Activation of the unfolded protein response is an early event in Alzheimer's and Parkinson's disease.

PubWeight™: 1.01‹?› | Rank: Top 15%

🔗 View Article (PMID 22302012)

Published in Neurodegener Dis on February 01, 2012

Authors

Jeroen J M Hoozemans1, Elise S van Haastert, Diana A T Nijholt, Annemieke J M Rozemuller, Wiep Scheper

Author Affiliations

1: Department of Pathology, VU University Medical Center, Amsterdam, The Netherlands.

Articles citing this

Remote control of gene function by local translation. Cell (2014) 1.72

Glucocerebrosidase is shaking up the synucleinopathies. Brain (2014) 1.50

Programmed cell death in Parkinson's disease. Cold Spring Harb Perspect Med (2012) 1.04

The Molecular Chaperone GRP78/BiP as a Therapeutic Target for Neurodegenerative Disorders: A Mini Review. J Genet Syndr Gene Ther (2013) 0.97

Unfolded protein response-induced ERdj3 secretion links ER stress to extracellular proteostasis. EMBO J (2014) 0.96

The human HSP70 family of chaperones: where do we stand? Cell Stress Chaperones (2016) 0.95

ER-stress in Alzheimer's disease: turning the scale? Am J Neurodegener Dis (2013) 0.91

Cannabidiol protects oligodendrocyte progenitor cells from inflammation-induced apoptosis by attenuating endoplasmic reticulum stress. Cell Death Dis (2012) 0.89

Interplay of endoplasmic reticulum stress and autophagy in neurodegenerative disorders. Autophagy (2016) 0.88

Seeking a mechanism for the toxicity of oligomeric α-synuclein. Biomolecules (2015) 0.88

The Role of Damage-Associated Molecular Patterns (DAMPs) in Human Diseases: Part II: DAMPs as diagnostics, prognostics and therapeutics in clinical medicine. Sultan Qaboos Univ Med J (2015) 0.84

The loss of glucose-regulated protein 78 (GRP78) during normal aging or from siRNA knockdown augments human alpha-synuclein (α-syn) toxicity to rat nigral neurons. Neurobiol Aging (2015) 0.84

Molecular chaperones and protein folding as therapeutic targets in Parkinson's disease and other synucleinopathies. Acta Neuropathol Commun (2013) 0.82

Hormesis in aging and neurodegeneration-a prodigy awaiting dissection. Int J Mol Sci (2013) 0.82

Endoplasmic reticulum stress promotes amyloid-beta peptides production in RGC-5 cells. Cell Stress Chaperones (2014) 0.81

Snord 3A: a molecular marker and modulator of prion disease progression. PLoS One (2013) 0.81

Gene expression and functional annotation of human choroid plexus epithelium failure in Alzheimer's disease. BMC Genomics (2015) 0.80

Endoplasmic reticulum stress mediates amyloid β neurotoxicity via mitochondrial cholesterol trafficking. Am J Pathol (2014) 0.80

Adaptive preconditioning in neurological diseases - therapeutic insights from proteostatic perturbations. Brain Res (2016) 0.79

Modulation of proteostasis by transcription factor NRF2 and impact in neurodegenerative diseases. Redox Biol (2017) 0.76

Sarco(endo)plasmic reticulum ATPase is a molecular partner of Wolfram syndrome 1 protein, which negatively regulates its expression. Hum Mol Genet (2014) 0.76

ER Stress Induced by Tunicamycin Triggers α-Synuclein Oligomerization, Dopaminergic Neurons Death and Locomotor Impairment: a New Model of Parkinson's Disease. Mol Neurobiol (2016) 0.75

ER stress and the unfolded protein response in neurodegeneration. Nat Rev Neurol (2017) 0.75

Impairment of PARK14-dependent Ca(2+) signalling is a novel determinant of Parkinson's disease. Nat Commun (2016) 0.75

