Published in Am J Pathol on December 01, 1989
Permeability of the blood-brain barrier predicts conversion from optic neuritis to multiple sclerosis. Brain (2015) 1.40
Evidence of persistent blood-brain barrier abnormalities in chronic-progressive multiple sclerosis. Acta Neuropathol (1995) 1.20
Adeno-associated viral-mediated catalase expression suppresses optic neuritis in experimental allergic encephalomyelitis. Proc Natl Acad Sci U S A (1998) 1.07
Mechanisms of edema formation in experimental autoimmune encephalomyelitis. The contribution of inflammatory cells. Am J Pathol (1990) 0.92
Age-related changes in brain support cells: Implications for stroke severity. Neurochem Int (2013) 0.89
Novel 3D analysis of Claudin-5 reveals significant endothelial heterogeneity among CNS microvessels. Microvasc Res (2012) 0.88
Inflammatory demyelination induces glia alterations and ganglion cell loss in the retina of an experimental autoimmune encephalomyelitis model. J Neuroinflammation (2013) 0.88
Effect of lymphocytic infiltration on the blood-retinal barrier in experimental autoimmune uveoretinitis. Clin Exp Immunol (1992) 0.84
Genetic mouse models to study blood-brain barrier development and function. Fluids Barriers CNS (2013) 0.83
Neurovascular damage in experimental allergic encephalomyelitis: a target for pharmacological control. Mediators Inflamm (1997) 0.79
Dose-dependent anti-inflammatory and neuroprotective effects of an ανβ3 integrin-binding peptide. Mediators Inflamm (2013) 0.78
Junctions between intimately apposed cell membranes in the vertebrate brain. J Cell Biol (1969) 10.33
Fine structural localization of a blood-brain barrier to exogenous peroxidase. J Cell Biol (1967) 9.74
A quantitative stereological description of the ultrastructure of normal rat liver parenchymal cells. J Cell Biol (1968) 4.95
Astrocytes induce blood-brain barrier properties in endothelial cells. Nature (1987) 4.70
Myelination in rat brain: method of myelin isolation. J Neurochem (1973) 4.01
ELECTRON MICROSCOPIC STUDIES ON THE VASCULAR PERMEABILITY AND THE MECHANISM OF DEMYELINATION IN EXPERIMENTAL ALLERGIC ENCEPHALOMYELITIS. J Neuropathol Exp Neurol (1965) 3.04
Evidence for a 'paravascular' fluid circulation in the mammalian central nervous system, provided by the rapid distribution of tracer protein throughout the brain from the subarachnoid space. Brain Res (1985) 2.43
Transcytosis of albumin in capillary endothelium. J Cell Biol (1987) 2.33
Developing nervous tissue induces formation of blood-brain barrier characteristics in invading endothelial cells: a study using quail--chick transplantation chimeras. Dev Biol (1981) 2.24
Immunohistochemical study of allergic encephalomyelitis. Am J Pathol (1968) 2.10
Acute experimental autoimmune encephalomyelitis in mice. I. Adjuvant action of Bordetella pertussis is due to vasoactive amine sensitization and increased vascular permeability of the central nervous system. Cell Immunol (1982) 1.77
The large apparent work capability of the blood-brain barrier: a study of the mitochondrial content of capillary endothelial cells in brain and other tissues of the rat. Ann Neurol (1977) 1.77
Polarity of the blood-brain barrier: distribution of enzymes between the luminal and antiluminal membranes of brain capillary endothelial cells. Brain Res (1980) 1.71
Three-dimensional organization of plasmalemmal vesicles in endothelial cells. An analysis by serial sectioning of frog mesenteric capillaries. J Ultrastruct Res (1980) 1.51
Fine structural alterations of the blood-brain barrier in experimental allergic encephalomyelitis. J Neuropathol Exp Neurol (1970) 1.46
Increased permeability of cerebral vessels to horseradish peroxidase induced by ischemia in Mongolian Gerbils. Acta Neuropathol (1976) 1.40
Blood-brain and blood-spinal cord barrier permeability during the course of experimental allergic encephalomyelitis in the rat. Brain Res (1984) 1.40
