Published in Cell Mol Life Sci on May 31, 2012
Discovery of GSK2795039, a Novel Small Molecule NADPH Oxidase 2 Inhibitor. Antioxid Redox Signal (2015) 2.02
TGF-β signaling in tissue fibrosis: redox controls, target genes and therapeutic opportunities. Cell Signal (2012) 1.82
Elevated NADPH oxidase activity contributes to oxidative stress and cell death in Huntington's disease. Hum Mol Genet (2012) 1.25
Evolution of NADPH Oxidase Inhibitors: Selectivity and Mechanisms for Target Engagement. Antioxid Redox Signal (2014) 1.23
Sustained production of ROS triggers compensatory proliferation and is required for regeneration to proceed. Sci Rep (2013) 1.18
Reactive oxygen species, vascular Noxs, and hypertension: focus on translational and clinical research. Antioxid Redox Signal (2013) 1.14
Genetic targeting or pharmacologic inhibition of NADPH oxidase nox4 provides renoprotection in long-term diabetic nephropathy. J Am Soc Nephrol (2014) 1.14
Interplay of oxidative, nitrosative/nitrative stress, inflammation, cell death and autophagy in diabetic cardiomyopathy. Biochim Biophys Acta (2014) 1.12
Fibrosis of two: Epithelial cell-fibroblast interactions in pulmonary fibrosis. Biochim Biophys Acta (2013) 1.11
NOX4 promotes non-small cell lung cancer cell proliferation and metastasis through positive feedback regulation of PI3K/Akt signaling. Oncotarget (2014) 1.10
From form to function: the role of Nox4 in the cardiovascular system. Front Physiol (2012) 1.07
New insights on NOX enzymes in the central nervous system. Antioxid Redox Signal (2014) 1.06
Increased p22(phox)/Nox4 expression is involved in remodeling through hydrogen peroxide signaling in experimental persistent pulmonary hypertension of the newborn. Antioxid Redox Signal (2013) 1.04
Neuroprotection after stroke by targeting NOX4 as a source of oxidative stress. Antioxid Redox Signal (2012) 1.03
Impact of glucose-6-phosphate dehydrogenase deficiency on the pathophysiology of cardiovascular disease. Am J Physiol Heart Circ Physiol (2012) 1.00
NADPH oxidases: a perspective on reactive oxygen species production in tumor biology. Antioxid Redox Signal (2013) 0.99
Nox4 and diabetic nephropathy: with a friend like this, who needs enemies? Free Radic Biol Med (2013) 0.98
Hydrogen peroxide signaling in vascular endothelial cells. Redox Biol (2014) 0.97
The quest for selective nox inhibitors and therapeutics: challenges, triumphs and pitfalls. Antioxid Redox Signal (2013) 0.96
Natural compounds as modulators of NADPH oxidases. Oxid Med Cell Longev (2013) 0.94
NADPH oxidase, NOX1, mediates vascular injury in ischemic retinopathy. Antioxid Redox Signal (2013) 0.93
Hepatocyte Nicotinamide Adenine Dinucleotide Phosphate Reduced Oxidase 4 Regulates Stress Signaling, Fibrosis, and Insulin Sensitivity During Development of Steatohepatitis in Mice. Gastroenterology (2015) 0.93
Role of protein kinase C δ in ER stress and apoptosis induced by oxidized LDL in human vascular smooth muscle cells. Cell Death Dis (2013) 0.92
RpoS contributes to phagocyte oxidase-mediated stress resistance during urinary tract infection by Escherichia coli CFT073. MBio (2013) 0.92
Role of NADPH oxidase-mediated reactive oxygen species in podocyte injury. Biomed Res Int (2013) 0.92
Role of reactive oxygen species in neonatal pulmonary vascular disease. Antioxid Redox Signal (2014) 0.91
Characterization of NADPH oxidase 5 expression in human tumors and tumor cell lines with a novel mouse monoclonal antibody. Free Radic Biol Med (2013) 0.90
Redox control of microglial function: molecular mechanisms and functional significance. Antioxid Redox Signal (2014) 0.90
IFNγ induces oxidative stress, DNA damage and tumor cell senescence via TGFβ/SMAD signaling-dependent induction of Nox4 and suppression of ANT2. Oncogene (2015) 0.90
NADPH oxidase biology and the regulation of tyrosine kinase receptor signaling and cancer drug cytotoxicity. Int J Mol Sci (2013) 0.89
Estrogen and estrogen receptors in cardiovascular oxidative stress. Pflugers Arch (2013) 0.89
Influenza virus replication in lung epithelial cells depends on redox-sensitive pathways activated by NOX4-derived ROS. Cell Microbiol (2014) 0.87
