Legionella pneumophila regulates the small GTPase Rab1 activity by reversible phosphorylcholination.

PubWeight™: 1.42‹?› | Rank: Top 5%

🔗 View Article (PMC 3248503)

Published in Proc Natl Acad Sci U S A on December 07, 2011

Authors

Yunhao Tan1, Randy J Arnold, Zhao-Qing Luo

Author Affiliations

1: Department of Biological Sciences, Purdue University, West Lafayette, IN 47907, USA.

Articles citing this

Ubiquitination independent of E1 and E2 enzymes by bacterial effectors. Nature (2016) 1.56

Exploitation of evolutionarily conserved amoeba and mammalian processes by Legionella. Trends Microbiol (2012) 1.16

Reversible phosphocholination of Rab proteins by Legionella pneumophila effector proteins. EMBO J (2012) 1.14

Cell biology of infection by Legionella pneumophila. Microbes Infect (2012) 1.10

Master manipulators: an update on Legionella pneumophila Icm/Dot translocated substrates and their host targets. Future Microbiol (2014) 1.06

A Rab-centric perspective of bacterial pathogen-occupied vacuoles. Cell Host Microbe (2013) 1.05

VipD of Legionella pneumophila targets activated Rab5 and Rab22 to interfere with endosomal trafficking in macrophages. PLoS Pathog (2012) 1.00

Identification of Coxiella burnetii type IV secretion substrates required for intracellular replication and Coxiella-containing vacuole formation. J Bacteriol (2013) 1.00

Doc toxin is a kinase that inactivates elongation factor Tu. J Biol Chem (2014) 0.99

Microbial modulation of host immunity with the small molecule phosphorylcholine. Infect Immun (2012) 0.96

Legionella pneumophila LidA affects nucleotide binding and activity of the host GTPase Rab1. J Bacteriol (2012) 0.95

Mechanism of Rab1b deactivation by the Legionella pneumophila GAP LepB. EMBO Rep (2013) 0.95

A novel link between Fic (filamentation induced by cAMP)-mediated adenylylation/AMPylation and the unfolded protein response. J Biol Chem (2015) 0.94

Identification of two Legionella pneumophila effectors that manipulate host phospholipids biosynthesis. PLoS Pathog (2012) 0.92

Posttranslational modifications of Rab proteins cause effective displacement of GDP dissociation inhibitor. Proc Natl Acad Sci U S A (2012) 0.92

Mass spectrometry-based proteomic approaches to study pathogenic bacteria-host interactions. Protein Cell (2015) 0.92

Activation of Ran GTPase by a Legionella effector promotes microtubule polymerization, pathogen vacuole motility and infection. PLoS Pathog (2013) 0.91

Structural basis of substrate recognition by a bacterial deubiquitinase important for dynamics of phagosome ubiquitination. Proc Natl Acad Sci U S A (2015) 0.90

Targeting of host organelles by pathogenic bacteria: a sophisticated subversion strategy. Nat Rev Microbiol (2015) 0.88

AMPylation is critical for Rab1 localization to vacuoles containing Legionella pneumophila. MBio (2014) 0.87

The machinery at endoplasmic reticulum-plasma membrane contact sites contributes to spatial regulation of multiple Legionella effector proteins. PLoS Pathog (2014) 0.86

Identification of novel Coxiella burnetii Icm/Dot effectors and genetic analysis of their involvement in modulating a mitogen-activated protein kinase pathway. Infect Immun (2014) 0.85

Toxicity and SidJ-Mediated Suppression of Toxicity Require Distinct Regions in the SidE Family of Legionella pneumophila Effectors. Infect Immun (2015) 0.85

Diverse mechanisms of metaeffector activity in an intracellular bacterial pathogen, Legionella pneumophila. Mol Syst Biol (2016) 0.85

Structure of the Legionella Virulence Factor, SidC Reveals a Unique PI(4)P-Specific Binding Domain Essential for Its Targeting to the Bacterial Phagosome. PLoS Pathog (2015) 0.84

