Degradation of basic protein in myelin by neutral proteases secreted by stimulated macrophages: a possible mechanism of inflammatory demyelination.

PubWeight™: 1.97‹?› | Rank: Top 2%

🔗 View Article (PMC 411512)

Published in Proc Natl Acad Sci U S A on March 01, 1978

Authors

W Cammer, B R Bloom, W T Norton, S Gordon

Articles citing this

Suppression of experimental allergic encephalomyelitis in Lewis rats after elimination of macrophages. J Exp Med (1990) 2.42

Ultrastructural immunohistochemical localization of virus in acute and chronic demyelinating Theiler's virus infection. Am J Pathol (1982) 1.81

The macrophage response to central and peripheral nerve injury. A possible role for macrophages in regeneration. J Exp Med (1987) 1.75

Susceptibility of inbred mice to chronic central nervous system infection by Theiler's murine encephalomyelitis virus. Infect Immun (1979) 1.50

Tissue plasminogen activator-mediated fibrinolysis protects against axonal degeneration and demyelination after sciatic nerve injury. J Cell Biol (2000) 1.43

Early events in canine distemper demyelinating encephalomyelitis. Acta Neuropathol (1979) 1.33

Accumulation of diabetic rat peripheral nerve myelin by macrophages increases with the presence of advanced glycosylation endproducts. J Exp Med (1984) 1.32

Theiler's virus replication in brain macrophages cultured in vitro. J Virol (1992) 1.30

Primary demyelination in experimental canine distemper virus induced encephalomyelitis in gnotobiotic dogs. Sequential immunologic and morphologic findings. Acta Neuropathol (1982) 1.22

Inflammation and white matter damage in vascular cognitive impairment. Stroke (2008) 1.21

Experimental autoimmune encephalomyelitis in the mouse. Curr Protoc Immunol (2007) 1.16

Schwann cell remyelination and recurrent demyelination in the central nervous system of mice infected with attenuated Theiler's virus. Am J Pathol (1980) 1.12

Increased calpain expression in activated glial and inflammatory cells in experimental allergic encephalomyelitis. Proc Natl Acad Sci U S A (1998) 1.07

Cytolytic effects of neutrophils: role for a membrane-bound neutral proteinase. Proc Natl Acad Sci U S A (1986) 1.03

Dominant T- and B-cell epitopes in an autoantigen linked to Chagas' disease. J Clin Invest (2001) 0.98

Involvement of tissue plasminogen activator in onset and effector phases of experimental allergic encephalomyelitis. J Neurosci (2002) 0.98

A new pattern of spinal-cord demyelination in guinea pigs with acute experimental allergic encephalomyelitis mimicking multiple sclerosis. Br J Exp Pathol (1980) 0.97

Multimodal markers of inflammation in the subcortical ischemic vascular disease type of vascular cognitive impairment. Stroke (2014) 0.96

The multiple sclerosis degradome: enzymatic cascades in development and progression of central nervous system inflammatory disease. Curr Top Microbiol Immunol (2008) 0.89

Murine central nervous system infection by a viral temperature-sensitive mutant: a subacute disease leading to demyelination. Am J Pathol (1981) 0.88

hsp70 synthesis in Schwann cells in response to heat shock and infection with Mycobacterium leprae. Infect Immun (1992) 0.86

Stem cells for spinal cord regeneration: Current status. Surg Neurol Int (2010) 0.85

Consensus statement for diagnosis of subcortical small vessel disease. J Cereb Blood Flow Metab (2016) 0.84

Myelin lesions in the rabbit eye model as a bystander effect of herpes simplex and visna virus sensitization. Acta Neuropathol (1979) 0.83

Mononuclear phagocyte hydrolytic enzyme activity associated with cerebral HIV-1 infection. Am J Pathol (1997) 0.83

Antibody-induced generation of reactive oxygen radicals by brain macrophages in canine distemper encephalitis: a mechanism for bystander demyelination. Acta Neuropathol (1989) 0.83

Immunoglobulins in demyelinating lesions in canine distemper encephalitis. An immunohistological study. Acta Neuropathol (1981) 0.83

