A dimer of the Toll-like receptor 4 cytoplasmic domain provides a specific scaffold for the recruitment of signalling adaptor proteins.

PubWeight™: 1.73‹?› | Rank: Top 3%

🔗 View Article (PMC 1945083)

Published in PLoS One on August 29, 2007

Authors

Ricardo Núñez Miguel1, Joyce Wong, Julian F Westoll, Heather J Brooks, Luke A J O'Neill, Nicholas J Gay, Clare E Bryant, Tom P Monie

Author Affiliations

1: Department of Biochemistry, University of Cambridge, Cambridge, United Kingdom.

Articles citing this

TRAM couples endocytosis of Toll-like receptor 4 to the induction of interferon-beta. Nat Immunol (2008) 7.87

Different modes of ubiquitination of the adaptor TRAF3 selectively activate the expression of type I interferons and proinflammatory cytokines. Nat Immunol (2009) 2.52

Therapeutic targeting of Toll-like receptors for infectious and inflammatory diseases and cancer. Pharmacol Rev (2009) 2.30

An oligomeric signaling platform formed by the Toll-like receptor signal transducers MyD88 and IRAK-4. J Biol Chem (2009) 1.85

The molecular basis of the host response to lipopolysaccharide. Nat Rev Microbiol (2010) 1.70

Structural basis for the multiple interactions of the MyD88 TIR domain in TLR4 signaling. Proc Natl Acad Sci U S A (2009) 1.65

TAG, a splice variant of the adaptor TRAM, negatively regulates the adaptor MyD88-independent TLR4 pathway. Nat Immunol (2009) 1.52

Assembly and localization of Toll-like receptor signalling complexes. Nat Rev Immunol (2014) 1.48

Crystal structure of Toll-like receptor adaptor MAL/TIRAP reveals the molecular basis for signal transduction and disease protection. Proc Natl Acad Sci U S A (2011) 1.38

Mal connects TLR2 to PI3Kinase activation and phagocyte polarization. EMBO J (2009) 1.30

Subversion of innate immune responses by Brucella through the targeted degradation of the TLR signaling adapter, MAL. J Immunol (2009) 1.15

A TIR domain variant of MyD88 adapter-like (Mal)/TIRAP results in loss of MyD88 binding and reduced TLR2/TLR4 signaling. J Biol Chem (2009) 1.09

Similar Structures but Different Roles - An Updated Perspective on TLR Structures. Front Physiol (2011) 1.06

Structural insights into TIR domain specificity of the bridging adaptor Mal in TLR4 signaling. PLoS One (2012) 1.05

Poxviral protein A46 antagonizes Toll-like receptor 4 signaling by targeting BB loop motifs in Toll-IL-1 receptor adaptor proteins to disrupt receptor:adaptor interactions. J Biol Chem (2012) 0.99

TIR8/SIGIRR is an Interleukin-1 Receptor/Toll Like Receptor Family Member with Regulatory Functions in Inflammation and Immunity. Front Immunol (2012) 0.99

The ectodomain of the Toll-like receptor 4 prevents constitutive receptor activation. J Biol Chem (2011) 0.99

Targeting TLR4 signaling by TLR4 Toll/IL-1 receptor domain-derived decoy peptides: identification of the TLR4 Toll/IL-1 receptor domain dimerization interface. J Immunol (2011) 0.98

Regulation of NF-κB signaling by caspases and MALT1 paracaspase. Cell Res (2010) 0.98

The crystal structure of human soluble CD14 reveals a bent solenoid with a hydrophobic amino-terminal pocket. J Immunol (2012) 0.97

Protective effect of naringenin against experimental colitis via suppression of Toll-like receptor 4/NF-κB signalling. Br J Nutr (2013) 0.96

Identification of interaction sites for dimerization and adapter recruitment in Toll/interleukin-1 receptor (TIR) domain of Toll-like receptor 4. J Biol Chem (2011) 0.95

Deletion of the vaccinia virus gene A46R, encoding for an inhibitor of TLR signalling, is an effective approach to enhance the immunogenicity in mice of the HIV/AIDS vaccine candidate NYVAC-C. PLoS One (2013) 0.92

Bacterial TIR-containing proteins and host innate immune system evasion. Med Microbiol Immunol (2012) 0.91

In silico approach to inhibition of signaling pathways of Toll-like receptors 2 and 4 by ST2L. PLoS One (2011) 0.91