Quantitative estimate of pinocytosis in experimental acute hypertension. Acta Neuropathol (1979) 1.37
Cerebral vascular permeability and cellular infiltration in experimental allergic encephalomyelitis. Immunology (1972) 1.28
Transcytotic pathway for blood-borne protein through the blood-brain barrier. Proc Natl Acad Sci U S A (1988) 1.28
Astrocyte-mediated induction of tight junctions in brain capillary endothelium: an efficient in vitro model. Brain Res (1987) 1.20
Effects of histamine on brain capillaries. Fine structural and immunohistochemical studies after intracarotid infusion. Exp Brain Res (1982) 1.14
Cell surface endothelial proteins altered in experimental allergic encephalomyelitis. J Neuroimmunol (1989) 1.03
Morphofunctional aspects of the normal and pathological blood-brain barrier. Acta Neuropathol Suppl (1983) 0.99
Enzyme cytochemistry of blood-brain barrier (BBB) disturbances. Acta Neuropathol Suppl (1983) 0.96
Prazosin treatment suppresses increased vascular permeability in both acute and passively transferred experimental autoimmune encephalomyelitis in the Lewis rat. J Immunol (1986) 0.95
Three-dimensional reconstruction of vesicles in endothelium of blood-brain barrier versus highly permeable microvessels. Anat Rec (1986) 0.92
Ultrastructural permeability properties of cerebral microvasculature under normal and experimental conditions after application of tracers. Adv Neurol (1980) 0.91
Prazosin, an alpha 1-adrenergic receptor antagonist, suppresses experimental autoimmune encephalomyelitis in the Lewis rat. Proc Natl Acad Sci U S A (1985) 0.90
Concomitant detection of changes in myelin basic protein and permeability of blood-spinal cord barrier in acute experimental autoimmune encephalomyelitis by electroimmunoblotting. J Neuroimmunol (1985) 0.90
Chronic permeability of the central nervous system to mononuclear cells in experimental allergic encephalomyelitis in the Lewis rat. J Immunol (1978) 0.90
Modification of the clinical and histopathologic expression of experimental allergic encephalomyelitis by the vasoactive amine antagonist cyproheptadine. Cell Immunol (1984) 0.90
Experimental autoimmune encephalomyelitis. An anatomically-based explanation of clinical progression in rodents. J Neuroimmunol (1982) 0.89
The effect of Freund's adjuvants on blood-cerebrospinal fluid barrier permeability. J Neurol Sci (1984) 0.89
Morphological correlates of permeability in the frog perineurium: vesicles and "transcellular channels". Cell Tissue Res (1982) 0.86
A quantitative assay for experimental allergic encephalomyelitis in the rat based on permeability of spinal cords to 125I-human gamma-globulin. J Immunol (1979) 0.85
High voltage electron microscopic studies of endothelial cell tubular structures in the mouse blood-brain barrier following brain trauma. Acta Neuropathol (1989) 0.84
Tubular profiles do not form transendothelial channels through the blood-brain barrier. J Neurocytol (1987) 0.80
The blood-brain barrier as a tight epithelium: where is information lacking? Ann N Y Acad Sci (1986) 0.79
Recombinant human lymphokines induce changes in visual evoked potentials in the rabbit. Ann N Y Acad Sci (1988) 0.77
Mitochondrial abnormalities in Alzheimer's disease. J Neurosci (2001) 4.39
Myelination in rat brain: method of myelin isolation. J Neurochem (1973) 4.01
Pathogenesis of tuberculosis: interaction of Mycobacterium tuberculosis with macrophages. Infect Immun (1993) 3.80
Cryptococcus neoformans is a facultative intracellular pathogen in murine pulmonary infection. Infect Immun (2000) 3.42
Peroxisomal and mitochondrial defects in the cerebro-hepato-renal syndrome. Science (1973) 2.91
Cytokine production by human fetal microglia and astrocytes. Differential induction by lipopolysaccharide and IL-1 beta. J Immunol (1993) 2.46
Cytotoxicity for lung epithelial cells is a virulence-associated phenotype of Mycobacterium tuberculosis. Infect Immun (1995) 2.41