Macrophage component gp160, a major trypsin-sensitive surface glycoprotein. J Exp Med (1980) 0.82

Oligodendrocyte infection and demyelination produced in mice by the M9 mutant of Semliki Forest virus. Acta Neuropathol (1983) 0.81

Electrolyte-induced demyelination in rats. 2. Ultrastructural evolution. Acta Neuropathol (1994) 0.80

Nerve damage following intraneural injection of Mycobacterium leprae into rabbits pre-sensitized to mycobacteria. Clin Exp Immunol (1983) 0.78

Binswanger's disease: toward a diagnosis agreement and therapeutic approach. Expert Rev Neurother (2014) 0.78

Rodent Models of Vascular Cognitive Impairment. Transl Stroke Res (2016) 0.77

T lymphocyte-derived demyelinating activity in multiple sclerosis patients in relapse. J Neurol Neurosurg Psychiatry (1987) 0.77

Matrix Metalloproteinase-Mediated Neuroinflammation in Vascular Cognitive Impairment of the Binswanger Type. Cell Mol Neurobiol (2016) 0.76

Effect of macrophage inactivation on the neuropathology of lysolecithin-induced demyelination. Br J Exp Pathol (1985) 0.76

3,4-Dihydroxyphenylalanine Peptides as Nonperturbative Quantum Dot Sensors of Aminopeptidase. ACS Nano (2016) 0.75

Loss of lysosomal neutral proteinase from leucocytes induced by the action of multiple sclerosis-specific brain antigens. Clin Exp Immunol (1980) 0.75

Articles cited by this

Protein measurement with the Folin phenol reagent. J Biol Chem (1951) 1743.91

Selective enzyme purification by affinity chromatography. Proc Natl Acad Sci U S A (1968) 10.63

Secretion of plasminogen activator by stimulated macrophages. J Exp Med (1974) 8.82

Elastase secretion by stimulated macrophages. Characterization and regulation. J Exp Med (1975) 4.60

Secretion of a specific collagenase by stimulated macrophages. J Exp Med (1975) 4.56

Induction of macrophage plasminogen activator by endotoxin stimulation and phagocytosis: evidence for a two-stage process. J Exp Med (1974) 4.45

Myelination in rat brain: method of myelin isolation. J Neurochem (1973) 4.01

Macrophage plasminogen activator: modulation of enzyme production by anti-inflammatory steroids, mitotic inhibitors, and cyclic nucleotides. Cell (1976) 3.13

Collagenase production by lymphokine-activated macrophages. Science (1975) 2.64

Macrophage plasminogen activator: induction by products of activated lymphoid cells. J Exp Med (1977) 2.00

Pathology of the early lesion in multiple sclerosis. Hum Pathol (1975) 1.75

Trypanosoma cruzi: the immunological induction of macrophage plasminogen activator requires thymus-derived lymphocytes. J Exp Med (1977) 1.74

An ultrastructural study of experimental demyelination and remyelination. I. Acute experimental allergic encephalomyelitis in the peripheral nervous system. Lab Invest (1969) 1.73

Primary demyelination as a nonspecific consequence of a cell-mediated immune reaction. J Exp Med (1975) 1.57

Chronic experimental allergic encephalomyelitis in inbred guinea pigs. An ultrastructural study. Lab Invest (1974) 1.44

Quaking mouse: isolation and characterization of myelin protein. J Neurochem (1971) 1.22

Radioimmunoassay of myelin basic protein in spinal fluid. An index of active demyelination. N Engl J Med (1976) 1.21

Lymphokine-induced secretion of plasminogen activator by murine macrophages. Eur J Immunol (1977) 1.20

Vesicular disruption of myelin in autoimmune demyelination. J Neurol Sci (1975) 1.16

Activation of alveolar macrophage collagenase by a neutral protease secreted by the same cell. Nature (1977) 1.11

Myelin encephalitogenic protein fragments in cerebrospinal fluid of persons with multiple sclerosis. Neurology (1977) 1.06

Proteolytic activity and basic protein loss in and around multiple sclerosis plaques: combined biochemical and histochemical observations. J Neurochem (1972) 0.97

