Innate immunity in the lungs.

Pathogenesis of Aspergillus fumigatus in Invasive Aspergillosis. Clin Microbiol Rev (2009) 3.10

Spatiotemporally separated antigen uptake by alveolar dendritic cells and airway presentation to T cells in the lung. J Exp Med (2012) 2.03

Neutrophil recruitment to the lungs during bacterial pneumonia. Infect Immun (2008) 1.87

Stimulation of lung innate immunity protects against lethal pneumococcal pneumonia in mice. Am J Respir Crit Care Med (2008) 1.44

Immune Defense Protein Expression in Highly Purified Mouse Lung Epithelial Cells. Am J Respir Cell Mol Biol (2016) 1.41

Stimulated innate resistance of lung epithelium protects mice broadly against bacteria and fungi. Am J Respir Cell Mol Biol (2009) 1.36

Inducible innate resistance of lung epithelium to infection. Annu Rev Physiol (2010) 1.34

Synergistic interactions of TLR2/6 and TLR9 induce a high level of resistance to lung infection in mice. J Immunol (2011) 1.16

Mechanical stretch induces epithelial-mesenchymal transition in alveolar epithelia via hyaluronan activation of innate immunity. J Biol Chem (2011) 1.12

Mucus clearance, MyD88-dependent and MyD88-independent immunity modulate lung susceptibility to spontaneous bacterial infection and inflammation. Mucosal Immunol (2012) 1.09

A role for IL-1 receptor-associated kinase-M in prostaglandin E2-induced immunosuppression post-bone marrow transplantation. J Immunol (2010) 1.07

Polymorphisms in surfactant protein-D are associated with chronic obstructive pulmonary disease. Am J Respir Cell Mol Biol (2010) 1.04

Pattern recognition receptor-dependent mechanisms of acute lung injury. Mol Med (2009) 1.04

Myeloid differentiation protein-2-dependent and -independent neutrophil accumulation during Escherichia coli pneumonia. Am J Respir Cell Mol Biol (2008) 1.02

The nuclear factor kappa-B pathway in airway epithelium regulates neutrophil recruitment and host defence following Pseudomonas aeruginosa infection. Clin Exp Immunol (2008) 1.01

Alveolar macrophage dynamics in murine lung regeneration. J Cell Physiol (2012) 0.99

Contrasting macrophage activation by fine and ultrafine titanium dioxide particles is associated with different uptake mechanisms. Part Fibre Toxicol (2011) 0.98

An agent-based model of inflammation and fibrosis following particulate exposure in the lung. Math Biosci (2011) 0.98

Inhaled innate immune ligands to prevent pneumonia. Br J Pharmacol (2011) 0.97

Luteolin Suppresses Inflammatory Mediator Expression by Blocking the Akt/NFκB Pathway in Acute Lung Injury Induced by Lipopolysaccharide in Mice. Evid Based Complement Alternat Med (2011) 0.95

Eicosanoid regulation of pulmonary innate immunity post-hematopoietic stem cell transplantation. Arch Immunol Ther Exp (Warsz) (2007) 0.95

CD11c(+)/CD11b(+) cells are critical for organic dust-elicited murine lung inflammation. Am J Respir Cell Mol Biol (2012) 0.92

PPARγ agonists regulate tobacco smoke-induced Toll like receptor 4 expression in alveolar macrophages. Respir Res (2014) 0.91

Alveolar macrophages in pulmonary host defence the unrecognized role of apoptosis as a mechanism of intracellular bacterial killing. Clin Exp Immunol (2013) 0.90

Interactions between mechanical and biological processes in acute lung injury. Proc Am Thorac Soc (2008) 0.90

The milieu of damaged alveolar epithelial type 2 cells stimulates alveolar wound repair by endogenous and exogenous progenitors. Am J Respir Cell Mol Biol (2011) 0.90

Inhaled therapeutics for prevention and treatment of pneumonia. Expert Opin Drug Saf (2009) 0.89