Conformational change as one of the earliest alterations of tau in Alzheimer's disease. Neurobiol Aging (2000) 2.40
Dynamic changes in the morphology of Cryptococcus neoformans during murine pulmonary infection. Microbiology (2001) 2.08
Homing to central nervous system vasculature by antigen-specific lymphocytes. I. Localization of 14C-labeled cells during acute, chronic, and relapsing experimental allergic encephalomyelitis. Lab Invest (1990) 2.03
Isolation of filaments from brain. Science (1971) 2.03
Identification of lymphotoxin and tumor necrosis factor in multiple sclerosis lesions. J Clin Invest (1991) 2.01
Degradation of basic protein in myelin by neutral proteases secreted by stimulated macrophages: a possible mechanism of inflammatory demyelination. Proc Natl Acad Sci U S A (1978) 1.97
MCP-1, MCP-2 and MCP-3 expression in multiple sclerosis lesions: an immunohistochemical and in situ hybridization study. J Neuroimmunol (1998) 1.96
Developmental plasticity of CNS microglia. Proc Natl Acad Sci U S A (2001) 1.95
The cytoskeleton of primary astrocytes in culture contains actin, glial fibrillary acidic protein, and the fibroblast-type filament protein, vimentin. J Neurochem (1981) 1.79
The effects of macrophage depletion on the clinical and pathologic expression of experimental allergic encephalomyelitis. J Immunol (1981) 1.79
Monoclonal antibodies to Alzheimer neurofibrillary tangles. 2. Demonstration of a common antigenic determinant between ANT and neurofibrillary degeneration in progressive supranuclear palsy. Am J Pathol (1985) 1.77
Isolation and characterization of glial filaments from human brain. J Cell Biol (1978) 1.74
Quantitative aspects of reactive gliosis: a review. Neurochem Res (1992) 1.74
Studies of in vitro infection by Trypanosoma cruzi. I. Ultrastructural studies on the invasion of macrophages and L-cells. Am J Trop Med Hyg (1975) 1.74
Cytokine cytotoxicity against oligodendrocytes. Apoptosis induced by lymphotoxin. J Immunol (1991) 1.73
Proliferation of astrocytes in vitro in response to cytokines. A primary role for tumor necrosis factor. J Immunol (1990) 1.71
Hippocampal degeneration differentiates diffuse Lewy body disease (DLBD) from Alzheimer's disease: light and electron microscopic immunocytochemistry of CA2-3 neurites specific to DLBD. Neurology (1991) 1.69
Colocalization of lymphocytes bearing gamma delta T-cell receptor and heat shock protein hsp65+ oligodendrocytes in multiple sclerosis. Proc Natl Acad Sci U S A (1991) 1.65
cAMP-dependent protein kinase phosphorylations on tau in Alzheimer's disease. J Neurosci (1999) 1.63
The lipid composition of purified bovine brain myelin. J Neurochem (1966) 1.62
Microglia in human disease, with an emphasis on acquired immune deficiency syndrome. Lab Invest (1991) 1.60
Myelination in rat brain: changes in myelin composition during brain maturation. J Neurochem (1973) 1.59
Expression of inducible nitric oxide synthase and nitrotyrosine in multiple sclerosis lesions. Am J Pathol (2001) 1.58
Another look at lead inclusion bodies. Am J Pathol (1968) 1.56
Axons: isolation from mammalian central nervous system. Science (1972) 1.55
Mouse adenovirus type 1 causes a fatal hemorrhagic encephalomyelitis in adult C57BL/6 but not BALB/c mice. J Virol (1995) 1.53
Localization of monocyte chemoattractant peptide-1 expression in the central nervous system in experimental autoimmune encephalomyelitis and trauma in the rat. J Immunol (1996) 1.52
Diffuse Lewy body disease: light and electron microscopic immunocytochemistry of senile plaques. Acta Neuropathol (1989) 1.52
Ubiquitin immunoreactive structures in normal human brains. Distribution and developmental aspects. Lab Invest (1990) 1.51
The M cell as a portal of entry to the lung for the bacterial pathogen Mycobacterium tuberculosis. Immunity (1999) 1.50
