Published in Gastroenterology on April 14, 2015
Pathophysiology of gadolinium-associated systemic fibrosis. Am J Physiol Renal Physiol (2016) 1.41
The Role of NADPH Oxidases (NOXs) in Liver Fibrosis and the Activation of Myofibroblasts. Front Physiol (2016) 0.86
Redox-fibrosis: Impact of TGFβ1 on ROS generators, mediators and functional consequences. Redox Biol (2015) 0.86
Promising Therapy Candidates for Liver Fibrosis. Front Physiol (2016) 0.85
Role of NADPH oxidases in the redox biology of liver fibrosis. Redox Biol (2015) 0.84
Reactive oxygen species and fibrosis: further evidence of a significant liaison. Cell Tissue Res (2016) 0.83
Targeting Hepatic Fibrosis in Autoimmune Hepatitis. Dig Dis Sci (2016) 0.81
Nature and Implications of Oxidative and Nitrosative Stresses in Autoimmune Hepatitis. Dig Dis Sci (2016) 0.78
Inhibition of NOX1/4 with GKT137831: a potential novel treatment to attenuate neuroglial cell inflammation in the retina. J Neuroinflammation (2015) 0.78
Liver inflammation and fibrosis. J Clin Invest (2017) 0.77
Dysregulation of redox pathways in liver fibrosis. Am J Physiol Gastrointest Liver Physiol (2016) 0.76
Global Deletion of Glutathione S-Transferase A4 Exacerbates Developmental Nonalcoholic Steatohepatitis. Am J Pathol (2016) 0.76
Getting to the core of fibrosis: targeting redox imbalance in aging. Ann Transl Med (2016) 0.75
High Dietary Fructose: Direct or Indirect Dangerous Factors Disturbing Tissue and Organ Functions. Nutrients (2017) 0.75
NOX4 Regulates CCR2 and CCL2 mRNA Stability in Alcoholic Liver Disease. Sci Rep (2017) 0.75
Glutathione protects against hepatic injury in a murine model of primary Sjögren's syndrome. Bosn J Basic Med Sci (2016) 0.75
Hepatocyte ERBB3 and EGFR are required for maximal CCl4-induced liver fibrosis. Am J Physiol Gastrointest Liver Physiol (2016) 0.75
Pigment Epithelium-Derived Factor (PEDF) Prevents Hepatic Fat Storage, Inflammation, and Fibrosis in Dietary Steatohepatitis of Mice. Dig Dis Sci (2017) 0.75
The NOX family of ROS-generating NADPH oxidases: physiology and pathophysiology. Physiol Rev (2007) 21.13
NOX enzymes and the biology of reactive oxygen. Nat Rev Immunol (2004) 12.93
PKR; a sentinel kinase for cellular stress. Oncogene (1999) 5.29
Endoplasmic reticulum stress in liver disease. J Hepatol (2010) 3.90
Toll-like receptor 9 promotes steatohepatitis by induction of interleukin-1beta in mice. Gastroenterology (2010) 3.52
The NAD(P)H oxidase homolog Nox4 modulates insulin-stimulated generation of H2O2 and plays an integral role in insulin signal transduction. Mol Cell Biol (2004) 3.35
Signal integration via PKR. Sci STKE (2001) 3.17
Novel role of PKR in inflammasome activation and HMGB1 release. Nature (2012) 3.13
Mechanisms of disease progression in nonalcoholic fatty liver disease. Semin Liver Dis (2008) 2.35
Mitochondrial dysfunction and oxidative stress in the pathogenesis of alcohol- and obesity-induced fatty liver diseases. Free Radic Biol Med (2008) 2.14
Decoding cell death signals in liver inflammation. J Hepatol (2013) 2.05
Fast food diet mouse: novel small animal model of NASH with ballooning, progressive fibrosis, and high physiological fidelity to the human condition. Am J Physiol Gastrointest Liver Physiol (2011) 1.85
Nox4 and nox2 NADPH oxidases mediate distinct cellular redox signaling responses to agonist stimulation. Arterioscler Thromb Vasc Biol (2008) 1.77
Differential requirement for c-Jun NH2-terminal kinase in TNFalpha- and Fas-mediated apoptosis in hepatocytes. FASEB J (2004) 1.76
NADPH oxidase links endoplasmic reticulum stress, oxidative stress, and PKR activation to induce apoptosis. J Cell Biol (2010) 1.74
c-Jun N-terminal kinase-1 from hematopoietic cells mediates progression from hepatic steatosis to steatohepatitis and fibrosis in mice. Gastroenterology (2009) 1.59
Liver fibrosis and hepatocyte apoptosis are attenuated by GKT137831, a novel NOX4/NOX1 inhibitor in vivo. Free Radic Biol Med (2012) 1.54
Nox2 NADPH oxidase has a critical role in insulin resistance-related endothelial cell dysfunction. Diabetes (2013) 1.51
Small-molecule inhibitors of PKR improve glucose homeostasis in obese diabetic mice. Diabetes (2013) 1.50
Nicotinamide adenine dinucleotide phosphate oxidase in experimental liver fibrosis: GKT137831 as a novel potential therapeutic agent. Hepatology (2012) 1.49