Different dimerisation mode for TLR4 upon endosomal acidification? Trends Biochem Sci (2011) 0.91

Targeting Toll-like receptor (TLR) signaling by Toll/interleukin-1 receptor (TIR) domain-containing adapter protein/MyD88 adapter-like (TIRAP/Mal)-derived decoy peptides. J Biol Chem (2012) 0.90

Anti-CD180 (RP105) activates B cells to rapidly produce polyclonal Ig via a T cell and MyD88-independent pathway. J Immunol (2011) 0.89

Identification of binding sites for myeloid differentiation primary response gene 88 (MyD88) and Toll-like receptor 4 in MyD88 adapter-like (Mal). J Biol Chem (2013) 0.88

Structures and interface mapping of the TIR domain-containing adaptor molecules involved in interferon signaling. Proc Natl Acad Sci U S A (2013) 0.85

Toll/interleukin-1 receptor domain dimers as the platform for activation and enhanced inhibition of Toll-like receptor signaling. J Biol Chem (2012) 0.84

The Architecture of the TIR Domain Signalosome in the Toll-like Receptor-4 Signaling Pathway. Sci Rep (2015) 0.84

Systems biology approaches to toll-like receptor signaling. Wiley Interdiscip Rev Syst Biol Med (2012) 0.84

Inhibition of TLR4 signaling by TRAM-derived decoy peptides in vitro and in vivo. J Immunol (2013) 0.84

An alanine-to-proline mutation in the BB-loop of TLR3 Toll/IL-1R domain switches signalling adaptor specificity from TRIF to MyD88. J Immunol (2013) 0.83

Type I interferon signaling contributes to the bias that Toll-like receptor 4 exhibits for signaling mediated by the adaptor protein TRIF. Sci Signal (2014) 0.83

Characterization and structure of the vaccinia virus NF-κB antagonist A46. J Biol Chem (2013) 0.82

The structural basis for endotoxin-induced allosteric regulation of the Toll-like receptor 4 (TLR4) innate immune receptor. J Biol Chem (2013) 0.82

Recruitment of TLR adapter TRIF to TLR4 signaling complex is mediated by the second helical region of TRIF TIR domain. Proc Natl Acad Sci U S A (2013) 0.82

Suppression of TLR signaling by targeting TIR domain-containing proteins. Curr Protein Pept Sci (2012) 0.81

Tanshinones and diethyl blechnics with anti-inflammatory and anti-cancer activities from Salvia miltiorrhiza Bunge (Danshen). Sci Rep (2016) 0.79

Energetics of Endotoxin Recognition in the Toll-Like Receptor 4 Innate Immune Response. Sci Rep (2015) 0.78

Toll-like receptor 4 signaling is required for induction of gluconeogenic gene expression by palmitate in human hepatic carcinoma cells. J Nutr Biochem (2013) 0.77

Contributions of unique intracellular domains to switchlike biosensing by Toll-like receptor 4. J Biol Chem (2015) 0.76

Modeling of the Toll-like receptor 3 and a putative Toll-like receptor 3 antagonist encoded by the African swine fever virus. Protein Sci (2011) 0.76

Interaction between Cannabinoid System and Toll-Like Receptors Controls Inflammation. Mediators Inflamm (2016) 0.76

Activity of the HMGB1-derived immunostimulatory peptide Hp91 resides in the helical C-terminal portion and is enhanced by dimerization. Mol Immunol (2013) 0.75

The relationship between toll like receptor 4 gene rs4986790 and rs4986791 polymorphisms and sepsis susceptibility: A meta-analysis. Sci Rep (2016) 0.75

Articles cited by this

Comparative protein modelling by satisfaction of spatial restraints. J Mol Biol (1993) 64.61

The interpretation of protein structures: estimation of static accessibility. J Mol Biol (1971) 40.24

Defective LPS signaling in C3H/HeJ and C57BL/10ScCr mice: mutations in Tlr4 gene. Science (1998) 37.15

Toll-like receptor signalling. Nat Rev Immunol (2004) 34.74

Innate immune recognition. Annu Rev Immunol (2001) 26.65

IKKepsilon and TBK1 are essential components of the IRF3 signaling pathway. Nat Immunol (2003) 15.67

Satisfying hydrogen bonding potential in proteins. J Mol Biol (1994) 14.79

Principles of protein-protein interactions. Proc Natl Acad Sci U S A (1996) 14.51