Lipid and basic protein interaction of myelin. Biochem J (1974) 0.96

Effect of proteolytic attack on the structure of CNS myelin membrane. J Neurochem (1974) 0.89

Increased protease activity and changes in basic proteins and lipids in multiple sclerosis plaques. J Neurol Sci (1970) 0.88

Histochemistry of myelin. 8. Proteolytic activity around multiple sclerosis plaques. Histochem J (1970) 0.88

Acid proteinases and other acid hydrolases in experimental allergic encephalomyelitis: pinpointing the source. J Neurochem (1975) 0.87

Changes in cathepsins B-1 and D, neutral proteinase and 2',3'-cyclic nucleotide-3'-phosphohydrolase activities in monkey brain with experimental allergic encephalomyelitis. J Neurol Sci (1974) 0.86

Experimental allergic optic neuritis (EAON) in the rabbit. A new model to study primary demyelinating diseases. J Neurol Sci (1975) 0.86

Studies on the pathogenesis of multiple sclerosis. Participation of lysosomes on demyelination in the central nervous system white matter outside plaques. Eur Neurol (1973) 0.85

Enzymatic degradation of myelin basic protein in central nervous system lesions of monkeys with experimental allergic encephalomyelitis. Neurobiology (1973) 0.85

Proteolytic enzymes in ordinary, hyperacute, monocytic and passive transfer forms of experimental allergic encephalomyelitis. Brain Res (1977) 0.85

Myelin composition in acute and chronic multiple sclerosis in relation to cerebral lysosomal activity. J Neurol Sci (1976) 0.84

The effects of trypsin on purified myelin. Biochim Biophys Acta (1973) 0.84

The quantitative histochemistry of multiple sclerosis plaques: acid proteinase and other acid hydrolases. J Neurochem (1976) 0.84

Disc gel electrophoresis of myelin proteins: new observations on development of the intermediate proteins (DM-20). Brain Res (1976) 0.84

Proteolytic enzymes and experimental demyelination in the rat and monkey. J Neurochem (1974) 0.84

Acid proteinase activity of white matter and plaques in multiple sclerosis. Acta Neurol Scand (1970) 0.83

Enzymic hydrolysis of myelin basic protein and other proteins in central nervous system and lymphoid tissues from normal and demyelinating rats. Biochem J (1976) 0.82

Production of collagenase by mouse peritoneal macrophages in vitro. Characterization of sites of cleavage of tropocollagen. Biochim Biophys Acta (1976) 0.81

Studies on the pathogenesis of multiple sclerosis. Basic proteins in the myelin and white matter of multiple sclerosis, subacute sclerosing panencephalitis and postvaccinal leucoencephalitis. Eur Neurol (1971) 0.81

The protein composition of myelin in multiple sclerosis (MS) and orthochromatic leukodystrophy (OLD). Z Neurol (1973) 0.79

Macrophages and cathepsin A activity in multiple sclerosis brain. J Neurol Sci (1974) 0.79

A lymph node neutral proteinase acting on myelin basic protein. J Neurochem (1976) 0.78

Articles by these authors

(truncated to the top 100)

An essential role for interferon gamma in resistance to Mycobacterium tuberculosis infection. J Exp Med (1993) 18.56

Mechanism of a reaction in vitro associated with delayed-type hypersensitivity. Science (1966) 13.12

Transmission of tuberculosis in New York City. An analysis by DNA fingerprinting and conventional epidemiologic methods. N Engl J Med (1994) 13.11

F4/80, a monoclonal antibody directed specifically against the mouse macrophage. Eur J Immunol (1981) 12.96

Tumor necrosis factor-alpha is required in the protective immune response against Mycobacterium tuberculosis in mice. Immunity (1995) 10.65

Delirium in mechanically ventilated patients: validity and reliability of the confusion assessment method for the intensive care unit (CAM-ICU). JAMA (2001) 10.63

Killing of virulent Mycobacterium tuberculosis by reactive nitrogen intermediates produced by activated murine macrophages. J Exp Med (1992) 10.08

Defining protective responses to pathogens: cytokine profiles in leprosy lesions. Science (1991) 8.85

