Published in Science on May 22, 1992
Glutamate receptor ion channels: structure, regulation, and function. Pharmacol Rev (2010) 11.25
X-ray structure, symmetry and mechanism of an AMPA-subtype glutamate receptor. Nature (2009) 6.81
Physiology and anatomy of synaptic connections between thick tufted pyramidal neurones in the developing rat neocortex. J Physiol (1997) 5.94
Synaptopodin: an actin-associated protein in telencephalic dendrites and renal podocytes. J Cell Biol (1997) 4.43
Neural syntax: cell assemblies, synapsembles, and readers. Neuron (2010) 3.75
Synaptic control of motoneuronal excitability. Physiol Rev (2000) 2.93
Retrograde modulation of presynaptic release probability through signaling mediated by PSD-95-neuroligin. Nat Neurosci (2007) 2.90
Ionotropic and metabotropic glutamate receptor structure and pharmacology. Psychopharmacology (Berl) (2005) 2.25
Control of NMDA receptor function by the NR2 subunit amino-terminal domain. J Neurosci (2009) 2.19
NMDA receptors in clinical neurology: excitatory times ahead. Lancet Neurol (2008) 2.13
Structure and assembly mechanism for heteromeric kainate receptors. Neuron (2011) 2.03
NMDA receptor structures reveal subunit arrangement and pore architecture. Nature (2014) 1.99
Female mouse fetal loss mediated by maternal autoantibody. J Exp Med (2012) 1.92
Fyn-mediated phosphorylation of NR2B Tyr-1336 controls calpain-mediated NR2B cleavage in neurons and heterologous systems. J Biol Chem (2007) 1.84
Developmental switch in the contribution of presynaptic and postsynaptic NMDA receptors to long-term depression. J Neurosci (2007) 1.81
Synaptic excitation of individual rat cerebellar granule cells in situ: evidence for the role of NMDA receptors. J Physiol (1995) 1.79
Distinct modes of AMPA receptor suppression at developing synapses by GluN2A and GluN2B: single-cell NMDA receptor subunit deletion in vivo. Neuron (2011) 1.78
Regulation of NMDA receptors by cyclin-dependent kinase-5. Proc Natl Acad Sci U S A (2001) 1.73
Obligatory role of NR2A for metaplasticity in visual cortex. Neuron (2007) 1.72
Subtype-specific regulation of recombinant NMDA receptor-channels by protein tyrosine kinases of the src family. J Physiol (1996) 1.72
Dimensions of the narrow portion of a recombinant NMDA receptor channel. Biophys J (1995) 1.72
Identification of a native low-conductance NMDA channel with reduced sensitivity to Mg2+ in rat central neurones. J Physiol (1996) 1.65
The major tyrosine-phosphorylated protein in the postsynaptic density fraction is N-methyl-D-aspartate receptor subunit 2B. Proc Natl Acad Sci U S A (1994) 1.61
Activation of recombinant NR1/NR2C NMDA receptors. J Physiol (2008) 1.57
A novel mechanism of activity-dependent NMDA receptor antagonism describes the effect of ifenprodil in rat cultured cortical neurones. J Physiol (1996) 1.56
Retention of NMDA receptor NR2 subunits in the lumen of endoplasmic reticulum in targeted NR1 knockout mice. Proc Natl Acad Sci U S A (2003) 1.53
Genetic predictors of the clinical response to opioid analgesics: clinical utility and future perspectives. Clin Pharmacokinet (2004) 1.51
Presynaptic NMDA receptors: newly appreciated roles in cortical synaptic function and plasticity. Neuroscientist (2008) 1.51
Modulating synaptic NMDA receptors. Neuropharmacology (2016) 1.51
Enhanced tyrosine phosphorylation of the 2B subunit of the N-methyl-D-aspartate receptor in long-term potentiation. Proc Natl Acad Sci U S A (1996) 1.50
Mechanisms of specificity in neuronal activity-regulated gene transcription. Prog Neurobiol (2011) 1.49
Synaptic NMDA receptors in developing mouse hippocampal neurones: functional properties and sensitivity to ifenprodil. J Physiol (1996) 1.48
Separation of domain contacts is required for heterotetrameric assembly of functional NMDA receptors. J Neurosci (2011) 1.47
Long-lasting adaptations of the NR2B-containing NMDA receptors in the dorsomedial striatum play a crucial role in alcohol consumption and relapse. J Neurosci (2010) 1.46
Kinetic basis of partial agonism at NMDA receptors. Nat Neurosci (2009) 1.45
Differential contribution of the NR1- and NR2A-subunits to the selectivity filter of recombinant NMDA receptor channels. J Physiol (1996) 1.45