Assessment of protein models with three-dimensional profiles. Nature (1992) 12.64

FUGUE: sequence-structure homology recognition using environment-specific substitution tables and structure-dependent gap penalties. J Mol Biol (2001) 10.02

A family of human receptors structurally related to Drosophila Toll. Proc Natl Acad Sci U S A (1998) 8.40

Molecular surface recognition: determination of geometric fit between proteins and their ligands by correlation techniques. Proc Natl Acad Sci U S A (1992) 6.86

LPS-TLR4 signaling to IRF-3/7 and NF-kappaB involves the toll adapters TRAM and TRIF. J Exp Med (2003) 5.97

Mal (MyD88-adapter-like) is required for Toll-like receptor-4 signal transduction. Nature (2001) 5.95

Essential role of MD-2 in LPS responsiveness and TLR4 distribution. Nat Immunol (2002) 5.41

Structural basis for signal transduction by the Toll/interleukin-1 receptor domains. Nature (2000) 4.36

A Mal functional variant is associated with protection against invasive pneumococcal disease, bacteremia, malaria and tuberculosis. Nat Genet (2007) 4.23

JOY: protein sequence-structure representation and analysis. Bioinformatics (1998) 4.10

Ligand-induced conformational changes allosterically activate Toll-like receptor 9. Nat Immunol (2007) 4.09

Suppressor of cytokine signaling 1 negatively regulates Toll-like receptor signaling by mediating Mal degradation. Nat Immunol (2006) 3.94

Solvent accessible surface area and excluded volume in proteins. Analytical equations for overlapping spheres and implications for the hydrophobic effect. J Mol Biol (1984) 3.91

Gram-negative endotoxin: an extraordinary lipid with profound effects on eukaryotic signal transduction. FASEB J (1991) 3.41

Structure and function of Toll receptors and their ligands. Annu Rev Biochem (2007) 3.30

Essential role of interferon regulatory factor 3 in direct activation of RANTES chemokine transcription. Mol Cell Biol (1999) 3.12

The Toll-IL-1 receptor adaptor family grows to five members. Trends Immunol (2003) 2.26

HOMSTRAD: adding sequence information to structure-based alignments of homologous protein families. Bioinformatics (2001) 1.97

Molecular genetic analysis of an endotoxin nonresponder mutant cell line: a point mutation in a conserved region of MD-2 abolishes endotoxin-induced signaling. J Exp Med (2001) 1.95

Lipid A antagonist, lipid IVa, is distinct from lipid A in interaction with Toll-like receptor 4 (TLR4)-MD-2 and ligand-induced TLR4 oligomerization. Int Immunol (2004) 1.91

Innate recognition of lipopolysaccharide by Toll-like receptor 4-MD-2. Trends Microbiol (2004) 1.89

Structural complementarity of Toll/interleukin-1 receptor domains in Toll-like receptors and the adaptors Mal and MyD88. J Biol Chem (2003) 1.81

MyD88 adapter-like (Mal) is phosphorylated by Bruton's tyrosine kinase during TLR2 and TLR4 signal transduction. J Biol Chem (2006) 1.77

pyDock: electrostatics and desolvation for effective scoring of rigid-body protein-protein docking. Proteins (2007) 1.69

Toll-like receptors as molecular switches. Nat Rev Immunol (2006) 1.60

NF-kappaB activation by the Toll-IL-1 receptor domain protein MyD88 adapter-like is regulated by caspase-1. Proc Natl Acad Sci U S A (2007) 1.54

MD-2: the Toll 'gatekeeper' in endotoxin signalling. Trends Biochem Sci (2004) 1.53

Differential involvement of BB loops of toll-IL-1 resistance (TIR) domain-containing adapter proteins in TLR4- versus TLR2-mediated signal transduction. J Immunol (2005) 1.44

Evaluation of GRAMM low-resolution docking methodology on the hemagglutinin-antibody complex. Proteins (1997) 1.38

The crystal structure of the BAR domain from human Bin1/amphiphysin II and its implications for molecular recognition. Biochemistry (2006) 1.35

Common interaction surfaces of the toll-like receptor 4 cytoplasmic domain stimulate multiple nuclear targets. Mol Cell Biol (2003) 1.16

Cutting Edge: Differential inhibition of TLR signaling pathways by cell-permeable peptides representing BB loops of TLRs. J Immunol (2007) 1.11

