Published in Heart Rhythm on May 25, 2006
KCNQ1 and KCNE1 in the IKs channel complex make state-dependent contacts in their extracellular domains. J Gen Physiol (2008) 1.52
An Examination of KCNE1 Mutations and Common Variants in Chronic Tinnitus. Genes (Basel) (2010) 0.93
Probing the interaction between KCNE2 and KCNQ1 in their transmembrane regions. J Membr Biol (2007) 0.91
KCNE1 and KCNE3: The yin and yang of voltage-gated K(+) channel regulation. Gene (2015) 0.89
Gating-related molecular motions in the extracellular domain of the IKs channel: implications for IKs channelopathy. J Membr Biol (2010) 0.87
From Single Variants to Protein Cascades: MULTISCALE MODELING OF SINGLE NUCLEOTIDE VARIANT SETS IN GENETIC DISORDERS. J Biol Chem (2015) 0.75
Mutations in KCNE1 in long QT syndrome (LQTS): insights into mechanism of LQTS and drug sensitivity? Heart Rhythm (2006) 0.75
An elt-3/elt-5/elt-6 GATA transcription circuit guides aging in C. elegans. Cell (2008) 4.72
Genome-wide patterns of genetic variation among elite maize inbred lines. Nat Genet (2010) 4.06
Exercise stimulates Pgc-1alpha transcription in skeletal muscle through activation of the p38 MAPK pathway. J Biol Chem (2005) 3.06
Renin-angiotensin system gene polymorphisms and atrial fibrillation. Circulation (2004) 3.02
Genome-wide genetic changes during modern breeding of maize. Nat Genet (2012) 2.60
Exercise prevents maternal high-fat diet-induced hypermethylation of the Pgc-1α gene and age-dependent metabolic dysfunction in the offspring. Diabetes (2014) 2.24
Using allopurinol above the dose based on creatinine clearance is effective and safe in patients with chronic gout, including those with renal impairment. Arthritis Rheum (2011) 2.21
Giant-stroke, superelastic carbon nanotube aerogel muscles. Science (2009) 2.19
Highly coordinated gene regulation in mouse skeletal muscle regeneration. J Biol Chem (2002) 2.17
Analysis of cell fate from single-cell gene expression profiles in C. elegans. Cell (2009) 2.16
Roles of the HIF-1 hypoxia-inducible factor during hypoxia response in Caenorhabditis elegans. J Biol Chem (2005) 2.07
Reduction in asthma-related emergency department visits after implementation of a smoke-free law. J Allergy Clin Immunol (2008) 2.02
Structure-based design of novel inhibitors of the MDM2-p53 interaction. J Med Chem (2012) 2.01
Comparative oncogenomics identifies breast tumors enriched in functional tumor-initiating cells. Proc Natl Acad Sci U S A (2011) 2.01
Pharmacokinetics of oral methotrexate in patients with rheumatoid arthritis. Arthritis Rheum (2008) 1.99
The interferon stimulated gene 15 functions as a proviral factor for the hepatitis C virus and as a regulator of the IFN response. Gut (2010) 1.77
PGC-1alpha plays a functional role in exercise-induced mitochondrial biogenesis and angiogenesis but not fiber-type transformation in mouse skeletal muscle. Am J Physiol Cell Physiol (2009) 1.72
Genetic analysis of pathways regulated by the von Hippel-Lindau tumor suppressor in Caenorhabditis elegans. PLoS Biol (2004) 1.72
Membrane translocation of small GTPase Rac1 and activation of STAT1 and STAT3 in pacing-induced sustained atrial fibrillation. Heart Rhythm (2008) 1.68
Facilitating pharmacogenetic studies using electronic health records and natural-language processing: a case study of warfarin. J Am Med Inform Assoc (2011) 1.67
Predicting warfarin dosage in European-Americans and African-Americans using DNA samples linked to an electronic health record. Pharmacogenomics (2012) 1.66
A hybrid system for temporal information extraction from clinical text. J Am Med Inform Assoc (2013) 1.63
Increased expression of extracellular matrix proteins in rapid atrial pacing-induced atrial fibrillation. Heart Rhythm (2007) 1.63
Increased expression of mineralocorticoid receptor in human atrial fibrillation and a cellular model of atrial fibrillation. J Am Coll Cardiol (2010) 1.62
Functional modulation of the transient outward current Ito by KCNE beta-subunits and regional distribution in human non-failing and failing hearts. Cardiovasc Res (2006) 1.62
Genes that escape X-inactivation in humans have high intraspecific variability in expression, are associated with mental impairment but are not slow evolving. Mol Biol Evol (2013) 1.61
Mechanical stretch of atrial myocyte monolayer decreases sarcoplasmic reticulum calcium adenosine triphosphatase expression and increases susceptibility to repolarization alternans. J Am Coll Cardiol (2011) 1.59
