Published in Proc Natl Acad Sci U S A on May 05, 2015
A New Generation of FRET Sensors for Robust Measurement of Gαi1, Gαi2 and Gαi3 Activation Kinetics in Single Cells. PLoS One (2016) 0.78
New Concepts and Mechanisms of Platelet Activation Signaling. Physiology (Bethesda) (2017) 0.75
Blunted apoptosis of erythrocytes in mice deficient in the heterotrimeric G-protein subunit Gαi2. Sci Rep (2016) 0.75
Myocardial reperfusion injury. N Engl J Med (2007) 13.41
Rat middle cerebral artery occlusion: evaluation of the model and development of a neurologic examination. Stroke (1986) 8.23
Ischemia and reperfusion--from mechanism to translation. Nat Med (2011) 6.64
Mechanisms of thrombus formation. N Engl J Med (2008) 4.67
Defective thrombus formation in mice lacking coagulation factor XII. J Exp Med (2005) 3.59
Complete reversal of acid-induced acute lung injury by blocking of platelet-neutrophil aggregation. J Clin Invest (2006) 3.38
Ulcerative colitis and adenocarcinoma of the colon in G alpha i2-deficient mice. Nat Genet (1995) 3.29
Pf4-Cre transgenic mice allow the generation of lineage-restricted gene knockouts for studying megakaryocyte and platelet function in vivo. Blood (2006) 2.88
Defective platelet aggregation and increased resistance to thrombosis in purinergic P2Y(1) receptor-null mice. J Clin Invest (1999) 2.34
Molecular identification and characterization of the platelet ADP receptor targeted by thienopyridine antithrombotic drugs. J Clin Invest (2001) 2.26
Decreased platelet aggregation, increased bleeding time and resistance to thromboembolism in P2Y1-deficient mice. Nat Med (1999) 2.25
Targeting platelets in acute experimental stroke: impact of glycoprotein Ib, VI, and IIb/IIIa blockade on infarct size, functional outcome, and intracranial bleeding. Circulation (2007) 2.23
Activation of platelet function through G protein-coupled receptors. Circ Res (2006) 2.13
An obligatory requirement for the heterotrimeric G protein Gi3 in the antiautophagic action of insulin in the liver. Proc Natl Acad Sci U S A (2007) 2.10
Hierarchical organization in the hemostatic response and its relationship to the platelet-signaling network. Blood (2013) 2.05
Arterial thrombosis--insidious, unpredictable and deadly. Nat Med (2011) 1.96
P2Y12 regulates platelet adhesion/activation, thrombus growth, and thrombus stability in injured arteries. J Clin Invest (2003) 1.90
Megakaryocyte-specific RhoA deficiency causes macrothrombocytopenia and defective platelet activation in hemostasis and thrombosis. Blood (2011) 1.88
Antiplatelet therapies for the treatment of cardiovascular disease. Nat Rev Drug Discov (2010) 1.66
Pleiotropic phenotype of a genomic knock-in of an RGS-insensitive G184S Gnai2 allele. Mol Cell Biol (2006) 1.51
Gαi2- and Gαi3-deficient mice display opposite severity of myocardial ischemia reperfusion injury. PLoS One (2014) 1.49
Ischaemic stroke: a thrombo-inflammatory disease? J Physiol (2011) 1.46
Activation of Rap1B by G(i) family members in platelets. J Biol Chem (2002) 1.39
PMNs facilitate translocation of platelets across human and mouse epithelium and together alter fluid homeostasis via epithelial cell-expressed ecto-NTPDases. J Clin Invest (2008) 1.35
A tail vein bleeding time model and delayed bleeding in hemophiliac mice. Thromb Haemost (2001) 1.33
Impaired activation of murine platelets lacking G alpha(i2). J Clin Invest (2001) 1.31
Platelet adhesion and activation mechanisms in arterial thrombosis and ischaemic stroke. J Thromb Haemost (2011) 1.30
Mouse gene knockout and knockin strategies in application to alpha subunits of Gi/Go family of G proteins. Methods Enzymol (2002) 1.24
Platelet-leukocyte interactions in cardiovascular disease and beyond. Arterioscler Thromb Vasc Biol (2010) 1.23
RGS/Gi2alpha interactions modulate platelet accumulation and thrombus formation at sites of vascular injury. Blood (2010) 1.18
Signaling through Gi family members in platelets. Redundancy and specificity in the regulation of adenylyl cyclase and other effectors. J Biol Chem (2002) 1.17
Primary cilium migration depends on G-protein signalling control of subapical cytoskeleton. Nat Cell Biol (2013) 1.13
The human platelet ADP receptor activates Gi2 proteins. Biochem J (1995) 1.12
Clopidogrel inhibits platelet-leukocyte adhesion and platelet-dependent leukocyte activation. Thromb Haemost (2005) 1.11
Purification and functional reconstitution of the human P2Y12 receptor. Mol Pharmacol (2003) 1.05
Platelet P2Y₁₂ blockers confer direct postconditioning-like protection in reperfused rabbit hearts. J Cardiovasc Pharmacol Ther (2012) 1.04
Gαi2 is the essential Gαi protein in immune complex-induced lung disease. J Immunol (2012) 1.01
Clopidogrel, but not abciximab, reduces platelet leukocyte conjugates and P-selectin expression in a human ex vivo in vitro model. Clin Pharmacol Ther (2002) 1.00
P2Y(12) receptors in platelets and other hematopoietic and non-hematopoietic cells. Purinergic Signal (2012) 1.00
Defective macrophage migration in Gαi2- but not Gαi3-deficient mice. J Immunol (2012) 0.99
Development of the mammalian axial skeleton requires signaling through the Gα(i) subfamily of heterotrimeric G proteins. Proc Natl Acad Sci U S A (2012) 0.96
Antagonism of P2Y12 or GPIIb/IIIa receptors reduces platelet-mediated myocardial injury after ischaemia and reperfusion in isolated rat hearts. Thromb Haemost (2010) 0.96
G proteins endogenously expressed in Sf 9 cells: interactions with mammalian histamine receptors. Naunyn Schmiedebergs Arch Pharmacol (1997) 0.94
Munc13-4-mediated secretion is essential for infarct progression but not intracranial hemostasis in acute stroke. J Thromb Haemost (2013) 0.93
Phosphorylation of vasodilator-stimulated phosphoprotein prevents platelet-neutrophil complex formation and dampens myocardial ischemia-reperfusion injury. Circulation (2011) 0.91
Reduced thrombus stability in mice lacking the alpha2A-adrenergic receptor. Blood (2006) 0.88
Gαi2- and Gαi3-specific regulation of voltage-dependent L-type calcium channels in cardiomyocytes. PLoS One (2011) 0.88
Historical lessons in translational medicine: cyclooxygenase inhibition and P2Y12 antagonism. Circ Res (2013) 0.81
Pharmacological modulation of the inflammatory actions of platelets. Handb Exp Pharmacol (2012) 0.78