Endoplasmic Reticulum Stress PERK-ATF4-CHOP Pathway Is Associated with Hypothalamic Neuronal Injury in Different Durations of Stress in Rats. Front Neurosci (2017) 0.75

Genetic and immunohistochemical analysis of HSPA5 in mouse and human retinas. Mol Vis (2016) 0.75

The Protective Role of microRNA-200c in Alzheimer's Disease Pathologies Is Induced by Beta Amyloid-Triggered Endoplasmic Reticulum Stress. Front Mol Neurosci (2016) 0.75

Interplay of Energetics and ER Stress Exacerbates Alzheimer's Amyloid-β (Aβ) Toxicity in Yeast. Front Mol Neurosci (2017) 0.75

Articles by these authors

Guidelines for the use and interpretation of assays for monitoring autophagy. Autophagy (2012) 20.08

Nomenclature and nosology for neuropathologic subtypes of frontotemporal lobar degeneration: an update. Acta Neuropathol (2009) 4.73

Nomenclature for neuropathologic subtypes of frontotemporal lobar degeneration: consensus recommendations. Acta Neuropathol (2008) 4.73

The clinical and pathological phenotype of C9ORF72 hexanucleotide repeat expansions. Brain (2012) 2.33

The unfolded protein response is activated in pretangle neurons in Alzheimer's disease hippocampus. Am J Pathol (2009) 1.92

Nrf2-induced antioxidant protection: a promising target to counteract ROS-mediated damage in neurodegenerative disease? Free Radic Biol Med (2008) 1.83

The unfolded protein response is associated with early tau pathology in the hippocampus of tauopathies. J Pathol (2012) 1.76

Neuroinflammation - an early event in both the history and pathogenesis of Alzheimer's disease. Neurodegener Dis (2010) 1.66

Phenotypic characterization of hypomyelination and congenital cataract. Ann Neurol (2007) 1.46

Prion protein amyloidosis with divergent phenotype associated with two novel nonsense mutations in PRNP. Acta Neuropathol (2009) 1.39

Pontocerebellar hypoplasia type 2: a neuropathological update. Acta Neuropathol (2007) 1.32

Amyloid Beta induces oxidative stress-mediated blood-brain barrier changes in capillary amyloid angiopathy. Antioxid Redox Signal (2011) 1.29

Abeta 1-42 induces mild endoplasmic reticulum stress in an aggregation state-dependent manner. Antioxid Redox Signal (2007) 1.23

Frequency of ubiquitin and FUS-positive, TDP-43-negative frontotemporal lobar degeneration. J Neurol (2009) 1.22

Oligomer-specific Abeta toxicity in cell models is mediated by selective uptake. Biochim Biophys Acta (2008) 1.14

Blood-brain barrier alterations in both focal and diffuse abnormalities on postmortem MRI in multiple sclerosis. Neurobiol Dis (2005) 1.14

Matrix metalloproteinase-12 is expressed in phagocytotic macrophages in active multiple sclerosis lesions. J Neuroimmunol (2003) 1.14

Microglia activation in sepsis: a case-control study. J Neuroinflammation (2007) 1.13

Cyclin D1 and cyclin E are co-localized with cyclo-oxygenase 2 (COX-2) in pyramidal neurons in Alzheimer disease temporal cortex. J Neuropathol Exp Neurol (2002) 1.07

Enhanced capillary amyloid angiopathy-associated pathology in Tg-SwDI mice with deleted nitric oxide synthase 2. Stroke (2010) 1.05

DNA polymerase-beta is expressed early in neurons of Alzheimer's disease brain and is loaded into DNA replication forks in neurons challenged with beta-amyloid. J Neurosci (2006) 0.99

The pre-eclampsia gene STOX1 controls a conserved pathway in placenta and brain upregulated in late-onset Alzheimer's disease. J Alzheimers Dis (2010) 0.99