Secretion of plasminogen activator by stimulated macrophages. J Exp Med (1974) 8.82

Induction of proinflammatory cytokines in human macrophages by influenza A (H5N1) viruses: a mechanism for the unusual severity of human disease? Lancet (2002) 8.70

Host defense mechanisms triggered by microbial lipoproteins through toll-like receptors. Science (1999) 8.63

Interleukin 4 potently enhances murine macrophage mannose receptor activity: a marker of alternative immunologic macrophage activation. J Exp Med (1992) 8.46

Major histocompatibility complex class I-restricted T cells are required for resistance to Mycobacterium tuberculosis infection. Proc Natl Acad Sci U S A (1992) 7.74

Genetic systems for mycobacteria. Methods Enzymol (1991) 7.50

Dissection of Mycobacterium tuberculosis antigens using recombinant DNA. Proc Natl Acad Sci U S A (1985) 7.46

In vitro synthesis and secretion of lysozyme by mononuclear phagocytes. J Exp Med (1974) 7.43

Immune recognition. A new receptor for beta-glucans. Nature (2001) 6.54

Genes for the major protein antigens of the leprosy parasite Mycobacterium leprae. Nature (1985) 6.54

Differing lymphokine profiles of functional subsets of human CD4 and CD8 T cell clones. Science (1991) 6.12

Macrophage receptors and immune recognition. Annu Rev Immunol (2005) 5.83

Rapid assessment of drug susceptibilities of Mycobacterium tuberculosis by means of luciferase reporter phages. Science (1993) 5.20

Natural and synthetic non-peptide antigens recognized by human gamma delta T cells. Nature (1995) 5.04

CD1-restricted T cell recognition of microbial lipoglycan antigens. Science (1995) 5.03

An antimicrobial activity of cytolytic T cells mediated by granulysin. Science (1998) 5.02

Lysogeny and transformation in mycobacteria: stable expression of foreign genes. Proc Natl Acad Sci U S A (1988) 4.90

Burden of disease--implications for future research. JAMA (2001) 4.75

Lymphocytes bearing antigen-specific gamma delta T-cell receptors accumulate in human infectious disease lesions. Nature (1989) 4.61

Elastase secretion by stimulated macrophages. Characterization and regulation. J Exp Med (1975) 4.60

Reactions in vivo and in vitro produced by a soluble substance associated with delayed-type hypersensitivity. Proc Natl Acad Sci U S A (1968) 4.57

Secretion of a specific collagenase by stimulated macrophages. J Exp Med (1975) 4.56

Heterogeneity in the distribution and morphology of microglia in the normal adult mouse brain. Neuroscience (1990) 4.52

Induction of direct antimicrobial activity through mammalian toll-like receptors. Science (2001) 4.46

Induction of macrophage plasminogen activator by endotoxin stimulation and phagocytosis: evidence for a two-stage process. J Exp Med (1974) 4.45

Selective primary health care: strategies for control of disease in the developing world. V. Leprosy. Rev Infect Dis (1983) 4.40

Effects of nitric oxide synthase inhibitors on murine infection with Mycobacterium tuberculosis. Infect Immun (1995) 4.28

The mononuclear phagocyte system of the mouse defined by immunohistochemical localization of antigen F4/80. Relationship between macrophages, Langerhans cells, reticular cells, and dendritic cells in lymphoid and hematopoietic organs. J Exp Med (1983) 4.13

Myelination in rat brain: method of myelin isolation. J Neurochem (1973) 4.01

Bipolar localization of the replication origin regions of chromosomes in vegetative and sporulating cells of B. subtilis. Cell (1997) 3.97

Mice deficient in CD4 T cells have only transiently diminished levels of IFN-gamma, yet succumb to tuberculosis. J Immunol (1999) 3.96

Transfer of delayed-type hypersensitivity. A critical review and experimental study in the guinea pig. Prog Allergy (1967) 3.86

Introduction of foreign DNA into mycobacteria using a shuttle phasmid. Nature (1987) 3.83

