Imbalance of the nerve growth factor and its precursor as a potential biomarker for diabetic retinopathy.

PubWeight™: 0.88‹?›

🔗 View Article (PMC 4380101)

Published in Biomed Res Int on March 17, 2015

Authors

B A Mysona1, S Matragoon1, M Stephens2, I N Mohamed1, A Farooq1, M L Bartasis1, A Y Fouda1, A Y Shanab1, D G Espinosa-Heidmann2, A B El-Remessy1

Author Affiliations

1: Program in Clinical and Experimental Therapeutics, College of Pharmacy, University of Georgia, Augusta, GA 30912, USA ; Culver Vision Discovery Institute, Georgia Regents University, Augusta, GA 30912, USA ; Charlie Norwood Veterans Affairs Medical Center, Augusta, GA 30904, Augusta, USA.
2: Culver Vision Discovery Institute, Georgia Regents University, Augusta, GA 30912, USA.

Articles cited by this

Vascular endothelial growth factor in ocular fluid of patients with diabetic retinopathy and other retinal disorders. N Engl J Med (1994) 16.24

The relationship of glycemic exposure (HbA1c) to the risk of development and progression of retinopathy in the diabetes control and complications trial. Diabetes (1995) 8.89

Trk receptors: roles in neuronal signal transduction. Annu Rev Biochem (2003) 8.83

Global prevalence and major risk factors of diabetic retinopathy. Diabetes Care (2012) 7.83

Neurotrophin-regulated signalling pathways. Philos Trans R Soc Lond B Biol Sci (2006) 7.18

Ranibizumab for diabetic macular edema: results from 2 phase III randomized trials: RISE and RIDE. Ophthalmology (2012) 6.35

Regulation of cell survival by secreted proneurotrophins. Science (2001) 6.32

The Wisconsin Epidemiologic Study of Diabetic Retinopathy. XV. The long-term incidence of macular edema. Ophthalmology (1995) 2.70

Secreted proNGF is a pathophysiological death-inducing ligand after adult CNS injury. Proc Natl Acad Sci U S A (2004) 1.98

Macular edema. A complication of diabetic retinopathy. Surv Ophthalmol (1984) 1.89

Vascular endothelial growth factor in ocular neovascularization and proliferative diabetic retinopathy. Diabetes Metab Rev (1997) 1.86

A multifocal electroretinogram model predicting the development of diabetic retinopathy. Prog Retin Eye Res (2006) 1.65

Proteolytic processing of the p75 neurotrophin receptor and two homologs generates C-terminal fragments with signaling capability. J Neurosci (2003) 1.58

Regulated intramembrane proteolysis of the p75 neurotrophin receptor modulates its association with the TrkA receptor. J Biol Chem (2003) 1.41

Cellular processing of the nerve growth factor precursor by the mammalian pro-protein convertases. Biochem J (1996) 1.41

Expression profiles of cytokines and chemokines in vitreous fluid in diabetic retinopathy and central retinal vein occlusion. Jpn J Ophthalmol (2011) 1.41

Unbalanced vitreous levels of pigment epithelium-derived factor and vascular endothelial growth factor in diabetic retinopathy. Am J Ophthalmol (2002) 1.40

Understanding proneurotrophin actions: Recent advances and challenges. Dev Neurobiol (2010) 1.35

Diabetes-induced peroxynitrite impairs the balance of pro-nerve growth factor and nerve growth factor, and causes neurovascular injury. Diabetologia (2010) 1.32

Differential RNA splicing predicts two distinct nerve growth factor precursors. Nature (1986) 1.31

Characterization of retinal leukostasis and hemodynamics in insulin resistance and diabetes: role of oxidants and protein kinase-C activation. Diabetes (2003) 1.21

Angiogenic Factors and Cytokines in Diabetic Retinopathy. J Clin Cell Immunol (2013) 1.15

Nonproliferative retinopathy in diabetes type 2. Initial stages and characterization of phenotypes. Prog Retin Eye Res (2004) 1.14

Microaneurysm turnover is a biomarker for diabetic retinopathy progression to clinically significant macular edema: findings for type 2 diabetics with nonproliferative retinopathy. Ophthalmologica (2009) 1.13

The predictive value of patient and eye characteristics on the course of subclinical diabetic macular edema. Am J Ophthalmol (2007) 1.12

Update on the treatment of diabetic retinopathy. Hong Kong Med J (2007) 1.10

Pathogenetic potential of leukocytes in diabetic retinopathy. Semin Ophthalmol (1999) 1.05

Phenotypes and biomarkers of diabetic retinopathy. Prog Retin Eye Res (2014) 1.04

Effect of p75NTR on the regulation of naturally occurring cell death and retinal ganglion cell number in the mouse eye. Dev Biol (2005) 1.01

