Published in Science on February 25, 2000
Growth factors essential for self-renewal and expansion of mouse spermatogonial stem cells. Proc Natl Acad Sci U S A (2004) 4.77
Functional hierarchy and reversibility within the murine spermatogenic stem cell compartment. Science (2010) 3.33
In vitro cytotoxicity of nanoparticles in mammalian germline stem cells. Toxicol Sci (2005) 2.89
Identifying genes important for spermatogonial stem cell self-renewal and survival. Proc Natl Acad Sci U S A (2006) 2.84
Regulation of spermatogonial stem cell self-renewal in mammals. Annu Rev Cell Dev Biol (2008) 2.79
ERM is required for transcriptional control of the spermatogonial stem cell niche. Nature (2005) 2.58
Isolation of male germ-line stem cells; influence of GDNF. Dev Biol (2005) 2.40
Plzf regulates germline progenitor self-renewal by opposing mTORC1. Cell (2010) 2.29
Mouse differentiating spermatogonia can generate germinal stem cells in vivo. Nat Cell Biol (2008) 2.05
Isolation and characterization of pluripotent human spermatogonial stem cell-derived cells. Stem Cells (2009) 2.05
Glial cell line-derived neurotrophic factor regulation of genes essential for self-renewal of mouse spermatogonial stem cells is dependent on Src family kinase signaling. J Biol Chem (2007) 1.98
Male germline stem cells: from mice to men. Science (2007) 1.97
MILI, a PIWI-interacting RNA-binding protein, is required for germ line stem cell self-renewal and appears to positively regulate translation. J Biol Chem (2008) 1.93
Maintenance of spermatogenesis requires TAF4b, a gonad-specific subunit of TFIID. Genes Dev (2005) 1.92
GLD-3 and control of the mitosis/meiosis decision in the germline of Caenorhabditis elegans. Genetics (2004) 1.92
The germline stem cell niche unit in mammalian testes. Physiol Rev (2012) 1.86
Paternal age effect mutations and selfish spermatogonial selection: causes and consequences for human disease. Am J Hum Genet (2012) 1.78
Spermatogonial stem cell regulation and spermatogenesis. Philos Trans R Soc Lond B Biol Sci (2010) 1.76
Colony stimulating factor 1 is an extrinsic stimulator of mouse spermatogonial stem cell self-renewal. Development (2009) 1.74
Activating mutations in FGFR3 and HRAS reveal a shared genetic origin for congenital disorders and testicular tumors. Nat Genet (2009) 1.72
Characterization, cryopreservation, and ablation of spermatogonial stem cells in adult rhesus macaques. Stem Cells (2007) 1.65
Isolation, characterization, and culture of human spermatogonia. Biol Reprod (2009) 1.64
Multiple endocrine neoplasia type 2 and RET: from neoplasia to neurogenesis. J Med Genet (2000) 1.61
Dedifferentiating spermatogonia outcompete somatic stem cells for niche occupancy in the Drosophila testis. Cell Stem Cell (2009) 1.61
Gdnf upregulates c-Fos transcription via the Ras/Erk1/2 pathway to promote mouse spermatogonial stem cell proliferation. Stem Cells (2007) 1.61
The DM domain protein DMRT1 is a dose-sensitive regulator of fetal germ cell proliferation and pluripotency. Proc Natl Acad Sci U S A (2009) 1.59
Positive selection for new disease mutations in the human germline: evidence from the heritable cancer syndrome multiple endocrine neoplasia type 2B. PLoS Genet (2012) 1.55
Germline stem cells. Cold Spring Harb Perspect Biol (2011) 1.53
Macrophages Contribute to the Spermatogonial Niche in the Adult Testis. Cell Rep (2015) 1.51
Production of knockout mice by random or targeted mutagenesis in spermatogonial stem cells. Proc Natl Acad Sci U S A (2006) 1.45
GDNF Overexpression from the Native Locus Reveals its Role in the Nigrostriatal Dopaminergic System Function. PLoS Genet (2015) 1.45
Role of Src family kinases and N-Myc in spermatogonial stem cell proliferation. Dev Biol (2006) 1.44
Repression of kit expression by Plzf in germ cells. Mol Cell Biol (2007) 1.42
