Published in Eur J Immunol on July 07, 2015
Class switch recombination and hypermutation require activation-induced cytidine deaminase (AID), a potential RNA editing enzyme. Cell (2000) 20.83
HSP90 and the chaperoning of cancer. Nat Rev Cancer (2005) 11.98
Activation-induced cytidine deaminase (AID) deficiency causes the autosomal recessive form of the Hyper-IgM syndrome (HIGM2). Cell (2000) 9.99
Genome-wide erasure of DNA methylation in mouse primordial germ cells is affected by AID deficiency. Nature (2010) 8.84
DNA demethylation in zebrafish involves the coupling of a deaminase, a glycosylase, and gadd45. Cell (2008) 8.62
Molecular mechanisms of antibody somatic hypermutation. Annu Rev Biochem (2007) 6.92
Two levels of protection for the B cell genome during somatic hypermutation. Nature (2008) 5.32
Hsp90 molecular chaperone inhibitors: are we there yet? Clin Cancer Res (2012) 4.01
AID is required for c-myc/IgH chromosome translocations in vivo. Cell (2004) 3.89
Helicobacter pylori infection triggers aberrant expression of activation-induced cytidine deaminase in gastric epithelium. Nat Med (2007) 3.70
Constitutive expression of AID leads to tumorigenesis. J Exp Med (2003) 3.16
AID is required for germinal center-derived lymphomagenesis. Nat Genet (2007) 2.79
The B cell mutator AID promotes B lymphoid blast crisis and drug resistance in chronic myeloid leukemia. Cancer Cell (2009) 2.42
Estrogen directly activates AID transcription and function. J Exp Med (2009) 2.37
Proteasomal degradation restricts the nuclear lifespan of AID. J Exp Med (2008) 1.80
Active nuclear import and cytoplasmic retention of activation-induced deaminase. Nat Struct Mol Biol (2009) 1.64
Expression of activation-induced cytidine deaminase in human hepatocytes via NF-kappaB signaling. Oncogene (2007) 1.43
17 AAG for HSP90 inhibition in cancer--from bench to bedside. Curr Mol Med (2009) 1.40
Regulation of activation-induced deaminase stability and antibody gene diversification by Hsp90. J Exp Med (2010) 1.33
Up-regulation of activation-induced cytidine deaminase causes genetic aberrations at the CDKN2b-CDKN2a in gastric cancer. Gastroenterology (2010) 0.95
Activation-induced cytidine deaminase (AID) is necessary for the epithelial-mesenchymal transition in mammary epithelial cells. Proc Natl Acad Sci U S A (2013) 0.90
AID/APOBEC deaminases and cancer. Oncoscience (2015) 0.89
HSP90 inhibitors decrease AID levels and activity in mice and in human cells. Eur J Immunol (2015) 0.88
AID induces intraclonal diversity and genomic damage in CD86(+) chronic lymphocytic leukemia cells. Eur J Immunol (2014) 0.84