Structure Guided Chemical Modifications of Propylthiouracil Reveal Novel Small Molecule Inhibitors of Cytochrome b5 Reductase 3 That Increase Nitric Oxide Bioavailability.

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Published in J Biol Chem on May 22, 2015

Authors

Md Mizanur Rahaman1, Fabio G Reinders2, David Koes2, Anh T Nguyen1, Stephanie M Mutchler3, Courtney Sparacino-Watkins1, Roger A Alvarez4, Megan P Miller1, Dongmei Cheng5, Bill B Chen6, Edwin K Jackson5, Carlos J Camacho2, Adam C Straub7

Author Affiliations

1: From the Heart, Lung, Blood, and Vascular Medicine Institute.
2: Department of Computational and Systems Biology.
3: From the Heart, Lung, Blood, and Vascular Medicine Institute, Department of Pharmacology and Chemical Biology, and.
4: From the Heart, Lung, Blood, and Vascular Medicine Institute, Pulmonary, Allergy, and Critical Care Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania 15213.
5: Department of Pharmacology and Chemical Biology, and.
6: Pulmonary, Allergy, and Critical Care Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania 15213.
7: From the Heart, Lung, Blood, and Vascular Medicine Institute, Department of Pharmacology and Chemical Biology, and astraub@pitt.edu.

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