Hepatitis B virus suppresses toll-like receptor-mediated innate immune responses in murine parenchymal and nonparenchymal liver cells. Hepatology (2009) 1.59
Methotrexate polyglutamate concentrations are not associated with disease control in rheumatoid arthritis patients receiving long-term methotrexate therapy. Arthritis Rheum (2010) 1.56
Congenital diaphragmatic hernia, kidney agenesis and cardiac defects associated with Slit3-deficiency in mice. Mech Dev (2003) 1.55
Effect of adiponectin overexpression on stability of preexisting plaques by inducing prolyl-4-hydroxylase expression. Circ J (2010) 1.54
KCNQ1 and KCNE1 in the IKs channel complex make state-dependent contacts in their extracellular domains. J Gen Physiol (2008) 1.52
Changes in integrin expression during adipocyte differentiation. Cell Metab (2005) 1.51
Renin-angiotensin system gene polymorphisms and coronary artery disease in a large angiographic cohort: detection of high order gene-gene interaction. Atherosclerosis (2006) 1.46
Structural and functional role of the extracellular s5-p linker in the HERG potassium channel. J Gen Physiol (2002) 1.46
Usefulness of high-frequency vascular ultrasound imaging and serum inflammatory markers to predict plaque rupture in patients with stable and unstable angina pectoris. Am J Cardiol (2007) 1.46
Restoration of heart rate turbulence by titrated beta-blocker therapy in patients with advanced congestive heart failure: positive correlation with enhanced vagal modulation of heart rate. J Cardiovasc Electrophysiol (2004) 1.46
Recognizing clinical entities in hospital discharge summaries using Structural Support Vector Machines with word representation features. BMC Med Inform Decis Mak (2013) 1.46
Left ventricular extracellular matrix remodeling in dogs with right ventricular apical pacing. J Cardiovasc Electrophysiol (2010) 1.45
Thermal enhancement with optically activated gold nanoshells sensitizes breast cancer stem cells to radiation therapy. Sci Transl Med (2010) 1.43
Clinical implication of blood levels of B-type natriuretic peptide in pediatric patients on mechanical circulatory support. Ann Thorac Surg (2006) 1.42
Cloning and characterization of a novel human pantothenate kinase gene. Int J Biochem Cell Biol (2002) 1.42
Plaque volume compression ratio, a novel biomechanical index, is independently associated with ischemic cerebrovascular events. J Hypertens (2009) 1.41
p38gamma mitogen-activated protein kinase is a key regulator in skeletal muscle metabolic adaptation in mice. PLoS One (2009) 1.41
The comparison of an inexpensive-modified transobturator vaginal tape versus TVT-O procedure for the surgical treatment of female stress urinary incontinence. Taiwan J Obstet Gynecol (2011) 1.40
Stimulation of P2X7 receptors elevates Ca2+ and kills retinal ganglion cells. Invest Ophthalmol Vis Sci (2005) 1.40
Atg16l1 is required for autophagy in intestinal epithelial cells and protection of mice from Salmonella infection. Gastroenterology (2013) 1.38
Can biologic pacemakers respond to physiologic emotional arousal? Heart Rhythm (2010) 1.38
Intratympanic versus intravenous delivery of methylprednisolone to cochlear perilymph. Otol Neurotol (2007) 1.36
Gephyrin clustering is required for the stability of GABAergic synapses. Mol Cell Neurosci (2007) 1.36
A role for AGL ubiquitination in the glycogen storage disorders of Lafora and Cori's disease. Genes Dev (2007) 1.32
Metformin inhibits TNF-alpha-induced IkappaB kinase phosphorylation, IkappaB-alpha degradation and IL-6 production in endothelial cells through PI3K-dependent AMPK phosphorylation. Int J Cardiol (2008) 1.31
Drinking behaviour among men and women in China: the 2007 China Chronic Disease and Risk Factor Surveillance. Addiction (2011) 1.31
A study of transportability of an existing smoking status detection module across institutions. AMIA Annu Symp Proc (2012) 1.31
Modulation of hepatitis B virus replication and hepatocyte differentiation by MicroRNA-1. Hepatology (2011) 1.30
Smoke-free laws and adult smoking prevalence. Prev Med (2008) 1.30
Oxidative phenotype protects myofibers from pathological insults induced by chronic heart failure in mice. Am J Pathol (2007) 1.29
KCNE2 protein is expressed in ventricles of different species, and changes in its expression contribute to electrical remodeling in diseased hearts. Circulation (2004) 1.29
