Published in Chin Med J (Engl) on June 20, 2015
Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) Method. Methods (2001) 414.27
Alternative projections of mortality and disability by cause 1990-2020: Global Burden of Disease Study. Lancet (1997) 44.03
Chronic obstructive pulmonary disease. N Engl J Med (2000) 8.23
The global burden of disease, 1990-2020. Nat Med (1998) 6.50
Nitric oxide in health and disease of the respiratory system. Physiol Rev (2004) 3.15
Inducible NOS inhibition reverses tobacco-smoke-induced emphysema and pulmonary hypertension in mice. Cell (2011) 2.51
Cloned human brain nitric oxide synthase is highly expressed in skeletal muscle. FEBS Lett (1993) 2.14
Cloning, characterization, and expression of a cDNA encoding an inducible nitric oxide synthase from the human chondrocyte. Proc Natl Acad Sci U S A (1993) 2.10
Decreased haem oxygenase-1 and increased inducible nitric oxide synthase in the lung of severe COPD patients. Eur Respir J (2003) 1.84
Molecular cloning and characterization of human endothelial nitric oxide synthase. FEBS Lett (1992) 1.79
Nitric oxide synthase isoenzyme expression and activity in peripheral lung tissue of patients with chronic obstructive pulmonary disease. Am J Respir Crit Care Med (2009) 1.67
Reactive nitrogen species and tyrosine nitration in the respiratory tract: epiphenomena or a pathobiologic mechanism of disease? Am J Respir Crit Care Med (1999) 1.65
Chronic obstructive pulmonary disease: risk factors, pathophysiology and pathogenesis. Annu Rev Med (1989) 1.65
Increase in reactive nitrogen species production in chronic obstructive pulmonary disease airways. Am J Respir Crit Care Med (2000) 1.64
Exhaled nitric oxide from lung periphery is increased in COPD. Eur Respir J (2005) 1.24
Nitrosative stress in the bronchial mucosa of severe chronic obstructive pulmonary disease. J Allergy Clin Immunol (2005) 1.17
Role of nitric oxide synthase/arginase balance in bronchial reactivity in patients with chronic obstructive pulmonary disease. Am J Physiol Lung Cell Mol Physiol (2007) 1.03
A polymorphism in the inducible nitric oxide synthase gene is associated with tuberculosis. Tuberculosis (Edinb) (2007) 1.01
Peroxynitrite elevation in exhaled breath condensate of COPD and its inhibition by fudosteine. Chest (2009) 0.99
Nitric oxide synthase polymorphisms and asthma phenotypes in Chinese children. Clin Exp Allergy (2005) 0.97
Inducible nitric oxide synthase (iNOS) gene polymorphism and disease prevalence. Scand J Immunol (2010) 0.96
Association of inducible nitric oxide synthase with asthma severity, total serum immunoglobulin E and blood eosinophil levels. Thorax (2007) 0.96
ACE I allele and eNOS G allele crosstalk may have a role in chronic obstructive pulmonary disease. Clin Biochem (2004) 0.83
Endothelial nitric oxide synthase gene variants contribute to oxidative stress in COPD. Biochem Biophys Res Commun (2007) 0.82
Exome sequencing identifies truncating mutations in PRRT2 that cause paroxysmal kinesigenic dyskinesia. Nat Genet (2011) 2.48
Characterization of an LQT5-related mutation in KCNE1, Y81C: implications for a role of KCNE1 cytoplasmic domain in IKs channel function. Heart Rhythm (2006) 1.45
Chinese patients with spinocerebellar ataxia type 3 presenting with rare clinical symptoms. J Neurol Sci (2012) 1.39
KCNE2 is colocalized with KCNQ1 and KCNE1 in cardiac myocytes and may function as a negative modulator of I(Ks) current amplitude in the heart. Heart Rhythm (2006) 1.20
Solution-processed and high-performance organic solar cells using small molecules with a benzodithiophene unit. J Am Chem Soc (2013) 1.17
Dynamic partnership between KCNQ1 and KCNE1 and influence on cardiac IKs current amplitude by KCNE2. J Biol Chem (2009) 1.10
Solution-processed organic solar cells based on dialkylthiol-substituted benzodithiophene unit with efficiency near 10%. J Am Chem Soc (2014) 1.10
Novel SLC20A2 mutations identified in southern Chinese patients with idiopathic basal ganglia calcification. Gene (2013) 1.07
