Folate levels modulate oncogene-induced replication stress and tumorigenicity.

PubWeight™: 0.82‹?›

🔗 View Article (PMC 4568948)

Published in EMBO Mol Med on July 21, 2015

Authors

Noa Lamm1, Karin Maoz1, Assaf C Bester1, Michael M Im2, Donna S Shewach2, Rotem Karni3, Batsheva Kerem4

Author Affiliations

1: Department of Genetics, The Alexander Silberman Institute of Life Sciences Edmond J. Safra Campus The Hebrew University of Jerusalem, Jerusalem, Israel.
2: Department of Pharmacology, University of Michigan Medical Center, Ann Arbor, MI, USA.
3: Department of Biochemistry and Molecular Biology, Institute for Medical Research Israel-Canada The Hebrew University-Hadassah Medical School, Jerusalem, Israel.
4: Department of Genetics, The Alexander Silberman Institute of Life Sciences Edmond J. Safra Campus The Hebrew University of Jerusalem, Jerusalem, Israel kerem@cc.huji.ac.il.

Articles cited by this

Hallmarks of cancer: the next generation. Cell (2011) 140.01

Genetic instabilities in human cancers. Nature (1998) 22.76

Extension of life-span by introduction of telomerase into normal human cells. Science (1998) 20.48

DNA damage response as a candidate anti-cancer barrier in early human tumorigenesis. Nature (2005) 18.30

Activation of the DNA damage checkpoint and genomic instability in human precancerous lesions. Nature (2005) 14.65

Cell-cycle checkpoints and cancer. Nature (2004) 13.19

An oncogene-induced DNA damage model for cancer development. Science (2008) 11.60

Oncogene-induced senescence is a DNA damage response triggered by DNA hyper-replication. Nature (2006) 11.18

Ras oncogenes: split personalities. Nat Rev Mol Cell Biol (2008) 7.91

Interactome networks and human disease. Cell (2011) 7.16

Genomic instability--an evolving hallmark of cancer. Nat Rev Mol Cell Biol (2010) 7.11

Nucleotide deficiency promotes genomic instability in early stages of cancer development. Cell (2011) 4.83

Deregulated cyclin E induces chromosome instability. Nature (1999) 4.75

Dormant origins licensed by excess Mcm2-7 are required for human cells to survive replicative stress. Genes Dev (2007) 4.60

Hydroxyurea-stalled replication forks become progressively inactivated and require two different RAD51-mediated pathways for restart and repair. Mol Cell (2010) 4.57

Folate deficiency causes uracil misincorporation into human DNA and chromosome breakage: implications for cancer and neuronal damage. Proc Natl Acad Sci U S A (1997) 4.38

Dynamics of DNA replication in mammalian somatic cells: nucleotide pool modulates origin choice and interorigin spacing. Cell (2003) 4.24

Cyclin E in normal and neoplastic cell cycles. Oncogene (2005) 3.16

Alcohol, low-methionine--low-folate diets, and risk of colon cancer in men. J Natl Cancer Inst (1995) 3.10

Methotrexate/6-mercaptopurine maintenance therapy influences the risk of a second malignant neoplasm after childhood acute lymphoblastic leukemia: results from the NOPHO ALL-92 study. Blood (2009) 2.53

Deregulation of cyclin E in human cells interferes with prereplication complex assembly. J Cell Biol (2004) 2.48

Chk1 regulates the density of active replication origins during the vertebrate S phase. EMBO J (2007) 2.44

Replication fork movement sets chromatin loop size and origin choice in mammalian cells. Nature (2008) 2.36

Folate and carcinogenesis: evidence, mechanisms, and implications. J Nutr Biochem (1999) 2.28

Cancer chromosomal instability: therapeutic and diagnostic challenges. EMBO Rep (2012) 2.28

The human Ha-ras oncogene induces genomic instability in murine fibroblasts within one cell cycle. Proc Natl Acad Sci U S A (1994) 2.15

Nutrient intake and risk of subtypes of esophageal and gastric cancer. Cancer Epidemiol Biomarkers Prev (2001) 2.13

Molecular basis of antifolate resistance. Cancer Metastasis Rev (2007) 2.02

Folylpolyglutamate synthesis and role in the regulation of one-carbon metabolism. Vitam Horm (1989) 1.94

Folate status: effects on pathways of colorectal carcinogenesis. J Nutr (2002) 1.88

