Published in PLoS Pathog on June 12, 2015
Endosome-ER Contacts Control Actin Nucleation and Retromer Function through VAP-Dependent Regulation of PI4P. Cell (2016) 0.94
Type II PI4-kinases control Weibel-Palade body biogenesis and von Willebrand factor structure in human endothelial cells. J Cell Sci (2016) 0.80
Exploiting the ubiquitin and phosphoinositide pathways by the Legionella pneumophila effector, SidC. Curr Genet (2015) 0.75
Phosphatidylinositol 4-kinase IIβ negatively regulates invadopodia formation and suppresses an invasive cellular phenotype. Mol Biol Cell (2016) 0.75
ER remodeling by the large GTPase atlastin promotes vacuolar growth of Legionella pneumophila. EMBO Rep (2017) 0.75
Direct interaction of the Golgi V-ATPase a-subunit isoform with PI(4)P drives localization of Golgi V-ATPases in yeast. Mol Biol Cell (2017) 0.75
Legionella RavZ Plays a Role in Preventing Ubiquitin Recruitment to Bacteria-Containing Vacuoles. Front Cell Infect Microbiol (2017) 0.75
Coot: model-building tools for molecular graphics. Acta Crystallogr D Biol Crystallogr (2004) 227.01
The CCP4 suite: programs for protein crystallography. Acta Crystallogr D Biol Crystallogr (1994) 187.88
Refinement of macromolecular structures by the maximum-likelihood method. Acta Crystallogr D Biol Crystallogr (1997) 137.43
Solvent content of protein crystals. J Mol Biol (1968) 106.07
Phosphoinositides in cell regulation and membrane dynamics. Nature (2006) 14.00
Rab GTPases as coordinators of vesicle traffic. Nat Rev Mol Cell Biol (2009) 13.01
Formation of a novel phagosome by the Legionnaires' disease bacterium (Legionella pneumophila) in human monocytes. J Exp Med (1983) 7.65
Legionella and Legionnaires' disease: 25 years of investigation. Clin Microbiol Rev (2002) 7.42
Conjugative transfer by the virulence system of Legionella pneumophila. Science (1998) 7.29
Two distinct defects in intracellular growth complemented by a single genetic locus in Legionella pneumophila. Mol Microbiol (1993) 5.99
Host cell killing and bacterial conjugation require overlapping sets of genes within a 22-kb region of the Legionella pneumophila genome. Proc Natl Acad Sci U S A (1998) 5.65
Association of Legionella pneumophila with the macrophage endoplasmic reticulum. Infect Immun (1995) 5.35
FAPPs control Golgi-to-cell-surface membrane traffic by binding to ARF and PtdIns(4)P. Nat Cell Biol (2004) 4.85
Multiple substrates of the Legionella pneumophila Dot/Icm system identified by interbacterial protein transfer. Proc Natl Acad Sci U S A (2004) 4.27
The Legionella pneumophila replication vacuole: making a cosy niche inside host cells. Nat Rev Microbiol (2008) 4.09
Legionella phagosomes intercept vesicular traffic from endoplasmic reticulum exit sites. Nat Cell Biol (2002) 3.98
Membrane-protein interactions in cell signaling and membrane trafficking. Annu Rev Biophys Biomol Struct (2005) 3.97
Legionella pneumophila proteins that regulate Rab1 membrane cycling. Nature (2007) 3.81
Interaction between the legionnaires' disease bacterium (Legionella pneumophila) and human alveolar macrophages. Influence of antibody, lymphokines, and hydrocortisone. J Clin Invest (1984) 3.59
Identification of pleckstrin-homology-domain-containing proteins with novel phosphoinositide-binding specificities. Biochem J (2000) 3.53
Targeting of Golgi-specific pleckstrin homology domains involves both PtdIns 4-kinase-dependent and -independent components. Curr Biol (2002) 3.23
The Legionella pneumophila LidA protein: a translocated substrate of the Dot/Icm system associated with maintenance of bacterial integrity. Mol Microbiol (2003) 3.20
A comparative analysis of the phosphoinositide binding specificity of pleckstrin homology domains. J Biol Chem (1997) 3.19
The Legionella pneumophila effector protein DrrA is a Rab1 guanine nucleotide-exchange factor. Nat Cell Biol (2006) 3.08
Targeting of host Rab GTPase function by the intravacuolar pathogen Legionella pneumophila. Dev Cell (2006) 3.06
How the parasitic bacterium Legionella pneumophila modifies its phagosome and transforms it into rough ER: implications for conversion of plasma membrane to the ER membrane. J Cell Sci (2001) 2.83
The Legionella effector protein DrrA AMPylates the membrane traffic regulator Rab1b. Science (2010) 2.73
Conformational flexibility underlies ubiquitin ligation mediated by the WWP1 HECT domain E3 ligase. Mol Cell (2003) 2.69
Insights into ubiquitin transfer cascades from a structure of a UbcH5B approximately ubiquitin-HECT(NEDD4L) complex. Mol Cell (2009) 2.58
Modulation of Rab GTPase function by a protein phosphocholine transferase. Nature (2011) 2.44
RNA interference analysis of Legionella in Drosophila cells: exploitation of early secretory apparatus dynamics. PLoS Pathog (2006) 2.44
A plasma membrane pool of phosphatidylinositol 4-phosphate is generated by phosphatidylinositol 4-kinase type-III alpha: studies with the PH domains of the oxysterol binding protein and FAPP1. Mol Biol Cell (2005) 2.39