Induction of nitric oxide synthase activity in human astrocytes by interleukin-1 beta and interferon-gamma. J Neuroimmunol (1993) 1.48
Trypanosoma cruzi: infection of normal and activated mouse macrophages. Exp Parasitol (1977) 1.44
Resistance of Trypanosoma cruzi to killing by macrophages. Nature (1975) 1.43
Fibrous long-spacing collagen in bacillary angiomatosis. Ultrastruct Pathol (1998) 1.41
Effects of protein calorie malnutrition on tuberculosis in mice. Proc Natl Acad Sci U S A (1996) 1.39
Characterization of primary human fetal dissociated central nervous system cultures with an emphasis on microglia. Lab Invest (1992) 1.39
Isolation of myelin from nerve tissue. Methods Enzymol (1974) 1.35
Reciprocal regulation of the junctional proteins claudin-1 and connexin43 by interleukin-1beta in primary human fetal astrocytes. J Neurosci (2000) 1.33
Activation of C-C beta-chemokines in human peripheral blood gammadelta T cells by isopentenyl pyrophosphate and regulation by cytokines. Blood (2000) 1.31
Mucolipidosis IV. Clinical, ultrastructural, histochemical, and chemical studies of a case, including a brain biopsy. Arch Neurol (1976) 1.29
Ubiquitin immunoelectron microscopy of dystrophic neurites in cerebellar senile plaques of Alzheimer's disease. Acta Neuropathol (1990) 1.28
A critical role for IL-4 in regulating disease severity in experimental allergic encephalomyelitis as demonstrated in IL-4-deficient C57BL/6 mice and BALB/c mice. J Immunol (1998) 1.26
Cryptococcus neoformans survive and replicate in human microglia. Lab Invest (1995) 1.26
Subacute sclerosing leukoencephalitis. II. Chemical studies including abnormal myelin and an abnormal ganglioside pattern. J Neuropathol Exp Neurol (1966) 1.24
IL-1beta differentially regulates calcium wave propagation between primary human fetal astrocytes via pathways involving P2 receptors and gap junction channels. Proc Natl Acad Sci U S A (1999) 1.23
Quaking mouse: isolation and characterization of myelin protein. J Neurochem (1971) 1.22
Evidence of persistent blood-brain barrier abnormalities in chronic-progressive multiple sclerosis. Acta Neuropathol (1995) 1.20
Bulk preparation of CNS cytoskeleton and the separation of individual neurofilament proteins by gel filtration: dye-binding characteristics and amino acid compositions. J Neurochem (1982) 1.19
MR microscopy of transgenic mice that spontaneously acquire experimental allergic encephalomyelitis. Magn Reson Med (1998) 1.19
Expression of CSF-1, c-fms, and MCP-1 in the central nervous system of rats with experimental allergic encephalomyelitis. J Immunol (1993) 1.19
Studies on demyelination by activated lymphocytes in the rabbit eye. II. Antibody-dependent cell-mediated demyelination. J Immunol (1977) 1.18
Human astrocytes inhibit Cryptococcus neoformans growth by a nitric oxide-mediated mechanism. J Exp Med (1994) 1.17
Detection of reovirus type 3 in the porta hepatis of an infant with extrahepatic biliary atresia: ultrastructural and immunocytochemical study. Hepatology (1985) 1.17
The effect of the echinocandin analogue caspofungin on cell wall glucan synthesis by Cryptococcus neoformans. J Infect Dis (2000) 1.16
Phenotypic and cytokine analysis of human peripheral blood gamma delta T cells expressing NK cell receptors. J Immunol (1997) 1.15
Cytokine induction of MIP-1 alpha and MIP-1 beta in human fetal microglia. J Immunol (1998) 1.14
Mouse adenovirus type-1 replication is restricted to vascular endothelium in the CNS of susceptible strains of mice. Virology (1998) 1.12
Primary malignant melanoma of the lower respiratory tract. Report of a case and literature review. Am J Clin Pathol (1990) 1.12
Neuronal soma and whole neuroglia of rat brain: a new isolation technique. Science (1970) 1.11
GM-CSF promotes proliferation of human fetal and adult microglia in primary cultures. Glia (1994) 1.10
Antibody interactions with the capsule of Cryptococcus neoformans. Infect Immun (2000) 1.10
