Published in J Biol Chem on May 27, 2015
NAMPT-Mediated NAD(+) Biosynthesis Is Essential for Vision In Mice. Cell Rep (2016) 1.40
Mouse Models of NMNAT1-Leber Congenital Amaurosis (LCA9) Recapitulate Key Features of the Human Disease. Am J Pathol (2016) 0.77
Diagnostic application of clinical exome sequencing in Leber congenital amaurosis. Mol Vis (2017) 0.75
NMNAT: It's an NAD(+) synthase… It's a chaperone… It's a neuroprotector. Curr Opin Genet Dev (2017) 0.75
The role of oxidative stress in the pathogenesis of age-related macular degeneration. Surv Ophthalmol (2000) 8.10
Native protein sequences are close to optimal for their structures. Proc Natl Acad Sci U S A (2000) 7.99
Increased nuclear NAD biosynthesis and SIRT1 activation prevent axonal degeneration. Science (2004) 7.29
Leber congenital amaurosis: genes, proteins and disease mechanisms. Prog Retin Eye Res (2008) 5.90
RPE lipofuscin and its role in retinal pathobiology. Exp Eye Res (2005) 3.52
Drosophila NMNAT maintains neural integrity independent of its NAD synthesis activity. PLoS Biol (2006) 2.70
Protein denaturation during heat shock and related stress. Escherichia coli beta-galactosidase and Photinus pyralis luciferase inactivation in mouse cells. J Biol Chem (1989) 2.65
Nicotinamide mononucleotide adenylyl transferase-mediated axonal protection requires enzymatic activity but not increased levels of neuronal nicotinamide adenine dinucleotide. J Neurosci (2009) 2.15
Mutations in NMNAT1 cause Leber congenital amaurosis and identify a new disease pathway for retinal degeneration. Nat Genet (2012) 1.96
Stimulation of nicotinamide adenine dinucleotide biosynthetic pathways delays axonal degeneration after axotomy. J Neurosci (2006) 1.89
NMNAT1 mutations cause Leber congenital amaurosis. Nat Genet (2012) 1.86
Transgenic mice expressing the Nmnat1 protein manifest robust delay in axonal degeneration in vivo. J Neurosci (2009) 1.69
Nmnat delays axonal degeneration caused by mitochondrial and oxidative stress. J Neurosci (2008) 1.54
Analysis of circular dichroism data. Methods Enzymol (2004) 1.39
Structure of human nicotinamide/nicotinic acid mononucleotide adenylyltransferase. Basis for the dual substrate specificity and activation of the oncolytic agent tiazofurin. J Biol Chem (2002) 1.38
Mutations in NMNAT1 cause Leber congenital amaurosis with early-onset severe macular and optic atrophy. Nat Genet (2012) 1.33
Exome sequencing identifies NMNAT1 mutations as a cause of Leber congenital amaurosis. Nat Genet (2012) 1.31
Light-induced damage to the retina: role of rhodopsin chromophore revisited. Photochem Photobiol (2005) 1.28
Reducing expression of NAD+ synthesizing enzyme NMNAT1 does not affect the rate of Wallerian degeneration. FEBS J (2011) 1.23
Initial-rate kinetics of human NMN-adenylyltransferases: substrate and metal ion specificity, inhibition by products and multisubstrate analogues, and isozyme contributions to NAD+ biosynthesis. Biochemistry (2007) 1.22
Identification of a locus (LCA9) for Leber's congenital amaurosis on chromosome 1p36. Eur J Hum Genet (2003) 1.21
Image-based screening identifies novel roles for IkappaB kinase and glycogen synthase kinase 3 in axonal degeneration. J Biol Chem (2011) 1.16
Automated selection of stabilizing mutations in designed and natural proteins. Proc Natl Acad Sci U S A (2012) 1.07
The cell stress machinery and retinal degeneration. FEBS Lett (2013) 1.07
A model of toxic neuropathy in Drosophila reveals a role for MORN4 in promoting axonal degeneration. J Neurosci (2012) 1.05
Mitochondrial dysfunction induces Sarm1-dependent cell death in sensory neurons. J Neurosci (2014) 1.03
Nonpenetrance of the most frequent autosomal recessive leber congenital amaurosis mutation in NMNAT1. JAMA Ophthalmol (2014) 0.91
Molecular chaperones protect against JNK- and Nmnat-regulated axon degeneration in Drosophila. J Cell Sci (2012) 0.83