Oncogene-induced replication stress preferentially targets common fragile sites in preneoplastic lesions. A genome-wide study. Oncogene (2007) 1.85

A prospective study of folate intake and the risk of breast cancer. JAMA (1999) 1.83

Role of folate in colon cancer development and progression. J Nutr (2003) 1.73

DNA replication origin interference increases the spacing between initiation events in human cells. Mol Biol Cell (2006) 1.66

Rad51-mediated replication fork reversal is a global response to genotoxic treatments in human cells. J Cell Biol (2015) 1.65

DNA replication and oncogene-induced replicative stress. Curr Biol (2014) 1.54

Increased replication initiation and conflicts with transcription underlie Cyclin E-induced replication stress. Oncogene (2012) 1.48

DNA instability (strand breakage, uracil misincorporation, and defective repair) is increased by folic acid depletion in human lymphocytes in vitro. FASEB J (1998) 1.46

Folate and cancer: how DNA damage, repair and methylation impact on colon carcinogenesis. J Inherit Metab Dis (2010) 1.40

Antifolates in cancer therapy: structure, activity and mechanisms of drug resistance. Drug Resist Updat (2012) 1.37

Are vitamin and mineral deficiencies a major cancer risk? Nat Rev Cancer (2002) 1.34

Dietary folate consumption and breast cancer risk. J Natl Cancer Inst (2000) 1.32

Folate deficiency in vitro induces uracil misincorporation and DNA hypomethylation and inhibits DNA excision repair in immortalized normal human colon epithelial cells. Nutr Cancer (2000) 1.29

Depletion of deoxyribonucleotide pools is an endogenous source of DNA damage in cells undergoing oncogene-induced senescence. Am J Pathol (2012) 1.27

The complex basis underlying common fragile site instability in cancer. Trends Genet (2012) 1.25

Folate and cancer prevention: a new medical application of folate beyond hyperhomocysteinemia and neural tube defects. Nutr Rev (1999) 1.21

Folate (vitamin B9) and vitamin B12 and their function in the maintenance of nuclear and mitochondrial genome integrity. Mutat Res (2011) 1.17

The role of diet and nutrition in cervical carcinogenesis: a review of recent evidence. Int J Cancer (2005) 1.17

Folate synthesized by bacteria in the human upper small intestine is assimilated by the host. Gastroenterology (1996) 1.14

Presence and consequence of uracil in preneoplastic DNA from folate/methyl-deficient rats. Carcinogenesis (1997) 1.11

Mismatched nucleotides as the lesions responsible for radiosensitization with gemcitabine: a new paradigm for antimetabolite radiosensitizers. Mol Cancer Ther (2007) 1.10

Folic acid deficiency increases chromosomal instability, chromosome 21 aneuploidy and sensitivity to radiation-induced micronuclei. Mutat Res (2005) 1.06

Uracil misincorporation, DNA strand breaks, and gene amplification are associated with tumorigenic cell transformation in folate deficient/repleted Chinese hamster ovary cells. Cancer Lett (1999) 1.06

Relationship of folate to colorectal and cervical cancer: review and recommendations for practitioners. J Am Diet Assoc (2002) 1.01

Diet-induced DNA damage and altered nucleotide metabolism in lymphocytes from methyl-donor-deficient rats. Carcinogenesis (1989) 1.01

Ras induces chromosome instability and abrogation of the DNA damage response. Cancer Res (2006) 0.99

'Spontaneous' genetic damage in man: evaluation of interindividual variability, relationship among markers of damage, and influence of nutritional status. Mutat Res (1997) 0.98

Introduction to molecular combing: genomics, DNA replication, and cancer. Methods Mol Biol (2009) 0.90

Uracil misincorporation in human DNA detected using single cell gel electrophoresis. Carcinogenesis (1997) 0.88

The response of human colonocytes to folate deficiency in vitro: functional and proteomic analyses. J Proteome Res (2008) 0.86

Role of vitamin B12 and folate deficiencies in carcinogenesis. Adv Exp Med Biol (1986) 0.86

Increased chromosome fragility as a consequence of blood folate levels, smoking status, and coffee consumption. Environ Mol Mutagen (1989) 0.84

DNA stability and genomic methylation status in colonocytes isolated from methyl-donor-deficient rats. Eur J Nutr (2000) 0.81

Influence of physiologic folate deficiency on human papillomavirus type 16 (HPV16)-harboring human keratinocytes in vitro and in vivo. J Biol Chem (2012) 0.79