Published in J Exp Med on June 08, 2015
Macrophage-secreted granulin supports pancreatic cancer metastasis by inducing liver fibrosis. Nat Cell Biol (2016) 2.20
Cisplatin-induced mesenchymal stromal cells-mediated mechanism contributing to decreased antitumor effect in breast cancer cells. Cell Commun Signal (2016) 1.47
Yes-associated protein mediates immune reprogramming in pancreatic ductal adenocarcinoma. Oncogene (2016) 1.39
Targeting metastasis. Nat Rev Cancer (2016) 1.26
The Nature of Myeloid-Derived Suppressor Cells in the Tumor Microenvironment. Trends Immunol (2016) 1.20
The role of myeloid cells in cancer therapies. Nat Rev Cancer (2016) 0.92
Tumor-associated macrophages: unwitting accomplices in breast cancer malignancy. NPJ Breast Cancer (2016) 0.92
In vivo subcellular resolution optical imaging in the lung reveals early metastatic proliferation and motility. Intravital (2016) 0.87
The Role of Chemokines in Promoting Colorectal Cancer Invasion/Metastasis. Int J Mol Sci (2016) 0.86
FLT1 signaling in metastasis-associated macrophages activates an inflammatory signature that promotes breast cancer metastasis. J Exp Med (2015) 0.86
Tumour-associated macrophages as treatment targets in oncology. Nat Rev Clin Oncol (2017) 0.86
The Multifaceted Role of Perivascular Macrophages in Tumors. Cancer Cell (2016) 0.84
CCL2 Produced by the Glioma Microenvironment Is Essential for the Recruitment of Regulatory T Cells and Myeloid-Derived Suppressor Cells. Cancer Res (2016) 0.83
Targeting the CCL2-CCR2 signaling axis in cancer metastasis. Oncotarget (2016) 0.81
Obesity-associated NLRC4 inflammasome activation drives breast cancer progression. Nat Commun (2016) 0.79
Therapeutic potential of chemokine signal inhibition for metastatic breast cancer. Pharmacol Res (2015) 0.78
Fatal attraction: How macrophages participate in tumor metastases. J Exp Med (2015) 0.78
Cancer immunosurveillance: role of patrolling monocytes. Cell Res (2015) 0.78
Macrophages: Regulators of the Inflammatory Microenvironment during Mammary Gland Development and Breast Cancer. Mediators Inflamm (2016) 0.77
Molecular Signatures of Human Regulatory T Cells in Colorectal Cancer and Polyps. Front Immunol (2017) 0.76
Neutrophils drive accelerated tumor progression in the collagen-dense mammary tumor microenvironment. Breast Cancer Res (2016) 0.76
A highly invasive subpopulation of MDA-MB-231 breast cancer cells shows accelerated growth, differential chemoresistance, features of apocrine tumors and reduced tumorigenicity in vivo. Oncotarget (2016) 0.75
Warburg metabolism in tumor-conditioned macrophages promotes metastasis in human pancreatic ductal adenocarcinoma. Oncoimmunology (2016) 0.75
On-chip human microvasculature assay for visualization and quantification of tumor cell extravasation dynamics. Nat Protoc (2017) 0.75
Benzopyrene promotes lung cancer A549 cell migration and invasion through up-regulating cytokine IL8 and chemokines CCL2 and CCL3 expression. Exp Biol Med (Maywood) (2016) 0.75
Biomaterials approaches to modeling macrophage-extracellular matrix interactions in the tumor microenvironment. Curr Opin Biotechnol (2016) 0.75
Harnessing antitumor immunity: Employment of tumor recall antigens to optimize the inflammatory response to cancer. Oncol Lett (2017) 0.75
CXCR3(+) monocytes/macrophages are required for establishment of pulmonary metastases. Sci Rep (2017) 0.75
Osteoprotegerin mediates tumor-promoting effects of Interleukin-1beta in breast cancer cells. Mol Cancer (2017) 0.75
Long-term High-Resolution Intravital Microscopy in the Lung with a Vacuum Stabilized Imaging Window. J Vis Exp (2016) 0.75
Changes in plasma chemokine C-C motif ligand 2 levels during treatment with eicosapentaenoic acid predict outcome in patients undergoing surgery for colorectal cancer liver metastasis. Oncotarget (2016) 0.75
Human Tumor-Infiltrating Myeloid Cells: Phenotypic and Functional Diversity. Front Immunol (2017) 0.75
Induction of the MCP chemokine cluster cascade in the periphery by cancer cell-derived CCL3. Cancer Lett (2016) 0.75
One microenvironment does not fit all: heterogeneity beyond cancer cells. Cancer Metastasis Rev (2016) 0.75
The Yin/Yan of CCL2: a minor role in neutrophil anti-tumor activity in vitro but a major role on the outgrowth of metastatic breast cancer lesions in the lung in vivo. BMC Cancer (2017) 0.75
CCL2/CCR2 Regulates the Tumor Microenvironment in HER-2/neu-Driven Mammary Carcinomas in Mice. PLoS One (2016) 0.75
Immune Regulation of the Metastatic Process: Implications for Therapy. Adv Cancer Res (2016) 0.75