Ligand-receptor and receptor-receptor interactions act in concert to activate signaling in the Drosophila toll pathway. J Biol Chem (2005) 1.04

Sequence patterns derived from the automated prediction of functional residues in structurally-aligned homologous protein families. Bioinformatics (2004) 0.87

Sepsis under siege: a new understanding of sepsis might lead to the development of therapies to treat septic shock. EMBO Rep (2006) 0.78

Articles by these authors

Negative regulation of toll-like receptor-mediated immune responses. Nat Rev Immunol (2005) 9.70

Activation of the NLRP3 inflammasome by islet amyloid polypeptide provides a mechanism for enhanced IL-1β in type 2 diabetes. Nat Immunol (2010) 6.64

Resolution of inflammation: state of the art, definitions and terms. FASEB J (2007) 5.12

Negative regulation of TLR4 via targeting of the proinflammatory tumor suppressor PDCD4 by the microRNA miR-21. Nat Immunol (2009) 5.05

A Mal functional variant is associated with protection against invasive pneumococcal disease, bacteremia, malaria and tuberculosis. Nat Genet (2007) 4.23

The interleukin-1 receptor/Toll-like receptor superfamily: signal transduction during inflammation and host defense. Sci STKE (2003) 4.14

Signal transduction by the lipopolysaccharide receptor, Toll-like receptor-4. Immunology (2004) 4.09

Suppressor of cytokine signaling 1 negatively regulates Toll-like receptor signaling by mediating Mal degradation. Nat Immunol (2006) 3.94

TLRs, NLRs and RLRs: a trinity of pathogen sensors that co-operate in innate immunity. Trends Immunol (2006) 3.75

Targeting Toll-like receptors: emerging therapeutics? Nat Rev Drug Discov (2010) 3.35

ST2 is an inhibitor of interleukin 1 receptor and Toll-like receptor 4 signaling and maintains endotoxin tolerance. Nat Immunol (2004) 3.19

Toll-like receptors: from the discovery of NFkappaB to new insights into transcriptional regulations in innate immunity. Biochem Pharmacol (2006) 3.00

Binding of the Drosophila cytokine Spätzle to Toll is direct and establishes signaling. Nat Immunol (2003) 2.99

The poxvirus protein A52R targets Toll-like receptor signaling complexes to suppress host defense. J Exp Med (2003) 2.85

A long noncoding RNA mediates both activation and repression of immune response genes. Science (2013) 2.85

A role for the NLRP3 inflammasome in metabolic diseases--did Warburg miss inflammation? Nat Immunol (2012) 2.59

NLRP3 has a protective role in age-related macular degeneration through the induction of IL-18 by drusen components. Nat Med (2012) 2.49

Uptake of particulate vaccine adjuvants by dendritic cells activates the NALP3 inflammasome. Proc Natl Acad Sci U S A (2009) 2.42

Therapeutic targeting of Toll-like receptors for infectious and inflammatory diseases and cancer. Pharmacol Rev (2009) 2.30

Signalling adaptors used by Toll-like receptors: an update. Cytokine (2008) 2.22

The myristoylation of TRIF-related adaptor molecule is essential for Toll-like receptor 4 signal transduction. Proc Natl Acad Sci U S A (2006) 2.13

Genetic variation in Toll-like receptors and disease susceptibility. Nat Immunol (2012) 2.09

Localisation and trafficking of Toll-like receptors: an important mode of regulation. Curr Opin Immunol (2010) 2.08

Plasminogen activator inhibitor-1 deficiency retards diabetic nephropathy. Kidney Int (2005) 2.02

Myocardial ischemia/reperfusion injury is mediated by leukocytic toll-like receptor-2 and reduced by systemic administration of a novel anti-toll-like receptor-2 antibody. Circulation (2009) 1.94

Bruton's tyrosine kinase is a Toll/interleukin-1 receptor domain-binding protein that participates in nuclear factor kappaB activation by Toll-like receptor 4. J Biol Chem (2003) 1.91

An oligomeric signaling platform formed by the Toll-like receptor signal transducers MyD88 and IRAK-4. J Biol Chem (2009) 1.85

Structural complementarity of Toll/interleukin-1 receptor domains in Toll-like receptors and the adaptors Mal and MyD88. J Biol Chem (2003) 1.81

MyD88 adapter-like (Mal) is phosphorylated by Bruton's tyrosine kinase during TLR2 and TLR4 signal transduction. J Biol Chem (2006) 1.77