Enhanced expression and activity of Nox2 and Nox4 in the macula densa in ANG II-induced hypertensive mice. Am J Physiol Renal Physiol (2013) 0.87
Oxidative stress and autophagy in cardiovascular homeostasis. Antioxid Redox Signal (2013) 0.86
Hypoxic pulmonary vasoconstriction in the absence of pretone: essential role for intracellular Ca2+ release. J Physiol (2013) 0.86
Mitochondrial oxidative metabolism and uncoupling proteins in the failing heart. Heart Fail Rev (2015) 0.86
Therapeutic targeting of redox signaling in myofibroblast differentiation and age-related fibrotic disease. Oxid Med Cell Longev (2012) 0.85
Current status of NADPH oxidase research in cardiovascular pharmacology. Vasc Health Risk Manag (2013) 0.85
Upstream regulators and downstream effectors of NADPH oxidases as novel therapeutic targets for diabetic kidney disease. Mol Cells (2015) 0.85
Targeting the redox balance in inflammatory skin conditions. Int J Mol Sci (2013) 0.84
Redox signaling as a therapeutic target to inhibit myofibroblast activation in degenerative fibrotic disease. Biomed Res Int (2014) 0.84
Emerging mechanisms of glutathione-dependent chemistry in biology and disease. J Cell Biochem (2013) 0.83
NADPH oxidases: key modulators in aging and age-related cardiovascular diseases? Clin Sci (Lond) (2016) 0.82
Inhibition of nuclear Nox4 activity by plumbagin: effect on proliferative capacity in human amniotic stem cells. Oxid Med Cell Longev (2013) 0.82
Reactive oxygen species from human astrocytes induced functional impairment and oxidative damage. Neurochem Res (2013) 0.82
Oxidative Stress and Skin Fibrosis. Curr Pathobiol Rep (2014) 0.80
Proteomic and functional investigation of the colon cancer relapse-associated genes NOX4 and ITGA3. J Proteome Res (2014) 0.80
Reactive Oxygen-Related Diseases: Therapeutic Targets and Emerging Clinical Indications. Antioxid Redox Signal (2015) 0.79
Pharmacology and Clinical Drug Candidates in Redox Medicine. Antioxid Redox Signal (2015) 0.79
Exploiting the Pleiotropic Antioxidant Effects of Established Drugs in Cardiovascular Disease. Int J Mol Sci (2015) 0.79
Non-steroidal anti-inflammatory drugs activate NADPH oxidase in adipocytes and raise the H2O2 pool to prevent cAMP-stimulated protein kinase a activation and inhibit lipolysis. BMC Biochem (2013) 0.79
NADPH oxidase enzymes in skin fibrosis: molecular targets and therapeutic agents. Arch Dermatol Res (2013) 0.79
Hydrogen Sulfide: A Therapeutic Candidate for Fibrotic Disease? Oxid Med Cell Longev (2015) 0.79
NADPH oxidase in brain injury and neurodegenerative disorders. Mol Neurodegener (2017) 0.78
Bidirectional interactions between NOX2-type NADPH oxidase and the F-actin cytoskeleton in neuronal growth cones. J Neurochem (2014) 0.77
An exposure to the oxidized DNA enhances both instability of genome and survival in cancer cells. PLoS One (2013) 0.77
Regulation of NADPH-dependent Nitric Oxide and reactive oxygen species signalling in endothelial and melanoma cells by a photoactive NADPH analogue. Oncotarget (2014) 0.77
NADPH oxidase 4 is involved in the triethylene glycol dimethacrylate-induced reactive oxygen species and apoptosis in human embryonic palatal mesenchymal and dental pulp cells. Clin Oral Investig (2014) 0.77
Pathophysiology and Treatments of Oxidative Injury in Ischemic Stroke: Focus on the Phagocytic NADPH Oxidase 2. Antioxid Redox Signal (2014) 0.77
Differential Roles of Protein Complexes NOX1-NOXO1 and NOX2-p47phox in Mediating Endothelial Redox Responses to Oscillatory and Unidirectional Laminar Shear Stress. J Biol Chem (2016) 0.77
Polymorphism of rs1836882 in NOX4 gene modifies associations between dietary caloric intake and ROS levels in peripheral blood mononuclear cells. PLoS One (2013) 0.76
Tuberin regulates reactive oxygen species in renal proximal cells, kidney from rodents, and kidney from patients with tuberous sclerosis complex. Cancer Sci (2016) 0.75
Role of redoximiRs in fibrogenesis. Redox Biol (2015) 0.75
Nox Inhibitors & Therapies: Rational Design of Peptidic and Small Molecule Inhibitors. Curr Pharm Des (2015) 0.75