The chemerin/ChemR23 system does not affect the pro-inflammatory response of mouse and human macrophages ex vivo. PLoS One (2012) 0.89

Innate immune response of alveolar macrophage to house dust mite allergen is mediated through TLR2/-4 co-activation. PLoS One (2013) 0.89

Monocytes and macrophages as nanomedicinal targets for improved diagnosis and treatment of disease. Expert Rev Mol Diagn (2013) 0.88

N-acetylcysteine improves group B streptococcus clearance in a rat model of chronic ethanol ingestion. Alcohol Clin Exp Res (2009) 0.88

Innate immunity and inflammation--two facets of the same anti-infectious reaction. Clin Exp Immunol (2009) 0.88

S100A7/psoriasin expression in the human lung: unchanged in patients with COPD, but upregulated upon positive S. aureus detection. BMC Pulm Med (2011) 0.85

PTEN limits alveolar macrophage function against Pseudomonas aeruginosa after bone marrow transplantation. Am J Respir Cell Mol Biol (2011) 0.84

Defective pulmonary innate immune responses post-stem cell transplantation; review and results from one model system. Front Immunol (2013) 0.83

Enhanced response to pulmonary Streptococcus pneumoniae infection is associated with primary ciliary dyskinesia in mice lacking Pcdp1 and Spef2. Cilia (2013) 0.82

Expansive generation of functional airway epithelium from human embryonic stem cells. Stem Cells Transl Med (2013) 0.82

CCR7 deficiency leads to leukocyte activation and increased clearance in response to pulmonary Pseudomonas aeruginosa infection. Infect Immun (2010) 0.82

Toll-like receptor 9 deficiency protects mice against Pseudomonas aeruginosa lung infection. PLoS One (2014) 0.82

Origin, Localization, and Immunoregulatory Properties of Pulmonary Phagocytes in Allergic Asthma. Front Immunol (2016) 0.82

Chemokine (C-C Motif) receptor 1 is required for efficient recruitment of neutrophils during respiratory infection with modified vaccinia virus Ankara. J Virol (2014) 0.81

Selective Toll--like receptor expression in human fetal lung. Pediatr Res (2010) 0.81

Respiratory syncytial virus-like nanoparticle vaccination induces long-term protection without pulmonary disease by modulating cytokines and T-cells partially through alveolar macrophages. Int J Nanomedicine (2015) 0.81

Diet-induced obesity reprograms the inflammatory response of the murine lung to inhaled endotoxin. Toxicol Appl Pharmacol (2013) 0.81

Role of ficolin-A and lectin complement pathway in the innate defense against pathogenic Aspergillus species. Infect Immun (2013) 0.80

Myeloid-derived suppressor cells impair alveolar macrophages through PD-1 receptor ligation during Pneumocystis pneumonia. Infect Immun (2014) 0.80

Perilla frutescens leaf extract inhibits mite major allergen Der p 2-induced gene expression of pro-allergic and pro-inflammatory cytokines in human bronchial epithelial cell BEAS-2B. PLoS One (2013) 0.80

H-ficolin binds Aspergillus fumigatus leading to activation of the lectin complement pathway and modulation of lung epithelial immune responses. Immunology (2015) 0.79

Inflammatory stress response in A549 cells as a result of exposure to coal: evidence for the role of pyrite in coal workers' pneumoconiosis pathogenesis. Chemosphere (2013) 0.79

Exon B of human surfactant protein A2 mRNA, alone or within its surrounding sequences, interacts with 14-3-3; role of cis-elements and secondary structure. Am J Physiol Lung Cell Mol Physiol (2013) 0.79

Serum opsonin ficolin-A enhances host-fungal interactions and modulates cytokine expression from human monocyte-derived macrophages and neutrophils following Aspergillus fumigatus challenge. Med Microbiol Immunol (2015) 0.79

MyD88-dependent signaling drives host survival and early cytokine production during Histoplasma capsulatum infection. Infect Immun (2015) 0.78