Post-translational modifications are key players of the Legionella pneumophila infection strategy. Front Microbiol (2015) 0.84

Characterization of enzymes from Legionella pneumophila involved in reversible adenylylation of Rab1 protein. J Biol Chem (2012) 0.83

The Legionella Kinase LegK2 Targets the ARP2/3 Complex To Inhibit Actin Nucleation on Phagosomes and Allow Bacterial Evasion of the Late Endocytic Pathway. MBio (2015) 0.82

Posttranslational modifications of Rab GTPases help their insertion into membranes. Proc Natl Acad Sci U S A (2012) 0.81

Structural basis for Rab1 de-AMPylation by the Legionella pneumophila effector SidD. PLoS Pathog (2013) 0.81

A Legionella effector modulates host cytoskeletal structure by inhibiting actin polymerization. Microbes Infect (2013) 0.81

Structural analyses of Legionella LepB reveal a new GAP fold that catalytically mimics eukaryotic RasGAP. Cell Res (2013) 0.81

Elucidating Host-Pathogen Interactions Based on Post-Translational Modifications Using Proteomics Approaches. Front Microbiol (2015) 0.81

Structure and function of Fic proteins. Nat Rev Microbiol (2015) 0.79

Lpg0393 of Legionella pneumophila is a guanine-nucleotide exchange factor for Rab5, Rab21 and Rab22. PLoS One (2015) 0.79

A Legionella Effector Disrupts Host Cytoskeletal Structure by Cleaving Actin. PLoS Pathog (2017) 0.77

The Type IV Secretion System Effector Protein CirA Stimulates the GTPase Activity of RhoA and Is Required for Virulence in a Mouse Model of Coxiella burnetii Infection. Infect Immun (2016) 0.77

Endoplasmic Reticulum Tubule Protein Reticulon 4 Associates with the Legionella pneumophila Vacuole and with Translocated Substrate Ceg9. Infect Immun (2015) 0.77

Induction of rapid cell death by an environmental isolate of Legionella pneumophila in mouse macrophages. Infect Immun (2013) 0.77

Innate immunity kinase TAK1 phosphorylates Rab1 on a hotspot for posttranslational modifications by host and pathogen. Proc Natl Acad Sci U S A (2016) 0.77

Beyond Rab GTPases Legionella activates the small GTPase Ran to promote microtubule polymerization, pathogen vacuole motility, and infection. Small GTPases (2014) 0.76

Subversion of Cell-Autonomous Immunity and Cell Migration by Legionella pneumophila Effectors. Front Immunol (2015) 0.76

Yersinia pestis Requires Host Rab1b for Survival in Macrophages. PLoS Pathog (2015) 0.76

Type II Secretion Is Necessary for Optimal Association of the Legionella-Containing Vacuole with Macrophage Rab1B but Enhances Intracellular Replication Mainly by Rab1B-Independent Mechanisms. Infect Immun (2016) 0.76

A unique deubiquitinase that deconjugates phosphoribosyl-linked protein ubiquitination. Cell Res (2017) 0.75

Dot/Icm Effector Translocation by Legionella longbeachae Creates a Replicative Vacuole Similar to That of Legionella pneumophila despite Translocation of Distinct Effector Repertoires. Infect Immun (2015) 0.75

Host FIH-Mediated Asparaginyl Hydroxylation of Translocated Legionella pneumophila Effectors. Front Cell Infect Microbiol (2017) 0.75

Life Stage-specific Proteomes of Legionella pneumophila Reveal a Highly Differential Abundance of Virulence-associated Dot/Icm effectors. Mol Cell Proteomics (2015) 0.75

How Bacteria Subvert Animal Cell Structure and Function. Annu Rev Cell Dev Biol (2016) 0.75

Conserved ion and amino acid transporters identified as phosphorylcholine-modified N-glycoproteins by metabolic labeling with propargylcholine in Caenorhabditis elegans cells. Glycobiology (2014) 0.75

Legionella and Coxiella effectors: strength in diversity and activity. Nat Rev Microbiol (2017) 0.75