Small molecules based on benzo[1,2-b:4,5-b']dithiophene unit for high-performance solution-processed organic solar cells. J Am Chem Soc (2012) 1.06
PICALM and CR1 variants are not associated with sporadic Alzheimer's disease in Chinese patients. J Alzheimers Dis (2011) 0.91
Involvement of Bcl-2 family in apoptosis and signal pathways induced by cigarette smoke extract in the human airway smooth muscle cells. DNA Cell Biol (2009) 0.90
Correlation of HDEFB1 polymorphism and susceptibility to chronic obstructive pulmonary disease in Chinese Han population. Chin Med J (Engl) (2004) 0.89
PRRT2 mutation correlated with phenotype of paroxysmal kinesigenic dyskinesia and drug response. Neurology (2013) 0.87
PRRT2 c.649dupC mutation derived from de novo in paroxysmal kinesigenic dyskinesia. CNS Neurosci Ther (2012) 0.85
NADPH oxidase activation: a mechanism of erectile dysfunction in a rat model of sleep apnea. J Androl (2012) 0.85
Reduced heat shock protein 70 in airway smooth muscle in patients with chronic obstructive pulmonary disease. Exp Lung Res (2010) 0.85
Knockdown of connective tissue growth factor by plasmid-based short hairpin RNA prevented pulmonary vascular remodeling in cigarette smoke-exposed rats. Arch Biochem Biophys (2011) 0.84
Expression of the Th1-specific cell-surface protein Tim-3 increases in a murine model of atopic asthma. J Asthma (2009) 0.83
N-Acetyl-L-cysteine and pyrrolidine dithiocarbamate inhibited nuclear factor-kappaB activation in alveolar macrophages by different mechanisms. Acta Pharmacol Sin (2006) 0.83
Up-regulation of cyclin D1 expression in asthma serum-sensitized human airway smooth muscle promotes proliferation via protein kinase C alpha. Exp Lung Res (2010) 0.82
Extracellular signal-regulated kinase activation in airway smooth muscle cell proliferation in chronic asthmatic rats. Sheng Li Xue Bao (2007) 0.80
TNF-alpha up-regulates matrix metalloproteinase-9 expression and activity in alveolar macrophages from patients with chronic obstructive pulmonary disease. J Huazhong Univ Sci Technolog Med Sci (2006) 0.79
Cigarette smoke extract induced rat pulmonary artery smooth muscle cells proliferation via PKCα-mediated cyclin D1 expression. J Cell Biochem (2011) 0.79
Contribution of protein kinase C to passively sensitized human airway smooth muscle cells proliferation. Chin Med J (Engl) (2004) 0.79
Change of extracellular signal-regulated kinase expression in pulmonary arteries from smokers with and without chronic obstructive pulmonary disease. Exp Lung Res (2013) 0.78
[Expression of protein kinase C and nuclear factor kappa B in lung tissue of patients with chronic obstructive pulmonary disease]. Zhonghua Nei Ke Za Zhi (2004) 0.78
[Smoking, the level of DNA adducts and chronic obstructive pulmonary diseases]. Zhonghua Jie He He Hu Xi Za Zhi (2004) 0.77
Focal adhesion kinase antisense oligodeoxynucleotides inhibit human pulmonary artery smooth muscle cells proliferation and promote human pulmonary artery smooth muscle cells apoptosis. Chin Med J (Engl) (2005) 0.77
Graphene quantum dots as the hole transport layer material for high-performance organic solar cells. Phys Chem Chem Phys (2013) 0.77
The effect of protein kinase C on voltage-gated potassium channel in pulmonary artery smooth muscle cells from rats exposed to chronic hypoxia. Chin Med J (Engl) (2004) 0.77
[A study of helper T cell (Th)1/Th2 immune response pattern of gammadeltaT cells in asthma]. Zhonghua Nei Ke Za Zhi (2004) 0.77
Cigarette smoke extract promotes human pulmonary artery smooth muscle cells proliferation through protein kinase C alpha-dependent induction of cyclin D1. Chin Med J (Engl) (2010) 0.77
Paroxysmal kinesigenic dyskinesia and myotonia congenita in the same family: coexistence of a PRRT2 mutation and two CLCN1 mutations. Neurosci Bull (2014) 0.77
PKC promotes proliferation of airway smooth muscle cells by regulating cyclinD1 expression in asthmatic rats. Acta Pharmacol Sin (2008) 0.77
[Effect of nuclear factor-kappaB on signal transduction of passively sensitized human airway smooth muscle cells proliferation]. Zhonghua Nei Ke Za Zhi (2004) 0.77