Cutting edge: miR-223 and EBV miR-BART15 regulate the NLRP3 inflammasome and IL-1β production. J Immunol (2012) 1.71

The molecular basis of the host response to lipopolysaccharide. Nat Rev Microbiol (2010) 1.70

New insights into the regulation of TLR signaling. J Leukoc Biol (2006) 1.68

IL-10 inhibits miR-155 induction by toll-like receptors. J Biol Chem (2010) 1.65

The Warburg effect then and now: from cancer to inflammatory diseases. Bioessays (2013) 1.64

TLR9 provokes inflammation in response to fetal DNA: mechanism for fetal loss in preterm birth and preeclampsia. J Immunol (2012) 1.63

Prognostic role of CMR in patients presenting with ventricular arrhythmias. JACC Cardiovasc Imaging (2013) 1.62

Treatment with OPN-305, a humanized anti-Toll-Like receptor-2 antibody, reduces myocardial ischemia/reperfusion injury in pigs. Circ Cardiovasc Interv (2012) 1.62

Structure, function and regulation of the Toll/IL-1 receptor adaptor proteins. Immunol Cell Biol (2007) 1.56

Inflammasomes in inflammatory disorders: the role of TLRs and their interactions with NLRs. Semin Immunopathol (2007) 1.54

NF-kappaB activation by the Toll-IL-1 receptor domain protein MyD88 adapter-like is regulated by caspase-1. Proc Natl Acad Sci U S A (2007) 1.54

MD-2: the Toll 'gatekeeper' in endotoxin signalling. Trends Biochem Sci (2004) 1.53

TAG, a splice variant of the adaptor TRAM, negatively regulates the adaptor MyD88-independent TLR4 pathway. Nat Immunol (2009) 1.52

A peptide motif in Raver1 mediates splicing repression by interaction with the PTB RRM2 domain. Nat Struct Mol Biol (2006) 1.52

Recent insights into the structure of Toll-like receptors and post-translational modifications of their associated signalling proteins. Biochem J (2009) 1.52

Adaptor usage and Toll-like receptor signaling specificity. FEBS Lett (2005) 1.50

Crystal structure of the Toll/interleukin-1 receptor domain of human IL-1RAPL. J Biol Chem (2004) 1.50

What the Myddosome structure tells us about the initiation of innate immunity. Trends Immunol (2011) 1.45

MyD88 adaptor-like is not essential for TLR2 signaling and inhibits signaling by TLR3. J Immunol (2009) 1.44

Expression and function of Toll-like receptor 4 in the endometrial cells of the uterus. Endocrinology (2005) 1.41

Signalling of toll-like receptors. Handb Exp Pharmacol (2008) 1.40

Crystal structure of Toll-like receptor adaptor MAL/TIRAP reveals the molecular basis for signal transduction and disease protection. Proc Natl Acad Sci U S A (2011) 1.38

Schlafen-1 causes a cell cycle arrest by inhibiting induction of cyclin D1. J Biol Chem (2005) 1.37

Structure and RNA interactions of the N-terminal RRM domains of PTB. Structure (2004) 1.35

Evidence for Marfan cardiomyopathy. Eur J Heart Fail (2010) 1.35

New insights into the regulation of signalling by toll-like receptors and nod-like receptors. J Innate Immun (2010) 1.35

The expanding family of MyD88-like adaptors in Toll-like receptor signal transduction. Mol Immunol (2004) 1.34

Trif-related adapter molecule is phosphorylated by PKC{epsilon} during Toll-like receptor 4 signaling. Proc Natl Acad Sci U S A (2006) 1.33

Salmonella infection induces recruitment of Caspase-8 to the inflammasome to modulate IL-1β production. J Immunol (2013) 1.32

Signaling by Toll-like receptors 8 and 9 requires Bruton's tyrosine kinase. J Biol Chem (2007) 1.32

Conformation of polypyrimidine tract binding protein in solution. Structure (2006) 1.30

The murine IRAK2 gene encodes four alternatively spliced isoforms, two of which are inhibitory. J Biol Chem (2004) 1.30

How important are Toll-like receptors for antimicrobial responses? Cell Microbiol (2007) 1.28

The inflammasome in atherosclerosis and type 2 diabetes. Sci Transl Med (2011) 1.26

Four N-linked glycosylation sites in human toll-like receptor 2 cooperate to direct efficient biosynthesis and secretion. J Biol Chem (2004) 1.26