Prostaglandin E2 reduces Toll-like receptor 4 expression in alveolar macrophages by inhibition of translation. Am J Respir Cell Mol Biol (2014) 0.76

Macrophage-derived apoptotic bodies promote the proliferation of the recipient cells via shuttling microRNA-221/222. J Leukoc Biol (2017) 0.75

Role for phospholipid acyl chains and cholesterol in pulmonary infections and inflammation. J Leukoc Biol (2016) 0.75

A low dimensional dynamical model of the initial pulmonary innate response to infection. Math Biosci (2012) 0.75

Uncovering the immune tumor microenvironment in non-small cell lung cancer to understand response rates to checkpoint blockade and radiation. Transl Lung Cancer Res (2017) 0.75

Regulation of Lung Epithelial Sodium Channels by Cytokines and Chemokines. Front Immunol (2017) 0.75

Ventilation with lower tidal volumes as compared with traditional tidal volumes for acute lung injury and the acute respiratory distress syndrome. The Acute Respiratory Distress Syndrome Network. N Engl J Med (2000) 48.03

Defective LPS signaling in C3H/HeJ and C57BL/10ScCr mice: mutations in Tlr4 gene. Science (1998) 37.15

A human homologue of the Drosophila Toll protein signals activation of adaptive immunity. Nature (1997) 23.92

CD14, a receptor for complexes of lipopolysaccharide (LPS) and LPS binding protein. Science (1990) 17.86

The dorsoventral regulatory gene cassette spätzle/Toll/cactus controls the potent antifungal response in Drosophila adults. Cell (1996) 17.42

Identification of Lps2 as a key transducer of MyD88-independent TIR signalling. Nature (2003) 10.97

MD-2, a molecule that confers lipopolysaccharide responsiveness on Toll-like receptor 4. J Exp Med (1999) 9.23

TLR4 mutations are associated with endotoxin hyporesponsiveness in humans. Nat Genet (2000) 8.79

MyD88 is an adaptor protein in the hToll/IL-1 receptor family signaling pathways. Mol Cell (1998) 8.73

The Toll-like receptor 2 is recruited to macrophage phagosomes and discriminates between pathogens. Nature (1999) 8.50

Structure and function of lipopolysaccharide binding protein. Science (1990) 7.76

Inferences, questions and possibilities in Toll-like receptor signalling. Nature (2004) 7.57

Toll-like receptor 4 polymorphisms and atherogenesis. N Engl J Med (2002) 6.00

Lower tidal volume ventilation and plasma cytokine markers of inflammation in patients with acute lung injury. Crit Care Med (2005) 5.76

Monocyte deactivation in septic patients: restoration by IFN-gamma treatment. Nat Med (1997) 5.19

NODs: intracellular proteins involved in inflammation and apoptosis. Nat Rev Immunol (2003) 5.07

Genetic influence on cytokine production and fatal meningococcal disease. Lancet (1997) 4.89

Role of C5a in inflammatory responses. Annu Rev Immunol (2005) 4.38

Lipopolysaccharide activation of human endothelial and epithelial cells is mediated by lipopolysaccharide-binding protein and soluble CD14. Proc Natl Acad Sci U S A (1993) 4.35

Upregulation of costimulatory molecules induced by lipopolysaccharide and double-stranded RNA occurs by Trif-dependent and Trif-independent pathways. Nat Immunol (2003) 4.15

Injurious ventilatory strategies increase cytokines and c-fos m-RNA expression in an isolated rat lung model. J Clin Invest (1997) 4.00

CD14 is a pattern recognition receptor. Immunity (1994) 3.79

Innate immunity: an overview. Mol Immunol (2004) 3.50

Primate defensins. Nat Rev Microbiol (2004) 3.29

The interface between innate and adaptive immunity. Nat Immunol (2004) 3.28

Association of low levels of mannan-binding protein with a common defect of opsonisation. Lancet (1989) 3.12

