Cardiovascular safety of linagliptin in type 2 diabetes: a comprehensive patient-level pooled analysis of prospectively adjudicated cardiovascular events.

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Published in Cardiovasc Diabetol on May 21, 2015

Authors

Julio Rosenstock1, Nikolaus Marx2, Dietmar Neubacher3, Thomas Seck4, Sanjay Patel5, Hans-Juergen Woerle6, Odd Erik Johansen7

Author Affiliations

1: Dallas Diabetes and Endocrine Center at Medical City, Dallas, TX, USA. juliorosenstock@dallasdiabetes.com.
2: Department of Internal Medicine I, University Hospital Aachen, Aachen, Germany. nmarx@ukaachen.de.
3: Boehringer Ingelheim, Biberach, Germany. dietmar.neubacher@boehringer-ingelheim.com.
4: Boehringer Ingelheim, Ingelheim, Germany. thomas.seck@boehringer-ingelheim.com.
5: Boehringer Ingelheim, Bracknell, Berkshire, UK. sanjay.patel@boehringer-ingelheim.com.
6: Boehringer Ingelheim, Ingelheim, Germany. hans-juergen.woerle@boehringer-ingelheim.com.
7: Boehringer Ingelheim, Drengsrudbekken 8, 1373 Asker, Oslo, Norway. odd_erik.johansen@boehringer-ingelheim.com.

Associated clinical trials:

CAROLINA: Cardiovascular Outcome Study of Linagliptin Versus Glimepiride in Patients With Type 2 Diabetes | NCT01243424

BI 1356 (Linagliptin) in Combination With Metformin and a Sulphonylurea in Type 2 Diabetes | NCT00602472

Efficacy and Safety of Linagliptin in Elderly Patients With Type 2 Diabetes | NCT01084005

Efficacy and Safety of BI 1356 in Combination With Metformin in Patients With Type 2 Diabetes | NCT00622284

Efficacy and Safety of Linagliptin in Combination With Insulin in Patients With Type 2 Diabetes | NCT00954447

Safety and Efficacy of Linagliptin (BI 1356) Plus Metformin in Type 2 Diabetes, Factorial Design | NCT00798161

Efficacy and Safety of BI 1356 (Linagliptin) Versus Placebo in Type 2 Diabetic Patients With Insufficient Glycemic Control | NCT00621140

Randomized, Double-blind (db), Placebo-controlled 18 Week Study of Linagliptin (BI 1356) in Type 2 Diabetic Patients With Insufficient Glycaemic Control on a Sulfonylurea Drug | NCT00819091

Efficacy and Safety of B I1356 (Linagliptin) vs. Placebo Added to Metformin Background Therapy in Patients With Type 2 Diabetes | NCT00601250

Efficacy vs Placebo as Initial Combination Therapy With Pioglitazone | NCT00641043

Japanese P III vs Voglibose and Placebo | NCT00654381

A Randomised, db, Placebo-controlled Study of BI 1356 for 18 Weeks Followed by a 34 Week Double-blind Extension Period (Placebo Patients Switched to Glimepiride) in Type 2 Diabetic Patients for Whom Treatment With Metformin is Inappropriate | NCT00740051

Linagliptin 2.5 mg Twice Daily Versus 5 mg Once Daily as add-on Therapy to Twice Daily Metformin in Type 2 Diabetes | NCT01012037

Efficacy and Safety of 3 Doses of BI1356 (Linagliptin) in Type 2 Diabetes Patients | NCT00328172

Efficacy and Safety of BI 1356 BS (Linagliptin) in Combination With Metformin in Patients With type2 Diabetes | NCT00309608

Treatment of Type 2 Diabetes With Linagliptin 2.5 mg Bid + Metformin 500 or 1000 mg Bid and Metformin 1000 mg Bid | NCT00915772

Efficacy and Safety of Linagliptin (BI 1356) in Black/African Americans With Type 2 Diabetes With a MTT Sub-study | NCT01194830

Linagliptin Versus Placebo in Type 2 Diabetic Patients With Inadequate Glycaemic Control on Metformin in Combination With Pioglitazone | NCT00996658

30 Week Parallel Group Comparison Study of Linagliptin + Pioglitazone (5+15, 5+30 and 5+45 mg) qd Versus Respective Monotherapies, Followed by a Comparison of 5mg+30mg and 5mg+45mg Versus Respective Monotherapies in Type 2 Diabetes for up to 54 Weeks | NCT01183013

Safety and Efficacy in Type 2 Diabetic Patients With Severe Chronic Renal Impairment, 5 mg BI 1356 (Linagliptin) vs. Placebo, Insulin Background Inclusive | NCT00800683

Safety and Efficacy of Linagliptin in Type-2-diabetes Mellitus Patients With Moderate to Severe Renal Impairment | NCT01087502

The Effect of Linagliptin (BI 1356) on 24h-glucose Control and Various Biomarkers in Type 2 Diabetic Patients | NCT00716092

Efficacy and Safety Study of Linagliptin (5 mg Administered Orally Once Daily) Over 24 Weeks, in Drug naïve or Previously Treated Type 2 Diabetic Patients With Insufficient Glycaemic Control | NCT01214239

Efficacy and Safety Study of Linagliptin (5 mg Administered Orally Once Daily) Over 24 Weeks in Type 2 Diabetic Patients With Insufficient Glycaemic Control Despite Metformin Therapy | NCT01215097

NCT 02183415

Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of BI 1356 BS in Patients With Type 2 Diabetes | NCT02183350

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