The association of human connexin 40 genetic polymorphisms with atrial fibrillation. Int J Cardiol (2006) 1.28
Effects of a smoke-free law on hair nicotine and respiratory symptoms of restaurant and bar workers. J Occup Environ Med (2006) 1.25
The cellular distribution and oxidation state of platinum(II) and platinum(IV) antitumour complexes in cancer cells. J Biol Inorg Chem (2003) 1.25
Elesclomol induces cancer cell apoptosis through oxidative stress. Mol Cancer Ther (2008) 1.24
Rabbit knee model of post-traumatic joint contractures: the long-term natural history of motion loss and myofibroblasts. J Orthop Res (2004) 1.24
Prevalence of COPD and its association with socioeconomic status in China: findings from China Chronic Disease Risk Factor Surveillance 2007. BMC Public Health (2011) 1.24
Reciprocity between abscisic acid and ethylene at the onset of berry ripening and after harvest. BMC Plant Biol (2010) 1.23
Up-regulation of thioredoxin interacting protein (Txnip) by p38 MAPK and FOXO1 contributes to the impaired thioredoxin activity and increased ROS in glucose-treated endothelial cells. Biochem Biophys Res Commun (2009) 1.23
GDE2 promotes neurogenesis by glycosylphosphatidylinositol-anchor cleavage of RECK. Science (2013) 1.23
Gating charges in the activation and inactivation processes of the HERG channel. J Gen Physiol (2004) 1.22
The use of a DNA biobank linked to electronic medical records to characterize pharmacogenomic predictors of tacrolimus dose requirement in kidney transplant recipients. Pharmacogenet Genomics (2012) 1.21
Negative charges in the transmembrane domains of the HERG K channel are involved in the activation- and deactivation-gating processes. J Gen Physiol (2003) 1.21
Toll-like receptor-induced innate immune responses in non-parenchymal liver cells are cell type-specific. Immunology (2009) 1.21
KCNE2 is colocalized with KCNQ1 and KCNE1 in cardiac myocytes and may function as a negative modulator of I(Ks) current amplitude in the heart. Heart Rhythm (2006) 1.20
Card9 mediates intestinal epithelial cell restitution, T-helper 17 responses, and control of bacterial infection in mice. Gastroenterology (2013) 1.19
Hepatitis C viral evolution in genotype 1 treatment-naïve and treatment-experienced patients receiving telaprevir-based therapy in clinical trials. PLoS One (2012) 1.19
Increased estrogen rather than decreased androgen action is associated with longer androgen receptor CAG repeats. J Clin Endocrinol Metab (2008) 1.19
The stomatin/prohibitin/flotillin/HflK/C domain of flotillin-1 contains distinct sequences that direct plasma membrane localization and protein interactions in 3T3-L1 adipocytes. J Biol Chem (2005) 1.18
[Prevalence of hypertension among Chinese adults in 2010]. Zhonghua Yu Fang Yi Xue Za Zhi (2012) 1.17
Autophagy is required for exercise training-induced skeletal muscle adaptation and improvement of physical performance. FASEB J (2013) 1.17
Suppression of 9-cis-epoxycarotenoid dioxygenase, which encodes a key enzyme in abscisic acid biosynthesis, alters fruit texture in transgenic tomato. Plant Physiol (2011) 1.17
Testing an intervention to promote children's adherence to asthma self-management. J Nurs Scholarsh (2007) 1.16
High rate of joint capsule matrix turnover in chronic human elbow contractures. Clin Orthop Relat Res (2005) 1.16
Robust cell migration and neuronal growth on pristine carbon nanotube sheets and yarns. J Biomater Sci Polym Ed (2007) 1.16
Molecular genetics of atrial fibrillation. J Am Coll Cardiol (2008) 1.15
Angiotensin II activates signal transducer and activators of transcription 3 via Rac1 in atrial myocytes and fibroblasts: implication for the therapeutic effect of statin in atrial structural remodeling. Circulation (2008) 1.15
Myofibroblast numbers are elevated in human elbow capsules after trauma. Clin Orthop Relat Res (2004) 1.14
Mapping the binding site of a human ether-a-go-go-related gene-specific peptide toxin (ErgTx) to the channel's outer vestibule. J Biol Chem (2002) 1.13
Serum bilirubin is inversely associated with insulin resistance and metabolic syndrome among children and adolescents. Atherosclerosis (2008) 1.13
Electroacupuncture improves neurological deficits and enhances proliferation and differentiation of endogenous nerve stem cells in rats with focal cerebral ischemia. Neurol Res (2009) 1.13