Uncoupling dendrite growth and patterning: single-cell knockout analysis of NMDA receptor 2B. Neuron (2009) 1.45
Glutamate receptor-mediated toxicity in optic nerve oligodendrocytes. Proc Natl Acad Sci U S A (1997) 1.45
Channelopathies linked to plasma membrane phosphoinositides. Pflugers Arch (2010) 1.42
Structure and dynamics of AMPA receptor GluA2 in resting, pre-open, and desensitized states. Cell (2014) 1.40
Cloning of an apparent splice variant of the rat N-methyl-D-aspartate receptor NMDAR1 with altered sensitivity to polyamines and activators of protein kinase C. Proc Natl Acad Sci U S A (1992) 1.37
Circuit-specific alterations of N-methyl-D-aspartate receptor subunit 1 in the dentate gyrus of aged monkeys. Proc Natl Acad Sci U S A (1996) 1.37
Stoichiometry of recombinant N-methyl-D-aspartate receptor channels inferred from single-channel current patterns. J Gen Physiol (1997) 1.34
Multiple effects of spermine on N-methyl-D-aspartic acid receptor responses of rat cultured hippocampal neurones. J Physiol (1993) 1.34
Potential neurotoxicity of ketamine in the developing rat brain. Toxicol Sci (2009) 1.33
Overexpression of motor protein KIF17 enhances spatial and working memory in transgenic mice. Proc Natl Acad Sci U S A (2002) 1.33
Splice variants of the N-methyl-D-aspartate receptor NR1 identify domains involved in regulation by polyamines and protein kinase C. Proc Natl Acad Sci U S A (1993) 1.33
Pharmacological insights obtained from structure-function studies of ionotropic glutamate receptors. Br J Pharmacol (2006) 1.29
Dehydroepiandrosterone: a potential signalling molecule for neocortical organization during development. Proc Natl Acad Sci U S A (1998) 1.29
Inhibition of NMDARs in the Nucleus Reticularis of the Thalamus Produces Delta Frequency Bursting. Front Neural Circuits (2009) 1.28
Genetic enhancement of memory and long-term potentiation but not CA1 long-term depression in NR2B transgenic rats. PLoS One (2009) 1.27
Modulation of glycine potency in rat recombinant NMDA receptors containing chimeric NR2A/2D subunits expressed in Xenopus laevis oocytes. J Physiol (2007) 1.24
Decline of the critical period of visual plasticity is concurrent with the reduction of NR2B subunit of the synaptic NMDA receptor in layer 4. J Neurosci (2003) 1.23
Differential usage of multiple brain-derived neurotrophic factor promoters in the rat brain following neuronal activation. Proc Natl Acad Sci U S A (1993) 1.23
A novel family of negative and positive allosteric modulators of NMDA receptors. J Pharmacol Exp Ther (2010) 1.22
Subunit-selective allosteric inhibition of glycine binding to NMDA receptors. J Neurosci (2012) 1.22
Ras-guanine nucleotide-releasing factor 1 (Ras-GRF1) controls activation of extracellular signal-regulated kinase (ERK) signaling in the striatum and long-term behavioral responses to cocaine. Biol Psychiatry (2009) 1.21
Quinazolin-4-one derivatives: A novel class of noncompetitive NR2C/D subunit-selective N-methyl-D-aspartate receptor antagonists. J Med Chem (2010) 1.20
Accuracy of hippocampal network activity is disrupted by neuroinflammation: rescue by memantine. Brain (2009) 1.20
Kv8.1, a new neuronal potassium channel subunit with specific inhibitory properties towards Shab and Shaw channels. EMBO J (1996) 1.20
Inducible expression of neuronal glutamate receptor channels in the NT2 human cell line. Proc Natl Acad Sci U S A (1993) 1.18
A single GluN2 subunit residue controls NMDA receptor channel properties via intersubunit interaction. Nat Neurosci (2012) 1.18
Amino terminal domains of the NMDA receptor are organized as local heterodimers. PLoS One (2011) 1.18
Hyperdopaminergia and NMDA receptor hypofunction disrupt neural phase signaling. J Neurosci (2009) 1.18
Structural and mechanistic determinants of a novel site for noncompetitive inhibition of GluN2D-containing NMDA receptors. J Neurosci (2011) 1.18
Chronic brain inflammation leads to a decline in hippocampal NMDA-R1 receptors. J Neuroinflammation (2004) 1.17
Alternative splicing generates functionally distinct N-methyl-D-aspartate receptors. Proc Natl Acad Sci U S A (1992) 1.16
The crossed phrenic phenomenon and recovery of function following spinal cord injury. Respir Physiol Neurobiol (2009) 1.16