Cytokine balance in the lungs of patients with acute respiratory distress syndrome. Am J Respir Crit Care Med (2001) 2.60

The innate immune response of the respiratory epithelium. Immunol Rev (2000) 2.40

Cutting edge: myeloid differentiation factor 88 is essential for pulmonary host defense against Pseudomonas aeruginosa but not Staphylococcus aureus. J Immunol (2004) 2.26

Serial changes in surfactant-associated proteins in lung and serum before and after onset of ARDS. Am J Respir Crit Care Med (1999) 2.20

Respiratory epithelial cells regulate lung inflammation in response to inhaled endotoxin. Am J Physiol Lung Cell Mol Physiol (2004) 2.19

Soluble CD14 acts as a shuttle in the neutralization of lipopolysaccharide (LPS) by LPS-binding protein and reconstituted high density lipoprotein. J Exp Med (1995) 1.90

CD14-dependent lipopolysaccharide-induced beta-defensin-2 expression in human tracheobronchial epithelium. J Biol Chem (2000) 1.89

Heritability estimates of innate immunity: an extended twin study. Genes Immun (2005) 1.86

Activation of human macrophages by mechanical ventilation in vitro. Am J Physiol (1998) 1.85

Monocytes recruited into the alveolar air space of mice show a monocytic phenotype but upregulate CD14. Am J Physiol Lung Cell Mol Physiol (2001) 1.85

Mechanical ventilation with moderate tidal volumes synergistically increases lung cytokine response to systemic endotoxin. Am J Physiol Lung Cell Mol Physiol (2004) 1.81

Assay of locus-specific genetic load implicates rare Toll-like receptor 4 mutations in meningococcal susceptibility. Proc Natl Acad Sci U S A (2003) 1.78

Identification of high and low responders to lipopolysaccharide in normal subjects: an unbiased approach to identify modulators of innate immunity. J Immunol (2005) 1.66

Endotoxin responsiveness of human airway epithelia is limited by low expression of MD-2. Am J Physiol Lung Cell Mol Physiol (2004) 1.64

Central role of toll-like receptor 4 signaling and host defense in experimental pneumonia caused by Gram-negative bacteria. Infect Immun (2005) 1.53

Lipopolysaccharide binding protein enhances the responsiveness of alveolar macrophages to bacterial lipopolysaccharide. Implications for cytokine production in normal and injured lungs. J Clin Invest (1992) 1.48

Surfactant-associated protein A inhibits LPS-induced cytokine and nitric oxide production in vivo. Am J Physiol Lung Cell Mol Physiol (2000) 1.45

Fas ligation on macrophages enhances IL-1R1-Toll-like receptor 4 signaling and promotes chronic inflammation. Nat Immunol (2004) 1.44

Distinct roles of pattern recognition receptors CD14 and Toll-like receptor 4 in acute lung injury. Infect Immun (2005) 1.39

Mechanical ventilation affects lung function and cytokine production in an experimental model of endotoxemia. Anesthesiology (2005) 1.34

TLR-4 pathway mediates the inflammatory response but not bacterial elimination in E. coli pneumonia. Am J Physiol Lung Cell Mol Physiol (2005) 1.32

The Toll-like receptors: analysis by forward genetic methods. Immunogenetics (2005) 1.31

Surfactant proteins A and D bind CD14 by different mechanisms. J Biol Chem (2000) 1.30

Relationship between soluble CD14, lipopolysaccharide binding protein, and the alveolar inflammatory response in patients with acute respiratory distress syndrome. Am J Respir Crit Care Med (1997) 1.28

Effect of CD14 blockade in rabbits with Escherichia coli pneumonia and sepsis. J Immunol (2000) 1.23

Production of the acute-phase protein lipopolysaccharide-binding protein by respiratory type II epithelial cells: implications for local defense to bacterial endotoxins. Am J Respir Cell Mol Biol (2000) 1.20

Microbial DNA induces a host defense reaction of human respiratory epithelial cells. J Immunol (2004) 1.18