Gpr132 sensing of lactate mediates tumor-macrophage interplay to promote breast cancer metastasis. Proc Natl Acad Sci U S A (2017) 0.75
Urine biomarkers in renal allograft. J Transl Int Med (2016) 0.75
Inducible nitric oxide synthase enhances disease aggressiveness in pancreatic cancer. Oncotarget (2016) 0.75
Immunosurveillance and immunoediting in MMTV-PyMT-induced mammary oncogenesis. Oncoimmunology (2016) 0.75
Patient-derived tumour xenografts for breast cancer drug discovery. Endocr Relat Cancer (2016) 0.75
Macrophages as Key Drivers of Cancer Progression and Metastasis. Mediators Inflamm (2017) 0.75
New Mechanisms of Tumor-Associated Macrophages on Promoting Tumor Progression: Recent Research Advances and Potential Targets for Tumor Immunotherapy. J Immunol Res (2016) 0.75
The Relationship Between Dormant Cancer Cells and Their Microenvironment. Adv Cancer Res (2016) 0.75
The Dr. Jekyll and Mr. Hyde complexity of the macrophage response in disease. J Leukoc Biol (2017) 0.75
Mammary tumor-derived CCL2 enhances pro-metastatic systemic inflammation through upregulation of IL1β in tumor-associated macrophages. Oncoimmunology (2017) 0.75
Chemokines in the cancer microenvironment and their relevance in cancer immunotherapy. Nat Rev Immunol (2017) 0.75
The histone demethylase KDM3A, and its downstream target MCAM, promote Ewing Sarcoma cell migration and metastasis. Oncogene (2017) 0.75
The cholesterol metabolite 27 hydroxycholesterol facilitates breast cancer metastasis through its actions on immune cells. Nat Commun (2017) 0.75
Reprogramming of Tumor-Associated Macrophages with Anticancer Therapies: Radiotherapy versus Chemo- and Immunotherapies. Front Immunol (2017) 0.75
Global cancer statistics. CA Cancer J Clin (2011) 185.92
Genes that mediate breast cancer metastasis to lung. Nature (2005) 19.85
Microenvironmental regulation of metastasis. Nat Rev Cancer (2008) 15.76
Macrophage diversity enhances tumor progression and metastasis. Cell (2010) 13.41
Stromal gene expression predicts clinical outcome in breast cancer. Nat Med (2008) 10.68
Colony-stimulating factor 1 promotes progression of mammary tumors to malignancy. J Exp Med (2001) 9.99
Accessories to the crime: functions of cells recruited to the tumor microenvironment. Cancer Cell (2012) 8.71
CCL2 recruits inflammatory monocytes to facilitate breast-tumour metastasis. Nature (2011) 8.62
Progression to malignancy in the polyoma middle T oncoprotein mouse breast cancer model provides a reliable model for human diseases. Am J Pathol (2003) 8.61
The role of tumour-associated macrophages in tumour progression: implications for new anticancer therapies. J Pathol (2002) 8.27
Monocyte-mediated defense against microbial pathogens. Annu Rev Immunol (2008) 7.21
Association of macrophage infiltration with angiogenesis and prognosis in invasive breast carcinoma. Cancer Res (1996) 5.38
Trophic macrophages in development and disease. Nat Rev Immunol (2009) 5.37
Identification of molecular apocrine breast tumours by microarray analysis. Oncogene (2005) 5.27
Survival of mononuclear phagocytes depends on a lineage-specific growth factor that the differentiated cells selectively destroy. Cell (1982) 5.19
Molecular cloning, functional expression, and signaling characteristics of a C-C chemokine receptor. Cell (1993) 4.93
Purification and characterization of a novel monocyte chemotactic and activating factor produced by a human myelomonocytic cell line. J Exp Med (1989) 4.64
Tissue-resident macrophages. Nat Immunol (2013) 4.09
The cellular and molecular origin of tumor-associated macrophages. Science (2014) 3.89
A distinct macrophage population mediates metastatic breast cancer cell extravasation, establishment and growth. PLoS One (2009) 3.86
CCL2 and interleukin-6 promote survival of human CD11b+ peripheral blood mononuclear cells and induce M2-type macrophage polarization. J Biol Chem (2009) 2.81
Alveolar macrophages: plasticity in a tissue-specific context. Nat Rev Immunol (2014) 2.71
Macrophage binding to receptor VCAM-1 transmits survival signals in breast cancer cells that invade the lungs. Cancer Cell (2011) 2.64
Syngeneic mouse mammary carcinoma cell lines: two closely related cell lines with divergent metastatic behavior. Clin Exp Metastasis (2005) 2.52
CCR1 blockade reduces tumor burden and osteolysis in vivo in a mouse model of myeloma bone disease. Blood (2012) 2.18
Specialized roles of the chemokine receptors CCR1 and CCR5 in the recruitment of monocytes and T(H)1-like/CD45RO(+) T cells. Blood (2001) 1.98
Overcoming hurdles in developing successful drugs targeting chemokine receptors. Nat Rev Immunol (2011) 1.91