Inhibition of Rac1 reduces store overload-induced calcium release and protects against ventricular arrhythmia. J Cell Mol Med (2016) 0.75
Mechanism of melanoma cells selective apoptosis induced by a photoactive NADPH analogue. Oncotarget (2016) 0.75
NADPH oxidases-do they play a role in TRPC regulation under hypoxia? Pflugers Arch (2015) 0.75
NOX1 and NOX4 are required for the differentiation of mouse F9 cells into extraembryonic endoderm. PLoS One (2017) 0.75
NADPH oxidase isoform expression is temporally regulated and may contribute to microglial/macrophage polarization after spinal cord injury. Mol Cell Neurosci (2016) 0.75
Sex-specific differences in mitochondria biogenesis, morphology, respiratory function, and ROS homeostasis in young mouse heart and brain. Physiol Rep (2017) 0.75
Microvascular NADPH oxidase in health and disease. Free Radic Biol Med (2017) 0.75
Prognostic significance of NADPH oxidase-4 as an indicator of reactive oxygen species stress in human retinoblastoma. Int J Clin Oncol (2016) 0.75
Decoding NADPH oxidase 4 expression in human tumors. Redox Biol (2017) 0.75
Characterization of Potent and Selective Iodonium-Class Inhibitors of NADPH Oxidases. Biochem Pharmacol (2017) 0.75
NADPH oxidase 5 (NOX5) - induced reactive oxygen signaling modulates normoxic HIF-1α and p27(Kip1) expression in malignant melanoma and other human tumors. Mol Carcinog (2017) 0.75
NADPH Oxidase 2 Regulates NLRP3 Inflammasome Activation in the Brain after Traumatic Brain Injury. Oxid Med Cell Longev (2017) 0.75
The NOX family of ROS-generating NADPH oxidases: physiology and pathophysiology. Physiol Rev (2007) 21.13
Mortality in randomized trials of antioxidant supplements for primary and secondary prevention: systematic review and meta-analysis. JAMA (2007) 11.87
NADPH oxidase: an update. Blood (1999) 7.65
Mouse model of X-linked chronic granulomatous disease, an inherited defect in phagocyte superoxide production. Nat Genet (1995) 7.34
Antioxidant supplements for prevention of gastrointestinal cancers: a systematic review and meta-analysis. Lancet (2004) 6.35
Apocynin is not an inhibitor of vascular NADPH oxidases but an antioxidant. Hypertension (2007) 5.80
A tissue-scale gradient of hydrogen peroxide mediates rapid wound detection in zebrafish. Nature (2009) 5.55
Use of antioxidant vitamins for the prevention of cardiovascular disease: meta-analysis of randomised trials. Lancet (2003) 5.34
Superoxide generation by endothelial nitric oxide synthase: the influence of cofactors. Proc Natl Acad Sci U S A (1998) 4.94
Functional analysis of Nox4 reveals unique characteristics compared to other NADPH oxidases. Cell Signal (2005) 4.74
NAD(P)H oxidase 4 mediates transforming growth factor-beta1-induced differentiation of cardiac fibroblasts into myofibroblasts. Circ Res (2005) 4.66
Distinct subcellular localizations of Nox1 and Nox4 in vascular smooth muscle cells. Arterioscler Thromb Vasc Biol (2003) 4.56
NADPH oxidase-4 mediates myofibroblast activation and fibrogenic responses to lung injury. Nat Med (2009) 4.05
Superoxide production and expression of nox family proteins in human atherosclerosis. Circulation (2002) 3.95
Nox proteins in signal transduction. Free Radic Biol Med (2009) 3.47
Direct interaction of the novel Nox proteins with p22phox is required for the formation of a functionally active NADPH oxidase. J Biol Chem (2004) 3.37
The NAD(P)H oxidase homolog Nox4 modulates insulin-stimulated generation of H2O2 and plays an integral role in insulin signal transduction. Mol Cell Biol (2004) 3.35
Hypoxia-dependent regulation of nonphagocytic NADPH oxidase subunit NOX4 in the pulmonary vasculature. Circ Res (2007) 3.28
Nox4 is required for maintenance of the differentiated vascular smooth muscle cell phenotype. Arterioscler Thromb Vasc Biol (2006) 3.13
Nox1 overexpression potentiates angiotensin II-induced hypertension and vascular smooth muscle hypertrophy in transgenic mice. Circulation (2005) 3.12
Studies on the inhibitory mechanism of iodonium compounds with special reference to neutrophil NADPH oxidase. Biochem J (1993) 3.12