Ca(2+)-independent reduction of N-methyl-D-aspartate channel activity by protein tyrosine phosphatase. Proc Natl Acad Sci U S A (1996) 1.16
Influence of the NR3A subunit on NMDA receptor functions. Prog Neurobiol (2010) 1.14
NMDA receptor contributions to visual contrast coding. Neuron (2010) 1.13
Stationary gating of GluN1/GluN2B receptors in intact membrane patches. Biophys J (2010) 1.12
NMDA hypofunction as a convergence point for progression and symptoms of schizophrenia. Front Cell Neurosci (2013) 1.12
Involvement of NMDAR2A tyrosine phosphorylation in depression-related behaviour. EMBO J (2009) 1.11
Amygdala infusions of an NR2B-selective or an NR2A-preferring NMDA receptor antagonist differentially influence fear conditioning and expression in the fear-potentiated startle test. Learn Mem (2008) 1.10
GluN2B-containing NMDA receptors regulate depression-like behavior and are critical for the rapid antidepressant actions of ketamine. Elife (2014) 1.10
Ca(2+) conduction by an amino acid-gated ion channel related to glutamate receptors. Plant Physiol (2012) 1.10
Molecular pathways: dysregulated glutamatergic signaling pathways in cancer. Clin Cancer Res (2012) 1.10
Probing the pore region of recombinant N-methyl-D-aspartate channels using external and internal magnesium block. Proc Natl Acad Sci U S A (1996) 1.10
Developmental regulation of the NMDA receptor subunits, NR3A and NR1, in human prefrontal cortex. Cereb Cortex (2008) 1.09
Activation of type 5 metabotropic glutamate receptors enhances NMDA responses in mice cortical wedges. Br J Pharmacol (2001) 1.09
Interactions between two divalent ion binding sites in N-methyl-D-aspartate receptor channels. Proc Natl Acad Sci U S A (1996) 1.09
Simultaneous measurement of Ca2+ influx and reversal potentials in recombinant N-methyl-D-aspartate receptor channels. Biophys J (1996) 1.09
The effects of aging on N-methyl-D-aspartate receptor subunits in the synaptic membrane and relationships to long-term spatial memory. Neuroscience (2009) 1.08
Increased NR2A:NR2B ratio compresses long-term depression range and constrains long-term memory. Sci Rep (2013) 1.08
D-Serine differently modulates NMDA receptor function in rat CA1 hippocampal pyramidal cells and interneurons. J Physiol (2003) 1.08
Molecular determinants of NMDA receptor function in GABAergic neurones of rat forebrain. J Physiol (1997) 1.08
Influence of GluN2 subunit identity on NMDA receptor function. Neuropharmacology (2013) 1.07
Early postnatal switch in magnesium sensitivity of NMDA receptors in rat CA1 pyramidal cells. J Physiol (1999) 1.07
Alcohol related changes in regulation of NMDA receptor functions. Curr Neuropharmacol (2008) 1.07
Modulation by magnesium of the affinity of NMDA receptors for glycine in murine hippocampal neurones. J Physiol (1995) 1.07
Mg2+ and memantine block of rat recombinant NMDA receptors containing chimeric NR2A/2D subunits expressed in Xenopus laevis oocytes. J Physiol (2007) 1.07
Schaffer collateral and perforant path inputs activate different subtypes of NMDA receptors on the same CA1 pyramidal cell. Br J Pharmacol (2004) 1.07
Neonatal inflammation produces selective behavioural deficits and alters N-methyl-D-aspartate receptor subunit mRNA in the adult rat brain. Eur J Neurosci (2008) 1.07
Blockade by ifenprodil of high voltage-activated Ca2+ channels in rat and mouse cultured hippocampal pyramidal neurones: comparison with N-methyl-D-aspartate receptor antagonist actions. Br J Pharmacol (1994) 1.06
Functional N-methyl-D-aspartate receptors in O-2A glial precursor cells: a critical role in regulating polysialic acid-neural cell adhesion molecule expression and cell migration. J Cell Biol (1996) 1.06
Brain tumors and epilepsy: pathophysiology of peritumoral changes. Neurosurg Rev (2009) 1.05
Calcium-dependent inactivation of heteromeric NMDA receptor-channels expressed in human embryonic kidney cells. J Physiol (1995) 1.05
Physiology and pathology of calcium signaling in the brain. Front Pharmacol (2012) 1.05
Therapeutic liabilities of in vivo viral vector tropism: adeno-associated virus vectors, NMDAR1 antisense, and focal seizure sensitivity. Mol Ther (2002) 1.03
Improved patch-clamp techniques for high-resolution current recording from cells and cell-free membrane patches. Pflugers Arch (1981) 134.60
