Caspase-8 functions as a key mediator of inflammation and pro-IL-1β processing via both canonical and non-canonical pathways.

Inflammasomes: mechanism of action, role in disease, and therapeutics. Nat Med (2015) 2.59

Converging roles of caspases in inflammasome activation, cell death and innate immunity. Nat Rev Immunol (2015) 1.10

Caspase-8 as an Effector and Regulator of NLRP3 Inflammasome Signaling. J Biol Chem (2015) 1.00

The Inflammasome Adaptor ASC Induces Procaspase-8 Death Effector Domain Filaments. J Biol Chem (2015) 0.82

Hydrogen-Rich Saline Promotes the Recovery of Renal Function after Ischemia/Reperfusion Injury in Rats via Anti-apoptosis and Anti-inflammation. Front Pharmacol (2016) 0.78

The inflammasome: firing up innate immunity. Immunol Rev (2015) 0.78

Sex- and disease-specific inflammasome signatures in circulating blood leukocytes of patients with abdominal aortic aneurysm. Mol Med (2016) 0.75

Critical role of caspase-8-mediated IL-1 signaling in promoting Th2 responses during asthma pathogenesis. Mucosal Immunol (2016) 0.75

Asbestos-Induced Mesothelial to Fibroblastic Transition Is Modulated by the Inflammasome. Am J Pathol (2017) 0.75

Immunity to uropathogens: the emerging roles of inflammasomes. Nat Rev Urol (2017) 0.75

Participation of Necroptosis in the Host Response to Acute Bacterial Pneumonia. J Innate Immun (2017) 0.75

Caspase-8: regulating life and death. Immunol Rev (2017) 0.75

Therapeutic targeting of Toll-like receptors for infectious and inflammatory diseases and cancer. Pharmacol Rev (2009) 2.30

A dimer of the Toll-like receptor 4 cytoplasmic domain provides a specific scaffold for the recruitment of signalling adaptor proteins. PLoS One (2007) 1.73

MyD88 adaptor-like is not essential for TLR2 signaling and inhibits signaling by TLR3. J Immunol (2009) 1.44

Expression and function of Toll-like receptor 4 in the endometrial cells of the uterus. Endocrinology (2005) 1.41

Salmonella infection induces recruitment of Caspase-8 to the inflammasome to modulate IL-1β production. J Immunol (2013) 1.32

Induction of proinflammatory responses in the human monocytic cell line THP-1 by Campylobacter jejuni. Infect Immun (2003) 1.26

Stimulation of Toll-like receptor 4 by lipopolysaccharide during cellular invasion by live Salmonella typhimurium is a critical but not exclusive event leading to macrophage responses. J Immunol (2003) 1.23

Ovarian follicular cells have innate immune capabilities that modulate their endocrine function. Reproduction (2007) 1.16

Annexin 1 regulates cell proliferation by disruption of cell morphology and inhibition of cyclin D1 expression through sustained activation of the ERK1/2 MAPK signal. Exp Cell Res (2003) 1.13

MAP kinase phosphatase-2 plays a critical role in response to infection by Leishmania mexicana. PLoS Pathog (2010) 1.09

Toll-like receptor 4 and MYD88-dependent signaling mechanisms of the innate immune system are essential for the response to lipopolysaccharide by epithelial and stromal cells of the bovine endometrium. Biol Reprod (2012) 1.08

Cell swelling and the NLRP3 inflammasome. Immunity (2013) 1.07

Toll-like receptor 4 signalling through MyD88 is essential to control Salmonella enterica serovar typhimurium infection, but not for the initiation of bacterial clearance. Immunology (2009) 1.06

Toll-like receptor expression in C3H/HeN and C3H/HeJ mice during Salmonella enterica serovar Typhimurium infection. Infect Immun (2003) 1.05

Caspase-3-dependent phagocyte death during systemic Salmonella enterica serovar Typhimurium infection of mice. Immunology (2008) 1.04

Activating immunity: lessons from the TLRs and NLRs. Trends Biochem Sci (2009) 1.03

Bacterial lipopolysaccharide induces an endocrine switch from prostaglandin F2alpha to prostaglandin E2 in bovine endometrium. Endocrinology (2008) 1.02

Salmonella-induced SipB-independent cell death requires Toll-like receptor-4 signalling via the adapter proteins Tram and Trif. Immunology (2007) 0.96

Expression of genes associated with immunity in the endometrium of cattle with disparate postpartum uterine disease and fertility. Reprod Biol Endocrinol (2009) 0.96

Dynamics of Salmonella infection of macrophages at the single cell level. J R Soc Interface (2012) 0.95

The equine TLR4/MD-2 complex mediates recognition of lipopolysaccharide from Rhodobacter sphaeroides as an agonist. J Endotoxin Res (2007) 0.92

Abnormal nasal nitric oxide production, ciliary beat frequency, and Toll-like receptor response in pulmonary nontuberculous mycobacterial disease epithelium. Am J Respir Crit Care Med (2013) 0.90

Leishmania mexicana promastigotes inhibit macrophage IL-12 production via TLR-4 dependent COX-2, iNOS and arginase-1 expression. Mol Immunol (2011) 0.90

Activation of innate immunity by lysozyme fibrils is critically dependent on cross-β sheet structure. Cell Mol Life Sci (2013) 0.90

Clostridium difficile modulates host innate immunity via toxin-independent and dependent mechanism(s). PLoS One (2013) 0.88

Bacterial infection of macrophages induces decrease in refractive index. J Biophotonics (2012) 0.87

Virulent Salmonella enterica infections can be exacerbated by concomitant infection of the host with a live attenuated S. enterica vaccine via Toll-like receptor 4-dependent interleukin-10 production with the involvement of both TRIF and MyD88. Immunology (2008) 0.86

Immunomodulatory effects of Pseudomonas aeruginosa quorum sensing small molecule probes on mammalian macrophages. Mol Biosyst (2006) 0.86

Sublethal infection of C57BL/6 mice with Salmonella enterica Serovar Typhimurium leads to an increase in levels of Toll-like receptor 1 (TLR1), TLR2, and TLR9 mRNA as well as a decrease in levels of TLR6 mRNA in infected organs. Infect Immun (2005) 0.85

Phagocytosis dynamics depends on target shape. Biophys J (2013) 0.84

A quantitative comparison of single-dye tracking analysis tools using Monte Carlo simulations. PLoS One (2013) 0.83

The structural basis for endotoxin-induced allosteric regulation of the Toll-like receptor 4 (TLR4) innate immune receptor. J Biol Chem (2013) 0.82

Differential modulatory effects of annexin 1 on nitric oxide synthase induction by lipopolysaccharide in macrophages. Immunology (2006) 0.81

Generation and characterisation of an equine macrophage cell line (e-CAS cells) derived from equine bone marrow cells. Vet Immunol Immunopathol (2004) 0.80

Multiple redundant stress resistance mechanisms are induced in Salmonella enterica serovar Typhimurium in response to alteration of the intracellular environment via TLR4 signalling. Microbiology (2009) 0.79

LPS ligand and culture additives improve production of monomeric MD-1 and 2 in Pichia pastoris by decreasing aggregation and intermolecular disulfide bonding. Protein Expr Purif (2010) 0.75