Recognition of bacterial endotoxin in the lungs. Am J Respir Cell Mol Biol (2000) 1.14

Enhancement of the endotoxin recognition pathway by ventilation with a large tidal volume in rabbits. Am J Physiol Lung Cell Mol Physiol (2003) 1.13

Sustained lipopolysaccharide-induced lung inflammation in mice is attenuated by functional deficiency of the Fas/Fas ligand system. Clin Diagn Lab Immunol (2004) 1.08

The Fas-associated death domain protein suppresses activation of NF-kappa B by LPS and IL-1 beta. J Clin Invest (2002) 1.05

Filgrastim in patients with pneumonia and severe sepsis or septic shock. Chest (2001) 1.03

Molecular cloning, characterization, and tissue distribution of rat lipopolysaccharide binding protein. Evidence for extrahepatic expression. J Immunol (1994) 1.02

Differential regulation of membrane CD14 expression and endotoxin-tolerance in alveolar macrophages. Am J Respir Cell Mol Biol (2004) 0.98

Soluble MD-2 activity in plasma from patients with severe sepsis and septic shock. Blood (2004) 0.98

History of immunology. Cellular versus humoral immunity: determinants and consequences of an epic 19th century battle. Cell Immunol (1979) 0.98

Surfactant protein-D regulates soluble CD14 through matrix metalloproteinase-12. J Immunol (2005) 0.97

The CD14 differentiation antigen mediates the development of endotoxin responsiveness during differentiation of mononuclear phagocytes. J Leukoc Biol (1994) 0.95

Lipopolysaccharide (LPS) binding protein catalyzes binding of LPS to lipoproteins. Prog Clin Biol Res (1995) 0.90

Gene expression of Toll-like receptor-2, Toll-like receptor-4, and MD2 is differentially regulated in rabbits with Escherichia coli pneumonia. Gene (2004) 0.88

Bronchoalveolar macrophage CD14 expression: shift between membrane-associated and soluble pools. Am J Physiol (1997) 0.79

Induction of lipopolysaccharide-binding protein gene expression in cultured rat pulmonary artery smooth muscle cells by interleukin 1 beta. Am J Respir Cell Mol Biol (1995) 0.78

Animal models of acute lung injury. Am J Physiol Lung Cell Mol Physiol (2008) 6.10

Essential role of MMP-12 in Fas-induced lung fibrosis. Am J Respir Cell Mol Biol (2007) 2.16

Spatial and temporal heterogeneity of ventilator-associated lung injury after surfactant depletion. J Appl Physiol (1985) (2008) 1.88

Mechanical ventilation with moderate tidal volumes synergistically increases lung cytokine response to systemic endotoxin. Am J Physiol Lung Cell Mol Physiol (2004) 1.81

Duffy antigen facilitates movement of chemokine across the endothelium in vitro and promotes neutrophil transmigration in vitro and in vivo. J Immunol (2003) 1.62

Fas (CD95) induces proinflammatory cytokine responses by human monocytes and monocyte-derived macrophages. J Immunol (2003) 1.57

Regulation and function of epithelial secreted phospholipase A2 group X in asthma. Am J Respir Crit Care Med (2013) 1.51

The Duffy antigen modifies systemic and local tissue chemokine responses following lipopolysaccharide stimulation. J Immunol (2006) 1.50

Optimal timing to repopulation of resident alveolar macrophages with donor cells following total body irradiation and bone marrow transplantation in mice. J Immunol Methods (2004) 1.32

TLR-4 pathway mediates the inflammatory response but not bacterial elimination in E. coli pneumonia. Am J Physiol Lung Cell Mol Physiol (2005) 1.32

Differential response of human lung epithelial cells to fas-induced apoptosis. Am J Pathol (2004) 1.27

Mechanical ventilation interacts with endotoxemia to induce extrapulmonary organ dysfunction. Crit Care (2006) 1.25

Kinetics of chemokine-glycosaminoglycan interactions control neutrophil migration into the airspaces of the lungs. J Immunol (2010) 1.23

