Published in Nat Genet on July 05, 2009
Genome-wide association study identifies five new breast cancer susceptibility loci. Nat Genet (2010) 7.62
A novel recurrent mutation in MITF predisposes to familial and sporadic melanoma. Nature (2011) 2.96
Genome-wide association study identifies variants at 9p21 and 22q13 associated with development of cutaneous nevi. Nat Genet (2009) 2.65
Variation in CDKN2A at 9p21.3 influences childhood acute lymphoblastic leukemia risk. Nat Genet (2010) 2.47
Variant of TYR and autoimmunity susceptibility loci in generalized vitiligo. N Engl J Med (2010) 2.47
An integration of genome-wide association study and gene expression profiling to prioritize the discovery of novel susceptibility Loci for osteoporosis-related traits. PLoS Genet (2010) 2.43
Comparing strategies to fine-map the association of common SNPs at chromosome 9p21 with type 2 diabetes and myocardial infarction. Nat Genet (2011) 2.42
Chromosome 9p21 SNPs Associated with Multiple Disease Phenotypes Correlate with ANRIL Expression. PLoS Genet (2010) 2.39
Genome-wide association study identifies three new melanoma susceptibility loci. Nat Genet (2011) 2.29
Genome-wide association study identifies novel loci predisposing to cutaneous melanoma. Hum Mol Genet (2011) 2.26
Expression of p16(INK4a) prevents cancer and promotes aging in lymphocytes. Blood (2011) 2.16
Architecture of inherited susceptibility to common cancer. Nat Rev Cancer (2010) 2.14
Interpretation of association signals and identification of causal variants from genome-wide association studies. Am J Hum Genet (2010) 2.06
A compendium of genome-wide associations for cancer: critical synopsis and reappraisal. J Natl Cancer Inst (2010) 2.00
The molecular pathology of cancer. Nat Rev Clin Oncol (2010) 1.86
Beyond genome-wide association studies: genetic heterogeneity and individual predisposition to cancer. Trends Genet (2010) 1.83
The melanomas: a synthesis of epidemiological, clinical, histopathological, genetic, and biological aspects, supporting distinct subtypes, causal pathways, and cells of origin. Pigment Cell Melanoma Res (2011) 1.81
Cis-acting noncoding RNAs: friends and foes. Nat Struct Mol Biol (2012) 1.73
Association of single nucleotide polymorphisms on chromosome 9p21.3 with platelet reactivity: a potential mechanism for increased vascular disease. Circ Cardiovasc Genet (2010) 1.64
GRASP: analysis of genotype-phenotype results from 1390 genome-wide association studies and corresponding open access database. Bioinformatics (2014) 1.64
A genome-wide association study identifies genetic variants in the CDKN2BAS locus associated with endometriosis in Japanese. Nat Genet (2010) 1.57
IRF4 variants have age-specific effects on nevus count and predispose to melanoma. Am J Hum Genet (2010) 1.55
Increased risk of second primary cancers after a diagnosis of melanoma. Arch Dermatol (2010) 1.48
Genetic factors associated with naevus count and dermoscopic patterns: preliminary results from the Study of Nevi in Children (SONIC). Br J Dermatol (2015) 1.47
Genome-wide association study identifies a new melanoma susceptibility locus at 1q21.3. Nat Genet (2011) 1.46
Genome-wide association studies of cancer. J Clin Oncol (2010) 1.45
Long non-coding RNAs in cancer progression. Front Genet (2012) 1.40
Genetic architecture of cancer and other complex diseases: lessons learned and future directions. Carcinogenesis (2011) 1.39
The melanoma revolution: from UV carcinogenesis to a new era in therapeutics. Science (2014) 1.37
Genome-wide association studies of pigmentation and skin cancer: a review and meta-analysis. Pigment Cell Melanoma Res (2010) 1.28
Variants affecting exon skipping contribute to complex traits. PLoS Genet (2012) 1.24
Relationship between sun exposure and melanoma risk for tumours in different body sites in a large case-control study in a temperate climate. Eur J Cancer (2011) 1.24
Genome-wide meta-analysis identifies five new susceptibility loci for cutaneous malignant melanoma. Nat Genet (2015) 1.23