Upregulation of Nox-based NAD(P)H oxidases in restenosis after carotid injury. Arterioscler Thromb Vasc Biol (2002) 3.10
Structure, regulation and evolution of Nox-family NADPH oxidases that produce reactive oxygen species. FEBS J (2008) 3.04
Nox4 NAD(P)H oxidase mediates hypertrophy and fibronectin expression in the diabetic kidney. J Biol Chem (2005) 2.98
T cells express a phagocyte-type NADPH oxidase that is activated after T cell receptor stimulation. Nat Immunol (2004) 2.96
NADPH oxidase 4 (Nox4) is a major source of oxidative stress in the failing heart. Proc Natl Acad Sci U S A (2010) 2.95
Poldip2, a novel regulator of Nox4 and cytoskeletal integrity in vascular smooth muscle cells. Circ Res (2009) 2.83
NADPH oxidases: functions and pathologies in the vasculature. Arterioscler Thromb Vasc Biol (2009) 2.83
A novel superoxide-producing NAD(P)H oxidase in kidney. J Biol Chem (2001) 2.80
Nox1 is involved in angiotensin II-mediated hypertension: a study in Nox1-deficient mice. Circulation (2005) 2.79
The mechanism of superoxide production by NADH:ubiquinone oxidoreductase (complex I) from bovine heart mitochondria. Proc Natl Acad Sci U S A (2006) 2.78
Subcellular localization of Nox4 and regulation in diabetes. Proc Natl Acad Sci U S A (2009) 2.73
Post-stroke inhibition of induced NADPH oxidase type 4 prevents oxidative stress and neurodegeneration. PLoS Biol (2010) 2.72
Distinct roles of Nox1 and Nox4 in basal and angiotensin II-stimulated superoxide and hydrogen peroxide production. Free Radic Biol Med (2008) 2.68
Upregulation of Nox4 by hypertrophic stimuli promotes apoptosis and mitochondrial dysfunction in cardiac myocytes. Circ Res (2010) 2.65
Transforming growth factor-beta1 induces Nox4 NAD(P)H oxidase and reactive oxygen species-dependent proliferation in human pulmonary artery smooth muscle cells. Am J Physiol Lung Cell Mol Physiol (2005) 2.62
Residual NADPH oxidase and survival in chronic granulomatous disease. N Engl J Med (2010) 2.61
A Ca(2+)-activated NADPH oxidase in testis, spleen, and lymph nodes. J Biol Chem (2001) 2.56
Reactive oxygen species regulate angiogenesis and tumor growth through vascular endothelial growth factor. Cancer Res (2007) 2.54
Contrasting roles of NADPH oxidase isoforms in pressure-overload versus angiotensin II-induced cardiac hypertrophy. Circ Res (2003) 2.50
Endothelial Nox4 NADPH oxidase enhances vasodilatation and reduces blood pressure in vivo. Arterioscler Thromb Vasc Biol (2011) 2.44
Two novel proteins activate superoxide generation by the NADPH oxidase NOX1. J Biol Chem (2002) 2.41
NAD(P)H oxidase Nox-4 mediates 7-ketocholesterol-induced endoplasmic reticulum stress and apoptosis in human aortic smooth muscle cells. Mol Cell Biol (2004) 2.38
The superoxide-producing NAD(P)H oxidase Nox4 in the nucleus of human vascular endothelial cells. Genes Cells (2005) 2.38
NADPH oxidase-4 mediates protection against chronic load-induced stress in mouse hearts by enhancing angiogenesis. Proc Natl Acad Sci U S A (2010) 2.36
Expression and localization of NOX2 and NOX4 in primary human endothelial cells. Antioxid Redox Signal (2005) 2.32
Role of uncoupled and non-coupled oxidations in maintenance of safely low levels of oxygen and its one-electron reductants. Q Rev Biophys (1996) 2.29
Reactive oxygen species produced by NAD(P)H oxidase inhibit apoptosis in pancreatic cancer cells. J Biol Chem (2004) 2.28
Nox4 acts as a switch between differentiation and proliferation in preadipocytes. Arterioscler Thromb Vasc Biol (2008) 2.21
The E-loop is involved in hydrogen peroxide formation by the NADPH oxidase Nox4. J Biol Chem (2011) 2.20
Novel human homologues of p47phox and p67phox participate in activation of superoxide-producing NADPH oxidases. J Biol Chem (2003) 2.12
Decreased blood pressure in NOX1-deficient mice. FEBS Lett (2005) 2.10
Role of xanthine oxidoreductase and NAD(P)H oxidase in endothelial superoxide production in response to oscillatory shear stress. Am J Physiol Heart Circ Physiol (2003) 2.09
Myeloperoxidase functions as a major enzymatic catalyst for initiation of lipid peroxidation at sites of inflammation. J Biol Chem (2002) 2.02
