Focusing and sustaining the antitumor CTL effector killer response by agonist anti-CD137 mAb.

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Published in Proc Natl Acad Sci U S A on June 01, 2015

Authors

Bettina Weigelin1, Elixabet Bolaños2, Alvaro Teijeira2, Ivan Martinez-Forero2, Sara Labiano2, Arantza Azpilikueta2, Aizea Morales-Kastresana2, José I Quetglas2, Esther Wagena1, Alfonso Rodríguez Sánchez-Paulete2, Lieping Chen3, Peter Friedl1, Ignacio Melero4

Author Affiliations

1: Department of Cell Biology, Radboud University Nijmegen Medical Center, 6525 GA Nijmegen, The Netherlands;
2: Centro de Investigación Médica Aplicada (CIMA) and Clinica Universidad de Navarra, University of Navarra, 31008 Pamplona, Spain;
3: Department of Immunobiology, Yale University School of Medicine, New Haven, CT 06511.
4: Centro de Investigación Médica Aplicada (CIMA) and Clinica Universidad de Navarra, University of Navarra, 31008 Pamplona, Spain; imelero@unav.es.

Associated clinical trials:

A Study Of PF-05082566 As A Single Agent And In Combination With Rituximab | NCT01307267

Safety, Tolerability, Pharmacokinetics, and Immunoregulatory Study of Urelumab (BMS-663513) in Subjects With Advanced and/or Metastatic Solid Tumors and Relapsed/Refractory B-cell Non-Hodgkin's Lymphoma | NCT01471210

Combination Study of Urelumab and Rituximab in Patients With B-cell Non-Hodgkins Lymphoma | NCT01775631

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