The molecular pathology of melanoma: an integrated taxonomy of melanocytic neoplasia. Annu Rev Pathol (2014) 1.22
Cancer and neurodegeneration: between the devil and the deep blue sea. PLoS Genet (2010) 1.21
Melanocytic nevi, nevus genes, and melanoma risk in a large case-control study in the United Kingdom. Cancer Epidemiol Biomarkers Prev (2010) 1.20
A variant in FTO shows association with melanoma risk not due to BMI. Nat Genet (2013) 1.17
Susceptibility loci for pigmentation and melanoma in relation to Parkinson's disease. Neurobiol Aging (2013) 1.17
Insights into the genetic architecture of early stage age-related macular degeneration: a genome-wide association study meta-analysis. PLoS One (2013) 1.16
Six decades of vitiligo genetics: genome-wide studies provide insights into autoimmune pathogenesis. J Invest Dermatol (2011) 1.15
The genetics of generalized vitiligo: autoimmune pathways and an inverse relationship with malignant melanoma. Genome Med (2010) 1.07
Joint analysis of three genome-wide association studies of esophageal squamous cell carcinoma in Chinese populations. Nat Genet (2014) 1.06
Integrative genomics identifies molecular alterations that challenge the linear model of melanoma progression. Cancer Res (2011) 1.06
Breed-predispositions to cancer in pedigree dogs. ISRN Vet Sci (2013) 1.06
Familial aggregation of glioma: a pooled analysis. Am J Epidemiol (2010) 1.06
The roles of microphthalmia-associated transcription factor and pigmentation in melanoma. Arch Biochem Biophys (2014) 1.05
Franklin H. Epstein Lecture. Both ends of the leash--the human links to good dogs with bad genes. N Engl J Med (2012) 1.05
Genome-wide "pleiotropy scan" identifies HNF1A region as a novel pancreatic cancer susceptibility locus. Cancer Res (2011) 1.05
A germline variant in the interferon regulatory factor 4 gene as a novel skin cancer risk locus. Cancer Res (2011) 1.04
Association of MC1R variants and host phenotypes with melanoma risk in CDKN2A mutation carriers: a GenoMEL study. J Natl Cancer Inst (2010) 1.04
Resequencing and clinical associations of the 9p21.3 region: a comprehensive investigation in the Framingham heart study. Circulation (2013) 1.03
Current aspects of vitiligo genetics. Postepy Dermatol Alergol (2014) 1.01
Update on the Epidemiology of Melanoma. Curr Dermatol Rep (2013) 1.01
Identification of Susceptibility Loci for Cutaneous Squamous Cell Carcinoma. J Invest Dermatol (2016) 1.01
Identification of a melanoma susceptibility locus and somatic mutation in TET2. Carcinogenesis (2014) 0.98
Inherited variants in the MC1R gene and survival from cutaneous melanoma: a BioGenoMEL study. Pigment Cell Melanoma Res (2012) 0.98
Methylthioadenosine (MTA) inhibits melanoma cell proliferation and in vivo tumor growth. BMC Cancer (2010) 0.98
Genetic variants at 6p21.1 and 7p15.3 are associated with risk of multiple cancers in Han Chinese. Am J Hum Genet (2012) 0.98
Inactivation of Pmel alters melanosome shape but has only a subtle effect on visible pigmentation. PLoS Genet (2011) 0.97
Associations of 9p21 variants with cutaneous malignant melanoma, nevi, and pigmentation phenotypes in melanoma-prone families with and without CDKN2A mutations. Fam Cancer (2010) 0.97
Shared genetic relationships underlying generalized vitiligo and autoimmune thyroid disease. Thyroid (2010) 0.95
A Genome-Wide Association Study Identifies the Skin Color Genes IRF4, MC1R, ASIP, and BNC2 Influencing Facial Pigmented Spots. J Invest Dermatol (2015) 0.93
Replication and predictive value of SNPs associated with melanoma and pigmentation traits in a Southern European case-control study. PLoS One (2013) 0.92
A unique genome-wide association analysis in extended Utah high-risk pedigrees identifies a novel melanoma risk variant on chromosome arm 10q. Hum Genet (2011) 0.92
Common genetic variants in the 9p21 region and their associations with multiple tumours. Br J Cancer (2013) 0.92