A system for shotgun DNA sequencing. Nucleic Acids Res (1981) 52.99
Supercoil sequencing: a fast and simple method for sequencing plasmid DNA. DNA (1985) 40.01
Single-channel currents recorded from membrane of denervated frog muscle fibres. Nature (1976) 13.78
Regulation of synaptic efficacy by coincidence of postsynaptic APs and EPSPs. Science (1997) 13.11
Human tumour necrosis factor: precursor structure, expression and homology to lymphotoxin. Nature (1985) 13.04
Developmental and regional expression in the rat brain and functional properties of four NMDA receptors. Neuron (1994) 11.44
Complete nucleotide sequences of the T24 human bladder carcinoma oncogene and its normal homologue. Nature (1983) 10.64
Fast events in single-channel currents activated by acetylcholine and its analogues at the frog muscle end-plate. J Physiol (1985) 9.25
Tyrosine kinase receptor with extensive homology to EGF receptor shares chromosomal location with neu oncogene. Science (1985) 9.12
Domain interaction between NMDA receptor subunits and the postsynaptic density protein PSD-95. Science (1995) 8.61
Nucleotide sequence and amplification in bacteria of structural gene for rat growth hormone. Nature (1977) 7.97
A new sensitive method for qualitative and quantitative assay of neomycin phosphotransferase in crude cell extracts. Gene (1984) 7.36
The primary structure and genetic organization of the bovine papillomavirus type 1 genome. Nature (1982) 7.24
Mechanism of anion permeation through channels gated by glycine and gamma-aminobutyric acid in mouse cultured spinal neurones. J Physiol (1987) 7.23
Fluctuations in the microsecond time range of the current through single acetylcholine receptor ion channels. Nature (1981) 7.16
A thin slice preparation for patch clamp recordings from neurones of the mammalian central nervous system. Pflugers Arch (1989) 6.98
RNA editing in brain controls a determinant of ion flow in glutamate-gated channels. Cell (1991) 6.97
Z/AP, a double reporter for cre-mediated recombination. Dev Biol (1999) 6.88
Single acetylcholine-activated channels show burst-kinetics in presence of desensitizing concentrations of agonist. Nature (1980) 6.83
Point mutation in an AMPA receptor gene rescues lethality in mice deficient in the RNA-editing enzyme ADAR2. Nature (2000) 6.67
Plasmid vector pBR322 and its special-purpose derivatives--a review. Gene (1986) 6.52
Rings of negatively charged amino acids determine the acetylcholine receptor channel conductance. Nature (1988) 6.35
Biological properties of human c-Ha-ras1 genes mutated at codon 12. Nature (1984) 6.21
Patch clamp measurements on Xenopus laevis oocytes: currents through endogenous channels and implanted acetylcholine receptor and sodium channels. Pflugers Arch (1986) 6.15
Physiology and anatomy of synaptic connections between thick tufted pyramidal neurones in the developing rat neocortex. J Physiol (1997) 5.94
Structure and organization of the human Ki-ras proto-oncogene and a related processed pseudogene. Nature (1983) 5.90
Human leukocyte interferon produced by E. coli is biologically active. Nature (1980) 5.86
Molecular basis of functional diversity of voltage-gated potassium channels in mammalian brain. EMBO J (1989) 5.66
RNA editing of AMPA receptor subunit GluR-B: a base-paired intron-exon structure determines position and efficiency. Cell (1993) 5.62
Patch-clamp recordings from the soma and dendrites of neurons in brain slices using infrared video microscopy. Pflugers Arch (1993) 5.33
Cloning and expression of human tissue-type plasminogen activator cDNA in E. coli. Nature (1983) 5.27
Control of kinetic properties of AMPA receptor channels by nuclear RNA editing. Science (1994) 5.21
The distribution of 13 GABAA receptor subunit mRNAs in the rat brain. I. Telencephalon, diencephalon, mesencephalon. J Neurosci (1992) 5.02
Tripartite structure of the avian erythroblastosis virus E26 transforming gene. Nature (1984) 4.99
Interaction of RNA polymerase with promoters from bacteriophage fd. Eur J Biochem (1977) 4.94
Penicillinase from Bacillus licheniformis: nucleotide sequence of the gene and implications for the biosynthesis of a secretory protein in a Gram-positive bacterium. Nucleic Acids Res (1981) 4.94