Mechanisms of vascular smooth muscle NADPH oxidase 1 (Nox1) contribution to injury-induced neointimal formation. Arterioscler Thromb Vasc Biol (2009) 2.01
Inducible nitric-oxide synthase generates superoxide from the reductase domain. J Biol Chem (1998) 2.00
Critical role of Nox4-based NADPH oxidase in glucose-induced oxidative stress in the kidney: implications in type 2 diabetic nephropathy. Am J Physiol Renal Physiol (2010) 1.95
Endothelium-derived hyperpolarizing factor synthase (Cytochrome P450 2C9) is a functionally significant source of reactive oxygen species in coronary arteries. Circ Res (2001) 1.94
Inhibition of NADPH oxidase 4 activates apoptosis via the AKT/apoptosis signal-regulating kinase 1 pathway in pancreatic cancer PANC-1 cells. Oncogene (2006) 1.94
Mechanism of Ca2+ activation of the NADPH oxidase 5 (NOX5). J Biol Chem (2004) 1.86
Point mutations in the proline-rich region of p22phox are dominant inhibitors of Nox1- and Nox2-dependent reactive oxygen generation. J Biol Chem (2005) 1.85
Neuronal expression of the NADPH oxidase NOX4, and its regulation in mouse experimental brain ischemia. Neuroscience (2005) 1.84
NOX2 and NOX4 mediate proliferative response in endothelial cells. Antioxid Redox Signal (2006) 1.83
NAD(P)H oxidase mediates TGF-beta1-induced activation of kidney myofibroblasts. J Am Soc Nephrol (2009) 1.80
A key role for NOX4 in epithelial cell death during development of lung fibrosis. Antioxid Redox Signal (2011) 1.79
Nox4 and nox2 NADPH oxidases mediate distinct cellular redox signaling responses to agonist stimulation. Arterioscler Thromb Vasc Biol (2008) 1.77
Antioxidant vitamin supplements and cardiovascular disease. Circulation (2004) 1.76
The NADPH oxidase NOX4 drives cardiac differentiation: Role in regulating cardiac transcription factors and MAP kinase activation. Mol Biol Cell (2006) 1.76
First in class, potent, and orally bioavailable NADPH oxidase isoform 4 (Nox4) inhibitors for the treatment of idiopathic pulmonary fibrosis. J Med Chem (2010) 1.74
Novel Nox inhibitor VAS2870 attenuates PDGF-dependent smooth muscle cell chemotaxis, but not proliferation. Cardiovasc Res (2006) 1.74
Proteins homologous to p47phox and p67phox support superoxide production by NAD(P)H oxidase 1 in colon epithelial cells. J Biol Chem (2003) 1.70
Fulvene-5 potently inhibits NADPH oxidase 4 and blocks the growth of endothelial tumors in mice. J Clin Invest (2009) 1.68
Comparative pharmacology of chemically distinct NADPH oxidase inhibitors. Br J Pharmacol (2010) 1.67
NADPH oxidase activity and function are profoundly greater in cerebral versus systemic arteries. Circ Res (2005) 1.65
NADPH oxidase is required for the sensory plasticity of the carotid body by chronic intermittent hypoxia. J Neurosci (2009) 1.65
Role of Nox4 and Nox2 in hyperoxia-induced reactive oxygen species generation and migration of human lung endothelial cells. Antioxid Redox Signal (2009) 1.64
Upregulation of the vascular NAD(P)H-oxidase isoforms Nox1 and Nox4 by the renin-angiotensin system in vitro and in vivo. Free Radic Biol Med (2001) 1.60
PPAR{gamma} regulates hypoxia-induced Nox4 expression in human pulmonary artery smooth muscle cells through NF-{kappa}B. Am J Physiol Lung Cell Mol Physiol (2010) 1.60
Peroxisome proliferator-activated receptor-gamma ligands regulate endothelial membrane superoxide production. Am J Physiol Cell Physiol (2004) 1.57
Tks5-dependent, nox-mediated generation of reactive oxygen species is necessary for invadopodia formation. Sci Signal (2009) 1.56
Early lipopolysaccharide-induced reactive oxygen species production evokes necrotic cell death in human umbilical vein endothelial cells. J Hypertens (2009) 1.56
Increased expression of NAD(P)H oxidase subunits, NOX4 and p22phox, in the kidney of streptozotocin-induced diabetic rats and its reversibity by interventive insulin treatment. Diabetologia (2003) 1.53
Nox4 NADPH oxidase mediates oxidative stress and apoptosis caused by TNF-alpha in cerebral vascular endothelial cells. Am J Physiol Cell Physiol (2008) 1.53