Addressing population-specific multiple testing burdens in genetic association studies. Ann Hum Genet (2015) 0.92
The chromosome 9p21.3 coronary heart disease risk allele is associated with altered gene expression in normal heart and vascular tissues. PLoS One (2012) 0.91
Recent progress in the genetics of generalized vitiligo. J Genet Genomics (2011) 0.91
Assessment of the 9p21.3 locus in severity of coronary artery disease in the presence and absence of type 2 diabetes. BMC Med Genet (2013) 0.90
Genetic polymorphisms in the 9p21 region associated with risk of multiple cancers. Carcinogenesis (2014) 0.90
MC1R genotype may modify the effect of sun exposure on melanoma risk in the GEM study. Cancer Causes Control (2010) 0.90
Polymorphisms in nevus-associated genes MTAP, PLA2G6, and IRF4 and the risk of invasive cutaneous melanoma. Twin Res Hum Genet (2011) 0.89
Genetic comorbidities in Parkinson's disease. Hum Mol Genet (2013) 0.89
Pathway-based analysis of a melanoma genome-wide association study: analysis of genes related to tumour-immunosuppression. PLoS One (2011) 0.88
Moderate- to low-risk variant alleles of cutaneous malignancies and nevi: lessons from genome-wide association studies. Genome Med (2009) 0.88
Inherited genetic variants associated with occurrence of multiple primary melanoma. Cancer Epidemiol Biomarkers Prev (2015) 0.88
Functional Variants in Notch Pathway Genes NCOR2, NCSTN, and MAML2 Predict Survival of Patients with Cutaneous Melanoma. Cancer Epidemiol Biomarkers Prev (2015) 0.87
Molecular genetics of coronary artery disease. J Hum Genet (2015) 0.87
Robust methods for population stratification in genome wide association studies. BMC Bioinformatics (2013) 0.87
Meta-analysis of genome-wide association studies identifies multiple lung cancer susceptibility loci in never-smoking Asian women. Hum Mol Genet (2016) 0.87
Melanoma as a subsequent neoplasm in adult survivors of childhood cancer: a report from the childhood cancer survivor study. Pediatr Blood Cancer (2012) 0.86
The use of race, ethnicity and ancestry in human genetic research. Hugo J (2011) 0.86
MC1R genotype as a predictor of early-onset melanoma, compared with self-reported and physician-measured traditional risk factors: an Australian case-control-family study. BMC Cancer (2013) 0.86
Variants at the 9p21 locus and melanoma risk. BMC Cancer (2013) 0.85
Genetic variation as a modifier of association between therapeutic exposure and subsequent malignant neoplasms in cancer survivors. Cancer (2014) 0.85
Network-based SNP meta-analysis identifies joint and disjoint genetic features across common human diseases. BMC Genomics (2012) 0.85
Promoter polymorphisms in matrix metallopeptidase 1 and risk of cutaneous melanoma. Eur J Cancer (2010) 0.84
Influence of genetic variants in type I interferon genes on melanoma survival and therapy. PLoS One (2012) 0.84
Fine mapping of genetic susceptibility loci for melanoma reveals a mixture of single variant and multiple variant regions. Int J Cancer (2014) 0.84
Biologic markers of sun exposure and melanoma risk in women: pooled case-control analysis. Int J Cancer (2010) 0.84
Copy number loss of the interferon gene cluster in melanomas is linked to reduced T cell infiltrate and poor patient prognosis. PLoS One (2014) 0.84
Pigmentary traits, family history of melanoma and the risk of endometriosis: a cohort study of US women. Int J Epidemiol (2014) 0.83
The delicate balance of melanoma immunotherapy. Clin Transl Immunology (2013) 0.83
Replication of associations between GWAS SNPs and melanoma risk in the Population Architecture Using Genomics and Epidemiology (PAGE) Study. J Invest Dermatol (2014) 0.83
Hereditary genodermatoses with cancer predisposition. Hematol Oncol Clin North Am (2010) 0.83
Vitamin D and melanoma. Dermatoendocrinol (2013) 0.82
Integrated pathway and epistasis analysis reveals interactive effect of genetic variants at TERF1 and AFAP1L2 loci on melanoma risk. Int J Cancer (2015) 0.82