Pathogenesis of tuberculosis: interaction of Mycobacterium tuberculosis with macrophages. Infect Immun (1993) 3.80

An integrated map of the genome of the tubercle bacillus, Mycobacterium tuberculosis H37Rv, and comparison with Mycobacterium leprae. Proc Natl Acad Sci U S A (1996) 3.78

Monoclonal antibody to the murine type 3 complement receptor inhibits adhesion of myelomonocytic cells in vitro and inflammatory cell recruitment in vivo. J Exp Med (1987) 3.74

Conditionally replicating mycobacteriophages: a system for transposon delivery to Mycobacterium tuberculosis. Proc Natl Acad Sci U S A (1997) 3.67

Exacerbation of murine listeriosis by a monoclonal antibody specific for the type 3 complement receptor of myelomonocytic cells. Absence of monocytes at infective foci allows Listeria to multiply in nonphagocytic cells. J Exp Med (1989) 3.60

Cellular and molecular mechanisms of action of bisphosphonates. Cancer (2000) 3.57

In vivo growth characteristics of leucine and methionine auxotrophic mutants of Mycobacterium bovis BCG generated by transposon mutagenesis. Infect Immun (1995) 3.56

Human T-cell clones recognize a major M. leprae protein antigen expressed in E. coli. Nature (1986) 3.51

In vitro approaches to the mechanism of cell-mediated immune reactions. Adv Immunol (1971) 3.49

Macrophage complement and lectin-like receptors bind Leishmania in the absence of serum. J Exp Med (1985) 3.44

Differential effects of cytolytic T cell subsets on intracellular infection. Science (1997) 3.39

Attenuation of and protection induced by a leucine auxotroph of Mycobacterium tuberculosis. Infect Immun (2000) 3.39

Macrosialin, a macrophage-restricted membrane sialoprotein differentially glycosylated in response to inflammatory stimuli. J Exp Med (1991) 3.30

IL-12 increases resistance of BALB/c mice to Mycobacterium tuberculosis infection. J Immunol (1995) 3.29

Mutually dependent secretion of proteins required for mycobacterial virulence. Proc Natl Acad Sci U S A (2005) 3.29

Immunohistochemical localization of macrophages and microglia in the adult and developing mouse brain. Neuroscience (1985) 3.27

Absence of Wallerian Degeneration does not Hinder Regeneration in Peripheral Nerve. Eur J Neurosci (1989) 3.24

Direct presentation of nonpeptide prenyl pyrophosphate antigens to human gamma delta T cells. Immunity (1995) 3.12

Quantitative analysis of total macrophage content in adult mouse tissues. Immunochemical studies with monoclonal antibody F4/80. J Exp Med (1985) 3.11

Allelic exchange in Mycobacterium tuberculosis with long linear recombination substrates. J Bacteriol (1996) 2.98

Peroxisomal and mitochondrial defects in the cerebro-hepato-renal syndrome. Science (1973) 2.91

Surface properties of bacillus Calmette-Guérin-activated mouse macrophages. Reduced expression of mannose-specific endocytosis, Fc receptors, and antigen F4/80 accompanies induction of Ia. J Exp Med (1981) 2.89

Lipoarabinomannan, a possible virulence factor involved in persistence of Mycobacterium tuberculosis within macrophages. Infect Immun (1991) 2.77

Turnover of resident microglia in the normal adult mouse brain. Neuroscience (1992) 2.73

Cytokine patterns of immunologically mediated tissue damage. J Immunol (1992) 2.72

Immunocytochemical characterization of the endocytic and phagolysosomal compartments in peritoneal macrophages. J Cell Biol (1992) 2.71

Insertional mutagenesis and illegitimate recombination in mycobacteria. Proc Natl Acad Sci U S A (1991) 2.69

Role for the class A macrophage scavenger receptor in the phagocytosis of apoptotic thymocytes in vitro. Proc Natl Acad Sci U S A (1996) 2.69

Trypanosoma cruzi: modification of macrophage function during infection. J Exp Med (1977) 2.69

Macrophage-melanocyte heterokaryons. I. Preparation and properties. J Exp Med (1970) 2.65