Epicatechin blocks pro-nerve growth factor (proNGF)-mediated retinal neurodegeneration via inhibition of p75 neurotrophin receptor expression in a rat model of diabetes [corrected]. Diabetologia (2010) 0.97

Microaneurysm formation rate as a predictive marker for progression to clinically significant macular edema in nonproliferative diabetic retinopathy. Retina (2014) 0.95

ProNGF mediates death of Natural Killer cells through activation of the p75NTR-sortilin complex. J Neuroimmunol (2010) 0.94

Enhanced protein expressions of sortilin and p75NTR in retina of rat following elevated intraocular pressure-induced retinal ischemia. Neurosci Lett (2007) 0.93

Intravitreal Bevacizumab (Avastin(®)) for Diabetic Retinopathy at 24-months: The 2008 Juan Verdaguer-Planas Lecture. Curr Diabetes Rev (2010) 0.93

Characterisation of the vitreous proteome in proliferative diabetic retinopathy. Proteome Sci (2012) 0.93

Advanced glycation end products decrease mesangial cell MMP-7: a role in matrix accumulation in diabetic nephropathy? Kidney Int (2007) 0.93

Effect of eye NGF administration on two animal models of retinal ganglion cells degeneration. Ann Ist Super Sanita (2011) 0.92

Computer-assisted microaneurysm turnover in the early stages of diabetic retinopathy. Ophthalmologica (2009) 0.91

Modulation of p75(NTR) prevents diabetes- and proNGF-induced retinal inflammation and blood-retina barrier breakdown in mice and rats. Diabetologia (2013) 0.90

Serum and tear levels of nerve growth factor in diabetic retinopathy patients. Am J Ophthalmol (2008) 0.90

Characterization of nerve growth factor precursor protein expression in rat round spermatids and the trophic effects of nerve growth factor in the maintenance of Sertoli cell viability. Mol Cell Endocrinol (1997) 0.89

The failure in NGF maturation and its increased degradation as the probable cause for the vulnerability of cholinergic neurons in Alzheimer's disease. Neurochem Res (2007) 0.88

Diabetes and overexpression of proNGF cause retinal neurodegeneration via activation of RhoA pathway. PLoS One (2013) 0.88

The proNGF-p75NTR-sortilin signalling complex as new target for the therapeutic treatment of Parkinson's disease. CNS Neurol Disord Drug Targets (2008) 0.87

Safety and pharmacokinetics of escalating doses of human recombinant nerve growth factor eye drops in a double-masked, randomized clinical trial. BioDrugs (2014) 0.87

Characterization and relevance of different diabetic retinopathy phenotypes. Dev Ophthalmol (2007) 0.85

NGF and VEGF effects on retinal ganglion cell fate: new evidence from an animal model of diabetes. Eur J Ophthalmol (2013) 0.85

High levels of the proNGF peptides LIP1 and LIP2 in the serum and synovial fluid of rheumatoid arthritis patients: evidence for two new cytokines. J Neuroimmunol (2007) 0.83

Nerve growth factor and expression of its receptors in patients with diabetic neuropathy. Diabet Med (2009) 0.82

New pathogenic candidates for diabetic macular edema detected by proteomic analysis. Diabetes Care (2010) 0.81

Nerve growth factor produced by activated human monocytes/macrophages is severely affected by ethanol. Alcohol (2005) 0.81

The p75 neurotrophin receptor appears in plasma in diabetic rats-characterisation of a potential early test for neuropathy. Diabetologia (2004) 0.80

Serum MMP-7 is increased in diabetic renal disease and diabetic diastolic dysfunction. Diabetes Res Clin Pract (2010) 0.80

Pronerve growth factor induces angiogenesis via activation of TrkA: possible role in proliferative diabetic retinopathy. J Diabetes Res (2013) 0.80

Synthesis of nerve growth factor mRNA and precursor protein in the thyroid and parathyroid glands of the rat. Proc Natl Acad Sci U S A (1986) 0.79

Three different phenotypes of mild nonproliferative diabetic retinopathy with different risks for development of clinically significant macular edema. Invest Ophthalmol Vis Sci (2013) 0.79

The impact of type 2 diabetes and atorvastatin treatment on serum levels of MMP-7 and MMP-8. Exp Clin Endocrinol Diabetes (2014) 0.79

Altered expression of nerve growth factor and its receptors in the kidneys of diabetic rats. J Nephrol (2011) 0.79

Microaneurysm turnover in diabetic retinopathy assessed by automated RetmarkerDR image analysis--potential role as biomarker of response to ranibizumab treatment. Ophthalmologica (2014) 0.77

Expression of nerve growth factor in human pancreatic beta cells. Growth Factors (2004) 0.77

Levels of three distinct p75 neurotrophin receptor forms found in human plasma are altered in type 2 diabetic patients. Diabetologia (2007) 0.77

Noninvasive evaluation of retinal leakage using optical coherence tomography. Ophthalmologica (2011) 0.76