Effects of puerarin on pulmonary vascular remodeling and protein kinase C-alpha in chronic cigarette smoke exposure smoke-exposed rats. J Huazhong Univ Sci Technolog Med Sci (2008) 0.77
The effect of Ginkgo Biloba extract on the expression of PKCalpha in the inflammatory cells and the level of IL-5 in induced sputum of asthmatic patients. J Huazhong Univ Sci Technolog Med Sci (2007) 0.77
Cigarette smoke extract promotes proliferation of airway smooth muscle cells in asthmatic rats via regulating cyclin D1 expression. Chin Med J (Engl) (2010) 0.77
Effect of nuclear factor-kappaB on airway remodeling in asthmatic rats. J Huazhong Univ Sci Technolog Med Sci (2004) 0.77
Noninvasive urine-derived cell lines derived from neurological genetic patients. Neuroreport (2013) 0.76
EGFP tags affect cellular localization of ATP7B mutants. CNS Neurosci Ther (2013) 0.76
Role of extracellular signal-regulated kinase in regulating expression of interleukin 13 in lymphocytes from an asthmatic rat model. Chin Med J (Engl) (2010) 0.76
[Nuclear factor-kappaB activity and its correlation with cell proliferation in non-small cell lung cancer tissues]. Zhonghua Jie He He Hu Xi Za Zhi (2007) 0.76
Isoprenaline and aminophylline relax bronchial smooth muscle by cAMP-induced stimulation of large-conductance Ca2+-activated K+ channels. Acta Pharmacol Sin (2003) 0.76
Role of the extracellular signal-regulated kinase 1/2 signaling pathway in regulating the secretion of bronchial smooth muscle cells in a rat model of chronic asthma. Chin Med J (Engl) (2008) 0.76
ERK1/2 signaling pathway modulates the airway smooth muscle cell phenotype in the rat model of chronic asthma. Respiration (2007) 0.76
A variant within FGF1 is associated with Alzheimer's disease in the Han Chinese population. Am J Med Genet B Neuropsychiatr Genet (2014) 0.76
Plasmid-based short hairpin RNA against cyclin D1 attenuated pulmonary vascular remodeling in smoking rats. Microvasc Res (2010) 0.76
[The expression of macrophage migration inhibition factor in pulmonary tissues of smokers with or without chronic obstructive pulmonary disease]. Zhonghua Nei Ke Za Zhi (2012) 0.76
K+ channels and their effects on membrane potential in rat bronchial smooth muscle cells. J Huazhong Univ Sci Technolog Med Sci (2003) 0.75
Effect of cigarette smoke extract on the role of protein kinase C in the proliferation of passively sensitized human airway smooth muscle cells. J Huazhong Univ Sci Technolog Med Sci (2005) 0.75
Heat shock protein 70 gene polymorphisms in Han nationality of China with chronic obstructive pulmonary diseases. J Huazhong Univ Sci Technolog Med Sci (2004) 0.75
[A study of protein kinase C signal pathway in regulating airway smooth muscle cell proliferation in asthmatic rats]. Zhonghua Jie He He Hu Xi Za Zhi (2003) 0.75
Effect of passive sensitization by serum from allergic asthmatic patients on the activity and expression of voltage-dependent delayed rectifier potassium channel in human bronchial smooth muscle cells. Chin Med J (Engl) (2004) 0.75
[DNA damage in lymphocytes from patients with chronic obstructive pulmonary disease]. Zhonghua Nei Ke Za Zhi (2005) 0.75
[Inhibition of NF-kappaB through IkappaBalpha transfection affects invasion of human lung cancer cell line A549]. Ai Zheng (2008) 0.75
[Effects of all-trans retinoic acid on phenotype switch and migration of human pulmonary artery smooth muscle cells in vitro and the possible mechanisms]. Zhonghua Jie He He Hu Xi Za Zhi (2006) 0.75
[Regulating effects of delayed rectifier potassium channel on the tone of human passively sensitized bronchial smooth muscle]. Zhongguo Ying Yong Sheng Li Xue Za Zhi (2006) 0.75
ABCD1 mutations and phenotype distribution in Chinese patients with X-linked adrenoleukodystrophy. Gene (2013) 0.75
A solution-processed high performance organic solar cell using a small molecule with the thieno[3,2-b]thiophene central unit. Chem Commun (Camb) (2015) 0.75