Articles cited by this

Two distinct defects in intracellular growth complemented by a single genetic locus in Legionella pneumophila. Mol Microbiol (1993) 5.99

Multiple substrates of the Legionella pneumophila Dot/Icm system identified by interbacterial protein transfer. Proc Natl Acad Sci U S A (2004) 4.27

The genomic sequence of the accidental pathogen Legionella pneumophila. Science (2004) 4.08

Legionella phagosomes intercept vesicular traffic from endoplasmic reticulum exit sites. Nat Cell Biol (2002) 3.98

Legionella pneumophila proteins that regulate Rab1 membrane cycling. Nature (2007) 3.81

Identification and structure of four yeast genes (SLY) that are able to suppress the functional loss of YPT1, a member of the RAS superfamily. Mol Cell Biol (1991) 3.68

Ankyrin repeat proteins comprise a diverse family of bacterial type IV effectors. Science (2008) 3.58

The Legionella pneumophila LidA protein: a translocated substrate of the Dot/Icm system associated with maintenance of bacterial integrity. Mol Microbiol (2003) 3.20

Targeting of host Rab GTPase function by the intravacuolar pathogen Legionella pneumophila. Dev Cell (2006) 3.06

Modulation of host cell function by Legionella pneumophila type IV effectors. Annu Rev Cell Dev Biol (2010) 2.92

How the parasitic bacterium Legionella pneumophila modifies its phagosome and transforms it into rough ER: implications for conversion of plasma membrane to the ER membrane. J Cell Sci (2001) 2.83

The Legionella effector protein DrrA AMPylates the membrane traffic regulator Rab1b. Science (2010) 2.73

Legionella subvert the functions of Rab1 and Sec22b to create a replicative organelle. J Exp Med (2004) 2.67

A bifunctional bacterial protein links GDI displacement to Rab1 activation. Science (2007) 2.60

Assembly of the ER to Golgi SNARE complex requires Uso1p. J Cell Biol (1996) 2.57

Modulation of Rab GTPase function by a protein phosphocholine transferase. Nature (2011) 2.44

RNA interference analysis of Legionella in Drosophila cells: exploitation of early secretory apparatus dynamics. PLoS Pathog (2006) 2.44

Comprehensive identification of protein substrates of the Dot/Icm type IV transporter of Legionella pneumophila. PLoS One (2011) 2.37

Protein interactions regulating vesicle transport between the endoplasmic reticulum and Golgi apparatus in mammalian cells. Cell (1997) 2.26

Legionella pneumophila replication vacuole formation involves rapid recruitment of proteins of the early secretory system. Infect Immun (2004) 2.25

Legionella metaeffector exploits host proteasome to temporally regulate cognate effector. PLoS Pathog (2010) 2.09

De-AMPylation of the small GTPase Rab1 by the pathogen Legionella pneumophila. Science (2011) 1.98

Legionella pneumophila SidD is a deAMPylase that modifies Rab1. Nature (2011) 1.96

RabGDI displacement by DrrA from Legionella is a consequence of its guanine nucleotide exchange activity. Mol Cell (2009) 1.94

Genome-scale identification of Legionella pneumophila effectors using a machine learning approach. PLoS Pathog (2009) 1.94

Inhibition of host vacuolar H+-ATPase activity by a Legionella pneumophila effector. PLoS Pathog (2010) 1.59

Minimization of the Legionella pneumophila genome reveals chromosomal regions involved in host range expansion. Proc Natl Acad Sci U S A (2011) 1.50

Large-scale identification of Legionella pneumophila Dot/Icm substrates that modulate host cell vesicle trafficking pathways. Cell Microbiol (2008) 1.47

The Legionella pneumophila PilT homologue DotB exhibits ATPase activity that is critical for intracellular growth. J Bacteriol (2004) 1.39

Bet1p activates the v-SNARE Bos1p. Mol Biol Cell (1997) 1.39

Targeting eEF1A by a Legionella pneumophila effector leads to inhibition of protein synthesis and induction of host stress response. Cell Microbiol (2009) 1.36