Fas-mediated acute lung injury requires fas expression on nonmyeloid cells of the lung. J Immunol (2005) 1.22

Inhalation of Burkholderia thailandensis results in lethal necrotizing pneumonia in mice: a surrogate model for pneumonic melioidosis. Trans R Soc Trop Med Hyg (2008) 1.20

Tissue inhibitor of metalloproteinase-1 deficiency amplifies acute lung injury in bleomycin-exposed mice. Am J Respir Cell Mol Biol (2005) 1.17

Enhancement of the endotoxin recognition pathway by ventilation with a large tidal volume in rabbits. Am J Physiol Lung Cell Mol Physiol (2003) 1.13

Blockade of the Fas/FasL system improves pneumococcal clearance from the lungs without preventing dissemination of bacteria to the spleen. J Infect Dis (2005) 1.06

Proteoglycans: key regulators of pulmonary inflammation and the innate immune response to lung infection. Anat Rec (Hoboken) (2010) 1.06

A Bayesian integration model of high-throughput proteomics and metabolomics data for improved early detection of microbial infections. Pac Symp Biocomput (2009) 1.03

Differential regulation of membrane CD14 expression and endotoxin-tolerance in alveolar macrophages. Am J Respir Cell Mol Biol (2004) 0.98

A new method for studying gradient-induced neutrophil desensitization based on an open microfluidic chamber. Lab Chip (2009) 0.96

Dysregulation of macrophage activation profiles by engineered nanoparticles. ACS Nano (2013) 0.96

Systemic inflammatory response syndrome in nonhuman primates culminating in multiple organ failure, acute lung injury, and disseminated intravascular coagulation. Toxicol Pathol (2009) 0.95

Enhanced expression of Duffy antigen in the lungs during suppurative pneumonia. J Histochem Cytochem (2003) 0.95

Effect of Toll-like receptor 4 blockade on pulmonary inflammation caused by mechanical ventilation and bacterial endotoxin. Exp Lung Res (2008) 0.93

Syndecan-4 regulates early neutrophil migration and pulmonary inflammation in response to lipopolysaccharide. Am J Respir Cell Mol Biol (2012) 0.91

Mechanical ventilation modulates Toll-like receptor-3-induced lung inflammation via a MyD88-dependent, TLR4-independent pathway: a controlled animal study. BMC Pulm Med (2010) 0.90

Gene expression of Toll-like receptor-2, Toll-like receptor-4, and MD2 is differentially regulated in rabbits with Escherichia coli pneumonia. Gene (2004) 0.88

Effects of age on the synergistic interactions between lipopolysaccharide and mechanical ventilation in mice. Am J Respir Cell Mol Biol (2009) 0.87

Anti-KC autoantibody:KC complexes cause severe lung inflammation in mice via IgG receptors. Am J Respir Cell Mol Biol (2007) 0.86

Expression of the integrin subunit alpha8 in murine lung development. J Histochem Cytochem (2003) 0.86

Dual transfer of GFP gene and MGd into stem-progenitor cells: toward in vivo MRI of stem cell-mediated gene therapy of atherosclerosis. Acad Radiol (2010) 0.84

Differential flux of macrophage inflammatory protein-2 and cytokine-induced neutrophil chemoattractant from the lung after intrapulmonary delivery. Am J Physiol Lung Cell Mol Physiol (2011) 0.78

Differentiation of gram-negative bacterial aerosol exposure using detected markers in bronchial-alveolar lavage fluid. PLoS One (2009) 0.77

Proteomic analysis of bronchoalveolar lavage fluid proteins from mice infected with Francisella tularensis ssp. novicida. J Proteome Res (2012) 0.77

Intranasal influenza infection of mice and methods to evaluate progression and outcome. Methods Mol Biol (2013) 0.77

Clinical significance of serum hyaluronan in chronic fibrotic interstitial pneumonia. Respirology (2013) 0.75