Comprehensive identification of protein substrates of the Dot/Icm type IV transporter of Legionella pneumophila. PLoS One (2011) 2.37
Rab1 guanine nucleotide exchange factor SidM is a major phosphatidylinositol 4-phosphate-binding effector protein of Legionella pneumophila. J Biol Chem (2008) 2.11
De-AMPylation of the small GTPase Rab1 by the pathogen Legionella pneumophila. Science (2011) 1.98
Legionella pneumophila SidD is a deAMPylase that modifies Rab1. Nature (2011) 1.96
Legionella pneumophila exploits PI(4)P to anchor secreted effector proteins to the replicative vacuole. PLoS Pathog (2006) 1.94
The multiple roles of PtdIns(4)P -- not just the precursor of PtdIns(4,5)P2. J Cell Sci (2008) 1.89
Multiple pools of phosphatidylinositol 4-phosphate detected using the pleckstrin homology domain of Osh2p. J Biol Chem (2004) 1.88
Structure of the Shigella T3SS effector IpaH defines a new class of E3 ubiquitin ligases. Nat Struct Mol Biol (2008) 1.65
Coordination of Golgi functions by phosphatidylinositol 4-kinases. Trends Cell Biol (2010) 1.64
Inhibition of host vacuolar H+-ATPase activity by a Legionella pneumophila effector. PLoS Pathog (2010) 1.59
Conditional peripheral membrane proteins: facing up to limited specificity. Structure (2011) 1.55
The Legionella pneumophila effector SidJ is required for efficient recruitment of endoplasmic reticulum proteins to the bacterial phagosome. Infect Immun (2006) 1.54
The Legionella pneumophila phosphatidylinositol-4 phosphate-binding type IV substrate SidC recruits endoplasmic reticulum vesicles to a replication-permissive vacuole. Cell Microbiol (2008) 1.46
Legionella pneumophila regulates the small GTPase Rab1 activity by reversible phosphorylcholination. Proc Natl Acad Sci U S A (2011) 1.42
Members of a Legionella pneumophila family of proteins with ExoU (phospholipase A) active sites are translocated to target cells. Infect Immun (2006) 1.36
Structural mechanism of host Rab1 activation by the bifunctional Legionella type IV effector SidM/DrrA. Proc Natl Acad Sci U S A (2010) 1.35
Immunocytochemical localization of the Golgi apparatus using protein-specific antibodies to galactosyltransferase. Eur J Cell Biol (1991) 1.35
A novel probe for phosphatidylinositol 4-phosphate reveals multiple pools beyond the Golgi. J Cell Biol (2014) 1.31
Expression and characterization of an inositol 1,4,5-trisphosphate binding domain of phosphatidylinositol-specific phospholipase C-delta 1. J Biol Chem (1994) 1.29
Molecular basis of phosphatidylinositol 4-phosphate and ARF1 GTPase recognition by the FAPP1 pleckstrin homology (PH) domain. J Biol Chem (2011) 1.21
AMoRe: classical and modern. Acta Crystallogr D Biol Crystallogr (2007) 1.19
The use of liposomes to study COPII- and COPI-coated vesicle formation and membrane protein sorting. Methods (2000) 1.15
High-affinity binding of phosphatidylinositol 4-phosphate by Legionella pneumophila DrrA. EMBO Rep (2010) 1.14
The inositol polyphosphate 5-phosphatase OCRL1 restricts intracellular growth of Legionella, localizes to the replicative vacuole and binds to the bacterial effector LpnE. Cell Microbiol (2008) 1.11
Structural basis for substrate recognition by a unique Legionella phosphoinositide phosphatase. Proc Natl Acad Sci U S A (2012) 1.07
A Rab-centric perspective of bacterial pathogen-occupied vacuoles. Cell Host Microbe (2013) 1.05
Crystal structures of two bacterial HECT-like E3 ligases in complex with a human E2 reveal atomic details of pathogen-host interactions. Proc Natl Acad Sci U S A (2012) 0.98
Bacterial pathogen manipulation of host membrane trafficking. Annu Rev Cell Dev Biol (2014) 0.97
The Legionella effector SidC defines a unique family of ubiquitin ligases important for bacterial phagosomal remodeling. Proc Natl Acad Sci U S A (2014) 0.93
Legionella pneumophila subversion of host vesicular transport by SidC effector proteins. Traffic (2014) 0.93
Live-cell imaging of phosphoinositide dynamics and membrane architecture during Legionella infection. MBio (2014) 0.92
Identification and structural characterization of a Legionella phosphoinositide phosphatase. J Biol Chem (2013) 0.91
The machinery at endoplasmic reticulum-plasma membrane contact sites contributes to spatial regulation of multiple Legionella effector proteins. PLoS Pathog (2014) 0.86
The structure of the N-terminal domain of the Legionella protein SidC. J Struct Biol (2014) 0.84
Structural basis for PI(4)P-specific membrane recruitment of the Legionella pneumophila effector DrrA/SidM. Structure (2014) 0.78
Type VI Secretion System Transports Zn2+ to Combat Multiple Stresses and Host Immunity. PLoS Pathog (2015) 0.88
Sensing cytosolic RpsL by macrophages induces lysosomal cell death and termination of bacterial infection. PLoS Pathog (2015) 0.77
Molecular basis for the binding and modulation of V-ATPase by a bacterial effector protein. PLoS Pathog (2017) 0.75