Reduced spermatogonial proliferation and decreased fertility in mice overexpressing cyclin E in spermatogonia. Cell Cycle (2010) 1.41
Foxo1 is required in mouse spermatogonial stem cells for their maintenance and the initiation of spermatogenesis. J Clin Invest (2011) 1.37
Gfra1 silencing in mouse spermatogonial stem cells results in their differentiation via the inactivation of RET tyrosine kinase. Biol Reprod (2007) 1.36
Drosophila follicle cells: morphogenesis in an eggshell. Semin Cell Dev Biol (2008) 1.36
MicroRNA-21 regulates the self-renewal of mouse spermatogonial stem cells. Proc Natl Acad Sci U S A (2011) 1.35
Gdnf signaling pathways within the mammalian spermatogonial stem cell niche. Mol Cell Endocrinol (2008) 1.32
Culture of rodent spermatogonial stem cells, male germline stem cells of the postnatal animal. Methods Cell Biol (2008) 1.32
Prepubertal testis development relies on retinoic acid but not rexinoid receptors in Sertoli cells. EMBO J (2006) 1.31
A GRFa2/Prop1/stem (GPS) cell niche in the pituitary. PLoS One (2009) 1.31
Silver nanoparticles disrupt GDNF/Fyn kinase signaling in spermatogonial stem cells. Toxicol Sci (2010) 1.31
Inhibitor of DNA binding 4 is expressed selectively by single spermatogonia in the male germline and regulates the self-renewal of spermatogonial stem cells in mice. Biol Reprod (2011) 1.30
Constitutive WNT/beta-catenin signaling in murine Sertoli cells disrupts their differentiation and ability to support spermatogenesis. Biol Reprod (2009) 1.26
Immortalization of mouse germ line stem cells. Stem Cells (2005) 1.25
Role of retinoid signaling in the regulation of spermatogenesis. Cytogenet Genome Res (2004) 1.23
Molecular dissection of the male germ cell lineage identifies putative spermatogonial stem cells in rhesus macaques. Hum Reprod (2009) 1.21
Oocyte-like cells induced from mouse spermatogonial stem cells. Cell Biosci (2012) 1.16
Transgenerational effects of di-(2-ethylhexyl) phthalate on testicular germ cell associations and spermatogonial stem cells in mice. Biol Reprod (2013) 1.16
Nodal signaling via an autocrine pathway promotes proliferation of mouse spermatogonial stem/progenitor cells through Smad2/3 and Oct-4 activation. Stem Cells (2009) 1.15
PAX7 expression defines germline stem cells in the adult testis. J Clin Invest (2014) 1.13
Mechanistic insights into the regulation of the spermatogonial stem cell niche. Cell Cycle (2006) 1.12
Effects of ETV5 (ets variant gene 5) on testis and body growth, time course of spermatogonial stem cell loss, and fertility in mice. Biol Reprod (2007) 1.12
Phenotypic plasticity of mouse spermatogonial stem cells. PLoS One (2009) 1.11
Sertoli cells dictate spermatogonial stem cell niches in the mouse testis. Biol Reprod (2010) 1.11
Patterned expression of neurotrophic factors and receptors in human limbal and corneal regions. Mol Vis (2007) 1.11
Peritubular myoid cells participate in male mouse spermatogonial stem cell maintenance. Endocrinology (2014) 1.09
Spermatogonial stem cells, infertility and testicular cancer. J Cell Mol Med (2011) 1.09
The power of mouse genetics to study spermatogenesis. J Androl (2009) 1.08
GDNF promotes tubulogenesis of GFRalpha1-expressing MDCK cells by Src-mediated phosphorylation of Met receptor tyrosine kinase. J Cell Biol (2003) 1.08
Targeting the Gdnf Gene in peritubular myoid cells disrupts undifferentiated spermatogonial cell development. Proc Natl Acad Sci U S A (2016) 1.07
Spermatogonial stem cell self-renewal requires ETV5-mediated downstream activation of Brachyury in mice. Biol Reprod (2011) 1.07
Sin3a is required by sertoli cells to establish a niche for undifferentiated spermatogonia, germ cell tumors, and spermatid elongation. Stem Cells (2010) 1.06
Loss of Etv5 decreases proliferation and RET levels in neonatal mouse testicular germ cells and causes an abnormal first wave of spermatogenesis. Biol Reprod (2009) 1.05