NADPH oxidase promotes pancreatic cancer cell survival via inhibiting JAK2 dephosphorylation by tyrosine phosphatases. Gastroenterology (2007) 1.52
Dystrophin-deficient cardiomyopathy in mouse: expression of Nox4 and Lox are associated with fibrosis and altered functional parameters in the heart. Neuromuscul Disord (2008) 1.52
Identification of structural elements in Nox1 and Nox4 controlling localization and activity. Antioxid Redox Signal (2009) 1.51
NOX2 complex-derived ROS as immune regulators. Antioxid Redox Signal (2011) 1.50
A new superoxide-generating oxidase in murine osteoclasts. J Biol Chem (2000) 1.50
Nox4 mediates TGF-beta1-induced retinoblastoma protein phosphorylation, proliferation, and hypertrophy in human airway smooth muscle cells. Am J Physiol Lung Cell Mol Physiol (2007) 1.49
The NADPH oxidase subunit NOX4 is a new target gene of the hypoxia-inducible factor-1. Mol Biol Cell (2010) 1.49
Role of the multidrug resistance protein-1 in hypertension and vascular dysfunction caused by angiotensin II. Arterioscler Thromb Vasc Biol (2007) 1.47
Genetic silencing of Nox2 and Nox4 reveals differential roles of these NADPH oxidase homologues in the vasopressor and dipsogenic effects of brain angiotensin II. Hypertension (2009) 1.45
Important role of Nox4 type NADPH oxidase in angiogenic responses in human microvascular endothelial cells in vitro. Arterioscler Thromb Vasc Biol (2007) 1.43
Nox4 NAD(P)H oxidase mediates Src-dependent tyrosine phosphorylation of PDK-1 in response to angiotensin II: role in mesangial cell hypertrophy and fibronectin expression. J Biol Chem (2008) 1.43
Structural insights into Nox4 and Nox2: motifs involved in function and cellular localization. Mol Cell Biol (2009) 1.41
NADPH oxidase 4 contributes to transformation phenotype of melanoma cells by regulating G2-M cell cycle progression. Cancer Res (2009) 1.41
Regulation of NAD(P)H oxidase by associated protein disulfide isomerase in vascular smooth muscle cells. J Biol Chem (2005) 1.40
Inhibition of NADPH oxidase activation by 4-(2-aminoethyl)-benzenesulfonyl fluoride and related compounds. J Biol Chem (1997) 1.40
Human urotensin II is a novel activator of NADPH oxidase in human pulmonary artery smooth muscle cells. Arterioscler Thromb Vasc Biol (2004) 1.39
Classical inhibitors of NOX NAD(P)H oxidases are not specific. Curr Drug Metab (2008) 1.39
Apocynin is not an inhibitor of vascular NADPH oxidases but an antioxidant. Hypertension (2007) 5.80
Direct interaction of the novel Nox proteins with p22phox is required for the formation of a functionally active NADPH oxidase. J Biol Chem (2004) 3.37
Hypoxia-dependent regulation of nonphagocytic NADPH oxidase subunit NOX4 in the pulmonary vasculature. Circ Res (2007) 3.28
Nox1 overexpression potentiates angiotensin II-induced hypertension and vascular smooth muscle hypertrophy in transgenic mice. Circulation (2005) 3.12
NO-independent stimulators and activators of soluble guanylate cyclase: discovery and therapeutic potential. Nat Rev Drug Discov (2006) 2.84
Post-stroke inhibition of induced NADPH oxidase type 4 prevents oxidative stress and neurodegeneration. PLoS Biol (2010) 2.72
Distinct roles of Nox1 and Nox4 in basal and angiotensin II-stimulated superoxide and hydrogen peroxide production. Free Radic Biol Med (2008) 2.68
Targeting the heme-oxidized nitric oxide receptor for selective vasodilatation of diseased blood vessels. J Clin Invest (2006) 2.52
Interaction between the Gly460Trp alpha-adducin gene variant and diuretics on the risk of myocardial infarction. J Hypertens (2009) 2.14
NADPH oxidase 1 plays a key role in diabetes mellitus-accelerated atherosclerosis. Circulation (2013) 1.78
Novel Nox inhibitor VAS2870 attenuates PDGF-dependent smooth muscle cell chemotaxis, but not proliferation. Cardiovasc Res (2006) 1.74
NADPH oxidase activity and function are profoundly greater in cerebral versus systemic arteries. Circ Res (2005) 1.65
NADPH oxidases in the vasculature: molecular features, roles in disease and pharmacological inhibition. Pharmacol Ther (2008) 1.58
Variation in Renin-Angiotensin system and salt-sensitivity genes and the risk of diabetes mellitus associated with the use of thiazide diuretics. Am J Hypertens (2009) 1.50
