MEDI4893* Promotes Survival and Extends the Antibiotic Treatment Window in a Staphylococcus aureus Immunocompromised Pneumonia Model.

PubWeight™: 0.86‹?›

🔗 View Article (PMID 25987629)

Published in Antimicrob Agents Chemother on May 18, 2015

Authors

L Hua1, T S Cohen1, Y Shi1, V Datta2, J J Hilliard1, C Tkaczyk1, J Suzich1, C K Stover1, B R Sellman3

Author Affiliations

1: Department of Infectious Disease, MedImmune, LLC, Gaithersburg, Maryland, USA.
2: Department of Translational Science, MedImmune, LLC, Gaithersburg, Maryland, USA.
3: Department of Infectious Disease, MedImmune, LLC, Gaithersburg, Maryland, USA sellmanb@medimmune.com.

Articles cited by this

NHSN annual update: antimicrobial-resistant pathogens associated with healthcare-associated infections: annual summary of data reported to the National Healthcare Safety Network at the Centers for Disease Control and Prevention, 2006-2007. Infect Control Hosp Epidemiol (2008) 13.49

Poring over pores: alpha-hemolysin and Panton-Valentine leukocidin in Staphylococcus aureus pneumonia. Nat Med (2007) 5.95

Epidemiology and outcomes of health-care-associated pneumonia: results from a large US database of culture-positive pneumonia. Chest (2005) 5.91

ADAM10 mediates E-cadherin shedding and regulates epithelial cell-cell adhesion, migration, and beta-catenin translocation. Proc Natl Acad Sci U S A (2005) 3.57

A Staphylococcus aureus pore-forming toxin subverts the activity of ADAM10 to cause lethal infection in mice. Nat Med (2011) 3.17

Staphylococcus aureus alpha-hemolysin activates the NLRP3-inflammasome in human and mouse monocytic cells. PLoS One (2009) 2.60

Properties of human IgG1s engineered for enhanced binding to the neonatal Fc receptor (FcRn). J Biol Chem (2006) 2.58

The influence of mini-BAL cultures on patient outcomes: implications for the antibiotic management of ventilator-associated pneumonia. Chest (1998) 2.15

Anti-alpha-hemolysin monoclonal antibodies mediate protection against Staphylococcus aureus pneumonia. Infect Immun (2009) 2.11

Innate immunity in the respiratory epithelium. Am J Respir Cell Mol Biol (2011) 2.04

Increasing the affinity of a human IgG1 for the neonatal Fc receptor: biological consequences. J Immunol (2002) 2.00

Staphylococcus aureus α-toxin: nearly a century of intrigue. Toxins (Basel) (2013) 1.99

A multifunctional bispecific antibody protects against Pseudomonas aeruginosa. Sci Transl Med (2014) 1.76

ADAM10 mediates vascular injury induced by Staphylococcus aureus α-hemolysin. J Infect Dis (2012) 1.56

Genetic requirement for ADAM10 in severe Staphylococcus aureus skin infection. J Invest Dermatol (2012) 1.41

Staphylococcus aureus α-hemolysin mediates virulence in a murine model of severe pneumonia through activation of the NLRP3 inflammasome. J Infect Dis (2012) 1.37

Staphylococcus aureus leukotoxin GH promotes inflammation. J Infect Dis (2012) 1.30

Systematic review and meta-analysis of in vitro synergy of polymyxins and carbapenems. Antimicrob Agents Chemother (2013) 1.27

Assessment of an anti-alpha-toxin monoclonal antibody for prevention and treatment of Staphylococcus aureus-induced pneumonia. Antimicrob Agents Chemother (2013) 1.25

A novel investigational Fc-modified humanized monoclonal antibody, motavizumab-YTE, has an extended half-life in healthy adults. Antimicrob Agents Chemother (2013) 1.24

Mechanism of action and in vivo efficacy of a human-derived antibody against Staphylococcus aureus α-hemolysin. J Mol Biol (2013) 1.17

Dissemination of a pSCFS3-like cfr-carrying plasmid in Staphylococcus aureus and Staphylococcus epidermidis clinical isolates recovered from hospitals in Ohio. Antimicrob Agents Chemother (2013) 1.14

Zyvox® Annual Appraisal of Potency and Spectrum (ZAAPS) program: report of linezolid activity over 9 years (2004-12). J Antimicrob Chemother (2014) 1.06

Mechanisms of linezolid resistance among coagulase-negative staphylococci determined by whole-genome sequencing. MBio (2014) 0.98

Mechanisms of neutralization of a human anti-α-toxin antibody. J Biol Chem (2014) 0.98

Anti-alpha-toxin monoclonal antibody and antibiotic combination therapy improves disease outcome and accelerates healing in a Staphylococcus aureus dermonecrosis model. Antimicrob Agents Chemother (2014) 0.97

Potential impact of vancomycin pulmonary distribution on treatment outcomes in patients with methicillin-resistant Staphylococcus aureus pneumonia. Pharmacotherapy (2006) 0.95

Management and prevention of ventilator-associated pneumonia caused by multidrug-resistant pathogens. Expert Rev Respir Med (2012) 0.90

A comparison of microbiology and demographics among patients with healthcare-associated, hospital-acquired, and ventilator-associated pneumonia: a retrospective analysis of 1184 patients from a large, international study. BMC Infect Dis (2013) 0.89

PcrV antibody-antibiotic combination improves survival in Pseudomonas aeruginosa-infected mice. Eur J Clin Microbiol Infect Dis (2011) 0.87

Methicillin-resistant Staphylococcus aureus pneumonia in adults. Expert Rev Respir Med (2014) 0.84