SALL4 expression in gonocytes and spermatogonial clones of postnatal mouse testes. PLoS One (2013) 1.05
Germline stem cells: origin and destiny. Cell Stem Cell (2012) 1.04
CD34+ testicular stromal cells support long-term expansion of embryonic and adult stem and progenitor cells. Stem Cells (2008) 1.04
Recovery of fertility in azoospermia rats after injection of adipose-tissue-derived mesenchymal stem cells: the sperm generation. Biomed Res Int (2013) 1.02
Human spermatogonial stem cells: a possible origin for spermatocytic seminoma. Int J Androl (2011) 1.01
Loss of Dicer in Sertoli cells has a major impact on the testicular proteome of mice. Mol Cell Proteomics (2010) 1.01
Neurotrophic factor GDNF promotes survival of salivary stem cells. J Clin Invest (2014) 1.01
Long glucocorticoid-induced leucine zipper (L-GILZ) protein interacts with ras protein pathway and contributes to spermatogenesis control. J Biol Chem (2011) 1.01
Spermatogonial culture medium: an effective and efficient nutrient mixture for culturing rat spermatogonial stem cells. Biol Reprod (2009) 1.00
MiRNA-20 and mirna-106a regulate spermatogonial stem cell renewal at the post-transcriptional level via targeting STAT3 and Ccnd1. Stem Cells (2013) 0.99
ETV5 regulates sertoli cell chemokines involved in mouse stem/progenitor spermatogonia maintenance. Stem Cells (2010) 0.98
MicroRNAs 221 and 222 regulate the undifferentiated state in mammalian male germ cells. Development (2012) 0.97
The Drosophila cyst stem cell lineage: Partners behind the scenes? Spermatogenesis (2012) 0.96
PW1 gene/paternally expressed gene 3 (PW1/Peg3) identifies multiple adult stem and progenitor cell populations. Proc Natl Acad Sci U S A (2011) 0.96
Global gene expression and Ingenuity biological functions analysis on PCBs 153 and 138 induced human PBMC in vitro reveals differential mode(s) of action in developing toxicities. Environ Int (2011) 0.96
Stage-specific changes in GDNF expression by rat Sertoli cells: a possible regulator of the replication and differentiation of stem spermatogonia. Biol Reprod (2011) 0.95
Skp1-Cullin-F-box (SCF)-type ubiquitin ligase FBXW7 negatively regulates spermatogonial stem cell self-renewal. Proc Natl Acad Sci U S A (2014) 0.95
An immunoprotective privilege of corneal epithelial stem cells against Th17 inflammatory stress by producing glial cell-derived neurotrophic factor. Stem Cells (2010) 0.95
The KH-type RNA-binding protein PSI is required for Drosophila viability, male fertility, and cellular mRNA processing. Genes Dev (2002) 0.95
Constitutive activation of NOTCH1 signaling in Sertoli cells causes gonocyte exit from quiescence. Dev Biol (2013) 0.94
In vivo and in vitro aging is detrimental to mouse spermatogonial stem cell function. Biol Reprod (2010) 0.94
CXCL12-CXCR4 signaling is required for the maintenance of mouse spermatogonial stem cells. J Cell Sci (2012) 0.94
Mutation in the type IB bone morphogenetic protein receptor Alk6b impairs germ-cell differentiation and causes germ-cell tumors in zebrafish. Proc Natl Acad Sci U S A (2011) 0.94
Glial cell line-derived neurotrophic factor and endothelial cells promote self-renewal of rabbit germ cells with spermatogonial stem cell properties. FASEB J (2011) 0.93
The differential axonal degradation of Ret accounts for cell-type-specific function of glial cell line-derived neurotrophic factor as a retrograde survival factor. J Neurosci (2010) 0.93
Capacity for stochastic self-renewal and differentiation in mammalian spermatogonial stem cells. J Cell Biol (2009) 0.93
Transcriptional control of spermatogonial maintenance and differentiation. Semin Cell Dev Biol (2014) 0.93
NEUROG3 is a critical downstream effector for STAT3-regulated differentiation of mammalian stem and progenitor spermatogonia. Biol Reprod (2012) 0.92