Induction of proinflammatory responses in the human monocytic cell line THP-1 by Campylobacter jejuni. Infect Immun (2003) 1.26

Pathogen sensing by nucleotide-binding oligomerization domain-containing protein 2 (NOD2) is mediated by direct binding to muramyl dipeptide and ATP. J Biol Chem (2012) 1.26

Listeria monocytogenes infection in the face of innate immunity. Cell Microbiol (2009) 1.25

Functional and genetic evidence that the Mal/TIRAP allele variant 180L has been selected by providing protection against septic shock. Proc Natl Acad Sci U S A (2009) 1.25

Stimulation of Toll-like receptor 4 by lipopolysaccharide during cellular invasion by live Salmonella typhimurium is a critical but not exclusive event leading to macrophage responses. J Immunol (2003) 1.23

How metabolism generates signals during innate immunity and inflammation. J Biol Chem (2013) 1.22

Modulatory mechanisms controlling the NLRP3 inflammasome in inflammation: recent developments. Curr Opin Immunol (2013) 1.19

Assembly of oligomeric death domain complexes during Toll receptor signaling. J Biol Chem (2008) 1.19

Tunable silk: using microfluidics to fabricate silk fibers with controllable properties. Biomacromolecules (2011) 1.19

The cytokine release inhibitory drug CRID3 targets ASC oligomerisation in the NLRP3 and AIM2 inflammasomes. PLoS One (2011) 1.19

Biochemical regulation of the inflammasome. Crit Rev Biochem Mol Biol (2012) 1.18

Interferon regulatory factor-3-mediated activation of the interferon-sensitive response element by Toll-like receptor (TLR) 4 but not TLR3 requires the p65 subunit of NF-kappa. J Biol Chem (2003) 1.16

Ras participates in the activation of p38 MAPK by interleukin-1 by associating with IRAK, IRAK2, TRAF6, and TAK-1. J Biol Chem (2001) 1.16

Ovarian follicular cells have innate immune capabilities that modulate their endocrine function. Reproduction (2007) 1.16

Disease-associated amyloid and misfolded protein aggregates activate the inflammasome. Trends Mol Med (2011) 1.15

Sensing of Gram-positive bacteria in Drosophila: GNBP1 is needed to process and present peptidoglycan to PGRP-SA. EMBO J (2006) 1.13

Annexin 1 regulates cell proliferation by disruption of cell morphology and inhibition of cyclin D1 expression through sustained activation of the ERK1/2 MAPK signal. Exp Cell Res (2003) 1.13

Characterization of signaling pathways activated by the interleukin 1 (IL-1) receptor homologue T1/ST2. A role for Jun N-terminal kinase in IL-4 induction. J Biol Chem (2002) 1.12

Structural insight into the mechanism of activation of the Toll receptor by the dimeric ligand Spätzle. J Biol Chem (2008) 1.12

New developments in Toll-like receptor targeted therapeutics. Curr Opin Pharmacol (2012) 1.10

Toll-6 and Toll-7 function as neurotrophin receptors in the Drosophila melanogaster CNS. Nat Neurosci (2013) 1.10

A TIR domain variant of MyD88 adapter-like (Mal)/TIRAP results in loss of MyD88 binding and reduced TLR2/TLR4 signaling. J Biol Chem (2009) 1.09

The GOLD domain-containing protein TMED7 inhibits TLR4 signalling from the endosome upon LPS stimulation. Nat Commun (2012) 1.09

Diversity and regulation in the NF-kappaB system. Trends Biochem Sci (2007) 1.09

MAP kinase phosphatase-2 plays a critical role in response to infection by Leishmania mexicana. PLoS Pathog (2010) 1.09

Toll-like receptors: key activators of leucocytes and regulator of haematopoiesis. Br J Haematol (2007) 1.09

Toll-like receptor 4 and MYD88-dependent signaling mechanisms of the innate immune system are essential for the response to lipopolysaccharide by epithelial and stromal cells of the bovine endometrium. Biol Reprod (2012) 1.08

High-resolution structure of murine interleukin 1 homologue IL-1F5 reveals unique loop conformations for receptor binding specificity. Biochemistry (2003) 1.08

Glucocorticoids inhibit IRF3 phosphorylation in response to Toll-like receptor-3 and -4 by targeting TBK1 activation. J Biol Chem (2008) 1.07

Cell swelling and the NLRP3 inflammasome. Immunity (2013) 1.07