Non-steroidal anti-inflammatory drugs and cyclooxygenase in Alzheimer's disease. Curr Drug Targets (2003) 0.98

Protein translocation across the endoplasmic reticulum membrane in cold-adapted organisms. J Cell Sci (2003) 0.98

Human prion diseases in the Netherlands (1998-2009): clinical, genetic and molecular aspects. PLoS One (2012) 0.98

Transglutaminases and transglutaminase-catalyzed cross-links colocalize with the pathological lesions in Alzheimer's disease brain. Brain Pathol (2008) 0.96

The role of cyclo-oxygenase 1 and 2 activity in prostaglandin E(2) secretion by cultured human adult microglia: implications for Alzheimer's disease. Brain Res (2002) 0.96

Neuronal COX-2 expression and phosphorylation of pRb precede p38 MAPK activation and neurofibrillary changes in AD temporal cortex. Neurobiol Dis (2004) 0.96

CX3CL1 and CX3CR1 expression in human brain tissue: noninflammatory control versus multiple sclerosis. J Neuropathol Exp Neurol (2003) 0.96

The unfolded protein response and proteostasis in Alzheimer disease: preferential activation of autophagy by endoplasmic reticulum stress. Autophagy (2011) 0.95

Endoplasmic reticulum: the unfolded protein response is tangled in neurodegeneration. Int J Biochem Cell Biol (2012) 0.95

CC chemokine receptor 5 gene promoter activation by the cyclic AMP response element binding transcription factor. Blood (2008) 0.94

Versatile and efficient targeting using a single nanoparticulate platform: application to cancer and Alzheimer's disease. ACS Nano (2012) 0.91

Branched KLVFF tetramers strongly potentiate inhibition of beta-amyloid aggregation. Chembiochem (2007) 0.91

Maximal COX-2 and ppRb expression in neurons occurs during early Braak stages prior to the maximal activation of astrocytes and microglia in Alzheimer's disease. J Neuroinflammation (2005) 0.89

Characteristics of dyshoric capillary cerebral amyloid angiopathy. J Neuropathol Exp Neurol (2010) 0.89

Neuroinflammation and blood-brain barrier changes in capillary amyloid angiopathy. Neurodegener Dis (2012) 0.87

PEGylated nanoparticles bind to and alter amyloid-beta peptide conformation: toward engineering of functional nanomedicines for Alzheimer's disease. ACS Nano (2012) 0.86

Ubiquitin proteasome system as a pharmacological target in neurodegeneration. Expert Rev Neurother (2006) 0.86

Stage-dependent nigral neuronal loss in incidental Lewy body and Parkinson's disease. Mov Disord (2014) 0.85

Novel role of transglutaminase 1 in corpora amylacea formation? Neurobiol Aging (2009) 0.85

Neuroinflammation in plaque and vascular beta-amyloid disorders: clinical and therapeutic implications. Neurodegener Dis (2008) 0.85

Association of Parkinson disease-related protein PINK1 with Alzheimer disease and multiple sclerosis brain lesions. Free Radic Biol Med (2010) 0.84

Intracellular accumulation of aggregated pyroglutamate amyloid beta: convergence of aging and Aβ pathology at the lysosome. Age (Dordr) (2012) 0.84

Rab6 is a modulator of the unfolded protein response: implications for Alzheimer's disease. J Alzheimers Dis (2012) 0.83

Small heat shock proteins induce a cerebral inflammatory reaction. J Neurosci (2011) 0.83

A novel seven-octapeptide repeat insertion in the prion protein gene (PRNP) in a Dutch pedigree with Gerstmann-Sträussler-Scheinker disease phenotype: comparison with similar cases from the literature. Acta Neuropathol (2010) 0.83

Innate immunity and the etiology of late-onset Alzheimer's disease. Neurodegener Dis (2012) 0.82

Neuroinflammation in Alzheimer's disease wanes with age. J Neuroinflammation (2011) 0.82