Transmission distortion by loss of p21 or p27 cyclin-dependent kinase inhibitors following competitive spermatogonial transplantation. Proc Natl Acad Sci U S A (2010) 0.92
Role of glial cell line-derived neurotrophic factor in germ-line stem cell fate. Ann N Y Acad Sci (2005) 0.92
Functional differences between GDNF-dependent and FGF2-dependent mouse spermatogonial stem cell self-renewal. Stem Cell Reports (2015) 0.92
Ehd4 is required to attain normal prepubertal testis size but dispensable for fertility in male mice. Genesis (2010) 0.92
Retinoic acid regulates Kit translation during spermatogonial differentiation in the mouse. Dev Biol (2014) 0.91
Cyclical and patch-like GDNF distribution along the basal surface of Sertoli cells in mouse and hamster testes. PLoS One (2011) 0.91
Identification of glial cell line-derived neurotrophic factor-regulated genes important for spermatogonial stem cell self-renewal in the rat. Biol Reprod (2009) 0.91
Efficient in vivo manipulation of mouse genomic sequences at the zygote stage. Proc Natl Acad Sci U S A (1996) 12.92
Cyclopia and defective axial patterning in mice lacking Sonic hedgehog gene function. Nature (1996) 11.46
Targeted oncogene activation by site-specific recombination in transgenic mice. Proc Natl Acad Sci U S A (1992) 9.19
The integrated state of viral DNA in SV40-transformed cells. Proc Natl Acad Sci U S A (1968) 8.38
The K+/Cl- co-transporter KCC2 renders GABA hyperpolarizing during neuronal maturation. Nature (1999) 7.66
Targeted disruption of the alpha isoform of the peroxisome proliferator-activated receptor gene in mice results in abolishment of the pleiotropic effects of peroxisome proliferators. Mol Cell Biol (1995) 7.12
WT-1 is required for early kidney development. Cell (1993) 7.05
Hyperplasia of lymphatic vessels in VEGF-C transgenic mice. Science (1997) 6.37
The LIM-only protein Lmo2 is a bridging molecule assembling an erythroid, DNA-binding complex which includes the TAL1, E47, GATA-1 and Ldb1/NLI proteins. EMBO J (1997) 6.36
TGFbeta2 knockout mice have multiple developmental defects that are non-overlapping with other TGFbeta knockout phenotypes. Development (1997) 6.31
Viral DNA in polyoma- and SV40-transformed cell lines. Proc Natl Acad Sci U S A (1968) 4.24
Nonspecific acid esterase activity: a criterion for differentiation of T and B lymphocytes in mouse lymph nodes. Eur J Immunol (1975) 4.16
Defects in enteric innervation and kidney development in mice lacking GDNF. Nature (1996) 3.82
SV40 DNA strand selection by Escherichia coli RNA polymerase. J Mol Biol (1970) 3.77
A new test based on 'salting out' to measure relative surface hydrophobicity of bacterial cells. Biochim Biophys Acta (1981) 3.63
Essential role for Sonic hedgehog during hair follicle morphogenesis. Dev Biol (1999) 3.62
Sonic hedgehog is essential to foregut development. Nat Genet (1998) 3.50
Multiple promoters direct tissue-specific expression of the rat BDNF gene. Neuron (1993) 3.44
Oncogenesis of the lens in transgenic mice. Science (1987) 3.40
Early neonatal death in mice homozygous for a null allele of the insulin receptor gene. Nat Genet (1996) 3.40
Dickkopf1 is required for embryonic head induction and limb morphogenesis in the mouse. Dev Cell (2001) 3.30
Defective placental vasculogenesis causes embryonic lethality in VHL-deficient mice. Proc Natl Acad Sci U S A (1997) 3.27
Receptor for advanced glycation end products (RAGE)-mediated neurite outgrowth and activation of NF-kappaB require the cytoplasmic domain of the receptor but different downstream signaling pathways. J Biol Chem (1999) 3.12
Spliced adenovirus-associated virus RNA. Proc Natl Acad Sci U S A (1979) 2.99
Altered brain serotonin homeostasis and locomotor insensitivity to 3, 4-methylenedioxymethamphetamine ("Ecstasy") in serotonin transporter-deficient mice. Mol Pharmacol (1998) 2.94
Acute doxorubicin cardiotoxicity involves cardiomyocyte apoptosis. Cancer Res (2000) 2.84