Chemokine (C-C motif) ligand 2 engages CCR2+ stromal cells of monocytic origin to promote breast cancer metastasis to lung and bone. J Biol Chem (2009) 1.81
High-density gene expression analysis of tumor-associated macrophages from mouse mammary tumors. Am J Pathol (2009) 1.80
Cessation of CCL2 inhibition accelerates breast cancer metastasis by promoting angiogenesis. Nature (2014) 1.79
Chemokines induce migrational responses in human breast carcinoma cell lines. Int J Cancer (1997) 1.58
Chemokines regulate T cell adherence to recombinant adhesion molecules and extracellular matrix proteins. J Immunol (1996) 1.51
Chemokine receptor CCR1 but not CCR5 mediates leukocyte recruitment and subsequent renal fibrosis after unilateral ureteral obstruction. J Am Soc Nephrol (2004) 1.41
Macrophage inflammatory protein-1alpha (MIP-1alpha) is required for the efferent phase of pulmonary cell-mediated immunity to a Cryptococcus neoformans infection. J Immunol (1997) 1.39
Inactivation of chemokine (C-C motif) receptor 1 (CCR1) suppresses colon cancer liver metastasis by blocking accumulation of immature myeloid cells in a mouse model. Proc Natl Acad Sci U S A (2010) 1.33
Increase of CCR1 and CCR5 expression and enhanced functional response to MIP-1 alpha during differentiation of human monocytes to macrophages. J Leukoc Biol (2001) 1.30
CCL3-CCR5 axis regulates intratumoral accumulation of leukocytes and fibroblasts and promotes angiogenesis in murine lung metastasis process. J Immunol (2008) 1.30
Conditional deletion of the colony stimulating factor-1 receptor (c-fms proto-oncogene) in mice. Genesis (2006) 1.29
Distant metastasis from subcutaneously grown E0771 medullary breast adenocarcinoma. Anticancer Res (2005) 1.29
MIP-1alpha utilizes both CCR1 and CCR5 to induce osteoclast formation and increase adhesion of myeloma cells to marrow stromal cells. Exp Hematol (2005) 1.23
MIP-1alpha[CCL3] acting on the CCR1 receptor mediates neutrophil migration in immune inflammation via sequential release of TNF-alpha and LTB4. J Leukoc Biol (2005) 1.22
Inflammation triggers emergency granulopoiesis through a density-dependent feedback mechanism. PLoS One (2011) 1.21
CCL3 and CXCL12 regulate trafficking of mouse bone marrow NK cell subsets. Blood (2008) 1.20
A first-in-human, first-in-class, phase I study of carlumab (CNTO 888), a human monoclonal antibody against CC-chemokine ligand 2 in patients with solid tumors. Cancer Chemother Pharmacol (2013) 1.19
Systemic delivery of neutralizing antibody targeting CCL2 for glioma therapy. J Neurooncol (2010) 1.19
Host-derived MCP-1 and MIP-1α regulate protective anti-tumor immunity to localized and metastatic B16 melanoma. Am J Pathol (2011) 1.09
Pharmacokinetic and pharmacodynamic evaluation of the novel CCR1 antagonist CCX354 in healthy human subjects: implications for selection of clinical dose. Clin Pharmacol Ther (2011) 0.99
RANTES-induced chemokine cascade in dendritic cells. J Immunol (2001) 0.99
Macrophage inflammatory protein-2 and KC induce chemokine production by mouse astrocytes. J Immunol (2000) 0.98
A key role for CC chemokine receptor 1 in T-cell-mediated respiratory inflammation. Am J Pathol (2008) 0.97
M1 polarization of human monocyte-derived macrophages restricts pre and postintegration steps of HIV-1 replication. AIDS (2013) 0.96
Macrophages and the hypoxic tumour microenvironment. Front Biosci (2007) 0.94
Monocyte chemoattractant protein-1/CC chemokine ligand 2 enhances apoptotic cell removal by macrophages through Rac1 activation. Biochem Biophys Res Commun (2010) 0.92
Chemokine receptor CCR1 antagonist CCX354-C treatment for rheumatoid arthritis: CARAT-2, a randomised, placebo controlled clinical trial. Ann Rheum Dis (2012) 0.91
Chemokines induce the cellular migration of MCF-7 human breast carcinoma cells: subpopulations of tumour cells display positive and negative chemotaxis and differential in vivo growth potentials. Clin Exp Metastasis (1999) 0.90
Differential expression and regulation of macrophage inflammatory protein (MIP)-1alpha and MIP-2 genes by alveolar and peritoneal macrophages in LPS-hyporesponsive C3H/HeJ mice. Cell Immunol (2000) 0.88
Tumor cell apoptosis induces tumor-specific immunity in a CC chemokine receptor 1- and 5-dependent manner in mice. J Leukoc Biol (2008) 0.87
Control of both myeloid cell infiltration and angiogenesis by CCR1 promotes liver cancer metastasis development in mice. Neoplasia (2013) 0.80
Macrophage inflammatory protein 1alpha enhances in a different manner adhesion of hematopoietic progenitor cells from bone marrow, cord blood, and mobilized peripheral blood. Exp Hematol (1999) 0.78