Target-cell-specific facilitation and depression in neocortical circuits. Nat Neurosci (1998) 4.88
Active propagation of somatic action potentials into neocortical pyramidal cell dendrites. Nature (1994) 4.87
Multiple conductance states of single acetylcholine receptor channels in embryonic muscle cells. Nature (1981) 4.81
Identification of CRE1 as a cytokinin receptor from Arabidopsis. Nature (2001) 4.77
Conductance properties of single inwardly rectifying potassium channels in ventricular cells from guinea-pig heart. J Physiol (1984) 4.70
Comparative sequence analysis of duck and human hepatitis B virus genomes. J Med Virol (1985) 4.68
Ca2+ buffering and action potential-evoked Ca2+ signaling in dendrites of pyramidal neurons. Biophys J (1996) 4.58
Importance of AMPA receptors for hippocampal synaptic plasticity but not for spatial learning. Science (1999) 4.56
Divalent ion permeability of AMPA receptor channels is dominated by the edited form of a single subunit. Neuron (1992) 4.53
The structure of eight distinct cloned human leukocyte interferon cDNAs. Nature (1981) 4.50
The distribution of thirteen GABAA receptor subunit mRNAs in the rat brain. III. Embryonic and postnatal development. J Neurosci (1992) 4.45
Importance of a novel GABAA receptor subunit for benzodiazepine pharmacology. Nature (1989) 4.45
The extracellular patch clamp: a method for resolving currents through individual open channels in biological membranes. Pflugers Arch (1978) 4.42
Replication strategy of human hepatitis B virus. J Virol (1987) 4.42
Calcium influx and transmitter release in a fast CNS synapse. Nature (1996) 4.39
Expression of active human factor VIII from recombinant DNA clones. Nature (1984) 4.36
Molecular distinction between fetal and adult forms of muscle acetylcholine receptor. Nature (1986) 4.30
Activity-dependent action potential invasion and calcium influx into hippocampal CA1 dendrites. Science (1995) 4.29
Relative abundance of subunit mRNAs determines gating and Ca2+ permeability of AMPA receptors in principal neurons and interneurons in rat CNS. Neuron (1995) 4.24
Activation of Ki-ras2 gene in human colon and lung carcinomas by two different point mutations. Nature (1983) 4.15
A new cellular mechanism for coupling inputs arriving at different cortical layers. Nature (1999) 4.10
Voltage-dependent inactivation of inward-rectifying single-channel currents in the guinea-pig heart cell membrane. J Physiol (1984) 4.08
Quantal components of unitary EPSCs at the mossy fibre synapse on CA3 pyramidal cells of rat hippocampus. J Physiol (1993) 3.92
A mammalian RNA editing enzyme. Nature (1996) 3.90
A family of AMPA-selective glutamate receptors. Science (1990) 3.85
Direct expression in Escherichia coli of a DNA sequence coding for human growth hormone. Nature (1979) 3.80
Action potential initiation and backpropagation in neurons of the mammalian CNS. Trends Neurosci (1997) 3.69
Flip and flop: a cell-specific functional switch in glutamate-operated channels of the CNS. Science (1990) 3.53
Differential signal transduction by five splice variants of the PACAP receptor. Nature (1993) 3.38
Acetylcholine activation of single muscarinic K+ channels in isolated pacemaker cells of the mammalian heart. Nature (1983) 3.34
Activation of multiple-conductance state chloride channels in spinal neurones by glycine and GABA. Nature (1983) 3.32
Dendritic glutamate receptor channels in rat hippocampal CA3 and CA1 pyramidal neurons. J Physiol (1995) 3.20
Voltage-dependence of drug-induced conductance in frog neuromuscular junction. Proc Natl Acad Sci U S A (1975) 3.18
Action potential initiation and propagation in rat neocortical pyramidal neurons. J Physiol (1997) 3.18
Structural determinants of ion flow through recombinant glutamate receptor channels. Science (1991) 3.18
Construction and analysis of recombinant DNA for human chorionic somatomammotropin. Nature (1977) 3.13
Determinants of Ca2+ permeability in both TM1 and TM2 of high affinity kainate receptor channels: diversity by RNA editing. Neuron (1993) 3.08
Action of brief pulses of glutamate on AMPA/kainate receptors in patches from different neurones of rat hippocampal slices. J Physiol (1992) 3.06