Impaired host defense, hematopoiesis, granulomatous inflammation and type 1-type 2 cytokine balance in mice lacking CC chemokine receptor 1. J Exp Med (1997) 2.79
Coregulation of neurite outgrowth and cell survival by amphoterin and S100 proteins through receptor for advanced glycation end products (RAGE) activation. J Biol Chem (2000) 2.78
Spermiogenesis deficiency and germ-cell apoptosis in CREM-mutant mice. Nature (1996) 2.74
The structure of adenovirus 2 early nuclear and cytoplasmic RNAs. J Mol Biol (1980) 2.74
A quantitative study of spermatogonial multiplication and stem cell renewal in the C3H/101 F1 hybrid mouse. Mutat Res (1993) 2.73
Variable and tissue-specific hormone resistance in heterotrimeric Gs protein alpha-subunit (Gsalpha) knockout mice is due to tissue-specific imprinting of the gsalpha gene. Proc Natl Acad Sci U S A (1998) 2.71
E1A 13S and 12S mRNA products made in Escherichia coli both function as nucleus-localized transcription activators but do not directly bind DNA. Mol Cell Biol (1985) 2.68
Lhx2, a LIM homeobox gene, is required for eye, forebrain, and definitive erythrocyte development. Development (1997) 2.66
Functions of LIM-homeobox genes. Trends Genet (2000) 2.66
Mouse models of Tay-Sachs and Sandhoff diseases differ in neurologic phenotype and ganglioside metabolism. Nat Genet (1995) 2.64
Loop structures in hybrids of early RNA and the separated strands of adenovirus DNA. Proc Natl Acad Sci U S A (1977) 2.60
Early organogenesis of the kidney. Pediatr Nephrol (1987) 2.60
Interactions of the LIM-domain-binding factor Ldb1 with LIM homeodomain proteins. Nature (1996) 2.57
LIM homeodomain factors Lhx3 and Lhx4 assign subtype identities for motor neurons. Cell (1998) 2.50
Apoptosis in human acute myocardial infarction. Circulation (1997) 2.45
Sox9 induces testis development in XX transgenic mice. Nat Genet (2001) 2.43
Nonmuscle myosin II-B is required for normal development of the mouse heart. Proc Natl Acad Sci U S A (1997) 2.35
A cascade of adenovirus early functions is required for expression of adeno-associated virus. Cell (1981) 2.33
Lens-specific expression and developmental regulation of the bacterial chloramphenicol acetyltransferase gene driven by the murine alpha A-crystallin promoter in transgenic mice. Proc Natl Acad Sci U S A (1985) 2.22
GDNF signalling through the Ret receptor tyrosine kinase. Nature (1996) 2.21
Differential expression of c-kit in mouse undifferentiated and differentiating type A spermatogonia. Endocrinology (1999) 2.18
Specification of pituitary cell lineages by the LIM homeobox gene Lhx3. Science (1996) 2.18
Apoptosis in testis germ cells: developmental changes in gonadotropin dependence and localization to selective tubule stages. Endocrinology (1995) 2.14
Vasculogenesis and angiogenesis in embryonic-stem-cell-derived embryoid bodies. Development (1988) 2.12
T cell development in mice that lack the zeta chain of the T cell antigen receptor complex. Science (1993) 2.06
Cardiomyocyte apoptosis and progression of heart failure to transplantation. Eur J Clin Invest (1999) 2.06
Glial-cell-line-derived neurotrophic factor is required for bud initiation from ureteric epithelium. Development (1997) 2.05
Male sterility and enhanced radiation sensitivity in TLS(-/-) mice. EMBO J (2000) 2.05
Re-assessment of Boyden's technique for measuring chemotaxis. J Immunol Methods (1972) 2.05
Association of cortactin with dynamic actin in lamellipodia and on endosomal vesicles. J Cell Sci (2000) 2.04
Length measurements of RNA synthesized in vitro by Escherichia coli RNA polymerase. J Mol Biol (1973) 2.02
Muscle-eye-brain disease (MEB) Brain Dev (1989) 2.00
Distinct but overlapping roles of histone acetylase PCAF and of the closely related PCAF-B/GCN5 in mouse embryogenesis. Proc Natl Acad Sci U S A (2000) 1.99