AMPylation: Something Old is New Again. Front Microbiol (2010) 1.29

Comparative analysis of Histophilus somni immunoglobulin-binding protein A (IbpA) with other fic domain-containing enzymes reveals differences in substrate and nucleotide specificities. J Biol Chem (2011) 1.15

Adenylylation: renaissance of a forgotten post-translational modification. Trends Biochem Sci (2011) 1.09

Identification of a novel mammalian post-translational modification, phosphocholine, on placental secretory polypeptides. J Mol Endocrinol (2007) 0.92

Searching new targets for anthelminthic strategies: Interference with glycosphingolipid biosynthesis and phosphorylcholine metabolism affects development of Caenorhabditis elegans. Int J Parasitol (2005) 0.89

Immunomodulation by phosphocholine--biosynthesis, structures and immunological implications of parasitic PC-epitopes. Mol Immunol (2009) 0.87

Articles by these authors

A computational approach toward label-free protein quantification using predicted peptide detectability. Bioinformatics (2006) 2.48

Comprehensive identification of protein substrates of the Dot/Icm type IV transporter of Legionella pneumophila. PLoS One (2011) 2.37

Legionella pneumophila inhibits macrophage apoptosis by targeting pro-death members of the Bcl2 protein family. Proc Natl Acad Sci U S A (2007) 1.96

Legionella pneumophila SidD is a deAMPylase that modifies Rab1. Nature (2011) 1.96

Secreted bacterial effectors that inhibit host protein synthesis are critical for induction of the innate immune response to virulent Legionella pneumophila. PLoS Pathog (2011) 1.78

Large-scale identification and translocation of type IV secretion substrates by Coxiella burnetii. Proc Natl Acad Sci U S A (2010) 1.67

Inhibition of host vacuolar H+-ATPase activity by a Legionella pneumophila effector. PLoS Pathog (2010) 1.59

The Legionella pneumophila effector SidJ is required for efficient recruitment of endoplasmic reticulum proteins to the bacterial phagosome. Infect Immun (2006) 1.54

The E Block motif is associated with Legionella pneumophila translocated substrates. Cell Microbiol (2010) 1.51

Targeting eEF1A by a Legionella pneumophila effector leads to inhibition of protein synthesis and induction of host stress response. Cell Microbiol (2009) 1.36

Members of a Legionella pneumophila family of proteins with ExoU (phospholipase A) active sites are translocated to target cells. Infect Immun (2006) 1.36

Influences of capsule on cell shape and chain formation of wild-type and pcsB mutants of serotype 2 Streptococcus pneumoniae. J Bacteriol (2009) 1.33

A bayesian approach to protein inference problem in shotgun proteomics. J Comput Biol (2009) 1.26

A proteomic survey of rat cerebral cortical synaptosomes. Proteomics (2005) 1.16

Advancement in protein inference from shotgun proteomics using peptide detectability. Pac Symp Biocomput (2007) 1.15

Unnatural amino acid substitution as a probe of the allosteric coupling pathway in a mycobacterial Cu(I) sensor. J Am Chem Soc (2009) 1.14

A cancer-associated PCNA expressed in breast cancer has implications as a potential biomarker. Proc Natl Acad Sci U S A (2006) 1.13

The discovery of labile methyl esters on proliferating cell nuclear antigen by MS/MS. Proteomics (2006) 1.12

AidH, an alpha/beta-hydrolase fold family member from an Ochrobactrum sp. strain, is a novel N-acylhomoserine lactonase. Appl Environ Microbiol (2010) 1.11

Cell biology of infection by Legionella pneumophila. Microbes Infect (2012) 1.10

Mapping the proteome of Drosophila melanogaster: analysis of embryos and adult heads by LC-IMS-MS methods. J Proteome Res (2005) 1.10

Helicobacter pylori vacuolating cytotoxin A (VacA) engages the mitochondrial fission machinery to induce host cell death. Proc Natl Acad Sci U S A (2011) 1.08

Structural basis for substrate recognition by a unique Legionella phosphoinositide phosphatase. Proc Natl Acad Sci U S A (2012) 1.07