Association between melanocytic nevi and risk of breast diseases: The French E3N prospective cohort. PLoS Med (2014) 0.82
Transposon mutagenesis identifies genetic drivers of Braf(V600E) melanoma. Nat Genet (2015) 0.82
Molecular bases of cutaneous and uveal melanomas. Patholog Res Int (2011) 0.81
PLINK: a tool set for whole-genome association and population-based linkage analyses. Am J Hum Genet (2007) 209.92
Genome-wide association study of 14,000 cases of seven common diseases and 3,000 shared controls. Nature (2007) 144.95
Haploview: analysis and visualization of LD and haplotype maps. Bioinformatics (2004) 125.23
Principal components analysis corrects for stratification in genome-wide association studies. Nat Genet (2006) 115.71
A new multipoint method for genome-wide association studies by imputation of genotypes. Nat Genet (2007) 52.68
Population structure and eigenanalysis. PLoS Genet (2006) 37.21
Genes mirror geography within Europe. Nature (2008) 14.23
Polygenic inheritance of breast cancer: Implications for design of association studies. Genet Epidemiol (2003) 4.94
A genome-wide association study identifies novel alleles associated with hair color and skin pigmentation. PLoS Genet (2008) 4.57
ASIP and TYR pigmentation variants associate with cutaneous melanoma and basal cell carcinoma. Nat Genet (2008) 3.90
Common sequence variants on 20q11.22 confer melanoma susceptibility. Nat Genet (2008) 3.79
Analysis of the p16 gene (CDKN2) as a candidate for the chromosome 9p melanoma susceptibility locus. Nat Genet (1994) 3.05
Melanoma and sun exposure: an overview of published studies. Int J Cancer (1997) 2.65
Testing for association on the X chromosome. Biostatistics (2008) 2.55
High frequency of multiple melanomas and breast and pancreas carcinomas in CDKN2A mutation-positive melanoma families. J Natl Cancer Inst (2000) 2.41
MC1R variants, melanoma and red hair color phenotype: a meta-analysis. Int J Cancer (2008) 2.37
Combined effects of obesity, acid reflux and smoking on the risk of adenocarcinomas of the oesophagus. Gut (2007) 2.28
Features associated with germline CDKN2A mutations: a GenoMEL study of melanoma-prone families from three continents. J Med Genet (2006) 2.17
Screening of germline mutations in the CDKN2A and CDKN2B genes in Swedish families with hereditary cutaneous melanoma. J Natl Cancer Inst (1997) 1.91
Population-based study of natural variation in the melanocortin-1 receptor gene and melanoma. Cancer Res (2006) 1.80
Risk of cutaneous melanoma in relation to the numbers, types and sites of naevi: a case-control study. Br J Cancer (1996) 1.71
The Queensland Study of Melanoma: environmental and genetic associations (Q-MEGA); study design, baseline characteristics, and repeatability of phenotype and sun exposure measures. Twin Res Hum Genet (2008) 1.71
The prevalence of CDKN2A germ-line mutations and relative risk for cutaneous malignant melanoma: an international population-based study. Cancer Epidemiol Biomarkers Prev (2006) 1.51
A pooled analysis of melanocytic nevus phenotype and the risk of cutaneous melanoma at different latitudes. Int J Cancer (2009) 1.51
Cutaneous melanoma in women. I. Exposure to sunlight, ability to tan, and other risk factors related to ultraviolet light. Am J Epidemiol (1995) 1.44
Pigmentary characteristics and moles in relation to melanoma risk. Int J Cancer (2005) 1.40
Influence of genes, nevi, and sun sensitivity on melanoma risk in a family sample unselected by family history and in melanoma-prone families. J Natl Cancer Inst (2004) 1.25
Cutaneous malignant melanoma in women. Phenotypic characteristics, sun exposure, and hormonal factors: a case-control study from Italy. Ann Epidemiol (2005) 1.24
Role of the CDKN2A locus in patients with multiple primary melanomas. J Clin Oncol (2005) 1.22
Increased incidence of melanoma in renal transplantation recipients. Cancer (2005) 1.17