Mouse MutS-like protein Msh5 is required for proper chromosome synapsis in male and female meiosis. Genes Dev (1999) 1.95
Late arrest of spermiogenesis and germ cell apoptosis in mice lacking the TBP-like TLF/TRF2 gene. Mol Cell (2001) 1.94
An enhancer/locus control region is not sufficient to open chromatin. Mol Cell Biol (1993) 1.93
Functions of purified E1A protein microinjected into mammalian cells. Proc Natl Acad Sci U S A (1984) 1.92
Intervening polyadenylate sequences in RNA transcripts of vesicular stomatitis virus. Cell (1978) 1.92
Glucose-6-phosphatase dependent substrate transport in the glycogen storage disease type-1a mouse. Nat Genet (1996) 1.88
The O75X adhesin of uropathogenic Escherichia coli is a type IV collagen-binding protein. Mol Microbiol (1989) 1.87
A truncated laminin chain homologous to the B2 chain: structure, spatial expression, and chromosomal assignment. J Cell Biol (1992) 1.84
The structural basis of the different affinities of two types of acidic N-glycosidic glycopeptides for concanavalin A--sepharose. FEBS Lett (1976) 1.84
Differentiation and oncogenesis: phenotypically distinct lens tumors in transgenic mice. New Biol (1989) 1.82
Site-independent expression of the chicken beta A-globin gene in transgenic mice. Nature (1991) 1.82
Multistep control of pituitary organogenesis. Science (1997) 1.82
Strain and gender differences in the behavior of mouse lines commonly used in transgenic studies. Physiol Behav (2001) 1.81
Brain-derived neurotrophic factor and neurotrophin 3 mRNAs in the peripheral target fields of developing inner ear ganglia. Proc Natl Acad Sci U S A (1992) 1.76
Functional relationship between obesity and male reproduction: from humans to animal models. Hum Reprod Update (2011) 1.76
Rescue of hearing, auditory hair cells, and neurons by CEP-1347/KT7515, an inhibitor of c-Jun N-terminal kinase activation. J Neurosci (2000) 1.75
Specific antibody within lymphoid germinal center cells of mice after primary immunization with horseradish peroxidase: a light and electron microscopic study. J Exp Med (1970) 1.75
Expression patterns of neurotrophin and their receptor mRNAs in the rat inner ear. Hear Res (1993) 1.73
Long-term individual housing in C57BL/6J and DBA/2 mice: assessment of behavioral consequences. Genes Brain Behav (2005) 1.70
Viral encephalitis: a review of diagnostic methods and guidelines for management. Eur J Neurol (2005) 1.69
Formation of Rathke's pouch requires dual induction from the diencephalon. Development (1998) 1.68
Targeting bacteriophage T7 RNA polymerase to the mammalian cell nucleus. Gene (1988) 1.67
Abnormal structure and expression of the p53 gene in human ovarian carcinoma cell lines. Cancer Res (1992) 1.64
Tissue-specific expression in transgenic mice of a fused gene containing RSV terminal sequences. Science (1986) 1.64
The LIM homeobox gene Lhx9 is essential for mouse gonad formation. Nature (2000) 1.61
GDNF family neurotrophic factor signaling: four masters, one servant? Mol Cell Neurosci (1999) 1.59
Functional overlap between murine Inpp5b and Ocrl1 may explain why deficiency of the murine ortholog for OCRL1 does not cause Lowe syndrome in mice. J Clin Invest (1998) 1.59
Late endosomal traffic of the epidermal growth factor receptor ensures spatial and temporal fidelity of mitogen-activated protein kinase signaling. Mol Biol Cell (2007) 1.57
Regulation of the seminiferous epithelium. Endocr Rev (1982) 1.57
Human laminin M chain (merosin): complete primary structure, chromosomal assignment, and expression of the M and A chain in human fetal tissues. J Cell Biol (1994) 1.57
Real-time observation of acrosomal dispersal from mouse sperm using GFP as a marker protein. FEBS Lett (1999) 1.57
Mapping of adenovirus messenger RNA by electron microscopy. Proc Natl Acad Sci U S A (1976) 1.56
Dependence of kidney morphogenesis on the expression of nerve growth factor receptor. Science (1991) 1.54