suppression of oxidative stress and stabilization of calcium homeostasis. Exp Neurol (1999) 1.95
Inactivation of human manganese-superoxide dismutase by peroxynitrite is caused by exclusive nitration of tyrosine 34 to 3-nitrotyrosine. J Biol Chem (1998) 1.95
Inhibition of mitochondrial electron transport by peroxynitrite. Arch Biochem Biophys (1994) 1.94
Necrostatin-1 protects against glutamate-induced glutathione depletion and caspase-independent cell death in HT-22 cells. J Neurochem (2007) 1.88
Excitotoxicity and stroke: identifying novel targets for neuroprotection. Prog Neurobiol (2013) 1.87
Extrasynaptic NMDA receptors couple preferentially to excitotoxicity via calpain-mediated cleavage of STEP. J Neurosci (2009) 1.87
cGMP and S-nitrosylation: two routes for modulation of neuronal excitability by NO. Trends Neurosci (2002) 1.86
Vulnerability of oligodendroglia to glutamate: pharmacology, mechanisms, and prevention. J Neurosci (1993) 1.86
Immature cortical neurons are uniquely sensitive to glutamate toxicity by inhibition of cystine uptake. FASEB J (1990) 1.86
GOSPEL: a neuroprotective protein that binds to GAPDH upon S-nitrosylation. Neuron (2009) 1.83
Pharmacological studies on lamotrigine, a novel potential antiepileptic drug: II. Neurochemical studies on the mechanism of action. Epilepsia (1986) 1.82
Multiple pathways of peroxynitrite cytotoxicity. Toxicol Lett (2003) 1.77
SH-SY5Y human neuroblastoma cell line: in vitro cell model of dopaminergic neurons in Parkinson's disease. Chin Med J (Engl) (2010) 1.76
Recharacterization of the RGC-5 retinal ganglion cell line. Invest Ophthalmol Vis Sci (2009) 1.74
Akt as a mediator of cell death. Proc Natl Acad Sci U S A (2003) 1.73
Oxidative stress induces a form of programmed cell death with characteristics of both apoptosis and necrosis in neuronal cells. J Neurochem (1998) 1.72
Excitotoxicity: bridge to various triggers in neurodegenerative disorders. Eur J Pharmacol (2012) 1.70
Voltage-dependent block by intracellular Mg2+ of N-methyl-D-aspartate-activated channels. Biophys J (1990) 1.68
Sigma-1 receptors (sigma(1) binding sites) form raft-like microdomains and target lipid droplets on the endoplasmic reticulum: roles in endoplasmic reticulum lipid compartmentalization and export. J Pharmacol Exp Ther (2003) 1.67
Insulin promotes rapid delivery of N-methyl-D- aspartate receptors to the cell surface by exocytosis. Proc Natl Acad Sci U S A (2001) 1.63
Mesenchymal stem cells protect CNS neurons against glutamate excitotoxicity by inhibiting glutamate receptor expression and function. Exp Neurol (2012) 1.62
Pituitary adenylate cyclase-activating polypeptide (PACAP-38) protects cerebellar granule neurons from apoptosis by activating the mitogen-activated protein kinase (MAP kinase) pathway. J Neurosci (1997) 1.58
NMDA receptor regulation by Src kinase signalling in excitatory synaptic transmission and plasticity. Curr Opin Neurobiol (2001) 1.58
Presynaptic Ca2+ channels: a functional patchwork. Trends Neurosci (2003) 1.57
Protein kinase C activation inhibits glutamate-induced cytotoxicity in a neuronal cell line. Brain Res (1994) 1.57
Oxytosis: A novel form of programmed cell death. Curr Top Med Chem (2001) 1.55
TrkB gene transfer protects retinal ganglion cells from axotomy-induced death in vivo. J Neurosci (2002) 1.51
Nitric oxide and neuronal death. Nitric Oxide (2010) 1.49
Bax involvement in p53-mediated neuronal cell death. J Neurosci (1998) 1.48
Mechanism of glutamate-induced neurotoxicity in HT22 mouse hippocampal cells. Eur J Pharmacol (2009) 1.48
Molecular and cellular mechanisms of excitotoxic neuronal death. Apoptosis (2010) 1.39
Survival signaling pathways activated by NMDA receptors. Curr Top Med Chem (2006) 1.38
The lysosomal-mitochondrial axis theory of postmitotic aging and cell death. Chem Biol Interact (2006) 1.38
The role of glutamate in epilepsy and other CNS disorders. Neurology (1994) 1.37
Neuroprotective actions of sex steroids in Parkinson's disease. Front Neuroendocrinol (2009) 1.37