Role of the multidrug resistance protein-1 in hypertension and vascular dysfunction caused by angiotensin II. Arterioscler Thromb Vasc Biol (2007) 1.47
Renal medullary effects of transient prehypertensive treatment in young spontaneously hypertensive rats. Acta Physiol (Oxf) (2008) 1.42
Upregulation of NAD(P)H oxidase 1 in hypoxia activates hypoxia-inducible factor 1 via increase in reactive oxygen species. Free Radic Biol Med (2004) 1.31
Novel Nox inhibitor of oxLDL-induced reactive oxygen species formation in human endothelial cells. Biochem Biophys Res Commun (2006) 1.30
Nitric oxide-independent vasodilator rescues heme-oxidized soluble guanylate cyclase from proteasomal degradation. Circ Res (2009) 1.29
Hemodynamic and biochemical adaptations to vascular smooth muscle overexpression of p22phox in mice. Am J Physiol Heart Circ Physiol (2004) 1.26
Activation of TRPC6 channels is essential for lung ischaemia-reperfusion induced oedema in mice. Nat Commun (2012) 1.25
Synaptic localization of nitric oxide synthase and soluble guanylyl cyclase in the hippocampus. J Neurosci (2002) 1.24
Good stress, bad stress--the delicate balance in the vasculature. Dtsch Arztebl Int (2009) 1.23
Oxidative stress and endothelial dysfunction in aortas of aged spontaneously hypertensive rats by NOX1/2 is reversed by NADPH oxidase inhibition. Hypertension (2010) 1.23
Calcium-dependent membrane association sensitizes soluble guanylyl cyclase to nitric oxide. Nat Cell Biol (2002) 1.21
Effect of gender on NADPH-oxidase activity, expression, and function in the cerebral circulation: role of estrogen. Stroke (2007) 1.13
3'UTRs of glutathione peroxidases differentially affect selenium-dependent mRNA stability and selenocysteine incorporation efficiency. Biol Chem (2003) 1.06
Pathogenetic role of eNOS uncoupling in cardiopulmonary disorders. Free Radic Biol Med (2010) 1.06
Translating the oxidative stress hypothesis into the clinic: NOX versus NOS. J Mol Med (Berl) (2009) 1.05
Dimerization region of soluble guanylate cyclase characterized by bimolecular fluorescence complementation in vivo. Mol Pharmacol (2007) 1.04
Reduced cGMP signaling associated with neointimal proliferation and vascular dysfunction in late-stage atherosclerosis. Proc Natl Acad Sci U S A (2004) 1.03
Neuroprotection after stroke by targeting NOX4 as a source of oxidative stress. Antioxid Redox Signal (2012) 1.03
Modulating endothelial nitric oxide synthase: a new cardiovascular therapeutic strategy. Am J Physiol Heart Circ Physiol (2011) 1.02
Identification of residues crucially involved in soluble guanylate cyclase activation. FEBS Lett (2006) 1.00
Distribution of soluble guanylyl cyclase in the rat brain. J Comp Neurol (2004) 0.99
The 'A's and 'O's of NADPH oxidase regulation: a commentary on "Subcellular localization and function of alternatively spliced Noxo1 isoforms". Free Radic Biol Med (2006) 0.98
There's NO binding like NOS binding: protein-protein interactions in NO/cGMP signaling. Proc Natl Acad Sci U S A (2002) 0.98
A constitutive NADPH oxidase-like system containing gp91phox homologs in human keratinocytes. J Invest Dermatol (2004) 0.98
cGMP in the vasculature. Handb Exp Pharmacol (2009) 0.94
Structural analysis of isoform-specific inhibitors targeting the tetrahydrobiopterin binding site of human nitric oxide synthases. J Med Chem (2005) 0.93
NADPH oxidase, NOX1, mediates vascular injury in ischemic retinopathy. Antioxid Redox Signal (2013) 0.93
Telomere length and its associations with oxidized-LDL, carotid artery distensibility and smoking. Front Biosci (Elite Ed) (2010) 0.91
Phosphorylation of blood vessel vasodilator-stimulated phosphoprotein at serine 239 as a functional biochemical marker of endothelial nitric oxide/cyclic GMP signaling. Mol Pharmacol (2002) 0.91
Heat shock protein 90 regulates stabilization rather than activation of soluble guanylate cyclase. FEBS Lett (2007) 0.90
L-arginine deficiency and supplementation in experimental acute renal failure and in human kidney transplantation. Kidney Int (2002) 0.90