Cutaneous melanoma in women. II. Phenotypic characteristics and other host-related factors. Am J Epidemiol (1995) 1.14
Analysis of the p16 gene, CDKN2, in 17 Australian melanoma kindreds. Oncogene (1995) 1.11
CDKN2A (P16(INK4a)) and CDK4 mutation analysis in 131 Australian melanoma probands: effect of family history and multiple primary melanomas. Genes Chromosomes Cancer (1999) 1.11
Genotype/phenotype and penetrance studies in melanoma families with germline CDKN2A mutations. J Invest Dermatol (2000) 1.03
Common variants of DNA repair genes and malignant melanoma. Eur J Cancer (2007) 1.02
Mutation testing in melanoma families: INK4A, CDK4 and INK4D. Br J Cancer (1999) 1.01
Genetic susceptibility in familial melanoma from northeastern Italy. J Med Genet (2004) 0.98
CDKN2A mutations and MC1R variants in Italian patients with single or multiple primary melanoma. Pigment Cell Melanoma Res (2008) 0.96
Genetic predisposition to cancer. Important Adv Oncol (1991) 0.94
Prevalence of variations in melanoma susceptibility genes among Slovenian melanoma families. BMC Med Genet (2008) 0.84
Common SNPs explain a large proportion of the heritability for human height. Nat Genet (2010) 35.02
Genome-wide association defines more than 30 distinct susceptibility loci for Crohn's disease. Nat Genet (2008) 30.20
Genome-wide association study identifies novel breast cancer susceptibility loci. Nature (2007) 29.23
Biological, clinical and population relevance of 95 loci for blood lipids. Nature (2010) 28.21
Newly identified loci that influence lipid concentrations and risk of coronary artery disease. Nat Genet (2008) 25.83
Genomewide association analysis of coronary artery disease. N Engl J Med (2007) 24.38
Association analyses of 249,796 individuals reveal 18 new loci associated with body mass index. Nat Genet (2010) 23.08
A genome-wide association study of global gene expression. Nat Genet (2007) 22.98
Common variants at 30 loci contribute to polygenic dyslipidemia. Nat Genet (2008) 20.66
International network of cancer genome projects. Nature (2010) 20.35
Hundreds of variants clustered in genomic loci and biological pathways affect human height. Nature (2010) 20.01
New genetic loci implicated in fasting glucose homeostasis and their impact on type 2 diabetes risk. Nat Genet (2010) 17.89
Genome-wide meta-analysis increases to 71 the number of confirmed Crohn's disease susceptibility loci. Nat Genet (2010) 17.38
A susceptibility locus for lung cancer maps to nicotinic acetylcholine receptor subunit genes on 15q25. Nature (2008) 16.10
Multiple newly identified loci associated with prostate cancer susceptibility. Nat Genet (2008) 15.43
Genome-wide association scan shows genetic variants in the FTO gene are associated with obesity-related traits. PLoS Genet (2007) 14.99
Genome-wide association study identifies variants at CLU and CR1 associated with Alzheimer's disease. Nat Genet (2009) 14.86
Genetic variants regulating ORMDL3 expression contribute to the risk of childhood asthma. Nature (2007) 14.43
Combined BRAF and MEK inhibition in melanoma with BRAF V600 mutations. N Engl J Med (2012) 13.48
Genetic variants in novel pathways influence blood pressure and cardiovascular disease risk. Nature (2011) 13.25
Whole-genome sequencing identifies recurrent mutations in chronic lymphocytic leukaemia. Nature (2011) 13.18
Cholinergic nicotinic receptor genes implicated in a nicotine dependence association study targeting 348 candidate genes with 3713 SNPs. Hum Mol Genet (2006) 13.16
Association scan of 14,500 nonsynonymous SNPs in four diseases identifies autoimmunity variants. Nat Genet (2007) 12.62
Genome-wide association study identifies eight loci associated with blood pressure. Nat Genet (2009) 12.44
Loci influencing lipid levels and coronary heart disease risk in 16 European population cohorts. Nat Genet (2008) 12.32
Genome-wide association study of CNVs in 16,000 cases of eight common diseases and 3,000 shared controls. Nature (2010) 12.27