Upregulation of the NADPH oxidase NOX4 by TGF-beta in hepatocytes is required for its pro-apoptotic activity. J Hepatol (2008) 1.44
The NOX toolbox: validating the role of NADPH oxidases in physiology and disease. Cell Mol Life Sci (2012) 1.44
Nonalcoholic fatty liver disease: an emerging threat to obese and diabetic individuals. Ann N Y Acad Sci (2013) 1.40
Mechanisms of lipotoxicity in NAFLD and clinical implications. J Pediatr Gastroenterol Nutr (2011) 1.35
The nicotinamide adenine dinucleotide phosphate oxidase (NOX) homologues NOX1 and NOX2/gp91(phox) mediate hepatic fibrosis in mice. Hepatology (2011) 1.33
Endoplasmic reticulum stress inhibition protects steatotic and non-steatotic livers in partial hepatectomy under ischemia-reperfusion. Cell Death Dis (2010) 1.31
NADPH oxidases in heart failure: poachers or gamekeepers? Antioxid Redox Signal (2012) 1.27
Hepatocyte NAD(P)H oxidases as an endogenous source of reactive oxygen species during hepatitis C virus infection. Hepatology (2010) 1.25
Redox signaling loops in the unfolded protein response. Cell Signal (2012) 1.24
Liver-specific protein-tyrosine phosphatase 1B (PTP1B) re-expression alters glucose homeostasis of PTP1B-/-mice. J Biol Chem (2005) 1.23
Apoptosis as a mechanism for liver disease progression. Semin Liver Dis (2010) 1.21
Apoptosis and cytokines in non-alcoholic steatohepatitis. Clin Liver Dis (2009) 1.21
CHOP is a multifunctional transcription factor in the ER stress response. J Biochem (2011) 1.20
Reduced nicotinamide adenine dinucleotide phosphate oxidase 2 plays a key role in stellate cell activation and liver fibrogenesis in vivo. Gastroenterology (2010) 1.18
Apoptotic body engulfment by hepatic stellate cells promotes their survival by the JAK/STAT and Akt/NF-kappaB-dependent pathways. J Hepatol (2009) 1.17
Mechanisms of disease progression in NASH: new paradigms. Clin Liver Dis (2012) 1.17
NADPH oxidase NOX4 mediates stellate cell activation and hepatocyte cell death during liver fibrosis development. PLoS One (2012) 1.17
Targeting endoplasmic reticulum stress in metabolic disease. Expert Opin Ther Targets (2013) 1.14
PTP1B and TCPTP--nonredundant phosphatases in insulin signaling and glucose homeostasis. FEBS J (2012) 1.09
Nox as a target for diabetic complications. Clin Sci (Lond) (2013) 1.05
Emerging role of redox dysregulation in alcoholic and nonalcoholic fatty liver disease. Antioxid Redox Signal (2011) 1.05
Phosphorylation of the RNA-dependent protein kinase regulates its RNA-binding activity. Nucleic Acids Res (2001) 1.05
Involvement of free radicals and oxidative stress in NAFLD/NASH. Free Radic Res (2013) 1.04
The impact of PKR activation: from neurodegeneration to cancer. FASEB J (2014) 1.04
Double-stranded RNA-activated protein kinase is a key modulator of insulin sensitivity in physiological conditions and in obesity in mice. Endocrinology (2012) 1.01
Nox4 and diabetic nephropathy: with a friend like this, who needs enemies? Free Radic Biol Med (2013) 0.98
Mixed lineage kinase 3 deficient mice are protected against the high fat high carbohydrate diet-induced steatohepatitis. Liver Int (2013) 0.96
A far-upstream AP-1/Smad binding box regulates human NOX4 promoter activation by transforming growth factor-β. Gene (2014) 0.95
Doxorubicin bypasses the cytoprotective effects of eIF2α phosphorylation and promotes PKR-mediated cell death. Cell Death Differ (2010) 0.93
CIDEC/FSP27 is regulated by peroxisome proliferator-activated receptor alpha and plays a critical role in fasting- and diet-induced hepatosteatosis. Hepatology (2015) 0.89
Double-stranded RNA-dependent protein kinase deficiency protects the heart from systolic overload-induced congestive heart failure. Circulation (2014) 0.87
Increased soluble leptin receptor levels in morbidly obese patients with insulin resistance and nonalcoholic fatty liver disease. Obesity (Silver Spring) (2010) 0.82
The specific PKR inhibitor C16 prevents apoptosis and IL-1β production in an acute excitotoxic rat model with a neuroinflammatory component. Neurochem Int (2013) 0.82
Advanced glycation endproducts induce fibrogenic activity in nonalcoholic steatohepatitis by modulating TNF-α-converting enzyme activity in mice. Hepatology (2013) 0.82
Liver disease in the morbidly obese: a review of 1000 consecutive patients undergoing weight loss surgery. Surg Obes Relat Dis (2014) 0.76
NOX4 Regulates CCR2 and CCL2 mRNA Stability in Alcoholic Liver Disease. Sci Rep (2017) 0.75