H-ficolin binds Aspergillus fumigatus leading to activation of the lectin complement pathway and modulation of lung epithelial immune responses.

Interactions of Aspergillus fumigatus Conidia with Airway Epithelial Cells: A Critical Review. Front Microbiol (2016) 0.75

A Sweet Response to a Sour Situation: The Role of Soluble Pattern Recognition Receptors in the Innate Immune Response to Invasive Aspergillus fumigatus Infections. PLoS Pathog (2016) 0.75

A New Ligand-Based Method for Purifying Active Human Plasma-Derived Ficolin-3 Complexes Supports the Phenomenon of Crosstalk between Pattern-Recognition Molecules and Immunoglobulins. PLoS One (2016) 0.75

Revised definitions of invasive fungal disease from the European Organization for Research and Treatment of Cancer/Invasive Fungal Infections Cooperative Group and the National Institute of Allergy and Infectious Diseases Mycoses Study Group (EORTC/MSG) Consensus Group. Clin Infect Dis (2008) 20.88

Immunity to fungal infections. Nat Rev Immunol (2011) 4.33

Clinical epidemiology of 960 patients with invasive aspergillosis from the PATH Alliance registry. J Infect (2012) 3.24

The beta-glucan receptor dectin-1 recognizes specific morphologies of Aspergillus fumigatus. PLoS Pathog (2005) 3.13

Requisite role for the dectin-1 beta-glucan receptor in pulmonary defense against Aspergillus fumigatus. J Immunol (2009) 2.74

Mannose-binding lectin binds to a range of clinically relevant microorganisms and promotes complement deposition. Infect Immun (2000) 2.71

Binding of pulmonary surfactant proteins A and D to Aspergillus fumigatus conidia enhances phagocytosis and killing by human neutrophils and alveolar macrophages. Infect Immun (1997) 1.97

A novel human serum lectin with collagen- and fibrinogen-like domains that functions as an opsonin. J Biol Chem (1996) 1.88

Toll-like receptor (TLR) signaling in response to Aspergillus fumigatus. J Biol Chem (2002) 1.87

Toll-like receptor (TLR) 2 and TLR4 are essential for Aspergillus-induced activation of murine macrophages. Cell Microbiol (2003) 1.86

Characterization of the A549 cell line as a type II pulmonary epithelial cell model for drug metabolism. Exp Cell Res (1998) 1.79

Cutting edge: complement-activating complex of ficolin and mannose-binding lectin-associated serine protease. J Immunol (2000) 1.67

Innate immunity in the lungs. Proc Am Thorac Soc (2005) 1.66

Structural insights into the innate immune recognition specificities of L- and H-ficolins. EMBO J (2007) 1.53

IL-8 induces neutrophil chemotaxis predominantly via type I IL-8 receptors. J Immunol (1995) 1.50

Collectins: players of the innate immune system. Eur J Biochem (2004) 1.46

Human L-ficolin: plasma levels, sugar specificity, and assignment of its lectin activity to the fibrinogen-like (FBG) domain. FEBS Lett (1998) 1.35

Development of an immunochromatographic lateral-flow device for rapid serodiagnosis of invasive aspergillosis. Clin Vaccine Immunol (2008) 1.32

Interactions between conidia of Aspergillus fumigatus and human complement component C3. Infect Immun (1992) 1.31

Synergy between ficolin-2 and pentraxin 3 boosts innate immune recognition and complement deposition. J Biol Chem (2009) 1.29

Epidemiology of invasive aspergillosis in critically ill patients: clinical presentation, underlying conditions, and outcomes. Crit Care (2015) 1.28

The lectin pathway of complement activation is a critical component of the innate immune response to pneumococcal infection. PLoS Pathog (2012) 1.28

Immunodeficiency associated with FCN3 mutation and ficolin-3 deficiency. N Engl J Med (2009) 1.24

Extracellular acidosis induces neutrophil activation by a mechanism dependent on activation of phosphatidylinositol 3-kinase/Akt and ERK pathways. J Immunol (2006) 1.19

Activation of the lectin complement pathway by H-ficolin (Hakata antigen). J Immunol (2002) 1.19

Binding and germination of Aspergillus fumigatus conidia on cultured A549 pneumocytes. J Infect Dis (1997) 1.14

Interaction of airway epithelial cells (A549) with spores and mycelium of Aspergillus fumigatus. J Infect (2005) 1.06

Hakata antigen, a new member of the ficolin/opsonin p35 family, is a novel human lectin secreted into bronchus/alveolus and bile. J Histochem Cytochem (1999) 1.05

Chemical and immunological analysis of the Aspergillus fumigatus cell wall. Microbiology (1994) 1.05

Aspergillus fumigatus-induced interleukin-8 synthesis by respiratory epithelial cells is controlled by the phosphatidylinositol 3-kinase, p38 MAPK, and ERK1/2 pathways and not by the toll-like receptor-MyD88 pathway. J Biol Chem (2008) 1.03

Helicobacter pylori induces interleukin-8 secretion by Toll-like receptor 2- and Toll-like receptor 5-dependent and -independent pathways. Infect Immun (2005) 1.03

Cell wall antigens in Aspergillus fumigatus. Arch Med Res (1993) 1.02

Helicobacter pylori heat-shock protein 60 induces interleukin-8 via a Toll-like receptor (TLR)2 and mitogen-activated protein (MAP) kinase pathway in human monocytes. J Med Microbiol (2007) 1.01

Detection of galactomannan in bronchoalveolar lavage fluid samples of patients at risk for invasive pulmonary aspergillosis: analytical and clinical validity. J Clin Microbiol (2012) 0.98

Biochemical and immunological studies on aspergillus. II. Immunological properties of protein and polysaccharide fractions obtained from Aspergillus fumigatus. Mycopathol Mycol Appl (1969) 0.97

Ficolin-1-PTX3 complex formation promotes clearance of altered self-cells and modulates IL-8 production. J Immunol (2013) 0.97

Aspergillus endophthalmitis: an unusual complication of disseminated infection in renal transplant patients. J Infect (2003) 0.94

Studies of the pattern recognition molecule H-ficolin: specificity and purification. J Biol Chem (2012) 0.90

Ficolin-2 defends against virulent Mycobacteria tuberculosis infection in vivo, and its insufficiency is associated with infection in humans. PLoS One (2013) 0.89

The interaction pattern of murine serum ficolin-A with microorganisms. PLoS One (2012) 0.86

The serum opsonin L-ficolin is detected in lungs of human transplant recipients following fungal infections and modulates inflammation and killing of Aspergillus fumigatus. J Infect Dis (2015) 0.83

Species-specific recognition of Aspergillus fumigatus by Toll-like receptor 1 and Toll-like receptor 6. J Infect Dis (2012) 0.82

Absence of the lectin activation pathway of complement does not increase susceptibility to Pseudomonas aeruginosa infections. Immunobiology (2011) 0.81

Mouse mannose-binding lectin-A and ficolin-A inhibit lipopolysaccharide-mediated pro-inflammatory responses on mast cells. BMB Rep (2013) 0.81

Role of ficolin-A and lectin complement pathway in the innate defense against pathogenic Aspergillus species. Infect Immun (2013) 0.80

Opsonizing properties of rat ficolin-A in the defence against Cryptococcus neoformans. Immunobiology (2012) 0.80