Published in Cell Cycle on January 01, 2015
Stem-ing mTOR: p53 maintains the male germline. Cell Cycle (2015) 0.75
Mice deficient for p53 are developmentally normal but susceptible to spontaneous tumours. Nature (1992) 25.54
Cancer. p53, guardian of the genome. Nature (1992) 16.36
Molecular mechanisms of mTOR-mediated translational control. Nat Rev Mol Cell Biol (2009) 13.89
Pten dependence distinguishes haematopoietic stem cells from leukaemia-initiating cells. Nature (2006) 11.86
Hematopoietic stem cell quiescence maintained by p21cip1/waf1. Science (2000) 10.81
Mammalian cell size is controlled by mTOR and its downstream targets S6K1 and 4EBP1/eIF4E. Genes Dev (2002) 8.31
Plzf is required in adult male germ cells for stem cell self-renewal. Nat Genet (2004) 5.75
Essential role of Plzf in maintenance of spermatogonial stem cells. Nat Genet (2004) 5.55
Regulation of cell fate decision of undifferentiated spermatogonia by GDNF. Science (2000) 5.44
The mouse Spo11 gene is required for meiotic chromosome synapsis. Mol Cell (2000) 5.16
In germ cells of mouse embryonic ovaries, the decision to enter meiosis precedes premeiotic DNA replication. Nat Genet (2006) 5.14
TSC-mTOR maintains quiescence and function of hematopoietic stem cells by repressing mitochondrial biogenesis and reactive oxygen species. J Exp Med (2008) 4.76
Ribosomal protein S6 phosphorylation is a determinant of cell size and glucose homeostasis. Genes Dev (2005) 4.41
All you wanted to know about spermatogonia but were afraid to ask. J Androl (2001) 3.80
Unravelling mechanisms of p53-mediated tumour suppression. Nat Rev Cancer (2014) 3.37
The choice between p53-induced senescence and quiescence is determined in part by the mTOR pathway. Aging (Albany NY) (2010) 3.27
p21 loss compromises the relative quiescence of forebrain stem cell proliferation leading to exhaustion of their proliferation capacity. Genes Dev (2005) 3.08
Stra8 and its inducer, retinoic acid, regulate meiotic initiation in both spermatogenesis and oogenesis in mice. Proc Natl Acad Sci U S A (2008) 2.91
Regulation of spermatogonial stem cell self-renewal in mammals. Annu Rev Cell Dev Biol (2008) 2.79
Two faces of p53: aging and tumor suppression. Nucleic Acids Res (2007) 2.78
mTOR mediates Wnt-induced epidermal stem cell exhaustion and aging. Cell Stem Cell (2009) 2.74
Sexual differentiation of germ cells in XX mouse gonads occurs in an anterior-to-posterior wave. Dev Biol (2003) 2.68
Plzf regulates germline progenitor self-renewal by opposing mTORC1. Cell (2010) 2.29
Stem cell defects in ATM-deficient undifferentiated spermatogonia through DNA damage-induced cell-cycle arrest. Cell Stem Cell (2008) 2.14
The first round of mouse spermatogenesis is a distinctive program that lacks the self-renewing spermatogonia stage. Development (2006) 2.07
Homologous pairing preceding SPO11-mediated double-strand breaks in mice. Dev Cell (2013) 1.96
Expression of stimulated by retinoic acid gene 8 (Stra8) in spermatogenic cells induced by retinoic acid: an in vivo study in vitamin A-sufficient postnatal murine testes. Biol Reprod (2008) 1.89
Sohlh1 is essential for spermatogonial differentiation. Dev Biol (2006) 1.74
GDNF family receptor alpha1 phenotype of spermatogonial stem cells in immature mouse testes. Biol Reprod (2005) 1.71
The RNA-binding protein NANOS2 is required to maintain murine spermatogonial stem cells. Science (2009) 1.65
Mice with reduced levels of p53 protein exhibit the testicular giant-cell degenerative syndrome. Proc Natl Acad Sci U S A (1993) 1.62
The role of the tumor suppressor p53 in spermatogenesis. Cell Death Differ (1998) 1.52
Autonomous transition into meiosis of mouse fetal germ cells in vitro and its inhibition by gp130-mediated signaling. Dev Biol (2001) 1.50
SOHLH1 and SOHLH2 coordinate spermatogonial differentiation. Dev Biol (2011) 1.39
Inhibitor of DNA binding 4 is expressed selectively by single spermatogonia in the male germline and regulates the self-renewal of spermatogonial stem cells in mice. Biol Reprod (2011) 1.30
Meiotic recombination provokes functional activation of the p53 regulatory network. Science (2010) 1.27
The meiotic specific synaptonemal complex protein SCP3 is expressed by female and male primordial germ cells of the mouse embryo. Int J Dev Biol (2000) 1.16
Functional and molecular features of the Id4+ germline stem cell population in mouse testes. Genes Dev (2014) 1.11
Rapamycin increases oxidative stress response gene expression in adult stem cells. Aging (Albany NY) (2012) 1.08
Dysregulation of the mTOR pathway in p53-deficient mice. Cancer Biol Ther (2013) 1.02
mTORC1 and p53: clash of the gods? Cell Cycle (2013) 0.98
p53: Pro-aging or pro-longevity? Aging (Albany NY) (2010) 0.98
Morphological characterization of the spermatogonial subtypes in the neonatal mouse testis. Biol Reprod (2003) 0.97
mTOR and the differentiation of mesenchymal stem cells. Acta Biochim Biophys Sin (Shanghai) (2011) 0.97
p53 in stem cells. World J Biol Chem (2011) 0.95
Comparative gene expression profiling of adult mouse ovary-derived oogonial stem cells supports a distinct cellular identity. Fertil Steril (2013) 0.90
The interfaces between signal transduction pathways: IGF-1/mTor, p53 and the Parkinson Disease pathway. Oncotarget (2012) 0.90
Fluorescence- and magnetic-activated cell sorting strategies to isolate and enrich human spermatogonial stem cells. Fertil Steril (2014) 0.88
Distinct germline progenitor subsets defined through Tsc2-mTORC1 signaling. EMBO Rep (2015) 0.82
mTOR signaling in neural stem cells: from basic biology to disease. Cell Mol Life Sci (2012) 0.81
Hypermaintenance and hypofunction of aged spermatogonia: insight from age-related increase of Plzf expression. Oncotarget (2015) 0.78