[Eleven years of autopsy on account of Creutzfeldt-Jakob disease in the Netherlands]. Ned Tijdschr Geneeskd (2009) 0.82

Unfolded protein response activates glycogen synthase kinase-3 via selective lysosomal degradation. Neurobiol Aging (2013) 0.82

The unfolded protein response affects neuronal cell cycle protein expression: implications for Alzheimer's disease pathogenesis. Exp Gerontol (2006) 0.82

Increased expression of the oligopeptidase THOP1 is a neuroprotective response to Abeta toxicity. Neurobiol Dis (2008) 0.82

A second case of Gerstmann-Sträussler-Scheinker disease linked to the G131V mutation in the prion protein gene in a Dutch patient. J Neuropathol Exp Neurol (2011) 0.82

Symmetrical corticobasal syndrome caused by a novel C.314dup progranulin mutation. J Mol Neurosci (2011) 0.80

Ubiquilin 2 is not associated with tau pathology. PLoS One (2013) 0.80

The pathological cascade of Alzheimer's disease: the role of inflammation and its therapeutic implications. Drugs Today (Barc) (2002) 0.79

Amyotrophic lateral sclerosis (ALS)-associated VAPB-P56S inclusions represent an ER quality control compartment. Acta Neuropathol Commun (2013) 0.79

Pin1 levels are downregulated during ER stress in human neuroblastoma cells. Neurogenetics (2006) 0.79

Inhibition of endoplasmic reticulum associated degradation reduces endoplasmic reticulum stress and alters lysosomal morphology and distribution. Mol Cells (2013) 0.79

Transglutaminase 1 and its regulator tazarotene-induced gene 3 localize to neuronal tau inclusions in tauopathies. J Pathol (2011) 0.79

STOX1A induces phosphorylation of tau proteins at epitopes hyperphosphorylated in Alzheimer's disease. Neurosci Lett (2012) 0.79

Tubuloreticular structures in different types of myositis: implications for pathogenesis. Ultrastruct Pathol (2008) 0.78

Disturbed Ca2+ homeostasis increases glutaminyl cyclase expression; connecting two early pathogenic events in Alzheimer's disease in vitro. PLoS One (2012) 0.78

Morphometric changes in the cortical microvascular network in Alzheimer's disease. J Alzheimers Dis (2010) 0.78

New method based on capillary electrophoresis with laser-induced fluorescence detection (CE-LIF) to monitor interaction between nanoparticles and the amyloid-β peptide. Anal Chem (2010) 0.78

Protein kinase activity profiling of postmortem human brain tissue. Neurodegener Dis (2012) 0.78

Apolipoprotein E and LRP1 Increase Early in Parkinson's Disease Pathogenesis. Am J Pathol (2011) 0.78

Neuroinflammation and common mechanism in Alzheimer's disease and prion amyloidosis: amyloid-associated proteins, neuroinflammation and neurofibrillary degeneration. Neurodegener Dis (2012) 0.77

[Human spongiform encephalopathies in the Netherlands]. Ned Tijdschr Geneeskd (2009) 0.77

Immunohistochemical characterization of novel monoclonal antibodies against the N-terminus of amyloid β-peptide. Amyloid (2013) 0.77

Simvastatin affects cell motility and actin cytoskeleton distribution of microglia. Glia (2006) 0.77

Neuropsychiatric symptoms in Alzheimer's disease and vascular dementia. J Alzheimers Dis (2013) 0.77

Stability of Aβ (1-42) peptide fibrils as consequence of environmental modifications. Eur Biophys J (2010) 0.76

Adult neurogenesis and the unfolded protein response; new cellular and molecular avenues in sleep research. Sleep Med Rev (2009) 0.75

Clinico-Pathological Correlations of the Frontal Lobe Syndrome: Results of a Large Brain Bank Study. Dement Geriatr Cogn Disord (2015) 0.75