[Pulmonary vascular remodeling and protein kinase C-alpha expression in chronic smoke exposure and/or hypoxia rats]. Zhonghua Jie He He Hu Xi Za Zhi (2005) 0.75
Effect of nuclear factor-kappa B on vascular endothelial growth factor mRNA expression of human pulmonary artery smooth muscle cells in hypoxia. J Huazhong Univ Sci Technolog Med Sci (2004) 0.75
[Effect of protein kinase C-nuclear factor-kappa B signal transduction pathway on proliferation and expression of vascular endothelial growth factor in human pulmonary artery smooth muscle cells]. Zhonghua Jie He He Hu Xi Za Zhi (2004) 0.75
Device characterization and optimization of small molecule organic solar cells assisted by modelling simulation of the current-voltage characteristics. Phys Chem Chem Phys (2015) 0.75
The discrepancy between the absence of copper deposition and the presence of neuronal damage in the brain of Atp7b(-/-) mice. Metallomics (2015) 0.75
[Recombination and identification of sense and antisence CyclinD1 eukaryotic expression vectors and the effects of the vectors on the proliferation of airway smooth muscle cell in asthmatic rats]. Yao Xue Xue Bao (2008) 0.75
Role of protein kinase C alpha and cyclin D1 in the proliferation of airway smooth muscle in asthmatic rats. Chin Med J (Engl) (2008) 0.75
[The effect of ERK signaling pathway on cell apoptosis in airway smooth muscle cells of chronic asthmatic rats]. Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi (2010) 0.75
[Surfactant protein A gene polymorphisms in chronic obstructive pulmonary disease]. Zhonghua Yi Xue Yi Chuan Xue Za Zhi (2005) 0.75
Inhibitory activity of nuclear factor-kappaB potentiates cisplatin-induced apoptosis in A549 cells. J Huazhong Univ Sci Technolog Med Sci (2008) 0.75
[Expression of β-catenin in human pulmonary tissues of smokers with and without chronic obstructive pulmonary disease]. Zhonghua Jie He He Hu Xi Za Zhi (2012) 0.75
Three new compounds from soil actinomycete Streptomyces albospinus 15-4-2. J Asian Nat Prod Res (2011) 0.75
[The isolation and expansion of gamma delta T cells in peripheral blood and bronchoalveolar lavage fluid]. Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi (2004) 0.75
[Role of extracellular signal-regulated kinase 1/2 signaling pathway in migration of bronchial smooth muscle cells of chronic asthmatic rats]. Sheng Li Xue Bao (2007) 0.75
[The effects of long-term application of L-arginine on K+ channel in pulmonary artery smooth muscle cells from rats exposed to chronic hypoxia]. Zhonghua Jie He He Hu Xi Za Zhi (2003) 0.75
[Effect of phosphodiesterase inhibitor on expression of IL-8 mRNA in peripheral blood mononuclear cells from COPD patients]. Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi (2005) 0.75
[Effect of potassium channel on the proliferation, apoptosis and related-gene expression in human bronchial smooth muscle cells]. Zhonghua Jie He He Hu Xi Za Zhi (2004) 0.75
[Effect of triptolide on airway remodeling and the expression of phosphoinositide 3-kinases in asthmatic rats]. Zhongguo Ying Yong Sheng Li Xue Za Zhi (2007) 0.75
[Effects of potassium channel blockers on the proliferation of rat bronchial smooth muscle cells]. Yao Xue Xue Bao (2003) 0.75
[Effect of protein kinase C on K(V) channel in rat bronchial smooth muscle]. Sheng Li Xue Bao (2003) 0.75
[The expression of nerve growth factor in inflammatory cells of induced sputum from patients with asthma]. Zhonghua Nei Ke Za Zhi (2003) 0.75
[Tumor necrosis factor alpha-induced expression and activity of alveolar macrophages matrix metalloproteinase-9 in chronic obstructive pulmonary disease]. Zhonghua Nei Ke Za Zhi (2006) 0.75
[PKCalpha-ERK1/2 cascade is involved in up-regulation of cyclinD1 and P21(cip1) in human airway smooth muscle cells sensitized by sera from atopic asthmatics]. Zhonghua Jie He He Hu Xi Za Zhi (2008) 0.75
[Effect of extracellular signal-regulated kinase antisense oligodeoxynucleotides on the proliferation of passively sensitized human airway smooth muscle cells]. Zhonghua Jie He He Hu Xi Za Zhi (2010) 0.75