Published in Neurobiol Aging on March 05, 2015
Gene Therapy: A Promising Approach for Neuroprotection in Parkinson's Disease? Front Neuroanat (2016) 1.39
Alpha-synuclein Toxicity in the Early Secretory Pathway: How It Drives Neurodegeneration in Parkinsons Disease. Front Neurosci (2015) 0.80
GRP78 at the Centre of the Stage in Cancer and Neuroprotection. Front Neurosci (2017) 0.78
Unfolded protein response is activated in aged retinas. Neurosci Lett (2015) 0.78
Dysfunction of the neurovascular unit in ischemic stroke and neurodegenerative diseases: An aging effect. Ageing Res Rev (2016) 0.77
How can rAAV-α-synuclein and the fibril α-synuclein models advance our understanding of Parkinson's disease? J Neurochem (2016) 0.76
Increased Glucose Transport into Neurons Rescues Aβ Toxicity in Drosophila. Curr Biol (2016) 0.76
Integrated molecular landscape of Parkinson's disease. NPJ Parkinsons Dis (2017) 0.76
The Neuroprotective Role of Protein Quality Control in Halting the Development of Alpha-Synuclein Pathology. Front Mol Neurosci (2017) 0.75
The unfolded protein response: controlling cell fate decisions under ER stress and beyond. Nat Rev Mol Cell Biol (2012) 8.52
Recombinant adeno-associated virus purification using novel methods improves infectious titer and yield. Gene Ther (1999) 7.96
A trip to the ER: coping with stress. Trends Cell Biol (2004) 7.67
Dopaminergic loss and inclusion body formation in alpha-synuclein mice: implications for neurodegenerative disorders. Science (2000) 6.28
Production and purification of serotype 1, 2, and 5 recombinant adeno-associated viral vectors. Methods (2002) 5.30
Modulation of neurodegeneration by molecular chaperones. Nat Rev Neurosci (2005) 5.00
Oral treatment targeting the unfolded protein response prevents neurodegeneration and clinical disease in prion-infected mice. Sci Transl Med (2013) 4.62
The biochemistry of Parkinson's disease. Annu Rev Biochem (2005) 3.79
The ER chaperone and signaling regulator GRP78/BiP as a monitor of endoplasmic reticulum stress. Methods (2005) 3.40
Parkinson-like neurodegeneration induced by targeted overexpression of alpha-synuclein in the nigrostriatal system. J Neurosci (2002) 3.12
α-Synuclein: membrane interactions and toxicity in Parkinson's disease. Annu Rev Cell Dev Biol (2010) 2.93
Subcellular localization of wild-type and Parkinson's disease-associated mutant alpha -synuclein in human and transgenic mouse brain. J Neurosci (2000) 2.49
Endoplasmic reticulum stress is important for the manifestations of α-synucleinopathy in vivo. J Neurosci (2012) 2.35
Age-associated increases of alpha-synuclein in monkeys and humans are associated with nigrostriatal dopamine depletion: Is this the target for Parkinson's disease? Neurobiol Dis (2006) 2.23
Characterization of behavioral and neurodegenerative changes following partial lesions of the nigrostriatal dopamine system induced by intrastriatal 6-hydroxydopamine in the rat. Exp Neurol (1998) 2.20
The phosphorylation state of Ser-129 in human alpha-synuclein determines neurodegeneration in a rat model of Parkinson disease. Proc Natl Acad Sci U S A (2008) 2.00
Bcl-2 family on guard at the ER. Am J Physiol Cell Physiol (2009) 1.99
Activation of the unfolded protein response in Parkinson's disease. Biochem Biophys Res Commun (2007) 1.98
Accumulation of toxic α-synuclein oligomer within endoplasmic reticulum occurs in α-synucleinopathy in vivo. J Neurosci (2012) 1.95
Dietary restriction and 2-deoxyglucose administration improve behavioral outcome and reduce degeneration of dopaminergic neurons in models of Parkinson's disease. J Neurosci Res (1999) 1.94
The critical role of GRP78 in physiologic and pathologic stress. Curr Opin Cell Biol (2010) 1.91
alpha-Synuclein and neuronal cell death. Mol Neurodegener (2009) 1.85
The stress rheostat: an interplay between the unfolded protein response (UPR) and autophagy in neurodegeneration. Curr Mol Med (2008) 1.42
The endoplasmic reticulum stress response in aging and age-related diseases. Front Physiol (2012) 1.35
In vivo RNAi-mediated alpha-synuclein silencing induces nigrostriatal degeneration. Mol Ther (2010) 1.26
Glucose regulated protein 78 diminishes α-synuclein neurotoxicity in a rat model of Parkinson disease. Mol Ther (2012) 1.24
The effect of aging on the chaperone concentrations in the hepatic, endoplasmic reticulum of male rats: the possible role of protein misfolding due to the loss of chaperones in the decline in physiological function seen with age. J Gerontol A Biol Sci Med Sci (2006) 1.13
Decreased enzyme activities of chaperones PDI and BiP in aged mouse livers. Biochem Biophys Res Commun (2007) 1.08
Activation of the unfolded protein response is an early event in Alzheimer's and Parkinson's disease. Neurodegener Dis (2012) 1.01
Methoxyflavones protect cells against endoplasmic reticulum stress and neurotoxin. Am J Physiol Cell Physiol (2006) 0.92
Post-treatment of a BiP inducer prevents cell death after middle cerebral artery occlusion in mice. Neurosci Lett (2010) 0.89
Suberoylanilide hydroxamic acid, a histone deacetylase inhibitor, protects dopaminergic neurons from neurotoxin-induced damage. Br J Pharmacol (2012) 0.87
Down-regulation of GRP78 enhances apoptosis via CHOP pathway in retinal ischemia-reperfusion injury. Neurosci Lett (2014) 0.86
α-Synuclein expression in rat substantia nigra suppresses phospholipase D2 toxicity and nigral neurodegeneration. Mol Ther (2010) 0.86
Dispersion of cisternae of rough endoplasmic reticulum in aging CNS neurons: a strictly linear trend. Am J Anat (1978) 0.82
Age and α-synuclein expression interact to reveal a dependence of dopaminergic axons on endogenous Akt/PKB signaling. Neurobiol Dis (2011) 0.80