Mouse macrophage hemagglutinin (sheep erythrocyte receptor) with specificity for sialylated glycoconjugates characterized by a monoclonal antibody. J Exp Med (1989) 2.63

Lymphocyte suppression in leprosy induced by unique M. leprae glycolipid. Nature (1984) 2.63

Genetic control of resistance to experimental infection with virulent Mycobacterium tuberculosis. Proc Natl Acad Sci U S A (2000) 2.63

Local opsonization by secreted macrophage complement components. Role of receptors for complement in uptake of zymosan. J Exp Med (1984) 2.53

Studies on the migration inhibitory factor associated with delayed-type hypersensitivity: cytodynamics and specificity. Transplantation (1967) 2.52

The macrophage. Int Rev Cytol (1973) 2.52

An anti-inflammatory role for gamma delta T lymphocytes in acquired immunity to Mycobacterium tuberculosis. J Immunol (1997) 2.46

Lepromin-induced suppressor cells in patients with leprosy. J Immunol (1979) 2.45

Molecular cloning of F4/80, a murine macrophage-restricted cell surface glycoprotein with homology to the G-protein-linked transmembrane 7 hormone receptor family. J Biol Chem (1996) 2.44

Mononuclear phagocyte system of the mouse defined by immunohistochemical localization of antigen F4/80. Identification of resident macrophages in renal medullary and cortical interstitium and the juxtaglomerular complex. J Exp Med (1983) 2.41

Is the class A macrophage scavenger receptor (SR-A) multifunctional? - The mouse's tale. J Clin Invest (2001) 2.41

The evolving relation between humans and Mycobacterium tuberculosis. N Engl J Med (1998) 2.39

The Fc receptors of primary and cultured phagocytic cells studied with homogeneous antibodies. J Immunol (1978) 2.38

Nonpeptide ligands for human gamma delta T cells. Proc Natl Acad Sci U S A (1994) 2.33

Macrophages and microglia in the nervous system. Trends Neurosci (1988) 2.32

Characterization of antibody-reactive epitopes on the 65-kilodalton protein of Mycobacterium leprae. Infect Immun (1987) 2.30

Aerosolized pentamidine for prophylaxis against Pneumocystis carinii pneumonia. The San Francisco community prophylaxis trial. N Engl J Med (1990) 2.29

Genetic relationships among Mycobacterium leprae, Mycobacterium tuberculosis, and candidate leprosy vaccine strains determined by DNA hybridization: identification of an M. leprae-specific repetitive sequence. Infect Immun (1989) 2.29

The macrophage scavenger receptor type A is expressed by activated macrophages and protects the host against lethal endotoxic shock. J Exp Med (1997) 2.28

Efflux pump of the proton antiporter family confers low-level fluoroquinolone resistance in Mycobacterium smegmatis. Proc Natl Acad Sci U S A (1996) 2.27

Use of in vivo complementation in Mycobacterium tuberculosis to identify a genomic fragment associated with virulence. Infect Immun (1994) 2.26

Expression of the macrophage-specific antigen F4/80 during differentiation of mouse bone marrow cells in culture. J Exp Med (1981) 2.25

CCR6, a CC chemokine receptor that interacts with macrophage inflammatory protein 3alpha and is highly expressed in human dendritic cells. J Exp Med (1997) 2.24

Metabolism of glucose, glutamine, long-chain fatty acids and ketone bodies by murine macrophages. Biochem J (1986) 2.21

Microbial glycolipids: possible virulence factors that scavenge oxygen radicals. Proc Natl Acad Sci U S A (1989) 2.21

Relative contributions of distinct MHC class I-dependent cell populations in protection to tuberculosis infection in mice. Proc Natl Acad Sci U S A (2000) 2.20

A novel transposon trap for mycobacteria: isolation and characterization of IS1096. J Bacteriol (1991) 2.20

Mutation of the principal sigma factor causes loss of virulence in a strain of the Mycobacterium tuberculosis complex. Proc Natl Acad Sci U S A (1995) 2.17

Expression of a mannosyl-fucosyl receptor for endocytosis on cultured primary macrophages and their hybrids. J Cell Biol (1982) 2.16