Expression of type II nitric oxide synthase in primary human astrocytes and microglia: role of IL-1beta and IL-1 receptor antagonist. J Immunol (1996) 1.09
Effect of antibody to capsular polysaccharide on eosinophilic pneumonia in murine infection with Cryptococcus neoformans. J Infect Dis (1998) 1.08
Mitotic phosphoepitopes precede paired helical filaments in Alzheimer's disease. Neurobiol Aging (1998) 1.08
Eosinophil-Cryptococcus neoformans interactions in vivo and in vitro. Infect Immun (1997) 1.08
Prevention and treatment of experimental autoimmune encephalomyelitis by CNI-1493, a macrophage-deactivating agent. J Immunol (1998) 1.07
Productive infection of human fetal microglia by HIV-1. Am J Pathol (1993) 1.07
Phenotypic diversity and kinetics of proliferating microglia and astrocytes following cortical stab wounds. Glia (1996) 1.06
Extracellular nucleotides differentially regulate interleukin-1beta signaling in primary human astrocytes: implications for inflammatory gene expression. J Neurosci (2001) 1.06
Delta 9-tetrahydrocannabinol: a novel treatment for experimental autoimmune encephalomyelitis. J Neuroimmunol (1989) 1.06
Ultrastructural studies of the blood-retina barrier after exposure to interleukin-1 beta or tumor necrosis factor-alpha. Lab Invest (1994) 1.06
A pathogenic role for gamma delta T cells in relapsing-remitting experimental allergic encephalomyelitis in the SJL mouse. J Immunol (1996) 1.05
Intermediate filaments from bovine, rat, and human CNS: mapping analysis of the major proteins. J Neurochem (1980) 1.05
Proteinase inhibitors suppress the development of experimental allergic encephalomyelitis. Nature (1980) 1.04
Cytokine, chemokine and chemokine receptor mRNA expression in different strains of normal mice: implications for establishment of a Th1/Th2 bias. J Neuroimmunol (1999) 1.03
Experimental autoimmune encephalomyelitis on the SJL mouse: effect of gamma delta T cell depletion on chemokine and chemokine receptor expression in the central nervous system. J Immunol (2000) 1.02
Nickel induction of Rosenthal fibers in rat brain. Brain Res (1981) 1.02
Experimental autoimmune encephalomyelitis. Augmentation of demyelination by different myelin lipids. Lab Invest (1984) 1.02
Differential induction of chemokines in human microglia by type I and II interferons. Glia (2000) 1.01
The effect of gammadelta T cell depletion on cytokine gene expression in experimental allergic encephalomyelitis. J Immunol (1998) 1.01
IL-12-mediated NKRP1A up-regulation and consequent enhancement of endothelial transmigration of V delta 2+ TCR gamma delta+ T lymphocytes from healthy donors and multiple sclerosis patients. J Immunol (1999) 1.00
IFNs are critical regulators of IL-1 receptor antagonist and IL-1 expression in human microglia. J Immunol (1998) 0.99
Macrophage colony-stimulating factor in human fetal astrocytes and microglia. Differential regulation by cytokines and lipopolysaccharide, and modulation of class II MHC on microglia. J Immunol (1993) 0.99
Interleukin-1, nitric oxide and reactive astrocytes. Brain Behav Immun (1995) 0.99
Intracellular crystal formation as a mechanism of cytotoxicity in murine pulmonary Cryptococcus neoformans infection. Infect Immun (2001) 0.99
Isolation of cold-sensitive mutants of measles virus from persistently infected murine neuroblastoma cells. J Virol (1984) 0.99
Nerve growth factor and neurotrophin-3 differentially regulate the proliferation and survival of developing rat brain oligodendrocytes. J Neurosci (1996) 0.98
Zinc ion-induced assembly of tubulin. J Biol Chem (1977) 0.98
The interaction of Mycobacterium tuberculosis with macrophages: a study of phagolysosome fusion. Infect Agents Dis (1993) 0.97
Differential chemokine induction by the mouse adenovirus type-1 in the central nervous system of susceptible and resistant strains of mice. J Neurovirol (1999) 0.97