L-Arginine counteracts nitric oxide deficiency and improves the recovery phase of ischemic acute renal failure in rats. Kidney Int (2003) 0.90
VAS2870 is a pan-NADPH oxidase inhibitor. Cell Mol Life Sci (2012) 0.88
Sildenafil in hypoxic pulmonary hypertension potentiates a compensatory up-regulation of NO-cGMP signaling. FASEB J (2007) 0.88
The 1027th target candidate in stroke: Will NADPH oxidase hold up? Exp Transl Stroke Med (2012) 0.87
Comment on: Sukumar et al. Nox2 NADPH oxidase has a critical role in insulin resistance-related endothelial cell dysfunction. Diabetes 2013;62:2130-2134. Diabetes (2013) 0.86
Characterization of the human alpha1 beta1 soluble guanylyl cyclase promoter: key role for NF-kappaB(p50) and CCAAT-binding factors in regulating expression of the nitric oxide receptor. J Biol Chem (2008) 0.85
Experimental autoimmune encephalomyelitis in mice with a targeted deletion of the inducible nitric oxide synthase gene: increased T-helper 1 response. Neurosci Lett (2004) 0.84
NOX4 is a Janus-faced reactive oxygen species generating NADPH oxidase. Circ Res (2012) 0.84
Fluorescence dequenching makes haem-free soluble guanylate cyclase detectable in living cells. PLoS One (2011) 0.83
Regional distribution of protein and activity of the nitric oxide receptor, soluble guanylyl cyclase, in rat brain suggests multiple mechanisms of regulation. Brain Res (2002) 0.82
Susceptibility to cardiac ischemia/reperfusion injury is modulated by chronic estrogen status. J Cardiovasc Pharmacol (2002) 0.82
Measuring oxidative burden and predicting pharmacological response in coronary artery disease patients with a novel direct activator of haem-free/oxidised sGC. Atherosclerosis (2011) 0.81
Type I nitric oxide synthase in the human lung is predominantly expressed in capillary endothelial cells. Respir Physiol (2002) 0.79
Structural requirements for inhibition of the neuronal nitric oxide synthase (NOS-I): 3D-QSAR analysis of 4-oxo- and 4-amino-pteridine-based inhibitors. J Med Chem (2002) 0.79
Renin-angiotensin system polymorphisms and the association between use of angiotensin II receptor blockers or angiotensin-converting enzyme inhibitors and the risk of diabetes. J Renin Angiotensin Aldosterone Syst (2009) 0.78
Reasons for non-response in observational pharmacogenetic research. Pharmacoepidemiol Drug Saf (2009) 0.78
Protective role of the cytokine-inducible isoform of nitric oxide synthase induction and nitrosative stress in experimental autoimmune encephalomyelitis of the DA rat. J Neurosci Res (2003) 0.78
Role of tetrahydrobiopterin (BH4) in hyperhomocysteinemia-induced endothelial dysfuction: new indication for this orphan-drug? Am J Physiol Endocrinol Metab (2011) 0.76
Effects of chronic endothelin ET(A) receptor blockade on blood pressure and vascular formation of cyclic guanosine-3',5'-monophosphate in spontaneously hypertensive rats. Arzneimittelforschung (2005) 0.76
Genetic variation in the renin--angiotensin system, use of renin--angiotensin system inhibitors and the risk of myocardial infarction. J Renin Angiotensin Aldosterone Syst (2010) 0.76
Perturbation of lipid metabolism by linoleic acid hydroperoxide in CaCo-2 cells. Biol Chem (2002) 0.76
Endothelial dysfunction after right coronary artery remodeling: a new pathogenetic role of eNOS uncoupling? J Appl Physiol (1985) (2011) 0.75
Effectiveness of statins in the reduction of the risk of myocardial infarction is modified by the GNB3 C825T variant. Pharmacogenet Genomics (2008) 0.75
[A premature with nail defects]. Ned Tijdschr Geneeskd (2010) 0.75
Community effort endorsing multiscale modelling, multiscale data science and multiscale computing for systems medicine. Brief Bioinform (2017) 0.75
In vitro detection of nitric oxide and nitroxyl by electron paramagnetic resonance. Methods Enzymol (2002) 0.75
Characterization of 11β-hydroxysteroid dehydrogenase activities in the renal cell line LLC-PK(1) : Evidence for a third isoform? Endocrine (1999) 0.75
Diagnosis and individual treatment of cardiovascular diseases: targeting vascular oxidative stress. Expert Rev Clin Pharmacol (2010) 0.75