An in vivo gene deletion system for determining temporal requirement of bacterial virulence factors. Proc Natl Acad Sci U S A (2008) 1.03

Phosphatidylcholine synthesis is required for optimal function of Legionella pneumophila virulence determinants. Cell Microbiol (2007) 1.00

Identification of Coxiella burnetii type IV secretion substrates required for intracellular replication and Coxiella-containing vacuole formation. J Bacteriol (2013) 1.00

Modulation of differentiation-related gene 1 expression by cell cycle blocker mimosine, revealed by proteomic analysis. Mol Cell Proteomics (2005) 0.95

HIP2: an online database of human plasma proteins from healthy individuals. BMC Med Genomics (2008) 0.93

The scaffolding and signalling functions of a localization factor impact polar development. Mol Microbiol (2012) 0.90

The importance of peptide detectability for protein identification, quantification, and experiment design in MS/MS proteomics. J Proteome Res (2010) 0.90

Domains formed within the N-terminal region of the quorum-sensing activator TraR are required for transcriptional activation and direct interaction with RpoA from agrobacterium. J Biol Chem (2004) 0.88

Combinatorial libraries of synthetic peptides as a model for shotgun proteomics. Anal Chem (2010) 0.88

Role of conserved cysteines in the alphavirus E3 protein. J Virol (2008) 0.87

Fast and accurate identification of semi-tryptic peptides in shotgun proteomics. Bioinformatics (2007) 0.86

Induction of caspase 3 activation by multiple Legionella pneumophila Dot/Icm substrates. Cell Microbiol (2013) 0.85

Changes in liver protein abundance in inbred alcohol-preferring rats due to chronic alcohol exposure, as measured through a proteomics approach. Proteomics (2006) 0.85

Co-ordinate synthesis and protein localization in a bacterial organelle by the action of a penicillin-binding-protein. Mol Microbiol (2013) 0.84

On the accuracy and limits of peptide fragmentation spectrum prediction. Anal Chem (2010) 0.83

Selenite and tellurite form mixed seleno- and tellurotrisulfides with CstR from Staphylococcus aureus. Metallomics (2013) 0.82

Human ABCC1 interacts and colocalizes with ATP synthase α, revealed by interactive proteomics analysis. J Proteome Res (2012) 0.80

The packaging of different cargo into enveloped viral nanoparticles. Mol Pharm (2012) 0.80

Genome Sequence of an Environmental Isolate of the Bacterial Pathogen Legionella pneumophila. Genome Announc (2013) 0.79

On the split personality of penultimate proline. J Am Soc Mass Spectrom (2014) 0.79

Take it and release it: The use of the Rab1 small GTPase at a bacterium's will. Cell Logist (2011) 0.79

Identification of interacting regions within the coiled coil of the Escherichia coli structural maintenance of chromosomes protein MukB. J Mol Biol (2009) 0.78

Induction of rapid cell death by an environmental isolate of Legionella pneumophila in mouse macrophages. Infect Immun (2013) 0.77

Elucidating the biochemical overwintering adaptations of Larval Cucujus clavipes puniceus, a nonmodel organism, via high throughput proteomics. J Proteome Res (2011) 0.77

Methods for determining protein translocation by the Legionella pneumophila Dot/Icm type IV secretion system. Methods Mol Biol (2013) 0.76

Effector translocation by the Legionella Dot/Icm type IV secretion system. Curr Top Microbiol Immunol (2013) 0.75

Extending the coverage of spectral libraries: a neighbor-based approach to predicting intensities of peptide fragmentation spectra. Proteomics (2013) 0.75

Legionella pneumophila infection of Drosophila S2 cells induces only minor changes in mitochondrial dynamics. PLoS One (2013) 0.75

Investigation of VUV Photodissociation Propensities Using Peptide Libraries. Int J Mass Spectrom (2011) 0.75

Investigating the deep supercooling ability of an Alaskan beetle, Cucujus clavipes puniceus, via high throughput proteomics. J Proteomics (2011) 0.75