Cisplatin-induced activation of mitogen-activated protein kinases in ovarian carcinoma cells: inhibition of extracellular signal-regulated kinase activity increases sensitivity to cisplatin. Clin Cancer Res (1999) 1.35
Phenotypic changes of human neuroblastoma cells in culture induced by 12-O-tetradecanoyl-phorbol-13-acetate. Int J Cancer (1981) 1.33
Phosphorylation and calmodulin binding of the metabotropic glutamate receptor subtype 5 (mGluR5) are antagonistic in vitro. J Biol Chem (1997) 1.32
Excitotoxic calcium overload in a subpopulation of mitochondria triggers delayed death in hippocampal neurons. J Neurosci (2004) 1.30
Mitochondrial calcium uniporter Mcu controls excitotoxicity and is transcriptionally repressed by neuroprotective nuclear calcium signals. Nat Commun (2013) 1.30
Delayed mitochondrial dysfunction in excitotoxic neuron death: cytochrome c release and a secondary increase in superoxide production. J Neurosci (2000) 1.29
S-nitrosation of glutathione by nitric oxide, peroxynitrite, and (*)NO/O(2)(*-). Free Radic Biol Med (2003) 1.28
The neuronal endosomal-lysosomal system in Alzheimer's disease. J Alzheimers Dis (2001) 1.27
Bid-induced release of AIF from mitochondria causes immediate neuronal cell death. Cell Death Differ (2008) 1.27
System xc⁻ cystine/glutamate antiporter: an update on molecular pharmacology and roles within the CNS. Br J Pharmacol (2012) 1.27
The role of glutamate in the photic regulation of the suprachiasmatic nucleus. Prog Neurobiol (1996) 1.23
Compartmentation of brain glutamate metabolism in neurons and glia. J Nutr (2000) 1.22
Protein kinase C-mediated enhancement of NMDA currents by metabotropic glutamate receptors in Xenopus oocytes. J Physiol (1992) 1.20
Inducible expression of neuronal glutamate receptor channels in the NT2 human cell line. Proc Natl Acad Sci U S A (1993) 1.18
Overview of glutamatergic neurotransmission in the nervous system. Pharmacol Biochem Behav (2011) 1.18
When apoptosis meets autophagy: deciding cell fate after trauma and sepsis. Trends Mol Med (2009) 1.17
Bid-mediated mitochondrial damage is a key mechanism in glutamate-induced oxidative stress and AIF-dependent cell death in immortalized HT-22 hippocampal neurons. Cell Death Differ (2010) 1.15
Competitive interaction of seven in absentia homolog-1A and Ca2+/calmodulin with the cytoplasmic tail of group 1 metabotropic glutamate receptors. Genes Cells (1999) 1.14
Caspase-dependent and caspase-independent oligodendrocyte death mediated by AMPA and kainate receptors. J Neurosci (2003) 1.13
mGluR1-mediated potentiation of NMDA receptors involves a rise in intracellular calcium and activation of protein kinase C. Neuropharmacology (2001) 1.13
sigma-1 receptors protect RGC-5 cells from apoptosis by regulating intracellular calcium, Bax levels, and caspase-3 activation. Invest Ophthalmol Vis Sci (2008) 1.13
Ca(2+)-dependent routes to Ras: mechanisms for neuronal survival, differentiation, and plasticity? Neuron (1996) 1.12
Brain-derived neurotrophic factor-mediated neuroprotection of adult rat retinal ganglion cells in vivo does not exclusively depend on phosphatidyl-inositol-3'-kinase/protein kinase B signaling. J Neurosci (2000) 1.11
Role of PPAR-gamma ligands in neuroprotection against glutamate-induced cytotoxicity in retinal ganglion cells. Invest Ophthalmol Vis Sci (2003) 1.09
Nitric-oxide-induced necrosis and apoptosis in PC12 cells mediated by mitochondria. J Neurochem (2000) 1.09
Hydrogen sulfide protects astrocytes against H(2)O(2)-induced neural injury via enhancing glutamate uptake. Free Radic Biol Med (2008) 1.08
Photic regulation of the mTOR signaling pathway in the suprachiasmatic circadian clock. Mol Cell Neurosci (2008) 1.07
Oxidative glutamate toxicity involves mitochondrial dysfunction and perturbation of intracellular Ca2+ homeostasis. Neurosci Res (2000) 1.06
IGF-I prevents glutamate-mediated bax translocation and cytochrome C release in O4+ oligodendrocyte progenitors. Glia (2004) 1.06
Metabotropic glutamate receptors as targets for multipotential treatment of neurological disorders. Neurotherapeutics (2009) 1.05