High frequency of BRAF mutations in nevi. Nat Genet (2002) 9.95
Genome-wide scan reveals association of psoriasis with IL-23 and NF-kappaB pathways. Nat Genet (2009) 9.45
Common variants at ABCA7, MS4A6A/MS4A4E, EPHA1, CD33 and CD2AP are associated with Alzheimer's disease. Nat Genet (2011) 9.23
Novel Crohn disease locus identified by genome-wide association maps to a gene desert on 5p13.1 and modulates expression of PTGER4. PLoS Genet (2007) 8.63
Genome partitioning of genetic variation for complex traits using common SNPs. Nat Genet (2011) 8.57
A versatile gene-based test for genome-wide association studies. Am J Hum Genet (2010) 8.44
Escalation of drug use in early-onset cannabis users vs co-twin controls. JAMA (2003) 8.29
Large-scale genotyping identifies 41 new loci associated with breast cancer risk. Nat Genet (2013) 8.24
Genetic relationship between five psychiatric disorders estimated from genome-wide SNPs. Nat Genet (2013) 8.02
Meta-analysis identifies 29 additional ulcerative colitis risk loci, increasing the number of confirmed associations to 47. Nat Genet (2011) 7.98
Meta-analysis identifies 13 new loci associated with waist-hip ratio and reveals sexual dimorphism in the genetic basis of fat distribution. Nat Genet (2010) 7.94
Novel genes identified in a high-density genome wide association study for nicotine dependence. Hum Mol Genet (2006) 7.90
A tumorigenic subpopulation with stem cell properties in melanomas. Cancer Res (2005) 7.86
Genome-wide association study identifies five susceptibility loci for glioma. Nat Genet (2009) 7.62
A common coding variant in CASP8 is associated with breast cancer risk. Nat Genet (2007) 7.35
Genome-wide association study identifies genes for biomarkers of cardiovascular disease: serum urate and dyslipidemia. Am J Hum Genet (2008) 7.33
Newly discovered breast cancer susceptibility loci on 3p24 and 17q23.2. Nat Genet (2009) 7.30
Prognostic and clinicopathologic associations of oncogenic BRAF in metastatic melanoma. J Clin Oncol (2011) 7.18
Assumption-free estimation of heritability from genome-wide identity-by-descent sharing between full siblings. PLoS Genet (2006) 7.13
Exome sequencing identifies recurrent somatic RAC1 mutations in melanoma. Nat Genet (2012) 7.00
Sequence variants at the TERT-CLPTM1L locus associate with many cancer types. Nat Genet (2009) 6.91
Sequence variants at CHRNB3-CHRNA6 and CYP2A6 affect smoking behavior. Nat Genet (2010) 6.49
Exome sequencing identifies recurrent mutations of the splicing factor SF3B1 gene in chronic lymphocytic leukemia. Nat Genet (2011) 6.43
Heritability of adult body height: a comparative study of twin cohorts in eight countries. Twin Res (2003) 6.43
A mega-analysis of genome-wide association studies for major depressive disorder. Mol Psychiatry (2012) 6.34
A genome-wide association study identifies colorectal cancer susceptibility loci on chromosomes 10p14 and 8q23.3. Nat Genet (2008) 6.26
Heterogeneity of breast cancer associations with five susceptibility loci by clinical and pathological characteristics. PLoS Genet (2008) 6.22
Dabrafenib in patients with melanoma, untreated brain metastases, and other solid tumours: a phase 1 dose-escalation trial. Lancet (2012) 6.21
Heritability of mammographic density, a risk factor for breast cancer. N Engl J Med (2002) 6.19
Menin associates with a trithorax family histone methyltransferase complex and with the hoxc8 locus. Mol Cell (2004) 6.08
Identification of seven new prostate cancer susceptibility loci through a genome-wide association study. Nat Genet (2009) 6.04
Colon Cancer Family Registry: an international resource for studies of the genetic epidemiology of colon cancer. Cancer Epidemiol Biomarkers Prev (2007) 6.00
Lung cancer susceptibility locus at 5p15.33. Nat Genet (2008) 5.99
DNA methylation profiles in monozygotic and dizygotic twins. Nat Genet (2009) 5.99
Multiple loci with different cancer specificities within the 8q24 gene desert. J Natl Cancer Inst (2008) 5.82